Zinc/copper imbalance reflects immune dysfunction in human leishmaniasis: an ex vivo and in vitro study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2004-11-17

AUTHORS

Johan Van Weyenbergh, Gisélia Santana, Argemiro D'Oliveira, Anibal F Santos, Carlos H Costa, Edgar M Carvalho, Aldina Barral, Manoel Barral-Netto

ABSTRACT

BackgroundThe process of elimination of intracellular pathogens, such as Leishmania, requires a Th1 type immune response, whereas a dominant Th2 response leads to exacerbated disease. Experimental human zinc deficiency decreases Th1 but not Th2 immune response. We investigated if zinc and copper levels differ in different clinical forms of leishmaniasis, and if these trace metals might be involved in the immune response towards the parasite.MethodsBlood was collected from 31 patients with either localized cutaneous (LCL), mucosal (ML) or visceral (VL) leishmaniasis, as well as from 25 controls from endemic and non-endemic areas. Anti-Leishmania humoral and cellular immune response were evaluated by quantifying specific plasma IgG, lymphoproliferation and cytokine production, respectively. Plasma levels of Cu and Zn were quantified by atomic absorption spectrophotometry.ResultsA significant decrease in plasma Zn was observed in all three patient groups (p < 0.01 for LCL and ML, p < 0.001 for VL), as compared to controls, but only VL (7/10) and ML (1/7) patients displayed overt Zn deficiency. Plasma Cu was increased in LCL and VL (p < 0.001) but not in ML, and was strongly correlated to anti-Leishmania IgG (Spearman r = 0.65, p = 0.0028). Cu/Zn ratios were highest in patients with deficient cellular (VL<LCL>ML) immune response. Ex vivo production of parasite-induced IFN-γ was negatively correlated to plasma Cu levels in LCL (r = -0.57, p = 0.01). In vitro, increased Cu levels inhibited IFN-γ production.Conclusions1. Zn deficiency in VL and ML indicate possible therapeutic administration of Zn in these severe forms of leishmaniasis. 2. Plasma Cu positively correlates to humoral immune response across patient groups. 3. Environmentally or genetically determined increases in Cu levels might augment susceptibility to infection with intracellular pathogens, by causing a decrease in IFN-γ production. More... »

