Asthma-susceptibility variants identified using probands in case-control and family-based analyses View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-12

AUTHORS

Blanca E Himes, Jessica Lasky-Su, Ann C Wu, Jemma B Wilk, Gary M Hunninghake, Barbara Klanderman, Amy J Murphy, Ross Lazarus, Manuel E Soto-Quiros, Lydiana Avila, Juan C Celedón, Christoph Lange, George T O'Connor, Benjamin A Raby, Edwin K Silverman, Scott T Weiss

ABSTRACT

BACKGROUND: Asthma is a chronic respiratory disease whose genetic basis has been explored for over two decades, most recently via genome-wide association studies. We sought to find asthma-susceptibility variants by using probands from a single population in both family-based and case-control association designs. METHODS: We used probands from the Childhood Asthma Management Program (CAMP) in two primary genome-wide association study designs: (1) probands were combined with publicly available population controls in a case-control design, and (2) probands and their parents were used in a family-based design. We followed a two-stage replication process utilizing three independent populations to validate our primary findings. RESULTS: We found that single nucleotide polymorphisms with similar case-control and family-based association results were more likely to replicate in the independent populations, than those with the smallest p-values in either the case-control or family-based design alone. The single nucleotide polymorphism that showed the strongest evidence for association to asthma was rs17572584, which replicated in 2/3 independent populations with an overall p-value among replication populations of 3.5E-05. This variant is near a gene that encodes an enzyme that has been implicated to act coordinately with modulators of Th2 cell differentiation and is expressed in human lung. CONCLUSIONS: Our results suggest that using probands from family-based studies in case-control designs, and combining results of both family-based and case-control approaches, may be a way to augment our ability to find SNPs associated with asthma and other complex diseases. More... »

