The INSIG2 rs7566605 genetic variant does not play a major role in obesity in a sample of 24,722 individuals from ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-12

AUTHORS

Jan Bressler, Myriam Fornage, Craig L Hanis, Wen Hong Linda Kao, Cora E Lewis, Ruth McPherson, Robert Dent, Thomas H Mosley, Len A Pennacchio, Eric Boerwinkle

ABSTRACT

BACKGROUND: In a genome-wide association study performed in the Framingham Offspring Cohort, individuals homozygous for the rs7566605 C allele located upstream of insulin-induced gene 2 (INSIG2) were reported to incur an increased risk of obesity. This finding was later replicated in four out of five populations examined. The goal of the study reported here was to assess the role of the INSIG2 single nucleotide polymorphism (SNP) in susceptibility to obesity in the prospective longitudinal Atherosclerosis Risk in Communities (ARIC) study (n = 14,566) and in three other cohorts: the Coronary Artery Risk Development in Young Adults (CARDIA) study (n = 3,888), the Genetic Epidemiology Network of Arteriopathy (GENOA) study (n = 4,766), and extremely obese and lean individuals ascertained at the University of Ottawa (n = 1,502). The combined study sample is comprised of 24,722 white, African-American, and Mexican-American participants. METHODS: Differences in mean body mass index (BMI) and other anthropometric measures including weight, waist circumference, and waist-to-hip ratio were assessed by a general linear model in individuals categorized by INSIG2 rs7566605 genotype. Multivariable logistic regression was used to predict the risk of obesity (BMI >or= 30 kg/m2). RESULTS: There was no discernable variation in the frequencies of the three INSIG2 SNP genotypes observed between white, Hispanic, and African-American obese individuals and non-obese study subjects. When the relationship between rs7566605 and BMI considered either as a categorical variable or a continuous variable was examined, no significant association with obesity was found for participants in any of the four study populations or in a combined analysis (p = 0.38) under a recessive genetic model. There was also no association between the INSIG2 polymorphism and the obesity-related quantitative traits except for a reduced waist-to-hip ratio in white ARIC study participants homozygous for the C allele, and an increased waist-to-hip ratio in African-Americans in the ARIC cohort with the same genotype (p = 0.04 and p = 0.01, respectively). An association with waist-to-hip ratio was not seen when the combined study sample was analyzed (p = 0.74). CONCLUSION: These results suggest that the INSIG2 rs7566605 variant does not play a major role in determining obesity risk in a racially and ethnically diverse sample of 24,722 individuals from four cohorts. More... »

PAGES

56

References to SciGraph publications

  • 2006-12. INSIG-2 promoter polymorphism and obesity related phenotypes: association study in 1428 members of 248 families in BMC MEDICAL GENETICS
  • 2007-06. Variation in FTO contributes to childhood obesity and severe adult obesity in NATURE GENETICS
  • 2008-12. INSIG2 gene polymorphism is associated with increased subcutaneous fat in women and poor response to resistance training in men in BMC MEDICAL GENETICS
  • 1990-02. Regulation of the mevalonate pathway in NATURE
  • 2008-06. Potential association of INSIG2 rs7566605 polymorphism with body weight in a Chinese subpopulation in EUROPEAN JOURNAL OF HUMAN GENETICS
  • 2009-02. Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations in NATURE GENETICS
  • 2008-09. INSIG2 gene rs7566605 polymorphism is associated with severe obesity in Japanese in JOURNAL OF HUMAN GENETICS
  • 2008-06. Common genetic variation near MC4R is associated with waist circumference and insulin resistance in NATURE GENETICS
  • 2009-01. Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity in NATURE GENETICS
  • 2008-06. Common variants near MC4R are associated with fat mass, weight and risk of obesity in NATURE GENETICS
  • 2005-10. A haplotype map of the human genome in NATURE
  • 2004-06. Modern science versus the stigma of obesity in NATURE MEDICINE
  • 2009-01. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation in NATURE GENETICS
  • 2007-11. INSIG2 gene polymorphism is not associated with obesity in Caucasian, Afro-Caribbean and Indian subjects in INTERNATIONAL JOURNAL OF OBESITY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/1471-2350-10-56