PAGES

50

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1471-2334-4-50

DOI

http://dx.doi.org/10.1186/1471-2334-4-50

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1015969526

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15546498


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibodies, Protozoan", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Case-Control Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Copper", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunity, Cellular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoglobulin G", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interferon-gamma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leishmania", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leishmaniasis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphocyte Activation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Th1 Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Th2 Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Zinc", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Institute for Immunological Investigation (iii, Instituto do Mil\u00eanio), Sao Paulo, SP, Brazil", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "LIMI, Gon\u00e7alo Moniz Research Center -Oswaldo Cruz Foundation (FIOCRUZ), Rua Waldemar Falcao 121, 40295-001, Salvador, BA, Brazil", 
            "Institute for Immunological Investigation (iii, Instituto do Mil\u00eanio), Sao Paulo, SP, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Van Weyenbergh", 
        "givenName": "Johan", 
        "id": "sg:person.01101335661.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101335661.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "LIMI, Gon\u00e7alo Moniz Research Center -Oswaldo Cruz Foundation (FIOCRUZ), Rua Waldemar Falcao 121, 40295-001, Salvador, BA, Brazil", 
          "id": "http://www.grid.ac/institutes/grid.418068.3", 
          "name": [
            "LIMI, Gon\u00e7alo Moniz Research Center -Oswaldo Cruz Foundation (FIOCRUZ), Rua Waldemar Falcao 121, 40295-001, Salvador, BA, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Santana", 
        "givenName": "Gis\u00e9lia", 
        "id": "sg:person.0716664637.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716664637.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Servi\u00e7o de Imunologia, HUPES, Salvador, BA, Brazil", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Servi\u00e7o de Imunologia, HUPES, Salvador, BA, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "D'Oliveira", 
        "givenName": "Argemiro", 
        "id": "sg:person.01204066053.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204066053.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Instituto de Quimica, UFBA, Salvador, BA, Brazil", 
          "id": "http://www.grid.ac/institutes/grid.8399.b", 
          "name": [
            "Instituto de Quimica, UFBA, Salvador, BA, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Santos", 
        "givenName": "Anibal F", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Infectious Disease Hospital, UFPI, Teresina, PI, Brazil", 
          "id": "http://www.grid.ac/institutes/grid.412380.c", 
          "name": [
            "Infectious Disease Hospital, UFPI, Teresina, PI, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Costa", 
        "givenName": "Carlos H", 
        "id": "sg:person.010237747022.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010237747022.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Servi\u00e7o de Imunologia, HUPES, Salvador, BA, Brazil", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Institute for Immunological Investigation (iii, Instituto do Mil\u00eanio), Sao Paulo, SP, Brazil", 
            "Servi\u00e7o de Imunologia, HUPES, Salvador, BA, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Carvalho", 
        "givenName": "Edgar M", 
        "id": "sg:person.01107467013.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107467013.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute for Immunological Investigation (iii, Instituto do Mil\u00eanio), Sao Paulo, SP, Brazil", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "LIP, Gon\u00e7alo Moniz Research Center -Oswaldo Cruz Foundation (FIOCRUZ), Rua Waldemar Falcao 121, 40295-001, Salvador, BA, Brazil", 
            "Institute for Immunological Investigation (iii, Instituto do Mil\u00eanio), Sao Paulo, SP, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Barral", 
        "givenName": "Aldina", 
        "id": "sg:person.0700341742.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700341742.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute for Immunological Investigation (iii, Instituto do Mil\u00eanio), Sao Paulo, SP, Brazil", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "LIMI, Gon\u00e7alo Moniz Research Center -Oswaldo Cruz Foundation (FIOCRUZ), Rua Waldemar Falcao 121, 40295-001, Salvador, BA, Brazil", 
            "Institute for Immunological Investigation (iii, Instituto do Mil\u00eanio), Sao Paulo, SP, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Barral-Netto", 
        "givenName": "Manoel", 
        "id": "sg:person.0646141714.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646141714.43"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s15010-003-3139-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075296727", 
