Lack of association of genetic variation in chromosome region 15q14-22.1 with type 2 diabetes in a Japanese population View Full Text


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Article Info

DATE

2008-03-27

AUTHORS

Yuka Yamaguchi, Maki Moritani, Toshihito Tanahashi, Dai Osabe, Kyoko Nomura, Yuka Fujita, Parvaneh Keshavarz, Kiyoshi Kunika, Naoto Nakamura, Toshikazu Yoshikawa, Eiichiro Ichiishi, Hiroshi Shiota, Natsuo Yasui, Hiroshi Inoue, Mitsuo Itakura

ABSTRACT

BackgroundChromosome 15q14-22.1 has been linked to type 2 diabetes (T2D) and its related traits in Japanese and other populations. The presence of T2D disease susceptibility variant(s) was assessed in the 21.8 Mb region between D15S118 and D15S117 in a Japanese population using a region-wide case-control association test.MethodsA two-stage association test was performed using Japanese subjects: The discovery panel (Stage 1) used 372 cases and 360 controls, while an independent replication panel (Stage 2) used 532 cases and 530 controls. A total of 1,317 evenly-spaced, common SNP markers with minor allele frequencies > 0.10 were typed for each stage. Captured genetic variation was examined in HapMap JPT SNPs, and a haplotype-based association test was performed.ResultsSNP2140 (rs2412747) (C/T) in intron 33 of the ubiquitin protein ligase E3 component n-recognin 1 (UBR1) gene was selected as a landmark SNP based on repeated significant associations in Stage 1 and Stage 2. However, the marginal p value (p = 0.0043 in the allelic test, OR = 1.26, 95% CI = 1.07–1.48 for combined samples) was weak in a single locus or haplotype-based association test. We failed to find any significant SNPs after correcting for multiple testing.ConclusionThe two-stage association test did not reveal a strong association between T2D and any common variants on chromosome 15q14-22.1 in 1,794 Japanese subjects. A further association test with a larger sample size and denser SNP markers is required to confirm these observations. More... »

PAGES

22

References to SciGraph publications

  • 1999-02. Loci on chromosomes 2 (NIDDM1) and 15 interact to increase susceptibility to diabetes in Mexican Americans in NATURE GENETICS
  • 2007-06. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls in NATURE
  • 2005-11-20. Deficiency of UBR1, a ubiquitin ligase of the N-end rule pathway, causes pancreatic dysfunction, malformations and mental retardation (Johanson-Blizzard syndrome) in NATURE GENETICS
  • 2007-09. Genome–wide association studies provide new insights into type 2 diabetes aetiology in NATURE REVIEWS GENETICS
  • 2004-10-14. Genome-wide linkage analysis of type 2 diabetes mellitus reconfirms the susceptibility locus on 11p13–p12 in Japanese in JOURNAL OF HUMAN GENETICS
  • 2005-10. A haplotype map of the human genome in NATURE
  • 2007-02-11. A genome-wide association study identifies novel risk loci for type 2 diabetes in NATURE
  • 1996-06. A genome–wide search for human non–insulin–dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2 in NATURE GENETICS
  • 2003-12. The International HapMap Project in NATURE
  • 2006-09-06. Association study on chromosome 20q11.21-13.13 locus and its contribution to type 2 diabetes susceptibility in Japanese in HUMAN GENETICS
  • 2007-04-06. Genetic association of single nucleotide polymorphisms in endonuclease G-like 1 gene with type 2 diabetes in a Japanese population in DIABETOLOGIA
  • 2007-04-26. A variant in CDKAL1 influences insulin response and risk of type 2 diabetes in NATURE GENETICS
  • 2008. dbSNP in ENCYCLOPEDIA OF GENETICS, GENOMICS, PROTEOMICS AND INFORMATICS
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    http://scigraph.springernature.com/pub.10.1186/1471-2350-9-22

    DOI

    http://dx.doi.org/10.1186/1471-2350-9-22

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1031577663

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/18366806


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        "description": "BackgroundChromosome 15q14-22.1 has been linked to type 2 diabetes (T2D) and its related traits in Japanese and other populations. The presence of T2D disease susceptibility variant(s) was assessed in the 21.8 Mb region between D15S118 and D15S117 in a Japanese population using a region-wide case-control association test.MethodsA two-stage association test was performed using Japanese subjects: The discovery panel (Stage 1) used 372 cases and 360 controls, while an independent replication panel (Stage 2) used 532 cases and 530 controls. A total of 1,317 evenly-spaced, common SNP markers with minor allele frequencies > 0.10 were typed for each stage. Captured genetic variation was examined in HapMap JPT SNPs, and a haplotype-based association test was performed.ResultsSNP2140 (rs2412747) (C/T) in intron 33 of the ubiquitin protein ligase E3 component n-recognin 1 (UBR1) gene was selected as a landmark SNP based on repeated significant associations in Stage 1 and Stage 2. However, the marginal p value (p = 0.0043 in the allelic test, OR = 1.26, 95% CI = 1.07\u20131.48 for combined samples) was weak in a single locus or haplotype-based association test. We failed to find any significant SNPs after correcting for multiple testing.ConclusionThe two-stage association test did not reveal a strong association between T2D and any common variants on chromosome 15q14-22.1 in 1,794 Japanese subjects. A further association test with a larger sample size and denser SNP markers is required to confirm these observations.", 
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    343 grid-institutes:grid.69566.3a schema:alternateName New Industry Creation Hatchery Center, Tohoku University, Aramaki, Aoba-ku, 980-8579, Miyagi, Sendai, Japan
    344 schema:name New Industry Creation Hatchery Center, Tohoku University, Aramaki, Aoba-ku, 980-8579, Miyagi, Sendai, Japan
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