    DOI

    http://dx.doi.org/10.1186/1471-2350-10-56

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1004510271

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19523229


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "African Americans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Alleles", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Atherosclerosis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Body Mass Index", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Case-Control Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cohort Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Coronary Artery Disease", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "European Continental Ancestry Group", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genome-Wide Association Study", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genotype", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Intracellular Signaling Peptides and Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Logistic Models", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Membrane Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mexican Americans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Obesity", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Polymorphism, Single Nucleotide", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Risk Factors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "United States", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Young Adult", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "The University of Texas Health Science Center at Houston", 
              "id": "https://www.grid.ac/institutes/grid.267308.8", 
              "name": [
                "Human Genetics Center, University of Texas Health Science Center at Houston, 1200 Herman Pressler Street, 77030, Houston, TX, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bressler", 
            "givenName": "Jan", 
            "id": "sg:person.01232615556.56", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232615556.56"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The University of Texas Health Science Center at Houston", 
              "id": "https://www.grid.ac/institutes/grid.267308.8", 
              "name": [
                "Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, 1825 Pressler Street, 77030, Houston, TX, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fornage", 
            "givenName": "Myriam", 
            "id": "sg:person.0751112610.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751112610.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The University of Texas Health Science Center at Houston", 
              "id": "https://www.grid.ac/institutes/grid.267308.8", 
              "name": [
                "Human Genetics Center, University of Texas Health Science Center at Houston, 1200 Herman Pressler Street, 77030, Houston, TX, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hanis", 
            "givenName": "Craig L", 
            "id": "sg:person.012563551257.73", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012563551257.73"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Johns Hopkins University", 
              "id": "https://www.grid.ac/institutes/grid.21107.35", 
              "name": [
                "Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, 21205, Baltimore, MD, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kao", 
            "givenName": "Wen Hong Linda", 
            "id": "sg:person.010012617237.52", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010012617237.52"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Alabama at Birmingham", 
              "id": "https://www.grid.ac/institutes/grid.265892.2", 
              "name": [
                "Division of Preventive Medicine, University of Alabama at Birmingham, 1717 11th Avenue South, 35205, Birmingham, AL, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lewis", 
            "givenName": "Cora E", 
            "id": "sg:person.012525005212.10", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012525005212.10"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Ottawa", 
              "id": "https://www.grid.ac/institutes/grid.28046.38", 
              "name": [
                "Division of Cardiology, University of Ottawa Heart Institute, 40 Ruskin Street, K1Y4W7, Ottawa, Ontario, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "McPherson", 
            "givenName": "Ruth", 
            "id": "sg:person.01177666174.92", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177666174.92"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Ottawa", 
              "id": "https://www.grid.ac/institutes/grid.28046.38", 
              "name": [
                "Division of Cardiology, University of Ottawa Heart Institute, 40 Ruskin Street, K1Y4W7, Ottawa, Ontario, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dent", 
            "givenName": "Robert", 
            "id": "sg:person.0615212120.49", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615212120.49"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Mississippi Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.410721.1", 
              "name": [
                "Division of Geriatrics, Department of Internal Medicine, University of Mississippi Medical Center, 2500 North State Street, 39216, Jackson, MS, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mosley", 
            "givenName": "Thomas H", 
            "id": "sg:person.011267342137.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011267342137.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Joint Genome Institute", 
              "id": "https://www.grid.ac/institutes/grid.451309.a", 
              "name": [
                "Genomics Division, Lawrence Berkeley National Laboratory, One Cyclotron Road, 94720, Berkeley, CA, USA", 
                "US Department of Energy Joint Genome Institute, 2800 Mitchell Drive, 94598, Walnut Creek, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pennacchio", 
            "givenName": "Len A", 
            "id": "sg:person.01022360446.35", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022360446.35"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The University of Texas Health Science Center at Houston", 
              "id": "https://www.grid.ac/institutes/grid.267308.8", 
              "name": [
                "Human Genetics Center, University of Texas Health Science Center at Houston, 1200 Herman Pressler Street, 77030, Houston, TX, USA", 
                "Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, 1825 Pressler Street, 77030, Houston, TX, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Boerwinkle", 
            "givenName": "Eric", 
            "id": "sg:person.01104262534.26", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104262534.26"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1001/jama.288.14.1723", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000543809"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(05)67663-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001633112"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.274", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001671795", 
              "https://doi.org/10.1038/ng.274"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/oby.2007.301", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003659436"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0197-2456(91)90002-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008536032"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0197-2456(91)90002-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008536032"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2350-7-83", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010256482", 
              "https://doi.org/10.1186/1471-2350-7-83"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/oby.2008.669", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012763402"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1388-1981(00)00140-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013940781"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0401715101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016788956"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1130012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016895627"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04226", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017293702", 
              "https://doi.org/10.1038/nature04226"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04226", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017293702", 
              "https://doi.org/10.1038/nature04226"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04226", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017293702", 
              "https://doi.org/10.1038/nature04226"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2350-9-117", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017359344", 
              "https://doi.org/10.1186/1471-2350-9-117"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.156", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018055467", 
              "https://doi.org/10.1038/ng.156"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.diabres.2008.03.022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018821512"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.301", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019269492", 
              "https://doi.org/10.1038/ng.301"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/abbi.2001.2615", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019583686"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jama.1986.03380010055024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019603908"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.162488899", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020405103"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m004793200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020611626"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m004793200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020611626"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.0030061", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025099272"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m310053200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025135045"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.140", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026795787", 
              "https://doi.org/10.1038/ng.140"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.287", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026939578", 