          "https://doi.org/10.1007/s15010-003-3139-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02789102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011543838", 
          "https://doi.org/10.1007/bf02789102"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2004-11-17", 
    "datePublishedReg": "2004-11-17", 
    "description": "BackgroundThe process of elimination of intracellular pathogens, such as Leishmania, requires a Th1 type immune response, whereas a dominant Th2 response leads to exacerbated disease. Experimental human zinc deficiency decreases Th1 but not Th2 immune response. We investigated if zinc and copper levels differ in different clinical forms of leishmaniasis, and if these trace metals might be involved in the immune response towards the parasite.MethodsBlood was collected from 31 patients with either localized cutaneous (LCL), mucosal (ML) or visceral (VL) leishmaniasis, as well as from 25 controls from endemic and non-endemic areas. Anti-Leishmania humoral and cellular immune response were evaluated by quantifying specific plasma IgG, lymphoproliferation and cytokine production, respectively. Plasma levels of Cu and Zn were quantified by atomic absorption spectrophotometry.ResultsA significant decrease in plasma Zn was observed in all three patient groups (p < 0.01 for LCL and ML, p < 0.001 for VL), as compared to controls, but only VL (7/10) and ML (1/7) patients displayed overt Zn deficiency. Plasma Cu was increased in LCL and VL (p < 0.001) but not in ML, and was strongly correlated to anti-Leishmania IgG (Spearman r = 0.65, p = 0.0028). Cu/Zn ratios were highest in patients with deficient cellular (VL<LCL>ML) immune response. Ex vivo production of parasite-induced IFN-\u03b3 was negatively correlated to plasma Cu levels in LCL (r = -0.57, p = 0.01). In vitro, increased Cu levels inhibited IFN-\u03b3 production.Conclusions1. Zn deficiency in VL and ML indicate possible therapeutic administration of Zn in these severe forms of leishmaniasis. 2. Plasma Cu positively correlates to humoral immune response across patient groups. 3. Environmentally or genetically determined increases in Cu levels might augment susceptibility to infection with intracellular pathogens, by causing a decrease in IFN-\u03b3 production.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/1471-2334-4-50", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2440059", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1024946", 
        "issn": [
          "1471-2334"
        ], 
        "name": "BMC Infectious Diseases", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "4"
      }
    ], 
    "keywords": [
      "IFN-\u03b3 production", 
      "humoral immune response", 
      "immune response", 
      "patient group", 
      "Th1-type immune response", 
      "intracellular pathogens", 
      "dominant Th2 response", 
      "type immune response", 
      "cellular immune responses", 
      "different clinical forms", 
      "non-endemic areas", 
      "human zinc deficiency", 
      "plasma Cu", 
      "Th2 responses", 
      "exacerbated disease", 
      "immune dysfunction", 
      "ML patients", 
      "cytokine production", 
      "plasma IgG", 
      "plasma levels", 
      "clinical forms", 
      "therapeutic administration", 
      "visceral leishmaniasis", 
      "human leishmaniasis", 
      "severe form", 
      "plasma Zn", 
      "Cu/Zn ratio", 
      "patients", 
      "zinc deficiency", 
      "leishmaniasis", 
      "significant decrease", 
      "Cu levels", 
      "Leishmania", 
      "copper levels", 
      "Zn deficiency", 
      "deficiency", 
      "VL", 
      "copper imbalance", 
      "response", 
      "Th1", 
      "lymphoproliferation", 
      "levels", 
      "pathogens", 
      "atomic absorption spectrophotometry", 
      "mL", 
      "group", 
      "IFN", 
      "dysfunction", 
      "MethodsBlood", 
      "infection", 
      "IgG", 
      "disease", 
      "administration", 
      "process of elimination", 
      "decrease", 
      "control", 
      "vivo", 
      "LCL", 
      "absorption spectrophotometry", 
      "ex", 
      "parasites", 
      "susceptibility", 
      "imbalance", 
      "elimination", 
      "production", 
      "study", 
      "increase", 
      "Zn ratio", 
      "form", 
      "ratio", 
      "zinc", 
      "area", 
      "spectrophotometry", 
      "process", 
      "Zn", 
      "trace metals", 
      "Cu", 
      "metals"
    ], 
    "name": "Zinc/copper imbalance reflects immune dysfunction in human leishmaniasis: an ex vivo and in vitro study", 
    "pagination": "50", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1015969526"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1471-2334-4-50"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "15546498"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1471-2334-4-50", 
      "https://app.dimensions.ai/details/publication/pub.1015969526"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-10-01T06:32", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_392.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/1471-2334-4-50"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1471-2334-4-50'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1471-2334-4-50'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1471-2334-4-50'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1471-2334-4-50'


