Toll-like receptor 2 gene polymorphisms, pulmonary tuberculosis, and natural killer cell counts View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-01-30

AUTHORS

Yung-Che Chen, Chang-Chun Hsiao, Chung-Jen Chen, Chien-Hung Chin, Shih-Feng Liu, Chao-Chien Wu, Hock-Liew Eng, Tung-Ying Chao, Chia-Cheng Tsen, Yi-Hsi Wang, Meng-Chih Lin

ABSTRACT

BackgroundTo investigate whether the toll-like receptor 2 polymorphisms could influence susceptibility to pulmonary TB, its phenotypes, and blood lymphocyte subsets.MethodsA total of 368 subjects, including 184 patients with pulmonary TB and 184 healthy controls, were examined for TLR2 polymorphisms over locus -100 (microsatellite guanine-thymine repeats), -16934 (T>A), -15607 (A>G), -196 to -174 (insertion>deletion), and 1350 (T>C). Eighty-six TB patients were examined to determine the peripheral blood lymphocyte subpopulations.ResultsWe newly identified an association between the haplotype [A-G-(insertion)-T] and susceptibility to pulmonary TB (p = 0.006, false discovery rate q = 0.072). TB patients with systemic symptoms had a lower -196 to -174 deletion/deletion genotype frequency than those without systemic symptoms (5.7% vs. 17.7%; p = 0.01). TB patients with the deletion/deletion genotype had higher blood NK cell counts than those carrying the insertion allele (526 vs. 243.5 cells/μl, p = 0.009). TB patients with pleuritis had a higher 1350 CC genotype frequency than those without pleuritis (12.5% vs. 2.1%; p = 0.004). TB patients with the 1350 CC genotype had higher blood NK cell counts than those carrying the T allele (641 vs. 250 cells/μl, p = 0.004). TB patients carrying homozygous short alleles for GT repeats had higher blood NK cell counts than those carrying one or no short allele (641 vs. 250 cells/μl, p = 0.004).ConclusionsTLR2 genetic polymorphisms influence susceptibility to pulmonary TB. TLR2 variants play a role in the development of TB phenotypes, probably by controlling the expansion of NK cells. More... »