PAGES

122

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1471-2350-11-122

DOI

http://dx.doi.org/10.1186/1471-2350-11-122

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020078800

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20698975


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Asthma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Case-Control Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Child", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Family", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Predisposition to Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Variation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genome-Wide Association Study", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymorphism, Single Nucleotide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Research Design", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Boston Children's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.2515.3", 
          "name": [
            "Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA, USA", 
            "Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA", 
            "Children's Hospital Informatics Program, Boston, MA, USA", 
            "Partners Center for Personalized Genetic Medicine, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Himes", 
        "givenName": "Blanca E", 
        "id": "sg:person.01334355135.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334355135.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Harvard University", 
          "id": "https://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lasky-Su", 
        "givenName": "Jessica", 
        "id": "sg:person.01225022742.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225022742.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Boston Children's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.2515.3", 
          "name": [
            "Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA", 
            "Department of General Pediatrics, Children's Hospital, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wu", 
        "givenName": "Ann C", 
        "id": "sg:person.016064306032.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016064306032.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Boston University School of Medicine", 
          "id": "https://www.grid.ac/institutes/grid.475010.7", 
          "name": [
            "Department of Medicine, Boston University School of Medicine, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wilk", 
        "givenName": "Jemma B", 
        "id": "sg:person.01045035274.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045035274.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Harvard University", 
          "id": "https://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hunninghake", 
        "givenName": "Gary M", 
        "id": "sg:person.01104142045.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104142045.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Harvard University", 
          "id": "https://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Klanderman", 
        "givenName": "Barbara", 
        "id": "sg:person.0755746605.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755746605.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Harvard University", 
          "id": "https://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Murphy", 
        "givenName": "Amy J", 
        "id": "sg:person.01047505230.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047505230.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Harvard University", 
          "id": "https://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lazarus", 
        "givenName": "Ross", 
        "id": "sg:person.0766744011.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766744011.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Nacional de Ni\u00f1os", 
          "id": "https://www.grid.ac/institutes/grid.440331.1", 
          "name": [
            "Division of Pediatric Pulmonology, Hospital Nacional de Ni\u00f1os, San Jos\u00e9, Costa Rica"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Soto-Quiros", 
        "givenName": "Manuel E", 
        "id": "sg:person.0710057745.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710057745.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Nacional de Ni\u00f1os", 
          "id": "https://www.grid.ac/institutes/grid.440331.1", 
          "name": [
            "Division of Pediatric Pulmonology, Hospital Nacional de Ni\u00f1os, San Jos\u00e9, Costa Rica"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Avila", 
        "givenName": "Lydiana", 
        "id": "sg:person.01036210634.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036210634.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Harvard University", 
          "id": "https://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Celed\u00f3n", 
        "givenName": "Juan C", 
        "id": "sg:person.01210111627.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210111627.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Harvard University", 
          "id": "https://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lange", 
        "givenName": "Christoph", 
        "id": "sg:person.01342332616.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342332616.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Boston University School of Medicine", 
          "id": "https://www.grid.ac/institutes/grid.475010.7", 
          "name": [
            "Department of Medicine, Boston University School of Medicine, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "O'Connor", 
        "givenName": "George T", 
        "id": "sg:person.010515035712.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010515035712.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Harvard University", 
          "id": "https://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Raby", 
        "givenName": "Benjamin A", 
        "id": "sg:person.01062144517.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062144517.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Harvard University", 
          "id": "https://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Silverman", 
        "givenName": "Edwin K", 
        "id": "sg:person.016516477137.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016516477137.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Harvard University", 
          "id": "https://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA", 
            "Partners Center for Personalized Genetic Medicine, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Weiss", 
        "givenName": "Scott T", 
        "id": "sg:person.013015301602.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013015301602.70"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.jaci.2009.11.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001648585"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaci.2008.01.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002632734"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa0708801", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005744340"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajhg.2009.08.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006057593"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/aje/kwm021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007948489"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/bth457", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008081196"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/rccm.200812-1860oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008411997"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.76", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009408087", 
          "https://doi.org/10.1038/ng.76"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.1000623", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010731657"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.1000197", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011211842"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1197/jamia.m2846", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013212272"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/19.1.149", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013784960"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature06014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014505872", 
