A cross-sectional study to estimate high-risk human papillomavirus prevalence and type distribution in Italian women aged 18–26 years View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-02-07

AUTHORS

Cristina Giambi, Serena Donati, Francesca Carozzi, Stefania Salmaso, Silvia Declich, Marta L Ciofi degli Atti, Guglielmo Ronco, Maria P Alibrandi, Silvia Brezzi, Natalina Collina, Daniela Franchi, Amedeo Lattanzi, Maria C Minna, Roberto Nannini, Elena Barretta, Elena Burroni, Anna Gillio-Tos, Vincenzo Macallini, Paola Pierotti, Antonino Bella

ABSTRACT

BackgroundPre-vaccination information on HPV type-specific prevalence in target populations is essential for designing and monitoring immunization strategies for cervical cancer (CC) prevention. Data on HPV prevalence in Italy are available for women over the age of 24 years, target of the population-based CC screening programmes; while data of HPV prevalence in younger ages are very limited. The present study enrolled Italian women aged 18–26 years in order to assess the prevalence and distribution of high-risk (HR) HPV types. Risk-factors correlated with HR-HPV positivity were also described.MethodsA sample of 2,289 women was randomly selected from the resident population lists of ten Local Health Units (LHUs) located in six Italian Regions scattered across the country; both rural and urban LHUs were involved. Women aged between 18 and 26 years and living in the selected LHUs were included in the study; pregnant women and women who did not speak Italian were excluded. A total of 1,102 women met the inclusion criteria and agreed to participate. Participants were offered pap test and Hybrid-Capture 2 (HC2) test for HR-HPV types and genotyping was performed on positive smears.ResultsOut of 1,094 valid samples, 205 (18.7%) were HR-HPV positive. Women with 2–4 (ORadj = 4.15, 95%CI: 2.56-6.72) and ≥5 lifetime partners (ORadj = 10.63, 95%CI: 6.16-18.36) and women who have used any contraceptive in the last six months (ORadj = 1.67, 95%CI: 1.09-2.54) had a higher risk to be infected; women living with their partner had a lower risk (ORadj = 0.56, 95%CI: 0.34-0.92) to acquire infection than women living with parents/friends/alone. Among HC2 positive women, HPV16 was the most prevalent type (30.9%), followed by 31 (19.6%), 66 (12.9%), 51 (11.3%), 18 (8.8%), 56 (8.8%). Co-infections of HR-HC2 targeted types were found in 20.4% of positive samples. The HR-HPV prevalence in women with abnormal cytology (52.4%) was significantly higher than in women with normal cytology (14.6%); however 33.0% of HR-HPV infected women had an abnormal cytology.ConclusionHR-HPV prevalence in Italian women aged 18–26 years was 19%, higher than what detected for older women, by other studies using the same molecular method and laboratory network; this result supports the choice of electing girls before the sexual debut as the primary target of HPV vaccination. The HPV type distribution found in this study may represent a baseline picture; an accurate post-vaccine surveillance is necessary to early detect a possible genotype replacement. The high prevalence of viral types other than vaccine-HPV types supports the necessity to guarantee the progression of CC screening programmes in vaccinated women. More... »

PAGES

74

Journal

TITLE

BMC Infectious Diseases

ISSUE

1

VOLUME

13

Author Affiliations

  • Communicable Disease Epidemiology Unit, National Centre for Epidemiology, Surveillance and Health Promotion;, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy
  • Analytical Cytology and Biomolecular Unit, Cancer Research and Prevention Institute, Via Cosimo il Vecchio 2, 50139, Florence, Italy
  • Medical Direction, Bambino Gesù Children’s Hospital, Piazza S. Onofrio 4, 00165, Rome, Italy
  • Unit of cancer epidemiology, Center for Cancer Prevention, S. Francesco da Paola 31, 10123, Turin, Italy
  • Hygiene and Public Health Unit, LHU Torino4, Via Aldisio 2, 10015, Ivrea, Turin, Italy
  • Department of Prevention, LHU Viterbo, via Enrico Fermi 15, 01100, Viterbo, Italy
  • Public Health Department, LHU Bologna, Via del Seminario 1, 40068, San Lazzaro di Savena, Bologna, Italy
  • Department of Prevention, LHU Avezzano-Sulmona-L’Aquila, Via Monte Velino 18, 67051, Avezzano, L’Aquila, Italy
  • San Liberatore Hospital, LHU Teramo, Viale Risorgimento, 64032, Atri, Teramo, Italy
  • Community Medicine Unit, LHU Pescara, Via Paolini 45, 65124, Pescara, Italy
  • Oncologic Screening Center, LHU Imola, viale Amendola 8, 40026, Imola, Bologna, Italy
  • Mother and Child Department, LHU Napoli 2 Nord, Corso Italia 129, 80010, Quarto, Napoli, Italy
  • Center for Experimental Research and Medical Science, University of Turin, Via Santena 7, 10126, Turin, Italy
  • S. Rinaldi Hospital, Via Serafino Rinaldi 63, 67057, Pescina, L’Aquila, Italy
  • Maggiore Hospital, LHU Bologna, Largo B. Nigrisoli 2, 40133, Bologna, Italy
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/1471-2334-13-74

    DOI

    http://dx.doi.org/10.1186/1471-2334-13-74

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1012756207

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23390953


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