              "https://doi.org/10.1038/ng.287"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/oby.2007.132", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027534797"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1141634", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027547166"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jama.295.13.1549", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029260331"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0197-2456(87)90008-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029735209"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0197-2456(87)90008-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029735209"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.0030115", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030172498"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.ijo.0803645", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030242191", 
              "https://doi.org/10.1038/sj.ijo.0803645"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.ijo.0803645", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030242191", 
              "https://doi.org/10.1038/sj.ijo.0803645"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm198601233140401", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030888872"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1129402", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030903064"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0002872", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030939238"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1017/s0007114508006557", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030946538"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1017/s0007114508006557", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030946538"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.amjmed.2003.12.032", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034585797"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jama.1988.03720100038035", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035964512"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0895-4356(88)90080-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037439545"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/hmg/ddn072", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037667357"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1399-0004.2007.00795.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037947643"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/strokeaha.108.523001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037959550"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/strokeaha.108.523001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037959550"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng2048", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040135512", 
              "https://doi.org/10.1038/ng2048"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1130571", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041586493"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ejhg.2008.8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042181642", 
              "https://doi.org/10.1038/ejhg.2008.8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/hy1201.100415", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042735011"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10038-008-0317-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042922160", 
              "https://doi.org/10.1007/s10038-008-0317-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jama.282.16.1523", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043154773"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(02)00872-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043415971"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/oby.2007.25", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044013239"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0130116100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044122750"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0604-563", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046050506", 
              "https://doi.org/10.1038/nm0604-563"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0604-563", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046050506", 
              "https://doi.org/10.1038/nm0604-563"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/343425a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047196635", 
              "https://doi.org/10.1038/343425a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm199005243222102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049052450"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/oby.2008.650", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049866480"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.96.20.11041", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052469813"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1097-2765(02)00591-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052532210"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jama.259.10.1520", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054148401"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1086/513471", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1058788998"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/oxfordjournals.aje.a115184", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059958072"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1124779", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062453553"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci15593", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063415406"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074778576", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/oxfordjournals.aje.a115083", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1079606415"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2009-12", 
        "datePublishedReg": "2009-12-01", 
        "description": "BACKGROUND: In a genome-wide association study performed in the Framingham Offspring Cohort, individuals homozygous for the rs7566605 C allele located upstream of insulin-induced gene 2 (INSIG2) were reported to incur an increased risk of obesity. This finding was later replicated in four out of five populations examined. The goal of the study reported here was to assess the role of the INSIG2 single nucleotide polymorphism (SNP) in susceptibility to obesity in the prospective longitudinal Atherosclerosis Risk in Communities (ARIC) study (n = 14,566) and in three other cohorts: the Coronary Artery Risk Development in Young Adults (CARDIA) study (n = 3,888), the Genetic Epidemiology Network of Arteriopathy (GENOA) study (n = 4,766), and extremely obese and lean individuals ascertained at the University of Ottawa (n = 1,502). The combined study sample is comprised of 24,722 white, African-American, and Mexican-American participants.\nMETHODS: Differences in mean body mass index (BMI) and other anthropometric measures including weight, waist circumference, and waist-to-hip ratio were assessed by a general linear model in individuals categorized by INSIG2 rs7566605 genotype. Multivariable logistic regression was used to predict the risk of obesity (BMI >or= 30 kg/m2).\nRESULTS: There was no discernable variation in the frequencies of the three INSIG2 SNP genotypes observed between white, Hispanic, and African-American obese individuals and non-obese study subjects. When the relationship between rs7566605 and BMI considered either as a categorical variable or a continuous variable was examined, no significant association with obesity was found for participants in any of the four study populations or in a combined analysis (p = 0.38) under a recessive genetic model. There was also no association between the INSIG2 polymorphism and the obesity-related quantitative traits except for a reduced waist-to-hip ratio in white ARIC study participants homozygous for the C allele, and an increased waist-to-hip ratio in African-Americans in the ARIC cohort with the same genotype (p = 0.04 and p = 0.01, respectively). An association with waist-to-hip ratio was not seen when the combined study sample was analyzed (p = 0.74).\nCONCLUSION: These results suggest that the INSIG2 rs7566605 variant does not play a major role in determining obesity risk in a racially and ethnically diverse sample of 24,722 individuals from four cohorts.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1186/1471-2350-10-56", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2637678", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2691511", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2430098", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2430056", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2430092", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2430097", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2534131", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2430099", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2694330", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2635791", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2430055", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2430054", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2430053", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2534129", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2637677", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2638717", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2534130", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2532690", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2430093", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2430096", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2629812", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2430095", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2534648", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2430178", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1024947", 
            "issn": [
              "1471-2350"
            ], 
            "name": "BMC Medical Genetics", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "10"
          }
        ], 
        "name": "The INSIG2 rs7566605 genetic variant does not play a major role in obesity in a sample of 24,722 individuals from four cohorts", 
        "pagination": "56", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "157db60a6211f7623c91b77ab5328b194af380ecaa72491ade430cd9f3b26cdb"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "19523229"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "100968552"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/1471-2350-10-56"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1004510271"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/1471-2350-10-56", 
          "https://app.dimensions.ai/details/publication/pub.1004510271"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T23:31", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8693_00000549.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1186%2F1471-2350-10-56"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1471-2350-10-56'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1471-2350-10-56'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1471-2350-10-56'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1471-2350-10-56'


