Methylenetetrahydrofolate reductase C677T polymorphism in patients with lung cancer in a Korean population View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-12

AUTHORS

Lian-Hua Cui, Min-Ho Shin, Hee Nam Kim, Hye-Rim Song, Jin-Mei Piao, Sun-Seog Kweon, Jin-Su Choi, Woo-Jun Yun, Young-Chul Kim, In-Jae Oh, Kyu-Sik Kim

ABSTRACT

BACKGROUND: This study was designed to investigate an association between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and the risk of lung cancer in a Korean population. METHODS: We conducted a large-scale, case-control study involving 3938 patients with newly diagnosed lung cancer and 1700 healthy controls. Genotyping was performed with peripheral blood DNA for MTHFR C677T polymorphisms. Statistical significance was estimated by logistic regression analysis. RESULTS: The MTHFR C677T frequencies of CC, CT, and TT genotypes were 34.5%, 48.5%, and 17% among lung cancer patients, and 31.8%, 50.7%, and 17.5% in the controls, respectively. The MTHFR 677CT and TT genotype showed a weak protection against lung cancer compared with the homozygous CC genotype, although the results did not reach statistical significance. The age- and gender-adjusted odds ratio (OR) of overall lung cancer was 0.90 (95% confidence interval (CI), 0.77-1.04) for MTHFR 677 CT and 0.88 (95% CI, 0.71-1.07) for MTHFR 677TT. However, after stratification analysis by histological type, the MTHFR 677CT genotype showed a significantly decreased risk for squamous cell carcinoma (age- and gender-adjusted OR, 0.78; 95% CI, 0.64-0.96). The combination of 677 TT homozygous with 677 CT heterozygous also appeared to have a protection effect on the risk of squamous cell carcinoma. We observed no significant interaction between the MTHFR C677T polymorphism and age and gender or smoking habit. CONCLUSIONS: This is the first reported study focusing on the association between MTHFR C677T polymorphisms and the risk of lung cancer in a Korean population. The T allele was found to provide a weak protective association with lung squamous cell carcinoma. More... »

PAGES

28

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1471-2350-12-28

DOI

http://dx.doi.org/10.1186/1471-2350-12-28

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026968145

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21342495


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RDF/XML is a standard XML format for linked data.

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315 Genome Research Center for Hematopoietic Diseases, Chonnam National University Hwasun Hospital, Hwasun, Jeollanam-do, South Korea
316 Jeonnam Regional Cancer Center, Chonnam National University Hwasun Hospital, Hwasun, Jeollanam-do, South Korea
317 rdf:type schema:Organization
318 https://www.grid.ac/institutes/grid.440752.0 schema:alternateName Yanbian University
319 schema:name Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, South Korea
320 Yanbian University Medical College, 121 Juzi Street, Yanji, Jilin Province, China
321 rdf:type schema:Organization
 




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