Trends in anemia management in US hemodialysis patients 2004–2010 View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-12

AUTHORS

Dana C Miskulin, Jing Zhou, Navdeep Tangri, Karen Bandeen-Roche, Courtney Cook, Patti L Ephraim, Deidra C Crews, Julia J Scialla, Stephen M Sozio, Tariq Shafi, Bernard G Jaar, L Ebony Boulware, The DEcIDE Network Patient Outcomes in End Stage Renal Disease Study Investigators

ABSTRACT

BACKGROUND: There have been major changes in the management of anemia in US hemodialysis patients in recent years. We sought to determine the influence of clinical trial results, safety regulations, and changes in reimbursement policy on practice. METHODS: We examined indicators of anemia management among incident and prevalent hemodialysis patients from a medium-sized dialysis provider over three time periods: (1) 2004 to 2006 (2) 2007 to 2009, and (3) 2010. Trends across the three time periods were compared using generalized estimating equations. RESULTS: Prior to 2007, the median proportion of patients with monthly hemoglobin >12 g/dL for patients on dialysis 0 to 3, 4 to 6 and 7 to 18 months, respectively, was 42%, 55% and 46% declined to 41%, 54%, and 40% after 2007, and declined more sharply in 2010 to 34%, 41%, and 30%. Median weekly Epoeitin alpha doses over the same periods were 18,000, 12,400, and 9,100 units before 2007; remained relatively unchanged from 2007 to 2009; and decreased sharply in the patients 3-6 and 6-18 months on dialysis to 10,200 and 7,800 units, respectively in 2010. Iron doses, serum ferritin, and transferrin saturation levels increased over time with more pronounced increases in 2010. CONCLUSION: Modest changes in anemia management occurred between 2007 and 2009, followed by more dramatic changes in 2010. Studies are needed to examine the effects of declining erythropoietin use and hemoglobin levels and increasing intravenous iron use on quality of life, transplantation rates, infection rates and survival. More... »