     

    This table displays all metadata directly associated to this object as RDF triples.

    472 TRIPLES      21 PREDICATES      110 URIs      41 LITERALS      29 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/1471-2350-10-56 schema:about N17fc4c822a71444ba12c47a02e2304c8
    2 N254365883c56468999f5ebf04c95c41b
    3 N28bb8ed77da8484ab14f91ab93a22c8b
    4 N317115bfad2249f2b8e603499e02f3c5
    5 N3804233090eb40d793138fd3337a58d6
    6 N49e6a01f36ee4f638a45a48edded1552
    7 N4b7eab9ae5124ecc9f3a7a4c2fa20b72
    8 N579e74a4fde14a1c99fac23e1cac839b
    9 N6a48315961fe4920b3a7bce290edb920
    10 N752460cded624fbaab20f266c6d9a5e0
    11 N8346bdecf6a741f49367e13b0b824559
    12 N8833ea2ea6d247f9a84d9061e3e753ab
    13 N9a7ec3a54c3446ecb851c29a43ff3476
    14 Na56224832dd44be9916034ca5d5531da
    15 Nb1f2fd12350b4aad9aa61c0e410f3a0f
    16 Nb66e82c42b1440988308711b6cf87e89
    17 Nb792e84fb4ba4398ac078cfd4c630821
    18 Ndff2ebfddcb34d189e9ce07e19a4ec18
    19 Ne103b232a793400ab413034c38f2ad41
    20 Ne7fc610848f942948d570742d344c835
    21 anzsrc-for:06
    22 anzsrc-for:0604
    23 schema:author N5997ddad4a334114a48cd5abc5f275b3
    24 schema:citation sg:pub.10.1007/s10038-008-0317-8
    25 sg:pub.10.1038/343425a0
    26 sg:pub.10.1038/ejhg.2008.8
    27 sg:pub.10.1038/nature04226
    28 sg:pub.10.1038/ng.140
    29 sg:pub.10.1038/ng.156
    30 sg:pub.10.1038/ng.274
    31 sg:pub.10.1038/ng.287
    32 sg:pub.10.1038/ng.301
    33 sg:pub.10.1038/ng2048
    34 sg:pub.10.1038/nm0604-563
    35 sg:pub.10.1038/sj.ijo.0803645
    36 sg:pub.10.1186/1471-2350-7-83
    37 sg:pub.10.1186/1471-2350-9-117
    38 https://app.dimensions.ai/details/publication/pub.1074778576
    39 https://doi.org/10.1001/jama.1986.03380010055024
    40 https://doi.org/10.1001/jama.1988.03720100038035
    41 https://doi.org/10.1001/jama.259.10.1520
    42 https://doi.org/10.1001/jama.282.16.1523
    43 https://doi.org/10.1001/jama.288.14.1723
    44 https://doi.org/10.1001/jama.295.13.1549
    45 https://doi.org/10.1006/abbi.2001.2615
    46 https://doi.org/10.1016/0197-2456(87)90008-0
    47 https://doi.org/10.1016/0197-2456(91)90002-4
    48 https://doi.org/10.1016/0895-4356(88)90080-7
    49 https://doi.org/10.1016/j.amjmed.2003.12.032
    50 https://doi.org/10.1016/j.diabres.2008.03.022
    51 https://doi.org/10.1016/s0092-8674(02)00872-3
    52 https://doi.org/10.1016/s0140-6736(05)67663-5
    53 https://doi.org/10.1016/s1097-2765(02)00591-9
    54 https://doi.org/10.1016/s1388-1981(00)00140-2
    55 https://doi.org/10.1017/s0007114508006557
    56 https://doi.org/10.1038/oby.2007.132
    57 https://doi.org/10.1038/oby.2007.25
    58 https://doi.org/10.1038/oby.2007.301
    59 https://doi.org/10.1038/oby.2008.650
    60 https://doi.org/10.1038/oby.2008.669
    61 https://doi.org/10.1056/nejm198601233140401
    62 https://doi.org/10.1056/nejm199005243222102
    63 https://doi.org/10.1073/pnas.0130116100
    64 https://doi.org/10.1073/pnas.0401715101
    65 https://doi.org/10.1073/pnas.162488899
    66 https://doi.org/10.1073/pnas.96.20.11041
    67 https://doi.org/10.1074/jbc.m004793200
    68 https://doi.org/10.1074/jbc.m310053200
    69 https://doi.org/10.1086/513471
    70 https://doi.org/10.1093/hmg/ddn072
    71 https://doi.org/10.1093/oxfordjournals.aje.a115083
    72 https://doi.org/10.1093/oxfordjournals.aje.a115184
    73 https://doi.org/10.1111/j.1399-0004.2007.00795.x
    74 https://doi.org/10.1126/science.1124779
    75 https://doi.org/10.1126/science.1129402
    76 https://doi.org/10.1126/science.1130012
    77 https://doi.org/10.1126/science.1130571
    78 https://doi.org/10.1126/science.1141634
    79 https://doi.org/10.1161/hy1201.100415
    80 https://doi.org/10.1161/strokeaha.108.523001
    81 https://doi.org/10.1172/jci15593
    82 https://doi.org/10.1371/journal.pgen.0030061
    83 https://doi.org/10.1371/journal.pgen.0030115
    84 https://doi.org/10.1371/journal.pone.0002872
    85 schema:datePublished 2009-12
    86 schema:datePublishedReg 2009-12-01
    87 schema:description BACKGROUND: In a genome-wide association study performed in the Framingham Offspring Cohort, individuals homozygous for the rs7566605 C allele located upstream of insulin-induced gene 2 (INSIG2) were reported to incur an increased risk of obesity. This finding was later replicated in four out of five populations examined. The goal of the study reported here was to assess the role of the INSIG2 single nucleotide polymorphism (SNP) in susceptibility to obesity in the prospective longitudinal Atherosclerosis Risk in Communities (ARIC) study (n = 14,566) and in three other cohorts: the Coronary Artery Risk Development in Young Adults (CARDIA) study (n = 3,888), the Genetic Epidemiology Network of Arteriopathy (GENOA) study (n = 4,766), and extremely obese and lean individuals ascertained at the University of Ottawa (n = 1,502). The combined study sample is comprised of 24,722 white, African-American, and Mexican-American participants. METHODS: Differences in mean body mass index (BMI) and other anthropometric measures including weight, waist circumference, and waist-to-hip ratio were assessed by a general linear model in individuals categorized by INSIG2 rs7566605 genotype. Multivariable logistic regression was used to predict the risk of obesity (BMI >or= 30 kg/m2). RESULTS: There was no discernable variation in the frequencies of the three INSIG2 SNP genotypes observed between white, Hispanic, and African-American obese individuals and non-obese study subjects. When the relationship between rs7566605 and BMI considered either as a categorical variable or a continuous variable was examined, no significant association with obesity was found for participants in any of the four study populations or in a combined analysis (p = 0.38) under a recessive genetic model. There was also no association between the INSIG2 polymorphism and the obesity-related quantitative traits except for a reduced waist-to-hip ratio in white ARIC study participants homozygous for the C allele, and an increased waist-to-hip ratio in African-Americans in the ARIC cohort with the same genotype (p = 0.04 and p = 0.01, respectively). An association with waist-to-hip ratio was not seen when the combined study sample was analyzed (p = 0.74). CONCLUSION: These results suggest that the INSIG2 rs7566605 variant does not play a major role in determining obesity risk in a racially and ethnically diverse sample of 24,722 individuals from four cohorts.