PAGES

17

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1471-2350-11-17

DOI

http://dx.doi.org/10.1186/1471-2350-11-17

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1011907492

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20113509


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Alleles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Base Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Case-Control Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Primers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dinucleotide Repeats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Frequency", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Predisposition to Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Haplotypes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "INDEL Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunity, Innate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Killer Cells, Natural", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphocyte Count", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymorphism, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymorphism, Single Nucleotide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sequence Deletion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Toll-Like Receptor 2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tuberculosis, Pulmonary", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan", 
          "id": "http://www.grid.ac/institutes/grid.413804.a", 
          "name": [
            "Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Yung-Che", 
        "id": "sg:person.0656327675.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0656327675.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Graduate Institute of Clinical Medical Sciences, Chang Gung University Collage of Medicine, Kaohsiung, Taiwan", 
          "id": "http://www.grid.ac/institutes/grid.145695.a", 
          "name": [
            "Graduate Institute of Clinical Medical Sciences, Chang Gung University Collage of Medicine, Kaohsiung, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hsiao", 
        "givenName": "Chang-Chun", 
        "id": "sg:person.01327377462.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01327377462.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Rheumatology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan", 
          "id": "http://www.grid.ac/institutes/grid.413804.a", 
          "name": [
            "Division of Rheumatology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Chung-Jen", 
        "id": "sg:person.01042542222.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042542222.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan", 
          "id": "http://www.grid.ac/institutes/grid.413804.a", 
          "name": [
            "Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chin", 
        "givenName": "Chien-Hung", 
        "id": "sg:person.01337461675.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337461675.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan", 
          "id": "http://www.grid.ac/institutes/grid.413804.a", 
          "name": [
            "Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liu", 
        "givenName": "Shih-Feng", 
        "id": "sg:person.01102224007.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102224007.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan", 
          "id": "http://www.grid.ac/institutes/grid.413804.a", 
          "name": [
            "Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wu", 
        "givenName": "Chao-Chien", 
        "id": "sg:person.01216452407.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216452407.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Clinical Pathology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan", 
          "id": "http://www.grid.ac/institutes/grid.413804.a", 
          "name": [
            "Department of Clinical Pathology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Eng", 
        "givenName": "Hock-Liew", 
        "id": "sg:person.01013442323.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013442323.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan", 
          "id": "http://www.grid.ac/institutes/grid.413804.a", 
          "name": [
            "Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chao", 
        "givenName": "Tung-Ying", 
        "id": "sg:person.0655410107.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655410107.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan", 
          "id": "http://www.grid.ac/institutes/grid.413804.a", 
          "name": [
            "Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tsen", 
        "givenName": "Chia-Cheng", 
        "id": "sg:person.0771636507.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771636507.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan", 
          "id": "http://www.grid.ac/institutes/grid.413804.a", 
          "name": [
            "Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Yi-Hsi", 
        "id": "sg:person.01022511414.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022511414.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan", 
          "id": "http://www.grid.ac/institutes/grid.413804.a", 
          "name": [