PAGES

264

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1471-2369-14-264

DOI

http://dx.doi.org/10.1186/1471-2369-14-264

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1000511799

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24289058


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Public Health and Health Services", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anemia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Causality", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Comorbidity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Incidence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Practice Patterns, Physicians'", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Renal Dialysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Renal Insufficiency, Chronic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Rate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "United States", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Young Adult", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Tufts Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.67033.31", 
          "name": [
            "Division of Nephrology, Tufts University School of Medicine, Boston, MA, USA", 
            "Tufts Medical Center, 800 Washington St., 02111, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miskulin", 
        "givenName": "Dana C", 
        "id": "sg:person.01232362222.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232362222.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Division of General Internal Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA", 
            "Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhou", 
        "givenName": "Jing", 
        "id": "sg:person.0747143641.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747143641.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Manitoba", 
          "id": "https://www.grid.ac/institutes/grid.21613.37", 
          "name": [
            "Division of Nephrology, University of Manitoba, Winnipeg, Manitoba, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tangri", 
        "givenName": "Navdeep", 
        "id": "sg:person.0735754242.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735754242.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bandeen-Roche", 
        "givenName": "Karen", 
        "id": "sg:person.0643364144.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643364144.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Division of General Internal Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cook", 
        "givenName": "Courtney", 
        "id": "sg:person.01121273022.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121273022.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA", 
            "Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ephraim", 
        "givenName": "Patti L", 
        "id": "sg:person.01277773522.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277773522.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD, USA", 
            "Division of Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Crews", 
        "givenName": "Deidra C", 
        "id": "sg:person.01066126366.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066126366.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Miami", 
          "id": "https://www.grid.ac/institutes/grid.26790.3a", 
          "name": [
            "Department of Medicine, University of Miami School of Medicine, Miami, FL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Scialla", 
        "givenName": "Julia J", 
        "id": "sg:person.01153162150.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153162150.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD, USA", 
            "Division of Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sozio", 
        "givenName": "Stephen M", 
        "id": "sg:person.01357143434.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357143434.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD, USA", 
            "Division of Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shafi", 
        "givenName": "Tariq", 
        "id": "sg:person.0640673150.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640673150.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA", 
            "Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD, USA", 
            "Division of Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD, USA", 
            "Nephrology Center of Maryland, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jaar", 
        "givenName": "Bernard G", 
        "id": "sg:person.01335523750.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335523750.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Division of General Internal Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA", 
            "Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA", 
            "Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Boulware", 
        "givenName": "L Ebony", 
        "id": "sg:person.01274500717.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274500717.95"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "The DEcIDE Network Patient Outcomes in End Stage Renal Disease Study Investigators", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1681/asn.2006091034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002301102"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1681/asn.2006091034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002301102"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.ajkd.2012.10.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003795049"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199808273390903", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006538676"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.ajkd.2009.07.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012200204"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmp0912328", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015355426"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejme068233", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024811691"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa062276", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026055656"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa0907845", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038088933"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa065485", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044180198"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078478746", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-12", 
    "datePublishedReg": "2013-12-01", 
    "description": "BACKGROUND: There have been major changes in the management of anemia in US hemodialysis patients in recent years. We sought to determine the influence of clinical trial results, safety regulations, and changes in reimbursement policy on practice.\nMETHODS: We examined indicators of anemia management among incident and prevalent hemodialysis patients from a medium-sized dialysis provider over three time periods: (1) 2004 to 2006 (2) 2007 to 2009, and (3) 2010. Trends across the three time periods were compared using generalized estimating equations.\nRESULTS: Prior to 2007, the median proportion of patients with monthly hemoglobin >12 g/dL for patients on dialysis 0 to 3, 4 to 6 and 7 to 18 months, respectively, was 42%, 55% and 46% declined to 41%, 54%, and 40% after 2007, and declined more sharply in 2010 to 34%, 41%, and 30%. Median weekly Epoeitin alpha doses over the same periods were 18,000, 12,400, and 9,100 units before 2007; remained relatively unchanged from 2007 to 2009; and decreased sharply in the patients 3-6 and 6-18 months on dialysis to 10,200 and 7,800 units, respectively in 2010. Iron doses, serum ferritin, and transferrin saturation levels increased over time with more pronounced increases in 2010.\nCONCLUSION: Modest changes in anemia management occurred between 2007 and 2009, followed by more dramatic changes in 2010. Studies are needed to examine the effects of declining erythropoietin use and hemoglobin levels and increasing intravenous iron use on quality of life, transplantation rates, infection rates and survival.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/1471-2369-14-264", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2419045", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2418952", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2419038", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1024626", 
        "issn": [
          "1471-2369"
        ], 
        "name": "BMC Nephrology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "14"
      }
    ], 
    "name": "Trends in anemia management in US hemodialysis patients 2004\u20132010", 
    "pagination": "264", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "026f9a4257ce24ef8f547f52e435b562ba2a31a0c70de95b81df537fa09faf2c"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "24289058"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100967793"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1471-2369-14-264"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1000511799"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1471-2369-14-264", 
      "https://app.dimensions.ai/details/publication/pub.1000511799"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T19:59", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8681_00000519.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2F1471-2369-14-264"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1471-2369-14-264'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1471-2369-14-264'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1471-2369-14-264'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1471-2369-14-264'


 

This table displays all metadata directly associated to this object as RDF triples.

