Impact of maternal HIV-1 viremia on lymphocyte subsets among HIV-exposed uninfected infants: protective mechanism or immunodeficiency View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-05-05

AUTHORS

Fatima Kakkar, Valerie Lamarre, Thierry Ducruet, Marc Boucher, Silvie Valois, Hugo Soudeyns, Normand Lapointe

ABSTRACT

BackgroundReports of increased morbidity and mortality from infectious diseases among HIV Exposed Uninfected (HEU) infants have raised concern about a possible underlying immunodeficiency among them. The objective of this study was to assess the immunological profile of HEU infants born to mothers exhibiting different levels of HIV-1 viremia at the time of delivery.MethodsStudy subjects were enrolled in the Centre maternel et infantile sur le SIDA (CMIS) mother-child cohort between 1997 and 2010 (n =585). Infant CD4+ T cell, CD8+ T cell and CD19+ B cell counts were assessed at 2 and 6 months of age, and compared among HEU infants in groups defined by maternal viral load (VL) at the time of delivery (VL < 50 copies/ml, VL 50–1000 copies/ml, and VL > 1000 copies/ml) in a multivariable analysis.ResultsAt 2 months of age, infants born to mothers with VL > 1000 copies/ml had lower CD4+ T cell counts compared to those born to mothers with VL < 50 copies/ml at the time of delivery (44.3% versus 48.3%, p = 0.007, and 2884 vs. 2432 cells/mm3, p = 0.02). These differences remained significant after adjusting for maternal and infant antiretroviral drug use, gender, race and gestational age, and persisted at 6 months of age. There were no differences in CD8+ T cell count or absolute CD19+ B cell count between groups, though higher CD19+ B cell percentage was seen among infants born to mothers with VL > 1000 copies/ml.ConclusionsThese results suggest that exposure to high levels of HIV-1 viremia in utero, even in the absence of perinatal transmission, may affect the infant’s developing immune system. While further work needs to be done to confirm these findings, they reinforce the need for optimal treatment of HIV infected pregnant women, and careful follow-up of HEU infants. More... »

