Comparison of T2 and T2*-weighted MR molecular imaging of a mouse model of glioma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-07-18

AUTHORS

Barbara Blasiak, Samuel Barnes, Tadeusz Foniok, David Rushforth, John Matyas, Dragana Ponjevic, Wladyslaw P Weglarz, Randy Tyson, Umar Iqbal, Abedelnasser Abulrob, Garnette R Sutherland, Andre Obenaus, Boguslaw Tomanek

ABSTRACT

BACKGROUND: Standard MRI has been used for high-grade gliomas detection, albeit with limited success as it does not provide sufficient specificity and sensitivity to detect complex tumor structure. Therefore targeted contrast agents based on iron oxide, that shorten mostly T2 relaxation time, have been recently applied. However pulse sequences for molecular imaging in animal models of gliomas have not been yet fully studied. The aim of this study was therefore to compare contrast-to-noise ratio (CNR) and explain its origin using spin-echo (SE), gradient echo (GE), GE with flow compensation (GEFC) as well as susceptibility weighted imaging (SWI) in T2 and T2* contrast-enhanced molecular MRI of glioma. METHODS: A mouse model was used. U87MGdEGFRvIII cells (U87MG), derived from a human tumor, were injected intracerebrally. A 9.4 T MRI system was used and MR imaging was performed on the 10 day after the inoculation of the tumor. The CNR was measured prior, 20 min, 2 hrs and 24 hrs post intravenous tail administration of glioma targeted paramagnetic nanoparticles (NPs) using SE, SWI, GE and GEFC pulse sequences. RESULTS: The results showed significant differences in CNR among all pulse sequences prior injection. GEFC provided higher CNR post contrast agent injection when compared to GE and SE. Post injection CNR was the highest with SWI and significantly different from any other pulse sequence. CONCLUSIONS: Molecular MR imaging using targeted contrast agents can enhance the detection of glioma cells at 9.4 T if the optimal pulse sequence is used. Hence, the use of flow compensated pulse sequences, beside SWI, should to be considered in the molecular imaging studies. More... »

PAGES

20-20

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1471-2342-13-20

DOI

http://dx.doi.org/10.1186/1471-2342-13-20

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046485789

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23865826


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28 schema:description BACKGROUND: Standard MRI has been used for high-grade gliomas detection, albeit with limited success as it does not provide sufficient specificity and sensitivity to detect complex tumor structure. Therefore targeted contrast agents based on iron oxide, that shorten mostly T2 relaxation time, have been recently applied. However pulse sequences for molecular imaging in animal models of gliomas have not been yet fully studied. The aim of this study was therefore to compare contrast-to-noise ratio (CNR) and explain its origin using spin-echo (SE), gradient echo (GE), GE with flow compensation (GEFC) as well as susceptibility weighted imaging (SWI) in T2 and T2* contrast-enhanced molecular MRI of glioma. METHODS: A mouse model was used. U87MGdEGFRvIII cells (U87MG), derived from a human tumor, were injected intracerebrally. A 9.4 T MRI system was used and MR imaging was performed on the 10 day after the inoculation of the tumor. The CNR was measured prior, 20 min, 2 hrs and 24 hrs post intravenous tail administration of glioma targeted paramagnetic nanoparticles (NPs) using SE, SWI, GE and GEFC pulse sequences. RESULTS: The results showed significant differences in CNR among all pulse sequences prior injection. GEFC provided higher CNR post contrast agent injection when compared to GE and SE. Post injection CNR was the highest with SWI and significantly different from any other pulse sequence. CONCLUSIONS: Molecular MR imaging using targeted contrast agents can enhance the detection of glioma cells at 9.4 T if the optimal pulse sequence is used. Hence, the use of flow compensated pulse sequences, beside SWI, should to be considered in the molecular imaging studies.
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35 schema:keywords CNR
36 CNR post contrast agent injection
37 Comparison of T2
38 GEFC
39 GEFC pulse sequences
40 MR
41 MR imaging
42 MR molecular imaging
43 MRI
44 MRI system
45 SWI
46 Se
47 T2
48 T2 relaxation times
49 U87MGdEGFRvIII cells
50 administration
51 agent injection
52 agents
53 aim
54 animal models
55 cells
56 comparison
57 compensation
58 complex tumor structure
59 contrast
60 contrast agent injection
61 contrast agents
62 contrast-enhanced molecular MRI
63 days
64 detection
65 differences
66 echoes
67 flow
68 flow compensation
69 glioma cells
70 glioma detection
71 gliomas
72 gradient echo
73 high-grade gliomas detection
74 higher CNR post contrast agent injection
75 hr
76 hrs post intravenous tail administration
77 human tumors
78 imaging
79 imaging studies
80 injection
81 injection CNR
82 inoculation
83 intravenous tail administration
84 iron oxide
85 limited success
86 min
87 model
88 molecular MR
89 molecular MRI
90 molecular imaging
91 molecular imaging studies
92 mouse model
93 nanoparticles
94 noise ratio
95 optimal pulse sequences
96 origin
97 oxide
98 paramagnetic nanoparticles
99 post contrast agent injection
100 post intravenous tail administration
101 prior injection
102 pulse sequence
103 pulse sequences prior injection
104 ratio
105 relaxation time
106 results
107 sensitivity
108 sequence
109 sequences prior injection
110 significant differences
111 specificity
112 standard MRI
113 structure
114 study
115 success
116 sufficient specificity
117 susceptibility
118 system
119 tail administration
120 time
121 tumor structure
122 tumors
123 use
124 use of flow
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