275 TRIPLES      21 PREDICATES      58 URIs      40 LITERALS      28 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1471-2369-14-264 schema:about N13347e03fcff4647b146b17496fbe286
2 N1a4cc6a6b42f407b8f0e9bf6d3f591f6
3 N1d496a1a99d34afd8290f046dd8e40f5
4 N3ad4070d7f564d8d832ced2a8b31a39d
5 N40ae79b570904169895ef8330216f50d
6 N4795a33b6fae4fdf94d37d2cbf0d9e42
7 N537be5a8d5e74af2a7be3cd98db33ece
8 N57db3330bb6f418b82d8797ff33560b7
9 N5d2e02ab74f94820b80644f9a4972c06
10 N64ba36f15055474987a6e6c3ac3cb4f4
11 N6ae889e9c069493cab37fd8a4c90fb11
12 N8152a255a5414446923ef01a8b4cf9ac
13 N87f75ac2e1ac4ba6a066cf3eebd91535
14 Na3f47c10260349e5a992724b4dd67846
15 Na58c57cead494f139197b7a1b224743f
16 Naf4692e8e3f74481840fcd47267d4d76
17 Ncc6cb94e06424251a200bc3e367c2265
18 Ne7a473f7ce684d2485321ad90c4f7a68
19 Nf11b08fdfa3e4e50afe789084fdc9342
20 anzsrc-for:11
21 anzsrc-for:1117
22 schema:author N642ebedf15a34d06b59bbf29f4d617c6
23 schema:citation https://app.dimensions.ai/details/publication/pub.1078478746
24 https://doi.org/10.1053/j.ajkd.2009.07.010
25 https://doi.org/10.1053/j.ajkd.2012.10.002
26 https://doi.org/10.1056/nejm199808273390903
27 https://doi.org/10.1056/nejme068233
28 https://doi.org/10.1056/nejmoa062276
29 https://doi.org/10.1056/nejmoa065485
30 https://doi.org/10.1056/nejmoa0907845
31 https://doi.org/10.1056/nejmp0912328
32 https://doi.org/10.1681/asn.2006091034
33 schema:datePublished 2013-12
34 schema:datePublishedReg 2013-12-01
35 schema:description BACKGROUND: There have been major changes in the management of anemia in US hemodialysis patients in recent years. We sought to determine the influence of clinical trial results, safety regulations, and changes in reimbursement policy on practice. METHODS: We examined indicators of anemia management among incident and prevalent hemodialysis patients from a medium-sized dialysis provider over three time periods: (1) 2004 to 2006 (2) 2007 to 2009, and (3) 2010. Trends across the three time periods were compared using generalized estimating equations. RESULTS: Prior to 2007, the median proportion of patients with monthly hemoglobin >12 g/dL for patients on dialysis 0 to 3, 4 to 6 and 7 to 18 months, respectively, was 42%, 55% and 46% declined to 41%, 54%, and 40% after 2007, and declined more sharply in 2010 to 34%, 41%, and 30%. Median weekly Epoeitin alpha doses over the same periods were 18,000, 12,400, and 9,100 units before 2007; remained relatively unchanged from 2007 to 2009; and decreased sharply in the patients 3-6 and 6-18 months on dialysis to 10,200 and 7,800 units, respectively in 2010. Iron doses, serum ferritin, and transferrin saturation levels increased over time with more pronounced increases in 2010. CONCLUSION: Modest changes in anemia management occurred between 2007 and 2009, followed by more dramatic changes in 2010. Studies are needed to examine the effects of declining erythropoietin use and hemoglobin levels and increasing intravenous iron use on quality of life, transplantation rates, infection rates and survival.
36 schema:genre research_article
37 schema:inLanguage en
38 schema:isAccessibleForFree true
39 schema:isPartOf N2626dcc12e2a4c1dbafb115418372b26
40 N3c9cc2f2be9448158da6768d26d55540
41 sg:journal.1024626
42 schema:name Trends in anemia management in US hemodialysis patients 2004–2010
43 schema:pagination 264
44 schema:productId N5a8c6d1558b14d2fb94164e9e042fd31
45 Na93f36238031414db6cc635337457650
46 Na99a084cfb2c4c53a5741eb1c29dc31f
47 Nc4153633b88b44bb9ca20c393c962e63
48 Ndb5a52db8f504c519df6061d94b13f79
49 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000511799
50 https://doi.org/10.1186/1471-2369-14-264
51 schema:sdDatePublished 2019-04-10T19:59
52 schema:sdLicense https://scigraph.springernature.com/explorer/license/
53 schema:sdPublisher N69443653afda4b23b7ad40bc6ff56651
54 schema:url http://link.springer.com/10.1186%2F1471-2369-14-264
55 sgo:license sg:explorer/license/
56 sgo:sdDataset articles
57 rdf:type schema:ScholarlyArticle
58 N13347e03fcff4647b146b17496fbe286 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
59 schema:name Causality
60 rdf:type schema:DefinedTerm
61 N18e222992e46460e8d5caa91944e9456 rdf:first sg:person.01066126366.34
62 rdf:rest N98726beb84744c34a562ddfebaf509de
63 N1a4cc6a6b42f407b8f0e9bf6d3f591f6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
64 schema:name Female
65 rdf:type schema:DefinedTerm
66 N1d496a1a99d34afd8290f046dd8e40f5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
67 schema:name Humans
68 rdf:type schema:DefinedTerm
69 N2626dcc12e2a4c1dbafb115418372b26 schema:volumeNumber 14
70 rdf:type schema:PublicationVolume
71 N37d1c94aa0fc4398912900adf0c6eae8 rdf:first sg:person.0643364144.68
72 rdf:rest Nebe5eca51c464ee5a11df71e2cf8a82d
73 N3ad4070d7f564d8d832ced2a8b31a39d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
74 schema:name Practice Patterns, Physicians'
75 rdf:type schema:DefinedTerm
76 N3c9cc2f2be9448158da6768d26d55540 schema:issueNumber 1
77 rdf:type schema:PublicationIssue
78 N40ae79b570904169895ef8330216f50d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Risk Factors
80 rdf:type schema:DefinedTerm