    88 schema:genre research_article
    89 schema:inLanguage en
    90 schema:isAccessibleForFree true
    91 schema:isPartOf N17842d5bcc4c46c8941933616c80be41
    92 N5034b3ff8fe34da1a86637a88b192786
    93 sg:journal.1024947
    94 schema:name The INSIG2 rs7566605 genetic variant does not play a major role in obesity in a sample of 24,722 individuals from four cohorts
    95 schema:pagination 56
    96 schema:productId N33f70dae859649dc9ac59de1db5cda75
    97 N553c5d441e1e4e3b8d7fc79bd278c793
    98 N7a03ff6661bb4f528a67e490dccd6237
    99 Na3326959673e430795840f25a8b1ef7a
    100 Na693f4365cf748b0a667e34eeb4d2343
    101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004510271
    102 https://doi.org/10.1186/1471-2350-10-56
    103 schema:sdDatePublished 2019-04-10T23:31
    104 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    105 schema:sdPublisher Ne693365f8b5540539798147d0557d0ae
    106 schema:url http://link.springer.com/10.1186%2F1471-2350-10-56
    107 sgo:license sg:explorer/license/
    108 sgo:sdDataset articles
    109 rdf:type schema:ScholarlyArticle
    110 N11042162035e438a9271fac24974161d rdf:first sg:person.0615212120.49
    111 rdf:rest Neddc499a8dba48598750cb82efed0d28
    112 N16cc40060f394e5395eb2ee6d44bfa69 rdf:first sg:person.0751112610.31
    113 rdf:rest Nbb6f4ae666ce41e7b73c0296cfec4c79
    114 N17842d5bcc4c46c8941933616c80be41 schema:issueNumber 1
    115 rdf:type schema:PublicationIssue
    116 N17fc4c822a71444ba12c47a02e2304c8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    117 schema:name Case-Control Studies
    118 rdf:type schema:DefinedTerm
    119 N254365883c56468999f5ebf04c95c41b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    120 schema:name African Americans
    121 rdf:type schema:DefinedTerm
    122 N27c6bd37cd1c4164a173fb749dc96e8e rdf:first sg:person.01177666174.92
    123 rdf:rest N11042162035e438a9271fac24974161d
    124 N28bb8ed77da8484ab14f91ab93a22c8b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    125 schema:name Polymorphism, Single Nucleotide
    126 rdf:type schema:DefinedTerm
    127 N317115bfad2249f2b8e603499e02f3c5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    128 schema:name Cohort Studies
    129 rdf:type schema:DefinedTerm
    130 N33f70dae859649dc9ac59de1db5cda75 schema:name nlm_unique_id
    131 schema:value 100968552
    132 rdf:type schema:PropertyValue
    133 N3804233090eb40d793138fd3337a58d6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    134 schema:name Logistic Models
    135 rdf:type schema:DefinedTerm
    136 N49e6a01f36ee4f638a45a48edded1552 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    137 schema:name Young Adult
    138 rdf:type schema:DefinedTerm
    139 N4b7eab9ae5124ecc9f3a7a4c2fa20b72 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    140 schema:name Obesity
    141 rdf:type schema:DefinedTerm
    142 N5034b3ff8fe34da1a86637a88b192786 schema:volumeNumber 10
    143 rdf:type schema:PublicationVolume
    144 N553c5d441e1e4e3b8d7fc79bd278c793 schema:name readcube_id
    145 schema:value 157db60a6211f7623c91b77ab5328b194af380ecaa72491ade430cd9f3b26cdb
    146 rdf:type schema:PropertyValue
    147 N579e74a4fde14a1c99fac23e1cac839b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    148 schema:name Humans
    149 rdf:type schema:DefinedTerm
    150 N5997ddad4a334114a48cd5abc5f275b3 rdf:first sg:person.01232615556.56
    151 rdf:rest N16cc40060f394e5395eb2ee6d44bfa69
    152 N6a48315961fe4920b3a7bce290edb920 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    153 schema:name European Continental Ancestry Group
    154 rdf:type schema:DefinedTerm
    155 N752460cded624fbaab20f266c6d9a5e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    156 schema:name Genotype
    157 rdf:type schema:DefinedTerm
    158 N7a03ff6661bb4f528a67e490dccd6237 schema:name pubmed_id
    159 schema:value 19523229
    160 rdf:type schema:PropertyValue
    161 N8346bdecf6a741f49367e13b0b824559 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    162 schema:name Atherosclerosis
    163 rdf:type schema:DefinedTerm
    164 N8833ea2ea6d247f9a84d9061e3e753ab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    165 schema:name Mexican Americans
    166 rdf:type schema:DefinedTerm
    167 N9a7ec3a54c3446ecb851c29a43ff3476 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    168 schema:name Genome-Wide Association Study
    169 rdf:type schema:DefinedTerm
    170 Na3326959673e430795840f25a8b1ef7a schema:name dimensions_id
    171 schema:value pub.1004510271
    172 rdf:type schema:PropertyValue
    173 Na56224832dd44be9916034ca5d5531da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    174 schema:name Intracellular Signaling Peptides and Proteins
    175 rdf:type schema:DefinedTerm
    176 Na693f4365cf748b0a667e34eeb4d2343 schema:name doi
    177 schema:value 10.1186/1471-2350-10-56
    178 rdf:type schema:PropertyValue
    179 Nb1f2fd12350b4aad9aa61c0e410f3a0f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    180 schema:name United States
    181 rdf:type schema:DefinedTerm
    182 Nb66e82c42b1440988308711b6cf87e89 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    183 schema:name Body Mass Index
    184 rdf:type schema:DefinedTerm
    185 Nb792e84fb4ba4398ac078cfd4c630821 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    186 schema:name Membrane Proteins
    187 rdf:type schema:DefinedTerm
    188 Nbb6f4ae666ce41e7b73c0296cfec4c79 rdf:first sg:person.012563551257.73
    189 rdf:rest Ncbfe6bc754234f5eb3be315e1e05511a
    190 Nbccda78aa5da43acb35117a50b2d7063 rdf:first sg:person.01104262534.26
    191 rdf:rest rdf:nil
    192 Ncbfe6bc754234f5eb3be315e1e05511a rdf:first sg:person.010012617237.52
    193 rdf:rest Nd12ee04c6e54406fa1df504bde64f2b5