 

This table displays all metadata directly associated to this object as RDF triples.

281 TRIPLES      21 PREDICATES      123 URIs      113 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1471-2334-4-50 schema:about N083dc28e863e4206b22136a285c31ff9
2 N0ffba1dd17e045cbbea699d2447b40a1
3 N1d8f4e2d02cf490f9ff63d867acd1895
4 N205e66d1792d43f489a120d2ec4ae88d
5 N2abff04e0c004c88b742be0fc21aece5
6 N36ec97d225164279a8064bf13023395d
7 N3be9de57aa904eb099c2a30571e17375
8 N42f9032cb9e441b89b51db3c3e890a23
9 N58cb5aa00e2f47c5b8078aea249dc9fd
10 N63a907d0e95f45cd9875cc4545284418
11 N6536f232417e424aa09aa44c058e7a57
12 N855536ed96aa43cfa70d551349dcbc6b
13 N8bf46822fc9a4e178ec95a7cdc1c1a90
14 N9e10caf16554478b9f654cb81896481f
15 Nd12bccb9d4dc499ebd14c284b6297472
16 Ne7c69fd90cba40c48e92be82524484f5
17 Nec458fc1fc62423da375e3049d123194
18 Nf40daad2c2214a2398d6f64968d38ae1
19 anzsrc-for:11
20 anzsrc-for:1107
21 schema:author N19b64833acf04457a06750f11b5e7b9c
22 schema:citation sg:pub.10.1007/bf02789102
23 sg:pub.10.1007/s15010-003-3139-9
24 schema:datePublished 2004-11-17
25 schema:datePublishedReg 2004-11-17
26 schema:description BackgroundThe process of elimination of intracellular pathogens, such as Leishmania, requires a Th1 type immune response, whereas a dominant Th2 response leads to exacerbated disease. Experimental human zinc deficiency decreases Th1 but not Th2 immune response. We investigated if zinc and copper levels differ in different clinical forms of leishmaniasis, and if these trace metals might be involved in the immune response towards the parasite.MethodsBlood was collected from 31 patients with either localized cutaneous (LCL), mucosal (ML) or visceral (VL) leishmaniasis, as well as from 25 controls from endemic and non-endemic areas. Anti-Leishmania humoral and cellular immune response were evaluated by quantifying specific plasma IgG, lymphoproliferation and cytokine production, respectively. Plasma levels of Cu and Zn were quantified by atomic absorption spectrophotometry.ResultsA significant decrease in plasma Zn was observed in all three patient groups (p < 0.01 for LCL and ML, p < 0.001 for VL), as compared to controls, but only VL (7/10) and ML (1/7) patients displayed overt Zn deficiency. Plasma Cu was increased in LCL and VL (p < 0.001) but not in ML, and was strongly correlated to anti-Leishmania IgG (Spearman r = 0.65, p = 0.0028). Cu/Zn ratios were highest in patients with deficient cellular (VL<<LCL<ML) and exacerbated humoral (VL>LCL>ML) immune response. Ex vivo production of parasite-induced IFN-γ was negatively correlated to plasma Cu levels in LCL (r = -0.57, p = 0.01). In vitro, increased Cu levels inhibited IFN-γ production.Conclusions1. Zn deficiency in VL and ML indicate possible therapeutic administration of Zn in these severe forms of leishmaniasis. 2. Plasma Cu positively correlates to humoral immune response across patient groups. 3. Environmentally or genetically determined increases in Cu levels might augment susceptibility to infection with intracellular pathogens, by causing a decrease in IFN-γ production.
27 schema:genre article
28 schema:isAccessibleForFree true
29 schema:isPartOf Nd22f9bc2f8c74602b7efdfc3027927b7
30 Nef3757524e874bc6928e62d88048cd8d
31 sg:journal.1024946
32 schema:keywords Cu
33 Cu levels
34 Cu/Zn ratio
35 IFN
36 IFN-γ production
37 IgG
38 LCL
39 Leishmania
40 ML patients
41 MethodsBlood
42 Th1
43 Th1-type immune response
44 Th2 responses
45 VL
46 Zn
47 Zn deficiency
48 Zn ratio
49 absorption spectrophotometry
50 administration
51 area
52 atomic absorption spectrophotometry
53 cellular immune responses
54 clinical forms
55 control
56 copper imbalance
57 copper levels
58 cytokine production
59 decrease
60 deficiency
61 different clinical forms
62 disease
63 dominant Th2 response
64 dysfunction
65 elimination
66 ex
67 exacerbated disease
68 form
69 group
70 human leishmaniasis
71 human zinc deficiency
72 humoral immune response
73 imbalance
74 immune dysfunction
75 immune response
76 increase
77 infection
78 intracellular pathogens
79 leishmaniasis
80 levels
81 lymphoproliferation
82 mL
83 metals
84 non-endemic areas
85 parasites
86 pathogens
87 patient group
88 patients
89 plasma Cu
90 plasma IgG
91 plasma Zn
92 plasma levels
93 process
94 process of elimination
95 production
96 ratio
97 response
98 severe form
99 significant decrease
100 spectrophotometry
101 study
102 susceptibility
103 therapeutic administration
104 trace metals
105 type immune response