81 N4690321f8cbe433192c9d4989964837c rdf:first sg:person.01357143434.44
82 rdf:rest N88de38a02dc54f82ae015a8658c0c99b
83 N4795a33b6fae4fdf94d37d2cbf0d9e42 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Comorbidity
85 rdf:type schema:DefinedTerm
86 N52cdb44fbfad4938a9e2a6d1e68e93b2 rdf:first N9a15e3c57a52451aa9d32d1aa3a244ec
87 rdf:rest rdf:nil
88 N537be5a8d5e74af2a7be3cd98db33ece schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Young Adult
90 rdf:type schema:DefinedTerm
91 N57db3330bb6f418b82d8797ff33560b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Aged
93 rdf:type schema:DefinedTerm
94 N5a8c6d1558b14d2fb94164e9e042fd31 schema:name dimensions_id
95 schema:value pub.1000511799
96 rdf:type schema:PropertyValue
97 N5d2e02ab74f94820b80644f9a4972c06 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Adolescent
99 rdf:type schema:DefinedTerm
100 N642ebedf15a34d06b59bbf29f4d617c6 rdf:first sg:person.01232362222.40
101 rdf:rest N955a273861d64bbea936b4ecbea2dafb
102 N64ba36f15055474987a6e6c3ac3cb4f4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Anemia
104 rdf:type schema:DefinedTerm
105 N684c5aa9f79940b69c5c0e930797ca92 rdf:first sg:person.0735754242.18
106 rdf:rest N37d1c94aa0fc4398912900adf0c6eae8
107 N69443653afda4b23b7ad40bc6ff56651 schema:name Springer Nature - SN SciGraph project
108 rdf:type schema:Organization
109 N6ae889e9c069493cab37fd8a4c90fb11 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name United States
111 rdf:type schema:DefinedTerm
112 N8152a255a5414446923ef01a8b4cf9ac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Renal Dialysis
114 rdf:type schema:DefinedTerm
115 N87f75ac2e1ac4ba6a066cf3eebd91535 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Aged, 80 and over
117 rdf:type schema:DefinedTerm
118 N88de38a02dc54f82ae015a8658c0c99b rdf:first sg:person.0640673150.67
119 rdf:rest Nee0f11187c844818a1bcd434af03fb2f
120 N955a273861d64bbea936b4ecbea2dafb rdf:first sg:person.0747143641.89
121 rdf:rest N684c5aa9f79940b69c5c0e930797ca92
122 N98726beb84744c34a562ddfebaf509de rdf:first sg:person.01153162150.73
123 rdf:rest N4690321f8cbe433192c9d4989964837c
124 N9a15e3c57a52451aa9d32d1aa3a244ec schema:familyName The DEcIDE Network Patient Outcomes in End Stage Renal Disease Study Investigators
125 rdf:type schema:Person
126 Na3f47c10260349e5a992724b4dd67846 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Incidence
128 rdf:type schema:DefinedTerm
129 Na58c57cead494f139197b7a1b224743f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Male
131 rdf:type schema:DefinedTerm
132 Na93f36238031414db6cc635337457650 schema:name pubmed_id
133 schema:value 24289058
134 rdf:type schema:PropertyValue
135 Na99a084cfb2c4c53a5741eb1c29dc31f schema:name readcube_id
136 schema:value 026f9a4257ce24ef8f547f52e435b562ba2a31a0c70de95b81df537fa09faf2c
137 rdf:type schema:PropertyValue
138 Naf4692e8e3f74481840fcd47267d4d76 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Middle Aged
140 rdf:type schema:DefinedTerm
141 Nc4153633b88b44bb9ca20c393c962e63 schema:name doi
142 schema:value 10.1186/1471-2369-14-264
143 rdf:type schema:PropertyValue
144 Ncc6cb94e06424251a200bc3e367c2265 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Survival Rate
146 rdf:type schema:DefinedTerm
147 Nd0f54e20fda8418a9e7f9514c70658c3 rdf:first sg:person.01274500717.95
148 rdf:rest N52cdb44fbfad4938a9e2a6d1e68e93b2
149 Ndb5a52db8f504c519df6061d94b13f79 schema:name nlm_unique_id
150 schema:value 100967793
151 rdf:type schema:PropertyValue
152 Ne7a473f7ce684d2485321ad90c4f7a68 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Renal Insufficiency, Chronic
154 rdf:type schema:DefinedTerm
155 Nebe5eca51c464ee5a11df71e2cf8a82d rdf:first sg:person.01121273022.04
156 rdf:rest Nf8c75fd476db46e3933c6950023c2c5b
157 Nee0f11187c844818a1bcd434af03fb2f rdf:first sg:person.01335523750.44
158 rdf:rest Nd0f54e20fda8418a9e7f9514c70658c3
159 Nf11b08fdfa3e4e50afe789084fdc9342 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Adult
161 rdf:type schema:DefinedTerm
162 Nf8c75fd476db46e3933c6950023c2c5b rdf:first sg:person.01277773522.13
163 rdf:rest N18e222992e46460e8d5caa91944e9456
164 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
165 schema:name Medical and Health Sciences
166 rdf:type schema:DefinedTerm
167 anzsrc-for:1117 schema:inDefinedTermSet anzsrc-for:
168 schema:name Public Health and Health Services
169 rdf:type schema:DefinedTerm
170 sg:grant.2418952 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2369-14-264
171 rdf:type schema:MonetaryGrant
172 sg:grant.2419038 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2369-14-264
173 rdf:type schema:MonetaryGrant
174 sg:grant.2419045 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2369-14-264
175 rdf:type schema:MonetaryGrant
176 sg:journal.1024626 schema:issn 1471-2369
177 schema:name BMC Nephrology
178 rdf:type schema:Periodical
179 sg:person.01066126366.34 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
180 schema:familyName Crews
181 schema:givenName Deidra C
182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066126366.34
183 rdf:type schema:Person