    194 Nd12ee04c6e54406fa1df504bde64f2b5 rdf:first sg:person.012525005212.10
    195 rdf:rest N27c6bd37cd1c4164a173fb749dc96e8e
    196 Ndff2ebfddcb34d189e9ce07e19a4ec18 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    197 schema:name Risk Factors
    198 rdf:type schema:DefinedTerm
    199 Ne103b232a793400ab413034c38f2ad41 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    200 schema:name Alleles
    201 rdf:type schema:DefinedTerm
    202 Ne2c7afe796f440bc9550ee42030e567b rdf:first sg:person.01022360446.35
    203 rdf:rest Nbccda78aa5da43acb35117a50b2d7063
    204 Ne693365f8b5540539798147d0557d0ae schema:name Springer Nature - SN SciGraph project
    205 rdf:type schema:Organization
    206 Ne7fc610848f942948d570742d344c835 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    207 schema:name Coronary Artery Disease
    208 rdf:type schema:DefinedTerm
    209 Neddc499a8dba48598750cb82efed0d28 rdf:first sg:person.011267342137.34
    210 rdf:rest Ne2c7afe796f440bc9550ee42030e567b
    211 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    212 schema:name Biological Sciences
    213 rdf:type schema:DefinedTerm
    214 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    215 schema:name Genetics
    216 rdf:type schema:DefinedTerm
    217 sg:grant.2430053 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2350-10-56
    218 rdf:type schema:MonetaryGrant
    219 sg:grant.2430054 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2350-10-56
    220 rdf:type schema:MonetaryGrant
    221 sg:grant.2430055 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2350-10-56
    222 rdf:type schema:MonetaryGrant
    223 sg:grant.2430056 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2350-10-56
    224 rdf:type schema:MonetaryGrant
    225 sg:grant.2430092 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2350-10-56
    226 rdf:type schema:MonetaryGrant
    227 sg:grant.2430093 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2350-10-56
    228 rdf:type schema:MonetaryGrant
    229 sg:grant.2430095 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2350-10-56
    230 rdf:type schema:MonetaryGrant
    231 sg:grant.2430096 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2350-10-56
    232 rdf:type schema:MonetaryGrant
    233 sg:grant.2430097 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2350-10-56
    234 rdf:type schema:MonetaryGrant
    235 sg:grant.2430098 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2350-10-56
    236 rdf:type schema:MonetaryGrant
    237 sg:grant.2430099 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2350-10-56
    238 rdf:type schema:MonetaryGrant
    239 sg:grant.2430178 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2350-10-56
    240 rdf:type schema:MonetaryGrant
    241 sg:grant.2532690 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2350-10-56
    242 rdf:type schema:MonetaryGrant
    243 sg:grant.2534129 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2350-10-56
    244 rdf:type schema:MonetaryGrant
    245 sg:grant.2534130 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2350-10-56
    246 rdf:type schema:MonetaryGrant
    247 sg:grant.2534131 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2350-10-56
    248 rdf:type schema:MonetaryGrant
    249 sg:grant.2534648 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2350-10-56
    250 rdf:type schema:MonetaryGrant
    251 sg:grant.2629812 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2350-10-56
    252 rdf:type schema:MonetaryGrant
    253 sg:grant.2635791 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2350-10-56
    254 rdf:type schema:MonetaryGrant
    255 sg:grant.2637677 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2350-10-56
    256 rdf:type schema:MonetaryGrant
    257 sg:grant.2637678 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2350-10-56
    258 rdf:type schema:MonetaryGrant
    259 sg:grant.2638717 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2350-10-56
    260 rdf:type schema:MonetaryGrant
    261 sg:grant.2691511 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2350-10-56
    262 rdf:type schema:MonetaryGrant
    263 sg:grant.2694330 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2350-10-56
    264 rdf:type schema:MonetaryGrant
    265 sg:journal.1024947 schema:issn 1471-2350
    266 schema:name BMC Medical Genetics
    267 rdf:type schema:Periodical
    268 sg:person.010012617237.52 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
    269 schema:familyName Kao
    270 schema:givenName Wen Hong Linda
    271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010012617237.52
    272 rdf:type schema:Person
    273 sg:person.01022360446.35 schema:affiliation https://www.grid.ac/institutes/grid.451309.a
    274 schema:familyName Pennacchio
    275 schema:givenName Len A
    276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022360446.35
    277 rdf:type schema:Person
    278 sg:person.01104262534.26 schema:affiliation https://www.grid.ac/institutes/grid.267308.8
    279 schema:familyName Boerwinkle
    280 schema:givenName Eric
    281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104262534.26
    282 rdf:type schema:Person
    283 sg:person.011267342137.34 schema:affiliation https://www.grid.ac/institutes/grid.410721.1
    284 schema:familyName Mosley
    285 schema:givenName Thomas H
    286 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011267342137.34
    287 rdf:type schema:Person
    288 sg:person.01177666174.92 schema:affiliation https://www.grid.ac/institutes/grid.28046.38
    289 schema:familyName McPherson
    290 schema:givenName Ruth
    291 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177666174.92
    292 rdf:type schema:Person
    293 sg:person.01232615556.56 schema:affiliation https://www.grid.ac/institutes/grid.267308.8
    294 schema:familyName Bressler
    295 schema:givenName Jan
    296 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232615556.56
    297 rdf:type schema:Person
    298 sg:person.012525005212.10 schema:affiliation https://www.grid.ac/institutes/grid.265892.2