            "Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lin", 
        "givenName": "Meng-Chih", 
        "id": "sg:person.0610201224.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610201224.74"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/35021228", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011195594", 
          "https://doi.org/10.1038/35021228"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04226", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017293702", 
          "https://doi.org/10.1038/nature04226"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gene.6364405", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009480989", 
          "https://doi.org/10.1038/sj.gene.6364405"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gene.6364274", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020247462", 
          "https://doi.org/10.1038/sj.gene.6364274"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2010-01-30", 
    "datePublishedReg": "2010-01-30", 
    "description": "BackgroundTo investigate whether the toll-like receptor 2 polymorphisms could influence susceptibility to pulmonary TB, its phenotypes, and blood lymphocyte subsets.MethodsA total of 368 subjects, including 184 patients with pulmonary TB and 184 healthy controls, were examined for TLR2 polymorphisms over locus -100 (microsatellite guanine-thymine repeats), -16934 (T>A), -15607 (A>G), -196 to -174 (insertion>deletion), and 1350 (T>C). Eighty-six TB patients were examined to determine the peripheral blood lymphocyte subpopulations.ResultsWe newly identified an association between the haplotype [A-G-(insertion)-T] and susceptibility to pulmonary TB (p = 0.006, false discovery rate q = 0.072). TB patients with systemic symptoms had a lower -196 to -174 deletion/deletion genotype frequency than those without systemic symptoms (5.7% vs. 17.7%; p = 0.01). TB patients with the deletion/deletion genotype had higher blood NK cell counts than those carrying the insertion allele (526 vs. 243.5 cells/\u03bcl, p = 0.009). TB patients with pleuritis had a higher 1350 CC genotype frequency than those without pleuritis (12.5% vs. 2.1%; p = 0.004). TB patients with the 1350 CC genotype had higher blood NK cell counts than those carrying the T allele (641 vs. 250 cells/\u03bcl, p = 0.004). TB patients carrying homozygous short alleles for GT repeats had higher blood NK cell counts than those carrying one or no short allele (641 vs. 250 cells/\u03bcl, p = 0.004).ConclusionsTLR2 genetic polymorphisms influence susceptibility to pulmonary TB. TLR2 variants play a role in the development of TB phenotypes, probably by controlling the expansion of NK cells.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/1471-2350-11-17", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1039191", 
        "issn": [
          "1755-8794"
        ], 
        "name": "BMC Medical Genomics", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "11"
      }
    ], 
    "keywords": [
      "NK cell counts", 
      "TB patients", 
      "cell count", 
      "systemic symptoms", 
      "natural killer cell counts", 
      "peripheral blood lymphocyte subpopulations", 
      "Toll-Like Receptor 2 Polymorphisms", 
      "blood lymphocyte subsets", 
      "blood lymphocyte subpopulations", 
      "genotype frequencies", 
      "deletion/deletion genotype", 
      "Toll-like receptor 2 gene polymorphisms", 
      "homozygous short allele", 
      "short allele", 
      "CC genotype frequency", 
      "lymphocyte subsets", 
      "pulmonary TB", 
      "pulmonary tuberculosis", 
      "lymphocyte subpopulations", 
      "NK cells", 
      "TLR2 polymorphisms", 
      "healthy controls", 
      "TLR2 variant", 
      "CC genotype", 
      "patients", 
      "gene polymorphisms", 
      "T allele", 
      "deletion genotype", 
      "TB phenotypes", 
      "genetic polymorphisms", 
      "pleuritis", 
      "symptoms", 
      "count", 
      "TB", 
      "GT repeats", 
      "polymorphism", 
      "susceptibility", 
      "phenotype", 
      "alleles", 
      "BackgroundTo", 
      "insertion allele", 
      "tuberculosis", 
      "genotypes", 
      "ResultsWe", 
      "total", 
      "subpopulations", 
      "association", 
      "subjects", 
      "cells", 
      "subset", 
      "frequency", 
      "control", 
      "haplotypes", 
      "variants", 
      "role", 
      "development", 
      "repeats", 
      "expansion"
    ], 
    "name": "Toll-like receptor 2 gene polymorphisms, pulmonary tuberculosis, and natural killer cell counts", 
    "pagination": "17", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1011907492"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1471-2350-11-17"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "20113509"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1471-2350-11-17", 
      "https://app.dimensions.ai/details/publication/pub.1011907492"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-09-02T15:53", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_504.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/1471-2350-11-17"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1471-2350-11-17'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1471-2350-11-17'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1471-2350-11-17'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1471-2350-11-17'


