HIV-1 drug resistance in recently HIV-infected pregnant mother’s naïve to antiretroviral therapy in Dodoma urban, Tanzania View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-09-21

AUTHORS

Francesco Vairo, Emanuele Nicastri, Giuseppina Liuzzi, Zainab Chaula, Boniface Nguhuni, Nazario Bevilacqua, Federica Forbici, Alessandra Amendola, Lavinia Fabeni, Pasquale De Nardo, Carlo Federico Perno, Angela Cannas, Calistus Sakhoo, Maria Rosaria Capobianchi, Giuseppe Ippolito

ABSTRACT

BACKGROUND: HIV resistance affects virological response to therapy and efficacy of prophylaxis in mother-to-child-transmission. The study aims to assess the prevalence of HIV primary resistance in pregnant women naïve to antiretrovirals. METHODS: Cross sectional baseline analysis of a cohort of HIV + pregnant women (HPW) enrolled in the study entitled Antiretroviral Management of Antenatal and Natal HIV Infection (AMANI, peace in Kiswahili language). The AMANI study began in May 2010 in Dodoma, Tanzania. In this observational cohort, antiretroviral treatment was provided to all women from the 28th week of gestation until the end of the breastfeeding period. Baseline CD4 cell count, viral load and HIV drug-resistance genotype were collected. RESULTS: Drug-resistance analysis was performed on 97 naïve infected-mothers. The prevalence of all primary drug resistance and primary non-nucleoside reverse-transcriptase inhibitors resistance was 11.9% and 7.5%, respectively. K103S was found in two women with no M184V detection. HIV-1 subtype A was the most commonly identified, with a high prevalence of subtype A1, followed by C, D, C/D recombinant, A/C recombinant and A/D recombinant. HIV drug- resistance mutations were detected in A1 and C subtypes. CONCLUSION: Our study reports an 11.9% prevalence rate of primary drug resistance in naïve HIV-infected pregnant women from a remote area of Tanzania. Considering that the non-nucleoside reverse-transcriptase inhibitors are part of the first-line antiretroviral regimen in Tanzania and all of Africa, resistance surveys should be prioritized in settings where antiretroviral therapy programs are scaled up. More... »

PAGES

439-439

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1471-2334-13-439

DOI

http://dx.doi.org/10.1186/1471-2334-13-439

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1018425989

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24053581


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24 schema:description BACKGROUND: HIV resistance affects virological response to therapy and efficacy of prophylaxis in mother-to-child-transmission. The study aims to assess the prevalence of HIV primary resistance in pregnant women naïve to antiretrovirals. METHODS: Cross sectional baseline analysis of a cohort of HIV + pregnant women (HPW) enrolled in the study entitled Antiretroviral Management of Antenatal and Natal HIV Infection (AMANI, peace in Kiswahili language). The AMANI study began in May 2010 in Dodoma, Tanzania. In this observational cohort, antiretroviral treatment was provided to all women from the 28th week of gestation until the end of the breastfeeding period. Baseline CD4 cell count, viral load and HIV drug-resistance genotype were collected. RESULTS: Drug-resistance analysis was performed on 97 naïve infected-mothers. The prevalence of all primary drug resistance and primary non-nucleoside reverse-transcriptase inhibitors resistance was 11.9% and 7.5%, respectively. K103S was found in two women with no M184V detection. HIV-1 subtype A was the most commonly identified, with a high prevalence of subtype A1, followed by C, D, C/D recombinant, A/C recombinant and A/D recombinant. HIV drug- resistance mutations were detected in A1 and C subtypes. CONCLUSION: Our study reports an 11.9% prevalence rate of primary drug resistance in naïve HIV-infected pregnant women from a remote area of Tanzania. Considering that the non-nucleoside reverse-transcriptase inhibitors are part of the first-line antiretroviral regimen in Tanzania and all of Africa, resistance surveys should be prioritized in settings where antiretroviral therapy programs are scaled up.
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31 schema:keywords A1
32 AMANI study
33 Africa
34 CD4 cell count
35 Dodoma
36 Dodoma urban
37 HIV
38 HIV drug resistance mutations
39 HIV drug-resistance genotype
40 HIV infection
41 HIV primary resistance
42 HIV resistance
43 HIV-1 drug resistance
44 HIV-1 subtype A
45 K103
46 M184V detection
47 Natal HIV Infection
48 Tanzania
49 Urban
50 analysis
51 antenatal
52 antiretroviral management
53 antiretroviral regimen
54 antiretroviral therapy
55 antiretroviral therapy programs
56 antiretroviral treatment
57 antiretrovirals
58 area
59 baseline CD4 cell count
60 baseline analysis
61 breastfeeding period
62 cell count
63 cohort
64 cohort of HIV
65 count
66 detection
67 drug resistance
68 drug resistance analysis
69 drug resistance genotypes
70 drug resistance mutations
71 efficacy
72 efficacy of prophylaxis
73 end
74 first-line antiretroviral regimen
75 genotypes
76 gestation
77 high prevalence
78 infection
79 inhibitor resistance
80 inhibitors
81 load
82 management
83 mothers
84 mother’s naïve
85 mutations
86 naïve
87 naïve HIV
88 non-nucleoside reverse transcriptase inhibitor
89 non-nucleoside reverse transcriptase inhibitor resistance
90 observational cohort
91 part
92 period
93 pregnant mother’s naïve
94 pregnant women
95 pregnant women naïve
96 prevalence
97 prevalence rates
98 primary drug resistance
99 primary non-nucleoside reverse-transcriptase inhibitors resistance
100 primary resistance
101 program
102 prophylaxis
103 rate
104 recombinants
105 regimen
106 remote areas
107 resistance
108 resistance survey
109 response
110 reverse transcriptase inhibitor
111 reverse transcriptase inhibitor resistance
112 sectional baseline analysis
113 setting
114 study
115 subtype A
116 subtype A1
117 subtypes
118 survey
119 therapy
120 therapy program
121 treatment
122 viral load
123 virological response
124 weeks
125 weeks of gestation
126 women
127 women naïve
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