106 visceral leishmaniasis
107 vivo
108 zinc
109 zinc deficiency
110 schema:name Zinc/copper imbalance reflects immune dysfunction in human leishmaniasis: an ex vivo and in vitro study
111 schema:pagination 50
112 schema:productId N2a582c619ba541e0a3454b2a9e607994
113 N88179774b1fc46b997296130bfb80403
114 Ne3e85241c16a492bbe194fc4eda3eb87
115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015969526
116 https://doi.org/10.1186/1471-2334-4-50
117 schema:sdDatePublished 2022-10-01T06:32
118 schema:sdLicense https://scigraph.springernature.com/explorer/license/
119 schema:sdPublisher N2b583596b1884df88359ec63d7860105
120 schema:url https://doi.org/10.1186/1471-2334-4-50
121 sgo:license sg:explorer/license/
122 sgo:sdDataset articles
123 rdf:type schema:ScholarlyArticle
124 N083dc28e863e4206b22136a285c31ff9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Adolescent
126 rdf:type schema:DefinedTerm
127 N0c4fcfcdf4064456a96648b56bc3e6ce rdf:first N73e10241ece94881889d9c2d3b6833f4
128 rdf:rest Nf3a922333fe6409eac983079e0a41d1f
129 N0ffba1dd17e045cbbea699d2447b40a1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Adult
131 rdf:type schema:DefinedTerm
132 N19b64833acf04457a06750f11b5e7b9c rdf:first sg:person.01101335661.34
133 rdf:rest N92d17af0df64417ca957bbb15ca866cb
134 N1d8f4e2d02cf490f9ff63d867acd1895 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Leishmania
136 rdf:type schema:DefinedTerm
137 N205e66d1792d43f489a120d2ec4ae88d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Th1 Cells
139 rdf:type schema:DefinedTerm
140 N2a582c619ba541e0a3454b2a9e607994 schema:name dimensions_id
141 schema:value pub.1015969526
142 rdf:type schema:PropertyValue
143 N2abff04e0c004c88b742be0fc21aece5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Female
145 rdf:type schema:DefinedTerm
146 N2b583596b1884df88359ec63d7860105 schema:name Springer Nature - SN SciGraph project
147 rdf:type schema:Organization
148 N36ec97d225164279a8064bf13023395d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Lymphocyte Activation
150 rdf:type schema:DefinedTerm
151 N3be9de57aa904eb099c2a30571e17375 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Humans
153 rdf:type schema:DefinedTerm
154 N42f9032cb9e441b89b51db3c3e890a23 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Immunoglobulin G
156 rdf:type schema:DefinedTerm
157 N4936d65047d344abba4c3aacb21af7a5 rdf:first sg:person.0700341742.83
158 rdf:rest N817dcc7397ef416289a4f4599e549f3e
159 N58cb5aa00e2f47c5b8078aea249dc9fd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Zinc
161 rdf:type schema:DefinedTerm
162 N63a907d0e95f45cd9875cc4545284418 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Male
164 rdf:type schema:DefinedTerm
165 N6536f232417e424aa09aa44c058e7a57 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Leishmaniasis
167 rdf:type schema:DefinedTerm
168 N73e10241ece94881889d9c2d3b6833f4 schema:affiliation grid-institutes:grid.8399.b
169 schema:familyName Santos
170 schema:givenName Anibal F
171 rdf:type schema:Person
172 N817dcc7397ef416289a4f4599e549f3e rdf:first sg:person.0646141714.43
173 rdf:rest rdf:nil
174 N855536ed96aa43cfa70d551349dcbc6b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Animals
176 rdf:type schema:DefinedTerm
177 N88179774b1fc46b997296130bfb80403 schema:name doi
178 schema:value 10.1186/1471-2334-4-50
179 rdf:type schema:PropertyValue
180 N8bf46822fc9a4e178ec95a7cdc1c1a90 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Th2 Cells
182 rdf:type schema:DefinedTerm
183 N92d17af0df64417ca957bbb15ca866cb rdf:first sg:person.0716664637.33
184 rdf:rest Nb7515adeb3ce4935a8da00f422d52071
185 N9e10caf16554478b9f654cb81896481f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Antibodies, Protozoan
187 rdf:type schema:DefinedTerm
188 Na368ba34211c4b50b60da39c2fca18e8 rdf:first sg:person.01107467013.35
189 rdf:rest N4936d65047d344abba4c3aacb21af7a5
190 Nb7515adeb3ce4935a8da00f422d52071 rdf:first sg:person.01204066053.35
191 rdf:rest N0c4fcfcdf4064456a96648b56bc3e6ce
192 Nd12bccb9d4dc499ebd14c284b6297472 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name Copper
194 rdf:type schema:DefinedTerm
195 Nd22f9bc2f8c74602b7efdfc3027927b7 schema:issueNumber 1
196 rdf:type schema:PublicationIssue
197 Ne3e85241c16a492bbe194fc4eda3eb87 schema:name pubmed_id
198 schema:value 15546498
199 rdf:type schema:PropertyValue
200 Ne7c69fd90cba40c48e92be82524484f5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