PAGES

236

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1471-2334-14-236

DOI

http://dx.doi.org/10.1186/1471-2334-14-236

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1024262928

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24885498


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1114", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Paediatrics and Reproductive Medicine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CD4 Lymphocyte Count", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CD4-Positive T-Lymphocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CD8-Positive T-Lymphocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HIV Infections", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HIV Seropositivity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HIV-1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Infant", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Infant, Newborn", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Infectious Disease Transmission, Vertical", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphocyte Subsets", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mothers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pregnancy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pregnancy Complications, Infectious", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Viral Load", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Viremia", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Centre maternel et infantile sur le SIDA, CHU Sainte-Justine, Montreal, Canada", 
          "id": "http://www.grid.ac/institutes/grid.411418.9", 
          "name": [
            "Division of Infectious Diseases, CHU Sainte-Justine, 3175 C\u00f4te Sainte-Catherine, H3T 1C5, Montreal, Quebec, Canada", 
            "Department of Pediatrics, Faculty of Medicine, Universit\u00e9 de Montr\u00e9al, Montreal, Canada", 
            "Centre maternel et infantile sur le SIDA, CHU Sainte-Justine, Montreal, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kakkar", 
        "givenName": "Fatima", 
        "id": "sg:person.01213005376.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213005376.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre maternel et infantile sur le SIDA, CHU Sainte-Justine, Montreal, Canada", 
          "id": "http://www.grid.ac/institutes/grid.411418.9", 
          "name": [
            "Division of Infectious Diseases, CHU Sainte-Justine, 3175 C\u00f4te Sainte-Catherine, H3T 1C5, Montreal, Quebec, Canada", 
            "Department of Pediatrics, Faculty of Medicine, Universit\u00e9 de Montr\u00e9al, Montreal, Canada", 
            "Centre maternel et infantile sur le SIDA, CHU Sainte-Justine, Montreal, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lamarre", 
        "givenName": "Valerie", 
        "id": "sg:person.0722155715.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0722155715.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Unit\u00e9 de recherche clinique appliqu\u00e9e, CHU Sainte-Justine, Montreal, Canada", 
          "id": "http://www.grid.ac/institutes/grid.411418.9", 
          "name": [
            "Unit\u00e9 de recherche clinique appliqu\u00e9e, CHU Sainte-Justine, Montreal, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ducruet", 
        "givenName": "Thierry", 
        "id": "sg:person.01354006374.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354006374.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Obstetrics and Gynecology, CHU Sainte-Justine, Montreal, Canada", 
          "id": "http://www.grid.ac/institutes/grid.411418.9", 
          "name": [
            "Centre maternel et infantile sur le SIDA, CHU Sainte-Justine, Montreal, Canada", 
            "Division of Obstetrics and Gynecology, CHU Sainte-Justine, Montreal, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Boucher", 
        "givenName": "Marc", 
        "id": "sg:person.0734332577.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734332577.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre maternel et infantile sur le SIDA, CHU Sainte-Justine, Montreal, Canada", 
          "id": "http://www.grid.ac/institutes/grid.411418.9", 
          "name": [
            "Centre maternel et infantile sur le SIDA, CHU Sainte-Justine, Montreal, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Valois", 
        "givenName": "Silvie", 
        "id": "sg:person.01372475316.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372475316.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Microbiology, Infectious Diseases and Immunology, Faculty of Medicine, Universit\u00e9 de Montr\u00e9al, Montreal, Canada", 
          "id": "http://www.grid.ac/institutes/grid.14848.31", 
          "name": [
            "Department of Pediatrics, Faculty of Medicine, Universit\u00e9 de Montr\u00e9al, Montreal, Canada", 
            "Unit\u00e9 d\u2019immunopathologie virale, Centre de recherche du CHU Sainte-Justine, Montreal, Canada", 
            "Department of Microbiology, Infectious Diseases and Immunology, Faculty of Medicine, Universit\u00e9 de Montr\u00e9al, Montreal, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Soudeyns", 
        "givenName": "Hugo", 
        "id": "sg:person.01321765331.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321765331.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre maternel et infantile sur le SIDA, CHU Sainte-Justine, Montreal, Canada", 
          "id": "http://www.grid.ac/institutes/grid.411418.9", 
          "name": [
            "Department of Pediatrics, Faculty of Medicine, Universit\u00e9 de Montr\u00e9al, Montreal, Canada", 
            "Centre maternel et infantile sur le SIDA, CHU Sainte-Justine, Montreal, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lapointe", 