184 sg:person.01121273022.04 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
185 schema:familyName Cook
186 schema:givenName Courtney
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121273022.04
188 rdf:type schema:Person
189 sg:person.01153162150.73 schema:affiliation https://www.grid.ac/institutes/grid.26790.3a
190 schema:familyName Scialla
191 schema:givenName Julia J
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153162150.73
193 rdf:type schema:Person
194 sg:person.01232362222.40 schema:affiliation https://www.grid.ac/institutes/grid.67033.31
195 schema:familyName Miskulin
196 schema:givenName Dana C
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232362222.40
198 rdf:type schema:Person
199 sg:person.01274500717.95 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
200 schema:familyName Boulware
201 schema:givenName L Ebony
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274500717.95
203 rdf:type schema:Person
204 sg:person.01277773522.13 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
205 schema:familyName Ephraim
206 schema:givenName Patti L
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277773522.13
208 rdf:type schema:Person
209 sg:person.01335523750.44 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
210 schema:familyName Jaar
211 schema:givenName Bernard G
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335523750.44
213 rdf:type schema:Person
214 sg:person.01357143434.44 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
215 schema:familyName Sozio
216 schema:givenName Stephen M
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357143434.44
218 rdf:type schema:Person
219 sg:person.0640673150.67 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
220 schema:familyName Shafi
221 schema:givenName Tariq
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640673150.67
223 rdf:type schema:Person
224 sg:person.0643364144.68 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
225 schema:familyName Bandeen-Roche
226 schema:givenName Karen
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643364144.68
228 rdf:type schema:Person
229 sg:person.0735754242.18 schema:affiliation https://www.grid.ac/institutes/grid.21613.37
230 schema:familyName Tangri
231 schema:givenName Navdeep
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735754242.18
233 rdf:type schema:Person
234 sg:person.0747143641.89 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
235 schema:familyName Zhou
236 schema:givenName Jing
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747143641.89
238 rdf:type schema:Person
239 https://app.dimensions.ai/details/publication/pub.1078478746 schema:CreativeWork
240 https://doi.org/10.1053/j.ajkd.2009.07.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012200204
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1053/j.ajkd.2012.10.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003795049
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1056/nejm199808273390903 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006538676
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1056/nejme068233 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024811691
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1056/nejmoa062276 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026055656
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1056/nejmoa065485 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044180198
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1056/nejmoa0907845 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038088933
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1056/nejmp0912328 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015355426
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1681/asn.2006091034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002301102
257 rdf:type schema:CreativeWork
258 https://www.grid.ac/institutes/grid.21107.35 schema:alternateName Johns Hopkins University
259 schema:name Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
260 Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
261 Division of General Internal Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA
262 Division of Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
263 Nephrology Center of Maryland, Baltimore, MD, USA
264 Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD, USA
265 rdf:type schema:Organization
266 https://www.grid.ac/institutes/grid.21613.37 schema:alternateName University of Manitoba
267 schema:name Division of Nephrology, University of Manitoba, Winnipeg, Manitoba, Canada
268 rdf:type schema:Organization
269 https://www.grid.ac/institutes/grid.26790.3a schema:alternateName University of Miami
270 schema:name Department of Medicine, University of Miami School of Medicine, Miami, FL, USA
271 rdf:type schema:Organization
272 https://www.grid.ac/institutes/grid.67033.31 schema:alternateName Tufts Medical Center
273 schema:name Division of Nephrology, Tufts University School of Medicine, Boston, MA, USA
274 Tufts Medical Center, 800 Washington St., 02111, Boston, MA, USA
275 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...