201 schema:name Case-Control Studies
202 rdf:type schema:DefinedTerm
203 Nec458fc1fc62423da375e3049d123194 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
204 schema:name Immunity, Cellular
205 rdf:type schema:DefinedTerm
206 Nef3757524e874bc6928e62d88048cd8d schema:volumeNumber 4
207 rdf:type schema:PublicationVolume
208 Nf3a922333fe6409eac983079e0a41d1f rdf:first sg:person.010237747022.41
209 rdf:rest Na368ba34211c4b50b60da39c2fca18e8
210 Nf40daad2c2214a2398d6f64968d38ae1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
211 schema:name Interferon-gamma
212 rdf:type schema:DefinedTerm
213 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
214 schema:name Medical and Health Sciences
215 rdf:type schema:DefinedTerm
216 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
217 schema:name Immunology
218 rdf:type schema:DefinedTerm
219 sg:grant.2440059 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2334-4-50
220 rdf:type schema:MonetaryGrant
221 sg:journal.1024946 schema:issn 1471-2334
222 schema:name BMC Infectious Diseases
223 schema:publisher Springer Nature
224 rdf:type schema:Periodical
225 sg:person.010237747022.41 schema:affiliation grid-institutes:grid.412380.c
226 schema:familyName Costa
227 schema:givenName Carlos H
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010237747022.41
229 rdf:type schema:Person
230 sg:person.01101335661.34 schema:affiliation grid-institutes:None
231 schema:familyName Van Weyenbergh
232 schema:givenName Johan
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101335661.34
234 rdf:type schema:Person
235 sg:person.01107467013.35 schema:affiliation grid-institutes:None
236 schema:familyName Carvalho
237 schema:givenName Edgar M
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107467013.35
239 rdf:type schema:Person
240 sg:person.01204066053.35 schema:affiliation grid-institutes:None
241 schema:familyName D'Oliveira
242 schema:givenName Argemiro
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204066053.35
244 rdf:type schema:Person
245 sg:person.0646141714.43 schema:affiliation grid-institutes:None
246 schema:familyName Barral-Netto
247 schema:givenName Manoel
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646141714.43
249 rdf:type schema:Person
250 sg:person.0700341742.83 schema:affiliation grid-institutes:None
251 schema:familyName Barral
252 schema:givenName Aldina
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700341742.83
254 rdf:type schema:Person
255 sg:person.0716664637.33 schema:affiliation grid-institutes:grid.418068.3
256 schema:familyName Santana
257 schema:givenName Gisélia
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716664637.33
259 rdf:type schema:Person
260 sg:pub.10.1007/bf02789102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011543838
261 https://doi.org/10.1007/bf02789102
262 rdf:type schema:CreativeWork
263 sg:pub.10.1007/s15010-003-3139-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075296727
264 https://doi.org/10.1007/s15010-003-3139-9
265 rdf:type schema:CreativeWork
266 grid-institutes:None schema:alternateName Institute for Immunological Investigation (iii, Instituto do Milênio), Sao Paulo, SP, Brazil
267 Serviço de Imunologia, HUPES, Salvador, BA, Brazil
268 schema:name Institute for Immunological Investigation (iii, Instituto do Milênio), Sao Paulo, SP, Brazil
269 LIMI, Gonçalo Moniz Research Center -Oswaldo Cruz Foundation (FIOCRUZ), Rua Waldemar Falcao 121, 40295-001, Salvador, BA, Brazil
270 LIP, Gonçalo Moniz Research Center -Oswaldo Cruz Foundation (FIOCRUZ), Rua Waldemar Falcao 121, 40295-001, Salvador, BA, Brazil
271 Serviço de Imunologia, HUPES, Salvador, BA, Brazil
272 rdf:type schema:Organization
273 grid-institutes:grid.412380.c schema:alternateName Infectious Disease Hospital, UFPI, Teresina, PI, Brazil
274 schema:name Infectious Disease Hospital, UFPI, Teresina, PI, Brazil
275 rdf:type schema:Organization
276 grid-institutes:grid.418068.3 schema:alternateName LIMI, Gonçalo Moniz Research Center -Oswaldo Cruz Foundation (FIOCRUZ), Rua Waldemar Falcao 121, 40295-001, Salvador, BA, Brazil
277 schema:name LIMI, Gonçalo Moniz Research Center -Oswaldo Cruz Foundation (FIOCRUZ), Rua Waldemar Falcao 121, 40295-001, Salvador, BA, Brazil
278 rdf:type schema:Organization
279 grid-institutes:grid.8399.b schema:alternateName Instituto de Quimica, UFBA, Salvador, BA, Brazil
280 schema:name Instituto de Quimica, UFBA, Salvador, BA, Brazil
281 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...