        "givenName": "Normand", 
        "id": "sg:person.01305203606.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305203606.45"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1186/1471-2334-11-193", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047685188", 
          "https://doi.org/10.1186/1471-2334-11-193"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2431-11-69", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040787985", 
          "https://doi.org/10.1186/1471-2431-11-69"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-05-05", 
    "datePublishedReg": "2014-05-05", 
    "description": "BackgroundReports of increased morbidity and mortality from infectious diseases among HIV Exposed Uninfected (HEU) infants have raised concern about a possible underlying immunodeficiency among them. The objective of this study was to assess the immunological profile of HEU infants born to mothers exhibiting different levels of HIV-1 viremia at the time of delivery.MethodsStudy subjects were enrolled in the Centre maternel et infantile sur le SIDA (CMIS) mother-child cohort between 1997 and 2010 (n =585). Infant CD4+ T cell, CD8+ T cell and CD19+ B cell counts were assessed at 2 and 6\u00a0months of age, and compared among HEU infants in groups defined by maternal viral load (VL) at the time of delivery (VL\u2009<\u200950 copies/ml, VL 50\u20131000 copies/ml, and VL\u2009>\u20091000 copies/ml) in a multivariable analysis.ResultsAt 2\u00a0months of age, infants born to mothers with VL\u2009>\u20091000 copies/ml had lower CD4+ T cell counts compared to those born to mothers with VL\u2009<\u200950 copies/ml at the time of delivery (44.3% versus 48.3%, p\u2009=\u20090.007, and 2884 vs. 2432 cells/mm3, p\u2009=\u20090.02). These differences remained significant after adjusting for maternal and infant antiretroviral drug use, gender, race and gestational age, and persisted at 6\u00a0months of age. There were no differences in CD8+ T cell count or absolute CD19+ B cell count between groups, though higher CD19+ B cell percentage was seen among infants born to mothers with VL\u2009>\u20091000 copies/ml.ConclusionsThese results suggest that exposure to high levels of HIV-1 viremia in utero, even in the absence of perinatal transmission, may affect the infant\u2019s developing immune system. While further work needs to be done to confirm these findings, they reinforce the need for optimal treatment of HIV infected pregnant women, and careful follow-up of HEU infants.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/1471-2334-14-236", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1024946", 
        "issn": [
          "1471-2334"
        ], 
        "name": "BMC Infectious Diseases", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "14"
      }
    ], 
    "keywords": [
      "HIV-1 viremia", 
      "time of delivery", 
      "months of age", 
      "B-cell counts", 
      "T-cell counts", 
      "viral load", 
      "HEU infants", 
      "copies/", 
      "cell count", 
      "uninfected infants", 
      "T cells", 
      "possible underlying immunodeficiency", 
      "maternal viral load", 
      "antiretroviral drug use", 
      "B cell percentage", 
      "mother-child cohort", 
      "MethodsStudy subjects", 
      "infant CD4", 
      "low CD4", 
      "absolute CD19", 
      "higher CD19", 
      "perinatal transmission", 
      "lymphocyte subsets", 
      "underlying immunodeficiency", 
      "multivariable analysis", 
      "gestational age", 
      "pregnant women", 
      "immunological profile", 
      "optimal treatment", 
      "ResultsAt 2", 
      "cell percentage", 
      "drug use", 
      "immune system", 
      "infants", 
      "viremia", 
      "infectious diseases", 
      "CD19", 
      "protective mechanism", 
      "ConclusionsThese results", 
      "CD8", 
      "months", 
      "CD4", 
      "age", 
      "mothers", 
      "HIV", 
      "immunodeficiency", 
      "count", 
      "delivery", 
      "high levels", 
      "morbidity", 
      "cells", 
      "BackgroundReports", 
      "group", 
      "cohort", 
      "utero", 
      "mortality", 
      "disease", 
      "further work", 
      "women", 
      "infantile", 
      "levels", 
      "treatment", 
      "differences", 
      "exposure", 
      "subjects", 
      "gender", 
      "findings", 
      "percentage", 
      "subset", 
      "time", 
      "absence", 
      "race", 
      "study", 
      "different levels", 
      "transmission", 
      "profile", 
      "objective", 
      "mechanism", 
      "use", 
      "need", 
      "concern", 
      "impact", 
      "analysis", 
      "results", 
      "load", 
      "system", 
      "work"
    ], 
    "name": "Impact of maternal HIV-1 viremia on lymphocyte subsets among HIV-exposed uninfected infants: protective mechanism or immunodeficiency", 
    "pagination": "236", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1024262928"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1471-2334-14-236"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "24885498"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1471-2334-14-236", 
      "https://app.dimensions.ai/details/publication/pub.1024262928"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-10-01T06:39", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_618.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/1471-2334-14-236"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1471-2334-14-236'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1471-2334-14-236'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1471-2334-14-236'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1471-2334-14-236'