 

This table displays all metadata directly associated to this object as RDF triples.

303 TRIPLES      21 PREDICATES      110 URIs      98 LITERALS      30 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1471-2350-11-17 schema:about N01c6e6244593473b981dc2434687ab8b
2 N1c4bad7ca5aa430c8c2b38fa64de449a
3 N2d9a046e56d24fc0825ab7b58531b201
4 N3384571ebd7f4d94ad961eb1a7c566fc
5 N463a183677b9498ebc0516df0b5b572b
6 N5009e82a79604f559cad1bb28ec6377e
7 N589afd39de724746ae6be5fe0353662c
8 N5ff452b0e2ca4a2a9e43722df78ac7b2
9 N71d54ab2feda4e6b9fe37f21d8f8b4e1
10 N8384246680a74188adc86b2cb2b382bc
11 N87515c251ae14cbab967befb74d19c3c
12 N8c352617b8a649fc92c178acf7335b21
13 N8ef8c17070794420a884016490be883a
14 N9406d486c989449fab311d25eb0170c9
15 N9440dca461f54cb788e6e15956fd97c8
16 N95a114327ca24c8bb2a4adc3130e78ef
17 N9a2a09f9e14f4809b03adf34c85691c1
18 Nade10f2aca1e40559b01e80cdafa0f6d
19 Nae35344e9e2a42fe948729df948f9aff
20 Nc63962f7f363467f899b1b7914d58110
21 Nce8a18fe428c4fa1b5eb91aa9d2f94bb
22 Nde5d881d2e5042e0962a17816fdc6360
23 Neee3951eacc7432fba7963bb59afc5a5
24 anzsrc-for:11
25 anzsrc-for:1107
26 schema:author N2598a2ef1f774d48b1d3488934f763df
27 schema:citation sg:pub.10.1038/35021228
28 sg:pub.10.1038/nature04226
29 sg:pub.10.1038/sj.gene.6364274
30 sg:pub.10.1038/sj.gene.6364405
31 schema:datePublished 2010-01-30
32 schema:datePublishedReg 2010-01-30
33 schema:description BackgroundTo investigate whether the toll-like receptor 2 polymorphisms could influence susceptibility to pulmonary TB, its phenotypes, and blood lymphocyte subsets.MethodsA total of 368 subjects, including 184 patients with pulmonary TB and 184 healthy controls, were examined for TLR2 polymorphisms over locus -100 (microsatellite guanine-thymine repeats), -16934 (T>A), -15607 (A>G), -196 to -174 (insertion>deletion), and 1350 (T>C). Eighty-six TB patients were examined to determine the peripheral blood lymphocyte subpopulations.ResultsWe newly identified an association between the haplotype [A-G-(insertion)-T] and susceptibility to pulmonary TB (p = 0.006, false discovery rate q = 0.072). TB patients with systemic symptoms had a lower -196 to -174 deletion/deletion genotype frequency than those without systemic symptoms (5.7% vs. 17.7%; p = 0.01). TB patients with the deletion/deletion genotype had higher blood NK cell counts than those carrying the insertion allele (526 vs. 243.5 cells/μl, p = 0.009). TB patients with pleuritis had a higher 1350 CC genotype frequency than those without pleuritis (12.5% vs. 2.1%; p = 0.004). TB patients with the 1350 CC genotype had higher blood NK cell counts than those carrying the T allele (641 vs. 250 cells/μl, p = 0.004). TB patients carrying homozygous short alleles for GT repeats had higher blood NK cell counts than those carrying one or no short allele (641 vs. 250 cells/μl, p = 0.004).ConclusionsTLR2 genetic polymorphisms influence susceptibility to pulmonary TB. TLR2 variants play a role in the development of TB phenotypes, probably by controlling the expansion of NK cells.
34 schema:genre article
35 schema:isAccessibleForFree true
36 schema:isPartOf Nbb53d4851bd74c439a8541f078aa0790
37 Nf1a1e10bfa0c487392444c66e7d16ab1
38 sg:journal.1039191
39 schema:keywords BackgroundTo
40 CC genotype
41 CC genotype frequency
42 GT repeats
43 NK cell counts
44 NK cells
45 ResultsWe
46 T allele
47 TB
48 TB patients
49 TB phenotypes
50 TLR2 polymorphisms
51 TLR2 variant
52 Toll-Like Receptor 2 Polymorphisms
53 Toll-like receptor 2 gene polymorphisms
54 alleles
55 association
56 blood lymphocyte subpopulations
57 blood lymphocyte subsets
58 cell count
59 cells
60 control
61 count
62 deletion genotype
63 deletion/deletion genotype
64 development
65 expansion
66 frequency
67 gene polymorphisms
68 genetic polymorphisms
69 genotype frequencies
70 genotypes
71 haplotypes
72 healthy controls
73 homozygous short allele
74 insertion allele
75 lymphocyte subpopulations
76 lymphocyte subsets
77 natural killer cell counts
78 patients
79 peripheral blood lymphocyte subpopulations
80 phenotype
81 pleuritis
82 polymorphism
83 pulmonary TB
84 pulmonary tuberculosis
85 repeats
86 role
87 short allele
88 subjects
89 subpopulations
90 subset
91 susceptibility
92 symptoms
93 systemic symptoms
94 total
95 tuberculosis
96 variants
97 schema:name Toll-like receptor 2 gene polymorphisms, pulmonary tuberculosis, and natural killer cell counts
98 schema:pagination 17
99 schema:productId N9a51207eef524fea86251e4279610fbf
100 Nbc9d64c1e3f94e1680787b798379f6cf
101 Nd6b1ba0e21de4e3a8ab7550af3b3d65f
102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011907492
103 https://doi.org/10.1186/1471-2350-11-17
104 schema:sdDatePublished 2022-09-02T15:53
105 schema:sdLicense https://scigraph.springernature.com/explorer/license/
106 schema:sdPublisher N78719457c21b43a392090278a33353cb
107 schema:url https://doi.org/10.1186/1471-2350-11-17