          "https://doi.org/10.1038/nature06014"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaci.2006.12.609", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015217820"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/gepi.10182", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015746883"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajhg.2007.11.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016278126"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1398-9995.2008.01873.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018668444"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/519795", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019061180"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1398-9995.2008.01912.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019572312"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/rccm.200711-1644oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019582837"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0197-2456(98)00044-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021640226"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1472-6947-6-30", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024163546", 
          "https://doi.org/10.1186/1472-6947-6-30"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaci.2007.04.032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024777728"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.0030236", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027655636"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajhg.2009.04.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028680851"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1847", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031429813", 
          "https://doi.org/10.1038/ng1847"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1847", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031429813", 
          "https://doi.org/10.1038/ng1847"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0091-6749(03)02023-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033321556"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m804271200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035309298"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02714448", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038540574", 
          "https://doi.org/10.1007/bf02714448"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02714448", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038540574", 
          "https://doi.org/10.1007/bf02714448"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2350-8-s1-s1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039530988", 
          "https://doi.org/10.1186/1471-2350-8-s1-s1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaci.2008.06.041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044419949"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci34772", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046196569"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa0901867", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046205362"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gene.6364284", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048759804", 
          "https://doi.org/10.1038/sj.gene.6364284"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gene.6364284", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048759804", 
          "https://doi.org/10.1038/sj.gene.6364284"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaci.2007.09.038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051570455"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/302449", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058610023"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/381563", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058673343"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/424886", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058713966"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2010-12", 
    "datePublishedReg": "2010-12-01", 
    "description": "BACKGROUND: Asthma is a chronic respiratory disease whose genetic basis has been explored for over two decades, most recently via genome-wide association studies. We sought to find asthma-susceptibility variants by using probands from a single population in both family-based and case-control association designs.\nMETHODS: We used probands from the Childhood Asthma Management Program (CAMP) in two primary genome-wide association study designs: (1) probands were combined with publicly available population controls in a case-control design, and (2) probands and their parents were used in a family-based design. We followed a two-stage replication process utilizing three independent populations to validate our primary findings.\nRESULTS: We found that single nucleotide polymorphisms with similar case-control and family-based association results were more likely to replicate in the independent populations, than those with the smallest p-values in either the case-control or family-based design alone. The single nucleotide polymorphism that showed the strongest evidence for association to asthma was rs17572584, which replicated in 2/3 independent populations with an overall p-value among replication populations of 3.5E-05. This variant is near a gene that encodes an enzyme that has been implicated to act coordinately with modulators of Th2 cell differentiation and is expressed in human lung.\nCONCLUSIONS: Our results suggest that using probands from family-based studies in case-control designs, and combining results of both family-based and case-control approaches, may be a way to augment our ability to find SNPs associated with asthma and other complex diseases.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/1471-2350-11-122", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2537302", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2541256", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2414304", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2681181", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2442069", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2684700", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2404634", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2541406", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2437038", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2416678", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2635838", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2691801", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2691631", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2430005", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1024947", 
        "issn": [
          "1471-2350"
        ], 
        "name": "BMC Medical Genetics", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "11"
      }
    ], 
    "name": "Asthma-susceptibility variants identified using probands in case-control and family-based analyses", 
    "pagination": "122", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "5fab03fa3d9cc9f6cb22090b742bb76ca07e8e4cade1555544395013a4d3aa3e"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "20698975"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100968552"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1471-2350-11-122"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1020078800"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1471-2350-11-122", 
      "https://app.dimensions.ai/details/publication/pub.1020078800"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T16:40", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8669_00000504.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2F1471-2350-11-122"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1471-2350-11-122'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1471-2350-11-122'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1471-2350-11-122'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1471-2350-11-122'