 

This table displays all metadata directly associated to this object as RDF triples.

288 TRIPLES      21 PREDICATES      134 URIs      123 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1471-2334-14-236 schema:about N3390dbc49ac749d288751f135c6b7d5d
2 N37f5110f1886457b93b4e09dcf4f697e
3 N4352eaff55ab42698fc2181b5ef2ed7b
4 N451f8c7c5982453a9ab7cd87ffbd9b00
5 N47b7f126474c451a90356606aaa9d916
6 N5973a9eab38d4091af2ba3182da335f9
7 N70228cba319f4ee9b0245efd7ae8e9d6
8 N81c7670c286d4772bad1bbb003a1df85
9 N81f8eaa68c7441858bd09b6b3fbc6103
10 N8a2976d22bb941a89a9c237bdff15add
11 N9b4bae5fc81c49b69626d2188ae3d030
12 Na0cef02baf3d47c4a8de498a55088b5b
13 Na162a30e5b5740d8aeba3a4266c8f903
14 Na4a953d3c8584dd39836d8a371f0013c
15 Na7bdefe4c9674575bc8a083d807f2b15
16 Nafc35671751e45fd960c8e0abf16878b
17 Nc1d30a7757dc48e7bf10e0d1c684e38b
18 Nd69ee4ba75d642bfba1d4ef933a80f41
19 Ned6d36e80bd5447d8310ee8e14587e16
20 anzsrc-for:11
21 anzsrc-for:1107
22 anzsrc-for:1114
23 schema:author N1a72e115766f4390865c1ae2f88b9024
24 schema:citation sg:pub.10.1186/1471-2334-11-193
25 sg:pub.10.1186/1471-2431-11-69
26 schema:datePublished 2014-05-05
27 schema:datePublishedReg 2014-05-05
28 schema:description BackgroundReports of increased morbidity and mortality from infectious diseases among HIV Exposed Uninfected (HEU) infants have raised concern about a possible underlying immunodeficiency among them. The objective of this study was to assess the immunological profile of HEU infants born to mothers exhibiting different levels of HIV-1 viremia at the time of delivery.MethodsStudy subjects were enrolled in the Centre maternel et infantile sur le SIDA (CMIS) mother-child cohort between 1997 and 2010 (n =585). Infant CD4+ T cell, CD8+ T cell and CD19+ B cell counts were assessed at 2 and 6 months of age, and compared among HEU infants in groups defined by maternal viral load (VL) at the time of delivery (VL < 50 copies/ml, VL 50–1000 copies/ml, and VL > 1000 copies/ml) in a multivariable analysis.ResultsAt 2 months of age, infants born to mothers with VL > 1000 copies/ml had lower CD4+ T cell counts compared to those born to mothers with VL < 50 copies/ml at the time of delivery (44.3% versus 48.3%, p = 0.007, and 2884 vs. 2432 cells/mm3, p = 0.02). These differences remained significant after adjusting for maternal and infant antiretroviral drug use, gender, race and gestational age, and persisted at 6 months of age. There were no differences in CD8+ T cell count or absolute CD19+ B cell count between groups, though higher CD19+ B cell percentage was seen among infants born to mothers with VL > 1000 copies/ml.ConclusionsThese results suggest that exposure to high levels of HIV-1 viremia in utero, even in the absence of perinatal transmission, may affect the infant’s developing immune system. While further work needs to be done to confirm these findings, they reinforce the need for optimal treatment of HIV infected pregnant women, and careful follow-up of HEU infants.
29 schema:genre article
30 schema:isAccessibleForFree true
31 schema:isPartOf N145061cd9adc404b922c7a9f6207ac18
32 N3db523fab44c47708a1415e481758317
33 sg:journal.1024946
34 schema:keywords B cell percentage
35 B-cell counts
36 BackgroundReports
37 CD19
38 CD4
39 CD8
40 ConclusionsThese results
41 HEU infants
42 HIV
43 HIV-1 viremia
44 MethodsStudy subjects
45 ResultsAt 2
46 T cells
47 T-cell counts
48 absence
49 absolute CD19
50 age
51 analysis
52 antiretroviral drug use
53 cell count
54 cell percentage
55 cells
56 cohort
57 concern
58 copies/
59 count
60 delivery
61 differences
62 different levels
63 disease
64 drug use
65 exposure
66 findings
67 further work
68 gender
69 gestational age
70 group
71 high levels
72 higher CD19
73 immune system
74 immunodeficiency
75 immunological profile
76 impact
77 infant CD4
78 infantile
79 infants
80 infectious diseases
81 levels
82 load
83 low CD4
84 lymphocyte subsets
85 maternal viral load
86 mechanism
87 months
88 months of age
89 morbidity
90 mortality
91 mother-child cohort
92 mothers
93 multivariable analysis
94 need
95 objective
96 optimal treatment
97 percentage
98 perinatal transmission
99 possible underlying immunodeficiency
100 pregnant women
101 profile
102 protective mechanism
103 race
104 results
105 study
106 subjects
107 subset
108 system
109 time
110 time of delivery
111 transmission
112 treatment
113 underlying immunodeficiency
114 uninfected infants
115 use
116 utero
117 viral load
