ATA homozigosity in the IL-10gene promoter is a risk factor for schizophrenia in Spanish females: a case control study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-12

AUTHORS

Berta Almoguera, Rosa Riveiro-Alvarez, Jorge Lopez-Castroman, Pedro Dorado, Rosario Lopez-Rodriguez, Pablo Fernandez-Navarro, Enrique Baca-García, Jose Fernandez-Piqueras, Rafael Dal-Ré, Francisco Abad-Santos, Adrián LLerena, Carmen Ayuso, Spanish Consortium of Pharmacogenetics Research in Schizophrenia

ABSTRACT

BACKGROUND: Three IL-10 gene promoter single nucleotide polymorphisms -1082G > A, -819C > T and -592C > A and the haplotypes they define in Caucasians, GCC, ACC, ATA, associated with different IL-10 production rates, have been linked to schizophrenia in some populations with conflicting results. On the basis of the evidence of the sex-dependent effect of certain genes in many complex diseases, we conducted a sex-stratified case-control association study to verify the linkage of the IL-10 gene promoter SNPs and haplotypes with schizophrenia and the possible sex-specific genetic effect in a Spanish schizophrenic population. METHODS: 241 DSM-IV diagnosed Spanish schizophrenic patients and 435 ethnically matched controls were genotyped for -1082G > A and -592C > A SNPs. Chi squared tests were performed to assess for genetic association of alleles, genotypes and haplotypes with the disease. RESULTS: The -1082A allele (p = 0.027), A/A (p = 0.008) and ATA/ATA (p = 0.003) genotypes were significantly associated with schizophrenia in females while neither allelic nor genotypic frequencies reached statistical significance in the male population. CONCLUSIONS: Our results highlight the hypothesis of an imbalance towards an inflammatory syndrome as the immune abnormality of schizophrenia. Anyway, a better understanding of the involvement of the immune system would imply the search of immune abnormalities in endophenotypes in whose sex and ethnicity might be differential factors. It also reinforces the need of performing complex gene studies based on multiple cytokine SNPs, including anti and pro-inflammatory, to clarify the immune system abnormalities direction in the etiology of schizophrenia. More... »

PAGES

81

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1471-2350-12-81

DOI

http://dx.doi.org/10.1186/1471-2350-12-81

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034904474

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21658228


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