 

This table displays all metadata directly associated to this object as RDF triples.

385 TRIPLES      21 PREDICATES      79 URIs      33 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1471-2350-11-122 schema:about N12598fc2256c4b69bcc7b23ee09450ed
2 N14c0263940314c50b360a05fd28c04e1
3 N27af71a86b154de3ad6887c20aad8a7b
4 N2ccf576725334242bbda43f9068af64a
5 N4313d50953ed4e9b9a54f2e892e2eae8
6 N741004392fca4a4ea817442741e8bafd
7 N7bbd6c70b0a94deda166b4d74ca17d73
8 Nb6be2c41647e4b488ee8ba2917d6511b
9 Nda599fddc540445c8b73b9c167890994
10 Ndd3fa7e4fa6a41268a1b52779fb6d9b2
11 Nea632f92c93342ab8f1216125997cd83
12 Nedf0e08292474936b8da5e7fb74355d6
13 anzsrc-for:06
14 anzsrc-for:0604
15 schema:author N43c9e5c286e946249e5c6712575b7b74
16 schema:citation sg:pub.10.1007/bf02714448
17 sg:pub.10.1038/nature06014
18 sg:pub.10.1038/ng.76
19 sg:pub.10.1038/ng1847
20 sg:pub.10.1038/sj.gene.6364284
21 sg:pub.10.1186/1471-2350-8-s1-s1
22 sg:pub.10.1186/1472-6947-6-30
23 https://doi.org/10.1002/gepi.10182
24 https://doi.org/10.1016/j.ajhg.2007.11.003
25 https://doi.org/10.1016/j.ajhg.2009.04.006
26 https://doi.org/10.1016/j.ajhg.2009.08.007
27 https://doi.org/10.1016/j.jaci.2006.12.609
28 https://doi.org/10.1016/j.jaci.2007.04.032
29 https://doi.org/10.1016/j.jaci.2007.09.038
30 https://doi.org/10.1016/j.jaci.2008.01.015
31 https://doi.org/10.1016/j.jaci.2008.06.041
32 https://doi.org/10.1016/j.jaci.2009.11.018
33 https://doi.org/10.1016/s0091-6749(03)02023-2
34 https://doi.org/10.1016/s0197-2456(98)00044-0
35 https://doi.org/10.1056/nejmoa0708801
36 https://doi.org/10.1056/nejmoa0901867
37 https://doi.org/10.1074/jbc.m804271200
38 https://doi.org/10.1086/302449
39 https://doi.org/10.1086/381563
40 https://doi.org/10.1086/424886
41 https://doi.org/10.1086/519795
42 https://doi.org/10.1093/aje/kwm021
43 https://doi.org/10.1093/bioinformatics/19.1.149
44 https://doi.org/10.1093/bioinformatics/bth457
45 https://doi.org/10.1111/j.1398-9995.2008.01873.x
46 https://doi.org/10.1111/j.1398-9995.2008.01912.x
47 https://doi.org/10.1164/rccm.200711-1644oc
48 https://doi.org/10.1164/rccm.200812-1860oc
49 https://doi.org/10.1172/jci34772
50 https://doi.org/10.1197/jamia.m2846
51 https://doi.org/10.1371/journal.pgen.0030236
52 https://doi.org/10.1371/journal.pgen.1000197
53 https://doi.org/10.1371/journal.pgen.1000623
54 schema:datePublished 2010-12
55 schema:datePublishedReg 2010-12-01
56 schema:description BACKGROUND: Asthma is a chronic respiratory disease whose genetic basis has been explored for over two decades, most recently via genome-wide association studies. We sought to find asthma-susceptibility variants by using probands from a single population in both family-based and case-control association designs. METHODS: We used probands from the Childhood Asthma Management Program (CAMP) in two primary genome-wide association study designs: (1) probands were combined with publicly available population controls in a case-control design, and (2) probands and their parents were used in a family-based design. We followed a two-stage replication process utilizing three independent populations to validate our primary findings. RESULTS: We found that single nucleotide polymorphisms with similar case-control and family-based association results were more likely to replicate in the independent populations, than those with the smallest p-values in either the case-control or family-based design alone. The single nucleotide polymorphism that showed the strongest evidence for association to asthma was rs17572584, which replicated in 2/3 independent populations with an overall p-value among replication populations of 3.5E-05. This variant is near a gene that encodes an enzyme that has been implicated to act coordinately with modulators of Th2 cell differentiation and is expressed in human lung. CONCLUSIONS: Our results suggest that using probands from family-based studies in case-control designs, and combining results of both family-based and case-control approaches, may be a way to augment our ability to find SNPs associated with asthma and other complex diseases.
57 schema:genre research_article
58 schema:inLanguage en
59 schema:isAccessibleForFree true
60 schema:isPartOf N09e9fc694c73498bb9378e35a616733c
61 N1227101ab84345b8bd6372eadbc2d8ef
62 sg:journal.1024947
63 schema:name Asthma-susceptibility variants identified using probands in case-control and family-based analyses
64 schema:pagination 122
65 schema:productId N3ac0898577bc4316964ee4e2ca58ac91
66 N6cfd0f5363df46329744131f3e87b754
67 N8b13f2d9207b450ebfa2269f38ba7704
68 Ne4022428816f48ae8295cac1f0328ff2
69 Nf1b6eaa7cf9e4ec7b442323e683f190e
70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020078800
71 https://doi.org/10.1186/1471-2350-11-122
72 schema:sdDatePublished 2019-04-10T16:40
73 schema:sdLicense https://scigraph.springernature.com/explorer/license/
74 schema:sdPublisher Nefe0a0a2107b414aa14ac7ea11592093
75 schema:url http://link.springer.com/10.1186%2F1471-2350-11-122
76 sgo:license sg:explorer/license/
77 sgo:sdDataset articles
78 rdf:type schema:ScholarlyArticle
79 N06861ce81b324fe797527e74a4876e1d rdf:first sg:person.0766744011.63
80 rdf:rest Nfa8c3138cf1e46c2874fd8b5317d6bc0
81 N09e9fc694c73498bb9378e35a616733c schema:volumeNumber 11
82 rdf:type schema:PublicationVolume
83 N1227101ab84345b8bd6372eadbc2d8ef schema:issueNumber 1
84 rdf:type schema:PublicationIssue
85 N12598fc2256c4b69bcc7b23ee09450ed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Genetic Variation
87 rdf:type schema:DefinedTerm
