Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2006-12

AUTHORS

Deborah J Smyth, Joanna MM Howson, Felicity Payne, Lisa M Maier, Rebecca Bailey, Kieran Holland, Christopher E Lowe, Jason D Cooper, John S Hulme, Adrian Vella, Ingrid Dahlman, Alex C Lam, Sarah Nutland, Neil M Walker, Rebecca CJ Twells, John A Todd

ABSTRACT

BACKGROUND: The identification of the HLA class II, insulin (INS), CTLA-4 and PTPN22 genes as determinants of type 1 diabetes (T1D) susceptibility indicates that fine tuning of the immune system is centrally involved in disease development. Some genes have been shown to affect several immune-mediated diseases. Therefore, we tested the hypothesis that alleles of susceptibility genes previously associated with other immune-mediated diseases might perturb immune homeostasis, and hence also associate with predisposition to T1D. METHODS: We resequenced and genotyped tag single nucleotide polymorphisms (SNPs) from two genes, CRP and FCER1B, and genotyped 27 disease-associated polymorphisms from thirteen gene regions, namely FCRL3, CFH, SLC9A3R1, PADI4, RUNX1, SPINK5, IL1RN, IL1RA, CARD15, IBD5-locus (including SLC22A4), LAG3, ADAM33 and NFKB1. These genes have been associated previously with susceptibility to a range of immune-mediated diseases including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), Graves' disease (GD), psoriasis, psoriatic arthritis (PA), atopy, asthma, Crohn disease and multiple sclerosis (MS). Our T1D collections are divided into three sample subsets, consisting of set 1 families (up to 754 families), set 2 families (up to 743 families), and a case-control collection (ranging from 1,500 to 4,400 cases and 1,500 to 4,600 controls). Each SNP was genotyped in one or more of these subsets. Our study typically had approximately 80% statistical power for a minor allele frequency (MAF) >5% and odds ratios (OR) of 1.5 with the type 1 error rate, alpha = 0.05. RESULTS: We found no evidence of association with T1D at most of the loci studied 0.02

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PAGES

20

References to SciGraph publications

  • 2001-05. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease in NATURE
  • 1996-09. Epidemiology of childhood IDDM in Northern Ireland 1989–1994: Low incidence in areas with highest population density and most household crowding in DIABETOLOGIA
  • 2002-11. Characterization of a nuclear-factor-kappa B (NFκB) genetic marker in type 1 diabetes (T1DM) families in GENES & IMMUNITY
  • 2002-02. Parameters for reliable results in genetic association studies in common disease in NATURE GENETICS
  • 2004-04. A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes in NATURE GENETICS
  • 2005-11. Population structure, differential bias and genomic control in a large-scale, case-control association study in NATURE GENETICS
  • 2000-02. CTLA-4 in autoimmune diseases – a general susceptibility gene to autoimmunity? in GENES & IMMUNITY
  • 2003-05. Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease in NATURE
  • 2001-10. NFκB Polymorphisms and susceptibility to type 1 diabetes in GENES & IMMUNITY
  • 2002-07. Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness in NATURE
  • 2001-10. Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease in NATURE GENETICS
  • 2005-02. Genome-wide association studies: theoretical and practical concerns in NATURE REVIEWS GENETICS
  • 2004-08. NOD2 is a negative regulator of Toll-like receptor 2–mediated T helper type 1 responses in NATURE IMMUNOLOGY
  • 2001-05. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease in NATURE
  • 2001-09. CARD15 mutations in Blau syndrome in NATURE GENETICS
  • 2001-10. Gene polymorphism in Netherton and common atopic disease in NATURE GENETICS
  • 2004-12. Development of an integrated genome informatics, data management and workflow infrastructure: A toolbox for the study of complex disease genetics in HUMAN GENOMICS
  • 2003-08. Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis in NATURE GENETICS
  • 2002-02. Association between baseline levels of C-reactive protein (CRP) and a dinucleotide repeat polymorphism in the intron of the CRP gene in GENES & IMMUNITY
  • 2005-05. A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities in NATURE GENETICS
  • 2005-03. Two genes encoding immune-regulatory molecules (LAG3 and IL7R) confer susceptibility to multiple sclerosis in GENES & IMMUNITY
  • 1994-06. Association between atopy and variants of the β subunit of the high–affinity immunoglobulin E receptor in NATURE GENETICS
  • 2003-02. Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease in NATURE GENETICS
  • 2003-12. An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis in NATURE GENETICS
  • 2003-12. A putative RUNX1 binding site variant between SLC9A3R1 and NAT9 is associated with susceptibility to psoriasis in NATURE GENETICS
  • 2004-05. Functional variants of OCTN cation transporter genes are associated with Crohn disease in NATURE GENETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/1471-2350-7-20

    DOI

    http://dx.doi.org/10.1186/1471-2350-7-20

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1011369883

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/16519819


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    69 schema:description BACKGROUND: The identification of the HLA class II, insulin (INS), CTLA-4 and PTPN22 genes as determinants of type 1 diabetes (T1D) susceptibility indicates that fine tuning of the immune system is centrally involved in disease development. Some genes have been shown to affect several immune-mediated diseases. Therefore, we tested the hypothesis that alleles of susceptibility genes previously associated with other immune-mediated diseases might perturb immune homeostasis, and hence also associate with predisposition to T1D. METHODS: We resequenced and genotyped tag single nucleotide polymorphisms (SNPs) from two genes, CRP and FCER1B, and genotyped 27 disease-associated polymorphisms from thirteen gene regions, namely FCRL3, CFH, SLC9A3R1, PADI4, RUNX1, SPINK5, IL1RN, IL1RA, CARD15, IBD5-locus (including SLC22A4), LAG3, ADAM33 and NFKB1. These genes have been associated previously with susceptibility to a range of immune-mediated diseases including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), Graves' disease (GD), psoriasis, psoriatic arthritis (PA), atopy, asthma, Crohn disease and multiple sclerosis (MS). Our T1D collections are divided into three sample subsets, consisting of set 1 families (up to 754 families), set 2 families (up to 743 families), and a case-control collection (ranging from 1,500 to 4,400 cases and 1,500 to 4,600 controls). Each SNP was genotyped in one or more of these subsets. Our study typically had approximately 80% statistical power for a minor allele frequency (MAF) >5% and odds ratios (OR) of 1.5 with the type 1 error rate, alpha = 0.05. RESULTS: We found no evidence of association with T1D at most of the loci studied 0.02 <P < 1.0. Only a SNP in ADAM33, rs2787094, was any evidence of association obtained, P = 0.0004 in set 1 families (relative risk (RR) = 0.78), but further support was not observed in the 4,326 cases and 4,610 controls, P = 0.57 (OR = 1.02). CONCLUSION: Polymorphisms in a variety of genes previously associated with immune-mediated disease susceptibility and/or having effects on gene function and the immune system, are unlikely to be affecting T1D susceptibility in a major way, even though some of the genes tested encode proteins of immune pathways that are believed to be central to the development of T1D. We cannot, however, rule out effect sizes smaller than OR 1.5.
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