Implication of the Pro12Ala polymorphism of the PPAR-gamma 2gene in type 2 diabetes and obesity in the French population View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2005-12

AUTHORS

Maya Ghoussaini, David Meyre, Stéphane Lobbens, Guillaume Charpentier, Karine Clément, Marie-Aline Charles, Maïté Tauber, Jacques Weill, Philippe Froguel

ABSTRACT

BACKGROUND: The Pro12Ala Single Nucleotide Polymorphism (SNP) of the Peroxisome Proliferator-Activated Receptor gamma 2 (PPAR-gamma 2) has been associated with insulin resistance and type 2 diabetes (T2D) and also inconsistently with obesity. The aim of this study was to evaluate the impact of this SNP with regards to T2D and childhood and adult obesity in the French Caucasian population. METHODS: We conducted three independent case/control studies encompassing 2126 cases and 1124 controls. RESULTS: We found a significant association between PPAR-gamma 2 Pro12Ala SNP and T2D (p = 0.04, OR = 1.37), which was stronger when the T2D cohort was stratified according to the obesity status (p = 0.03, OR = 1.81 in obese T2D subjects). In contrast, there was no association between the Pro12Ala SNP and childhood and adulthood obesity. In normal glucose tolerant obese adults (but not in lean subjects), the Pro12 allele was associated with a significant increase in fasting insulin levels (p = 0.01), and in insulin resistance estimated by the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) (p = 0.003), after adjustment for age, gender and BMI. We didn't detect evidence for an interaction effect between the Pro12Ala SNP and the obesity status with respect to the HOMA-IR index in normal glucose tolerant children, but we found a borderline interaction (p = 0.06) in normal glucose tolerant adults. CONCLUSION: Our results showed that the Pro12Ala polymorphism is not associated with childhood or adult obesity in the French Caucasian population. In contrast, we confirm a contribution of the PPAR-gamma 2 Pro12 allele in the genetic risk forT2D, especially in obese subjects, where this allele worsens insulin resistanceand increases fasting insulin levels. More... »

PAGES

11

References to SciGraph publications

  • 2001-09. Studies of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-γ2 (PPAR-γ2) gene in relation to insulin sensitivity among glucose tolerant Caucasians in DIABETOLOGIA
  • 2000-06. Searching for genetic determinants in the new millennium in NATURE
  • 2000-09. The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes in NATURE GENETICS
  • 1998-11. A Pro12Ala substitution in PPARγ2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity in NATURE GENETICS
  • 1985-07. Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man in DIABETOLOGIA
  • 2002-10. A futile metabolic cycle activated in adipocytes by antidiabetic agents in NATURE MEDICINE
  • 1997-07. Determinants and nature of dietary underreporting in a free-living population: the Fleurbaix Laventie Ville Santé (FLVS) study in INTERNATIONAL JOURNAL OF OBESITY
  • 2004-12. The common PPAR-γ2 Pro12Ala variant is associated with greater insulin sensitivity in EUROPEAN JOURNAL OF HUMAN GENETICS
  • 2003-02. Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease in NATURE GENETICS
  • 2001-01. The hormone resistin links obesity to diabetes in NATURE
  • 2001-08. The adipocyte-secreted protein Acrp30 enhances hepatic insulin action in NATURE MEDICINE
  • 2000-09. Pro12Ala mutation in the peroxisome proliferator-activated receptor γ2 (PPARγ2) and severe obesity: a case–control study in INTERNATIONAL JOURNAL OF OBESITY
  • 2000-10. Guilt by association in NATURE GENETICS
  • 2004-03. Association of the Pro12Ala and C1431T variants of PPARG and their haplotypes with susceptibility to Type 2 diabetes in DIABETOLOGIA
  • 2000-03. The Pro115Gln and Pro12Ala PPAR gamma gene mutations in obesity and type 2 diabetes in INTERNATIONAL JOURNAL OF OBESITY
  • 2001-08. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity in NATURE MEDICINE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/1471-2350-6-11

    DOI

    http://dx.doi.org/10.1186/1471-2350-6-11

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1009295638

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/15784141


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