88 N14c0263940314c50b360a05fd28c04e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Genome-Wide Association Study
90 rdf:type schema:DefinedTerm
91 N22ea2ab046554920b98f033da6d1aa16 rdf:first sg:person.013015301602.70
92 rdf:rest rdf:nil
93 N22f5259f86ce4b3f98840efff99c2965 rdf:first sg:person.01104142045.88
94 rdf:rest N4493afc92f3c458a895941032fdff6f3
95 N27af71a86b154de3ad6887c20aad8a7b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Male
97 rdf:type schema:DefinedTerm
98 N2ccf576725334242bbda43f9068af64a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Humans
100 rdf:type schema:DefinedTerm
101 N2f932828d54e4918abc7a0e2b68868a7 rdf:first sg:person.01342332616.87
102 rdf:rest Nd7d626a57e564199b30684e857b28ca2
103 N2fff8546aec0414db8581b559de3f398 rdf:first sg:person.01210111627.99
104 rdf:rest N2f932828d54e4918abc7a0e2b68868a7
105 N3ac0898577bc4316964ee4e2ca58ac91 schema:name doi
106 schema:value 10.1186/1471-2350-11-122
107 rdf:type schema:PropertyValue
108 N4313d50953ed4e9b9a54f2e892e2eae8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Genetic Predisposition to Disease
110 rdf:type schema:DefinedTerm
111 N43c9e5c286e946249e5c6712575b7b74 rdf:first sg:person.01334355135.93
112 rdf:rest N470e70abd39b4ddcb034050adb6e394c
113 N4493afc92f3c458a895941032fdff6f3 rdf:first sg:person.0755746605.02
114 rdf:rest N88e0841b05e248f8a749cfb35b64800d
115 N470e70abd39b4ddcb034050adb6e394c rdf:first sg:person.01225022742.10
116 rdf:rest Na21c4e8ec0b940bfa7013a989da9a2d9
117 N6ae93e68161a433598f9aa6619dac70b rdf:first sg:person.01045035274.57
118 rdf:rest N22f5259f86ce4b3f98840efff99c2965
119 N6cfd0f5363df46329744131f3e87b754 schema:name dimensions_id
120 schema:value pub.1020078800
121 rdf:type schema:PropertyValue
122 N741004392fca4a4ea817442741e8bafd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Female
124 rdf:type schema:DefinedTerm
125 N7bbd6c70b0a94deda166b4d74ca17d73 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Family
127 rdf:type schema:DefinedTerm
128 N88e0841b05e248f8a749cfb35b64800d rdf:first sg:person.01047505230.76
129 rdf:rest N06861ce81b324fe797527e74a4876e1d
130 N8b13f2d9207b450ebfa2269f38ba7704 schema:name readcube_id
131 schema:value 5fab03fa3d9cc9f6cb22090b742bb76ca07e8e4cade1555544395013a4d3aa3e
132 rdf:type schema:PropertyValue
133 N9fd4b1b4e74f400d9794fabec4cb9010 rdf:first sg:person.01062144517.60
134 rdf:rest Nd5f082acd56d4d43a28e02a86add547d
135 Na21c4e8ec0b940bfa7013a989da9a2d9 rdf:first sg:person.016064306032.61
136 rdf:rest N6ae93e68161a433598f9aa6619dac70b
137 Nb6be2c41647e4b488ee8ba2917d6511b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Asthma
139 rdf:type schema:DefinedTerm
140 Ncf775c4cc0ea4995b422ca0016f0d4ea rdf:first sg:person.01036210634.29
141 rdf:rest N2fff8546aec0414db8581b559de3f398
142 Nd5f082acd56d4d43a28e02a86add547d rdf:first sg:person.016516477137.93
143 rdf:rest N22ea2ab046554920b98f033da6d1aa16
144 Nd7d626a57e564199b30684e857b28ca2 rdf:first sg:person.010515035712.31
145 rdf:rest N9fd4b1b4e74f400d9794fabec4cb9010
146 Nda599fddc540445c8b73b9c167890994 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Child
148 rdf:type schema:DefinedTerm
149 Ndd3fa7e4fa6a41268a1b52779fb6d9b2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Research Design
151 rdf:type schema:DefinedTerm
152 Ne4022428816f48ae8295cac1f0328ff2 schema:name nlm_unique_id
153 schema:value 100968552
154 rdf:type schema:PropertyValue
155 Nea632f92c93342ab8f1216125997cd83 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Case-Control Studies
157 rdf:type schema:DefinedTerm
158 Nedf0e08292474936b8da5e7fb74355d6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Polymorphism, Single Nucleotide
160 rdf:type schema:DefinedTerm
161 Nefe0a0a2107b414aa14ac7ea11592093 schema:name Springer Nature - SN SciGraph project
162 rdf:type schema:Organization
163 Nf1b6eaa7cf9e4ec7b442323e683f190e schema:name pubmed_id
164 schema:value 20698975
165 rdf:type schema:PropertyValue
166 Nfa8c3138cf1e46c2874fd8b5317d6bc0 rdf:first sg:person.0710057745.94
167 rdf:rest Ncf775c4cc0ea4995b422ca0016f0d4ea
168 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
169 schema:name Biological Sciences
170 rdf:type schema:DefinedTerm
171 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
172 schema:name Genetics
173 rdf:type schema:DefinedTerm
174 sg:grant.2404634 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2350-11-122
175 rdf:type schema:MonetaryGrant
176 sg:grant.2414304 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2350-11-122
177 rdf:type schema:MonetaryGrant
178 sg:grant.2416678 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2350-11-122
179 rdf:type schema:MonetaryGrant
180 sg:grant.2430005 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2350-11-122
181 rdf:type schema:MonetaryGrant
182 sg:grant.2437038 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2350-11-122
183 rdf:type schema:MonetaryGrant
184 sg:grant.2442069 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2350-11-122
185 rdf:type schema:MonetaryGrant
186 sg:grant.2537302 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2350-11-122
187 rdf:type schema:MonetaryGrant
188 sg:grant.2541256 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2350-11-122
189 rdf:type schema:MonetaryGrant
190 sg:grant.2541406 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2350-11-122
191 rdf:type schema:MonetaryGrant
192 sg:grant.2635838 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2350-11-122
193 rdf:type schema:MonetaryGrant