108 sgo:license sg:explorer/license/
109 sgo:sdDataset articles
110 rdf:type schema:ScholarlyArticle
111 N01c6e6244593473b981dc2434687ab8b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Genetic Predisposition to Disease
113 rdf:type schema:DefinedTerm
114 N198af9e7b6d94acca317e37986801afe rdf:first sg:person.01327377462.80
115 rdf:rest Nd17cb06e32f748f8addb101243f0b71f
116 N1c39b52bba8f44fba10174cdb7241812 rdf:first sg:person.0771636507.99
117 rdf:rest N2d3c993b3a404a7eaa4c3deeb383583d
118 N1c4bad7ca5aa430c8c2b38fa64de449a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Sequence Deletion
120 rdf:type schema:DefinedTerm
121 N23d38058d1334f05991a92f02ca3dc1e rdf:first sg:person.01102224007.59
122 rdf:rest N339bbbd986d4421596e479581599140d
123 N2598a2ef1f774d48b1d3488934f763df rdf:first sg:person.0656327675.12
124 rdf:rest N198af9e7b6d94acca317e37986801afe
125 N2d3c993b3a404a7eaa4c3deeb383583d rdf:first sg:person.01022511414.89
126 rdf:rest N641c96ca9b0648f2a185145859ccdd50
127 N2d9a046e56d24fc0825ab7b58531b201 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Lymphocyte Count
129 rdf:type schema:DefinedTerm
130 N3384571ebd7f4d94ad961eb1a7c566fc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Polymorphism, Single Nucleotide
132 rdf:type schema:DefinedTerm
133 N339bbbd986d4421596e479581599140d rdf:first sg:person.01216452407.34
134 rdf:rest Nbd28c5a5e77d4562922be2c8b229bdad
135 N463a183677b9498ebc0516df0b5b572b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Base Sequence
137 rdf:type schema:DefinedTerm
138 N5009e82a79604f559cad1bb28ec6377e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Haplotypes
140 rdf:type schema:DefinedTerm
141 N589afd39de724746ae6be5fe0353662c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name DNA Primers
143 rdf:type schema:DefinedTerm
144 N5ff452b0e2ca4a2a9e43722df78ac7b2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Middle Aged
146 rdf:type schema:DefinedTerm
147 N641c96ca9b0648f2a185145859ccdd50 rdf:first sg:person.0610201224.74
148 rdf:rest rdf:nil
149 N71d54ab2feda4e6b9fe37f21d8f8b4e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Alleles
151 rdf:type schema:DefinedTerm
152 N78719457c21b43a392090278a33353cb schema:name Springer Nature - SN SciGraph project
153 rdf:type schema:Organization
154 N8384246680a74188adc86b2cb2b382bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Female
156 rdf:type schema:DefinedTerm
157 N87515c251ae14cbab967befb74d19c3c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name INDEL Mutation
159 rdf:type schema:DefinedTerm
160 N8c352617b8a649fc92c178acf7335b21 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Humans
162 rdf:type schema:DefinedTerm
163 N8ef8c17070794420a884016490be883a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Adult
165 rdf:type schema:DefinedTerm
166 N9406d486c989449fab311d25eb0170c9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Case-Control Studies
168 rdf:type schema:DefinedTerm
169 N9440dca461f54cb788e6e15956fd97c8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Toll-Like Receptor 2
171 rdf:type schema:DefinedTerm
172 N95a114327ca24c8bb2a4adc3130e78ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Tuberculosis, Pulmonary
174 rdf:type schema:DefinedTerm
175 N9a2a09f9e14f4809b03adf34c85691c1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Male
177 rdf:type schema:DefinedTerm
178 N9a51207eef524fea86251e4279610fbf schema:name doi
179 schema:value 10.1186/1471-2350-11-17
180 rdf:type schema:PropertyValue
181 Nade10f2aca1e40559b01e80cdafa0f6d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Polymorphism, Genetic
183 rdf:type schema:DefinedTerm
184 Nae35344e9e2a42fe948729df948f9aff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Gene Frequency
186 rdf:type schema:DefinedTerm
187 Nbb53d4851bd74c439a8541f078aa0790 schema:volumeNumber 11
188 rdf:type schema:PublicationVolume
189 Nbc9d64c1e3f94e1680787b798379f6cf schema:name dimensions_id
190 schema:value pub.1011907492
191 rdf:type schema:PropertyValue
192 Nbd28c5a5e77d4562922be2c8b229bdad rdf:first sg:person.01013442323.62
193 rdf:rest Ncba4fa3a27f547309ea1cbe277071d32
194 Nc63962f7f363467f899b1b7914d58110 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Killer Cells, Natural
196 rdf:type schema:DefinedTerm
197 Ncba4fa3a27f547309ea1cbe277071d32 rdf:first sg:person.0655410107.69
198 rdf:rest N1c39b52bba8f44fba10174cdb7241812
199 Nce8a18fe428c4fa1b5eb91aa9d2f94bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Aged
201 rdf:type schema:DefinedTerm
202 Nd17cb06e32f748f8addb101243f0b71f rdf:first sg:person.01042542222.54
203 rdf:rest Nffb3c04bff984910854c47e69027e683
204 Nd6b1ba0e21de4e3a8ab7550af3b3d65f schema:name pubmed_id
205 schema:value 20113509
206 rdf:type schema:PropertyValue
207 Nde5d881d2e5042e0962a17816fdc6360 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
208 schema:name Dinucleotide Repeats