118 viremia
119 women
120 work
121 schema:name Impact of maternal HIV-1 viremia on lymphocyte subsets among HIV-exposed uninfected infants: protective mechanism or immunodeficiency
122 schema:pagination 236
123 schema:productId N57a51fa755de427fa337b544ed87086b
124 N97fd7e0d22e54d2baf40e5d606910cbe
125 Nec0d491a023b4bf8b3f781cf0409d76b
126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024262928
127 https://doi.org/10.1186/1471-2334-14-236
128 schema:sdDatePublished 2022-10-01T06:39
129 schema:sdLicense https://scigraph.springernature.com/explorer/license/
130 schema:sdPublisher N98cd3172d3764ed2bc0ab0af157c4eb0
131 schema:url https://doi.org/10.1186/1471-2334-14-236
132 sgo:license sg:explorer/license/
133 sgo:sdDataset articles
134 rdf:type schema:ScholarlyArticle
135 N145061cd9adc404b922c7a9f6207ac18 schema:issueNumber 1
136 rdf:type schema:PublicationIssue
137 N14fa26a7affd48c79285a9a7121f8e43 rdf:first sg:person.01305203606.45
138 rdf:rest rdf:nil
139 N1a72e115766f4390865c1ae2f88b9024 rdf:first sg:person.01213005376.68
140 rdf:rest N689aa0980c1b448886a1aaf012f8f6f9
141 N3390dbc49ac749d288751f135c6b7d5d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Infant, Newborn
143 rdf:type schema:DefinedTerm
144 N37f5110f1886457b93b4e09dcf4f697e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name HIV Infections
146 rdf:type schema:DefinedTerm
147 N3db523fab44c47708a1415e481758317 schema:volumeNumber 14
148 rdf:type schema:PublicationVolume
149 N4352eaff55ab42698fc2181b5ef2ed7b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name HIV-1
151 rdf:type schema:DefinedTerm
152 N451f8c7c5982453a9ab7cd87ffbd9b00 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name CD8-Positive T-Lymphocytes
154 rdf:type schema:DefinedTerm
155 N47b7f126474c451a90356606aaa9d916 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name CD4-Positive T-Lymphocytes
157 rdf:type schema:DefinedTerm
158 N533ca01b05354afd9ccdd2b413da27e4 rdf:first sg:person.01321765331.58
159 rdf:rest N14fa26a7affd48c79285a9a7121f8e43
160 N57a51fa755de427fa337b544ed87086b schema:name dimensions_id
161 schema:value pub.1024262928
162 rdf:type schema:PropertyValue
163 N5973a9eab38d4091af2ba3182da335f9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Pregnancy
165 rdf:type schema:DefinedTerm
166 N6863fadc86b74c97be90f3b22b8b1fc7 rdf:first sg:person.0734332577.19
167 rdf:rest Ncae0ca2abd784ccbae436d8c3a79bdf6
168 N689aa0980c1b448886a1aaf012f8f6f9 rdf:first sg:person.0722155715.95
169 rdf:rest N774a189ecb16441cbe3b3e512035a4f9
170 N70228cba319f4ee9b0245efd7ae8e9d6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Male
172 rdf:type schema:DefinedTerm
173 N774a189ecb16441cbe3b3e512035a4f9 rdf:first sg:person.01354006374.55
174 rdf:rest N6863fadc86b74c97be90f3b22b8b1fc7
175 N81c7670c286d4772bad1bbb003a1df85 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Female
177 rdf:type schema:DefinedTerm
178 N81f8eaa68c7441858bd09b6b3fbc6103 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name CD4 Lymphocyte Count
180 rdf:type schema:DefinedTerm
181 N8a2976d22bb941a89a9c237bdff15add schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Lymphocyte Subsets
183 rdf:type schema:DefinedTerm
184 N97fd7e0d22e54d2baf40e5d606910cbe schema:name pubmed_id
185 schema:value 24885498
186 rdf:type schema:PropertyValue
187 N98cd3172d3764ed2bc0ab0af157c4eb0 schema:name Springer Nature - SN SciGraph project
188 rdf:type schema:Organization
189 N9b4bae5fc81c49b69626d2188ae3d030 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Viremia
191 rdf:type schema:DefinedTerm
192 Na0cef02baf3d47c4a8de498a55088b5b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name Adult
194 rdf:type schema:DefinedTerm
195 Na162a30e5b5740d8aeba3a4266c8f903 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
196 schema:name HIV Seropositivity
197 rdf:type schema:DefinedTerm
198 Na4a953d3c8584dd39836d8a371f0013c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
199 schema:name Viral Load
200 rdf:type schema:DefinedTerm
201 Na7bdefe4c9674575bc8a083d807f2b15 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
202 schema:name Mothers
203 rdf:type schema:DefinedTerm
204 Nafc35671751e45fd960c8e0abf16878b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
205 schema:name Infant
206 rdf:type schema:DefinedTerm
207 Nc1d30a7757dc48e7bf10e0d1c684e38b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
208 schema:name Pregnancy Complications, Infectious