194 sg:grant.2681181 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2350-11-122
195 rdf:type schema:MonetaryGrant
196 sg:grant.2684700 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2350-11-122
197 rdf:type schema:MonetaryGrant
198 sg:grant.2691631 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2350-11-122
199 rdf:type schema:MonetaryGrant
200 sg:grant.2691801 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2350-11-122
201 rdf:type schema:MonetaryGrant
202 sg:journal.1024947 schema:issn 1471-2350
203 schema:name BMC Medical Genetics
204 rdf:type schema:Periodical
205 sg:person.01036210634.29 schema:affiliation https://www.grid.ac/institutes/grid.440331.1
206 schema:familyName Avila
207 schema:givenName Lydiana
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036210634.29
209 rdf:type schema:Person
210 sg:person.01045035274.57 schema:affiliation https://www.grid.ac/institutes/grid.475010.7
211 schema:familyName Wilk
212 schema:givenName Jemma B
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045035274.57
214 rdf:type schema:Person
215 sg:person.01047505230.76 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
216 schema:familyName Murphy
217 schema:givenName Amy J
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047505230.76
219 rdf:type schema:Person
220 sg:person.010515035712.31 schema:affiliation https://www.grid.ac/institutes/grid.475010.7
221 schema:familyName O'Connor
222 schema:givenName George T
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010515035712.31
224 rdf:type schema:Person
225 sg:person.01062144517.60 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
226 schema:familyName Raby
227 schema:givenName Benjamin A
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062144517.60
229 rdf:type schema:Person
230 sg:person.01104142045.88 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
231 schema:familyName Hunninghake
232 schema:givenName Gary M
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104142045.88
234 rdf:type schema:Person
235 sg:person.01210111627.99 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
236 schema:familyName Celedón
237 schema:givenName Juan C
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210111627.99
239 rdf:type schema:Person
240 sg:person.01225022742.10 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
241 schema:familyName Lasky-Su
242 schema:givenName Jessica
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225022742.10
244 rdf:type schema:Person
245 sg:person.013015301602.70 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
246 schema:familyName Weiss
247 schema:givenName Scott T
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013015301602.70
249 rdf:type schema:Person
250 sg:person.01334355135.93 schema:affiliation https://www.grid.ac/institutes/grid.2515.3
251 schema:familyName Himes
252 schema:givenName Blanca E
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334355135.93
254 rdf:type schema:Person
255 sg:person.01342332616.87 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
256 schema:familyName Lange
257 schema:givenName Christoph
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342332616.87
259 rdf:type schema:Person
260 sg:person.016064306032.61 schema:affiliation https://www.grid.ac/institutes/grid.2515.3
261 schema:familyName Wu
262 schema:givenName Ann C
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016064306032.61
264 rdf:type schema:Person
265 sg:person.016516477137.93 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
266 schema:familyName Silverman
267 schema:givenName Edwin K
268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016516477137.93
269 rdf:type schema:Person
270 sg:person.0710057745.94 schema:affiliation https://www.grid.ac/institutes/grid.440331.1
271 schema:familyName Soto-Quiros
272 schema:givenName Manuel E
273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710057745.94
274 rdf:type schema:Person
275 sg:person.0755746605.02 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
276 schema:familyName Klanderman
277 schema:givenName Barbara
278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755746605.02
279 rdf:type schema:Person
280 sg:person.0766744011.63 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
281 schema:familyName Lazarus
282 schema:givenName Ross
283 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766744011.63
284 rdf:type schema:Person
285 sg:pub.10.1007/bf02714448 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038540574
286 https://doi.org/10.1007/bf02714448
287 rdf:type schema:CreativeWork
288 sg:pub.10.1038/nature06014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014505872
289 https://doi.org/10.1038/nature06014
290 rdf:type schema:CreativeWork
291 sg:pub.10.1038/ng.76 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009408087
292 https://doi.org/10.1038/ng.76
293 rdf:type schema:CreativeWork
294 sg:pub.10.1038/ng1847 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031429813
295 https://doi.org/10.1038/ng1847
296 rdf:type schema:CreativeWork
297 sg:pub.10.1038/sj.gene.6364284 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048759804
298 https://doi.org/10.1038/sj.gene.6364284
299 rdf:type schema:CreativeWork
300 sg:pub.10.1186/1471-2350-8-s1-s1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039530988
301 https://doi.org/10.1186/1471-2350-8-s1-s1
302 rdf:type schema:CreativeWork
303 sg:pub.10.1186/1472-6947-6-30 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024163546
304 https://doi.org/10.1186/1472-6947-6-30
