Mutation screen and association studies for the fatty acid amide hydrolase (FAAH) gene and early onset and adult obesity View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-12

AUTHORS

Timo D Müller, Günter Brönner, Melanie Wandolski, Jophia Carrie, Trang T Nguyen, Brandon H Greene, André Scherag, Harald Grallert, Carla IG Vogel, Susann Scherag, Winfried Rief, Hans-Erich Wichmann, Thomas Illig, Helmut Schäfer, Johannes Hebebrand, Anke Hinney

ABSTRACT

BACKGROUND: The orexigenic effects of cannabinoids are limited by activation of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH). The aim of this study was to analyse whether FAAH alleles are associated with early and late onset obesity. METHODS: We initially assessed association of five single nucleotide polymorphisms (SNPs) in FAAH with early onset extreme obesity in up to 521 German obese children and both parents. SNPs with nominal p-values 0.05). CONCLUSIONS: As we observed some evidence for an association of the FAAH variants rs2295632 rs324420 with early onset but not adult obesity, we conclude that the FAAH variants analyzed here at least do not seem to play a major role in the etiology of obesity within our samples. More... »

PAGES

2

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1471-2350-11-2

DOI

http://dx.doi.org/10.1186/1471-2350-11-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048029004

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20044928


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