209 rdf:type schema:DefinedTerm
210 Ncae0ca2abd784ccbae436d8c3a79bdf6 rdf:first sg:person.01372475316.99
211 rdf:rest N533ca01b05354afd9ccdd2b413da27e4
212 Nd69ee4ba75d642bfba1d4ef933a80f41 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
213 schema:name Infectious Disease Transmission, Vertical
214 rdf:type schema:DefinedTerm
215 Nec0d491a023b4bf8b3f781cf0409d76b schema:name doi
216 schema:value 10.1186/1471-2334-14-236
217 rdf:type schema:PropertyValue
218 Ned6d36e80bd5447d8310ee8e14587e16 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
219 schema:name Humans
220 rdf:type schema:DefinedTerm
221 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
222 schema:name Medical and Health Sciences
223 rdf:type schema:DefinedTerm
224 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
225 schema:name Immunology
226 rdf:type schema:DefinedTerm
227 anzsrc-for:1114 schema:inDefinedTermSet anzsrc-for:
228 schema:name Paediatrics and Reproductive Medicine
229 rdf:type schema:DefinedTerm
230 sg:journal.1024946 schema:issn 1471-2334
231 schema:name BMC Infectious Diseases
232 schema:publisher Springer Nature
233 rdf:type schema:Periodical
234 sg:person.01213005376.68 schema:affiliation grid-institutes:grid.411418.9
235 schema:familyName Kakkar
236 schema:givenName Fatima
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213005376.68
238 rdf:type schema:Person
239 sg:person.01305203606.45 schema:affiliation grid-institutes:grid.411418.9
240 schema:familyName Lapointe
241 schema:givenName Normand
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305203606.45
243 rdf:type schema:Person
244 sg:person.01321765331.58 schema:affiliation grid-institutes:grid.14848.31
245 schema:familyName Soudeyns
246 schema:givenName Hugo
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321765331.58
248 rdf:type schema:Person
249 sg:person.01354006374.55 schema:affiliation grid-institutes:grid.411418.9
250 schema:familyName Ducruet
251 schema:givenName Thierry
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354006374.55
253 rdf:type schema:Person
254 sg:person.01372475316.99 schema:affiliation grid-institutes:grid.411418.9
255 schema:familyName Valois
256 schema:givenName Silvie
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372475316.99
258 rdf:type schema:Person
259 sg:person.0722155715.95 schema:affiliation grid-institutes:grid.411418.9
260 schema:familyName Lamarre
261 schema:givenName Valerie
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0722155715.95
263 rdf:type schema:Person
264 sg:person.0734332577.19 schema:affiliation grid-institutes:grid.411418.9
265 schema:familyName Boucher
266 schema:givenName Marc
267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734332577.19
268 rdf:type schema:Person
269 sg:pub.10.1186/1471-2334-11-193 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047685188
270 https://doi.org/10.1186/1471-2334-11-193
271 rdf:type schema:CreativeWork
272 sg:pub.10.1186/1471-2431-11-69 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040787985
273 https://doi.org/10.1186/1471-2431-11-69
274 rdf:type schema:CreativeWork
275 grid-institutes:grid.14848.31 schema:alternateName Department of Microbiology, Infectious Diseases and Immunology, Faculty of Medicine, Université de Montréal, Montreal, Canada
276 schema:name Department of Microbiology, Infectious Diseases and Immunology, Faculty of Medicine, Université de Montréal, Montreal, Canada
277 Department of Pediatrics, Faculty of Medicine, Université de Montréal, Montreal, Canada
278 Unité d’immunopathologie virale, Centre de recherche du CHU Sainte-Justine, Montreal, Canada
279 rdf:type schema:Organization
280 grid-institutes:grid.411418.9 schema:alternateName Centre maternel et infantile sur le SIDA, CHU Sainte-Justine, Montreal, Canada
281 Division of Obstetrics and Gynecology, CHU Sainte-Justine, Montreal, Canada
282 Unité de recherche clinique appliquée, CHU Sainte-Justine, Montreal, Canada
283 schema:name Centre maternel et infantile sur le SIDA, CHU Sainte-Justine, Montreal, Canada
284 Department of Pediatrics, Faculty of Medicine, Université de Montréal, Montreal, Canada
285 Division of Infectious Diseases, CHU Sainte-Justine, 3175 Côte Sainte-Catherine, H3T 1C5, Montreal, Quebec, Canada
286 Division of Obstetrics and Gynecology, CHU Sainte-Justine, Montreal, Canada
287 Unité de recherche clinique appliquée, CHU Sainte-Justine, Montreal, Canada
288 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...