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1002/gepi.10182 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015746883
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1016/j.ajhg.2007.11.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016278126
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1016/j.ajhg.2009.04.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028680851
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1016/j.ajhg.2009.08.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006057593
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1016/j.jaci.2006.12.609 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015217820
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1016/j.jaci.2007.04.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024777728
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1016/j.jaci.2007.09.038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051570455
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1016/j.jaci.2008.01.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002632734
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1016/j.jaci.2008.06.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044419949
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1016/j.jaci.2009.11.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001648585
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1016/s0091-6749(03)02023-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033321556
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1016/s0197-2456(98)00044-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021640226
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1056/nejmoa0708801 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005744340
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1056/nejmoa0901867 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046205362
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1074/jbc.m804271200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035309298
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1086/302449 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058610023
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1086/381563 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058673343
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1086/424886 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058713966
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1086/519795 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019061180
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1093/aje/kwm021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007948489
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1093/bioinformatics/19.1.149 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013784960
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1093/bioinformatics/bth457 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008081196
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1111/j.1398-9995.2008.01873.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1018668444
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1111/j.1398-9995.2008.01912.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1019572312
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1164/rccm.200711-1644oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1019582837
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1164/rccm.200812-1860oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1008411997
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1172/jci34772 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046196569
359 rdf:type schema:CreativeWork
360 https://doi.org/10.1197/jamia.m2846 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013212272
361 rdf:type schema:CreativeWork
362 https://doi.org/10.1371/journal.pgen.0030236 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027655636
363 rdf:type schema:CreativeWork
364 https://doi.org/10.1371/journal.pgen.1000197 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011211842
365 rdf:type schema:CreativeWork
366 https://doi.org/10.1371/journal.pgen.1000623 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010731657
367 rdf:type schema:CreativeWork
368 https://www.grid.ac/institutes/grid.2515.3 schema:alternateName Boston Children's Hospital
369 schema:name Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA
370 Children's Hospital Informatics Program, Boston, MA, USA
371 Department of General Pediatrics, Children's Hospital, Boston, MA, USA
372 Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA
373 Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA, USA
374 Partners Center for Personalized Genetic Medicine, Boston, MA, USA
375 rdf:type schema:Organization
376 https://www.grid.ac/institutes/grid.38142.3c schema:alternateName Harvard University
377 schema:name Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA
378 Partners Center for Personalized Genetic Medicine, Boston, MA, USA
379 rdf:type schema:Organization
380 https://www.grid.ac/institutes/grid.440331.1 schema:alternateName Hospital Nacional de Niños
381 schema:name Division of Pediatric Pulmonology, Hospital Nacional de Niños, San José, Costa Rica
382 rdf:type schema:Organization
383 https://www.grid.ac/institutes/grid.475010.7 schema:alternateName Boston University School of Medicine
384 schema:name Department of Medicine, Boston University School of Medicine, Boston, MA, USA
385 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...