209 rdf:type schema:DefinedTerm
210 Neee3951eacc7432fba7963bb59afc5a5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
211 schema:name Immunity, Innate
212 rdf:type schema:DefinedTerm
213 Nf1a1e10bfa0c487392444c66e7d16ab1 schema:issueNumber 1
214 rdf:type schema:PublicationIssue
215 Nffb3c04bff984910854c47e69027e683 rdf:first sg:person.01337461675.87
216 rdf:rest N23d38058d1334f05991a92f02ca3dc1e
217 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
218 schema:name Medical and Health Sciences
219 rdf:type schema:DefinedTerm
220 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
221 schema:name Immunology
222 rdf:type schema:DefinedTerm
223 sg:journal.1039191 schema:issn 1755-8794
224 schema:name BMC Medical Genomics
225 schema:publisher Springer Nature
226 rdf:type schema:Periodical
227 sg:person.01013442323.62 schema:affiliation grid-institutes:grid.413804.a
228 schema:familyName Eng
229 schema:givenName Hock-Liew
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013442323.62
231 rdf:type schema:Person
232 sg:person.01022511414.89 schema:affiliation grid-institutes:grid.413804.a
233 schema:familyName Wang
234 schema:givenName Yi-Hsi
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022511414.89
236 rdf:type schema:Person
237 sg:person.01042542222.54 schema:affiliation grid-institutes:grid.413804.a
238 schema:familyName Chen
239 schema:givenName Chung-Jen
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042542222.54
241 rdf:type schema:Person
242 sg:person.01102224007.59 schema:affiliation grid-institutes:grid.413804.a
243 schema:familyName Liu
244 schema:givenName Shih-Feng
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102224007.59
246 rdf:type schema:Person
247 sg:person.01216452407.34 schema:affiliation grid-institutes:grid.413804.a
248 schema:familyName Wu
249 schema:givenName Chao-Chien
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216452407.34
251 rdf:type schema:Person
252 sg:person.01327377462.80 schema:affiliation grid-institutes:grid.145695.a
253 schema:familyName Hsiao
254 schema:givenName Chang-Chun
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01327377462.80
256 rdf:type schema:Person
257 sg:person.01337461675.87 schema:affiliation grid-institutes:grid.413804.a
258 schema:familyName Chin
259 schema:givenName Chien-Hung
260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337461675.87
261 rdf:type schema:Person
262 sg:person.0610201224.74 schema:affiliation grid-institutes:grid.413804.a
263 schema:familyName Lin
264 schema:givenName Meng-Chih
265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610201224.74
266 rdf:type schema:Person
267 sg:person.0655410107.69 schema:affiliation grid-institutes:grid.413804.a
268 schema:familyName Chao
269 schema:givenName Tung-Ying
270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655410107.69
271 rdf:type schema:Person
272 sg:person.0656327675.12 schema:affiliation grid-institutes:grid.413804.a
273 schema:familyName Chen
274 schema:givenName Yung-Che
275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0656327675.12
276 rdf:type schema:Person
277 sg:person.0771636507.99 schema:affiliation grid-institutes:grid.413804.a
278 schema:familyName Tsen
279 schema:givenName Chia-Cheng
280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771636507.99
281 rdf:type schema:Person
282 sg:pub.10.1038/35021228 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011195594
283 https://doi.org/10.1038/35021228
284 rdf:type schema:CreativeWork
285 sg:pub.10.1038/nature04226 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017293702
286 https://doi.org/10.1038/nature04226
287 rdf:type schema:CreativeWork
288 sg:pub.10.1038/sj.gene.6364274 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020247462
289 https://doi.org/10.1038/sj.gene.6364274
290 rdf:type schema:CreativeWork
291 sg:pub.10.1038/sj.gene.6364405 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009480989
292 https://doi.org/10.1038/sj.gene.6364405
293 rdf:type schema:CreativeWork
294 grid-institutes:grid.145695.a schema:alternateName Graduate Institute of Clinical Medical Sciences, Chang Gung University Collage of Medicine, Kaohsiung, Taiwan
295 schema:name Graduate Institute of Clinical Medical Sciences, Chang Gung University Collage of Medicine, Kaohsiung, Taiwan
296 rdf:type schema:Organization
297 grid-institutes:grid.413804.a schema:alternateName Department of Clinical Pathology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
298 Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
299 Division of Rheumatology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
300 schema:name Department of Clinical Pathology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
301 Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
302 Division of Rheumatology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
303 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...