    299 schema:familyName Lewis
    300 schema:givenName Cora E
    301 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012525005212.10
    302 rdf:type schema:Person
    303 sg:person.012563551257.73 schema:affiliation https://www.grid.ac/institutes/grid.267308.8
    304 schema:familyName Hanis
    305 schema:givenName Craig L
    306 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012563551257.73
    307 rdf:type schema:Person
    308 sg:person.0615212120.49 schema:affiliation https://www.grid.ac/institutes/grid.28046.38
    309 schema:familyName Dent
    310 schema:givenName Robert
    311 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615212120.49
    312 rdf:type schema:Person
    313 sg:person.0751112610.31 schema:affiliation https://www.grid.ac/institutes/grid.267308.8
    314 schema:familyName Fornage
    315 schema:givenName Myriam
    316 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751112610.31
    317 rdf:type schema:Person
    318 sg:pub.10.1007/s10038-008-0317-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042922160
    319 https://doi.org/10.1007/s10038-008-0317-8
    320 rdf:type schema:CreativeWork
    321 sg:pub.10.1038/343425a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047196635
    322 https://doi.org/10.1038/343425a0
    323 rdf:type schema:CreativeWork
    324 sg:pub.10.1038/ejhg.2008.8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042181642
    325 https://doi.org/10.1038/ejhg.2008.8
    326 rdf:type schema:CreativeWork
    327 sg:pub.10.1038/nature04226 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017293702
    328 https://doi.org/10.1038/nature04226
    329 rdf:type schema:CreativeWork
    330 sg:pub.10.1038/ng.140 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026795787
    331 https://doi.org/10.1038/ng.140
    332 rdf:type schema:CreativeWork
    333 sg:pub.10.1038/ng.156 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018055467
    334 https://doi.org/10.1038/ng.156
    335 rdf:type schema:CreativeWork
    336 sg:pub.10.1038/ng.274 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001671795
    337 https://doi.org/10.1038/ng.274
    338 rdf:type schema:CreativeWork
    339 sg:pub.10.1038/ng.287 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026939578
    340 https://doi.org/10.1038/ng.287
    341 rdf:type schema:CreativeWork
    342 sg:pub.10.1038/ng.301 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019269492
    343 https://doi.org/10.1038/ng.301
    344 rdf:type schema:CreativeWork
    345 sg:pub.10.1038/ng2048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040135512
    346 https://doi.org/10.1038/ng2048
    347 rdf:type schema:CreativeWork
    348 sg:pub.10.1038/nm0604-563 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046050506
    349 https://doi.org/10.1038/nm0604-563
    350 rdf:type schema:CreativeWork
    351 sg:pub.10.1038/sj.ijo.0803645 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030242191
    352 https://doi.org/10.1038/sj.ijo.0803645
    353 rdf:type schema:CreativeWork
    354 sg:pub.10.1186/1471-2350-7-83 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010256482
    355 https://doi.org/10.1186/1471-2350-7-83
    356 rdf:type schema:CreativeWork
    357 sg:pub.10.1186/1471-2350-9-117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017359344
    358 https://doi.org/10.1186/1471-2350-9-117
    359 rdf:type schema:CreativeWork
    360 https://app.dimensions.ai/details/publication/pub.1074778576 schema:CreativeWork
    361 https://doi.org/10.1001/jama.1986.03380010055024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019603908
    362 rdf:type schema:CreativeWork
    363 https://doi.org/10.1001/jama.1988.03720100038035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035964512
    364 rdf:type schema:CreativeWork
    365 https://doi.org/10.1001/jama.259.10.1520 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054148401
    366 rdf:type schema:CreativeWork
    367 https://doi.org/10.1001/jama.282.16.1523 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043154773
    368 rdf:type schema:CreativeWork
    369 https://doi.org/10.1001/jama.288.14.1723 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000543809
    370 rdf:type schema:CreativeWork
    371 https://doi.org/10.1001/jama.295.13.1549 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029260331
    372 rdf:type schema:CreativeWork
    373 https://doi.org/10.1006/abbi.2001.2615 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019583686
    374 rdf:type schema:CreativeWork
    375 https://doi.org/10.1016/0197-2456(87)90008-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029735209
    376 rdf:type schema:CreativeWork
    377 https://doi.org/10.1016/0197-2456(91)90002-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008536032
    378 rdf:type schema:CreativeWork
    379 https://doi.org/10.1016/0895-4356(88)90080-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037439545
    380 rdf:type schema:CreativeWork
    381 https://doi.org/10.1016/j.amjmed.2003.12.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034585797
    382 rdf:type schema:CreativeWork
    383 https://doi.org/10.1016/j.diabres.2008.03.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018821512
    384 rdf:type schema:CreativeWork
    385 https://doi.org/10.1016/s0092-8674(02)00872-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043415971
    386 rdf:type schema:CreativeWork
    387 https://doi.org/10.1016/s0140-6736(05)67663-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001633112
    388 rdf:type schema:CreativeWork
    389 https://doi.org/10.1016/s1097-2765(02)00591-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052532210
    390 rdf:type schema:CreativeWork
    391 https://doi.org/10.1016/s1388-1981(00)00140-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013940781
    392 rdf:type schema:CreativeWork
    393 https://doi.org/10.1017/s0007114508006557 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030946538
    394 rdf:type schema:CreativeWork
    395 https://doi.org/10.1038/oby.2007.132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027534797
    396 rdf:type schema:CreativeWork
    397 https://doi.org/10.1038/oby.2007.25 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044013239
    398 rdf:type schema:CreativeWork
    399 https://doi.org/10.1038/oby.2007.301 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003659436
    400 rdf:type schema:CreativeWork
    401 https://doi.org/10.1038/oby.2008.650 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049866480
    402 rdf:type schema:CreativeWork
    403 https://doi.org/10.1038/oby.2008.669 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012763402
    404 rdf:type schema:CreativeWork
    405 https://doi.org/10.1056/nejm198601233140401 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030888872
    406 rdf:type schema:CreativeWork
    407 https://doi.org/10.1056/nejm199005243222102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049052450
    408 rdf:type schema:CreativeWork
    409 https://doi.org/10.1073/pnas.0130116100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044122750
    410 rdf:type schema:CreativeWork
    411 https://doi.org/10.1073/pnas.0401715101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016788956
    412 rdf:type schema:CreativeWork
    413 https://doi.org/10.1073/pnas.162488899 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020405103
    414 rdf:type schema:CreativeWork
    415 https://doi.org/10.1073/pnas.96.20.11041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052469813
    416 rdf:type schema:CreativeWork
    417 https://doi.org/10.1074/jbc.m004793200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020611626
    418 rdf:type schema:CreativeWork
    419 https://doi.org/10.1074/jbc.m310053200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025135045
    420 rdf:type schema:CreativeWork
    421 https://doi.org/10.1086/513471 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058788998
    422 rdf:type schema:CreativeWork
    423 https://doi.org/10.1093/hmg/ddn072 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037667357
    424 rdf:type schema:CreativeWork
    425 https://doi.org/10.1093/oxfordjournals.aje.a115083 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079606415
    426 rdf:type schema:CreativeWork
    427 https://doi.org/10.1093/oxfordjournals.aje.a115184 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059958072
    428 rdf:type schema:CreativeWork
    429 https://doi.org/10.1111/j.1399-0004.2007.00795.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1037947643
    430 rdf:type schema:CreativeWork
    431 https://doi.org/10.1126/science.1124779 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062453553
    432 rdf:type schema:CreativeWork
    433 https://doi.org/10.1126/science.1129402 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030903064
    434 rdf:type schema:CreativeWork
    435 https://doi.org/10.1126/science.1130012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016895627
    436 rdf:type schema:CreativeWork
    437 https://doi.org/10.1126/science.1130571 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041586493
    438 rdf:type schema:CreativeWork
    439 https://doi.org/10.1126/science.1141634 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027547166
    440 rdf:type schema:CreativeWork
    441 https://doi.org/10.1161/hy1201.100415 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042735011
    442 rdf:type schema:CreativeWork
    443 https://doi.org/10.1161/strokeaha.108.523001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037959550
    444 rdf:type schema:CreativeWork
    445 https://doi.org/10.1172/jci15593 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063415406
    446 rdf:type schema:CreativeWork
    447 https://doi.org/10.1371/journal.pgen.0030061 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025099272
    448 rdf:type schema:CreativeWork
    449 https://doi.org/10.1371/journal.pgen.0030115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030172498
    450 rdf:type schema:CreativeWork
    451 https://doi.org/10.1371/journal.pone.0002872 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030939238
    452 rdf:type schema:CreativeWork
    453 https://www.grid.ac/institutes/grid.21107.35 schema:alternateName Johns Hopkins University
    454 schema:name Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, 21205, Baltimore, MD, USA
    455 rdf:type schema:Organization
    456 https://www.grid.ac/institutes/grid.265892.2 schema:alternateName University of Alabama at Birmingham
    457 schema:name Division of Preventive Medicine, University of Alabama at Birmingham, 1717 11th Avenue South, 35205, Birmingham, AL, USA
    458 rdf:type schema:Organization
    459 https://www.grid.ac/institutes/grid.267308.8 schema:alternateName The University of Texas Health Science Center at Houston
    460 schema:name Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, 1825 Pressler Street, 77030, Houston, TX, USA
    461 Human Genetics Center, University of Texas Health Science Center at Houston, 1200 Herman Pressler Street, 77030, Houston, TX, USA
    462 rdf:type schema:Organization
    463 https://www.grid.ac/institutes/grid.28046.38 schema:alternateName University of Ottawa
    464 schema:name Division of Cardiology, University of Ottawa Heart Institute, 40 Ruskin Street, K1Y4W7, Ottawa, Ontario, Canada
    465 rdf:type schema:Organization
    466 https://www.grid.ac/institutes/grid.410721.1 schema:alternateName University of Mississippi Medical Center
    467 schema:name Division of Geriatrics, Department of Internal Medicine, University of Mississippi Medical Center, 2500 North State Street, 39216, Jackson, MS, USA
    468 rdf:type schema:Organization
    469 https://www.grid.ac/institutes/grid.451309.a schema:alternateName Joint Genome Institute
    470 schema:name Genomics Division, Lawrence Berkeley National Laboratory, One Cyclotron Road, 94720, Berkeley, CA, USA
    471 US Department of Energy Joint Genome Institute, 2800 Mitchell Drive, 94598, Walnut Creek, CA, USA
    472 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...