Difference in overall and age-specific prevalence of high-risk human papillomavirus infection in Italy: evidence from NTCC trial View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-05-24

AUTHORS

Iacopo Baussano, Silvia Franceschi, Anna Gillio-Tos, Francesca Carozzi, Massimo Confortini, Paolo Dalla Palma, Margherita De Lillo, Annarosa Del Mistro, Laura De Marco, Carlo Naldoni, Paola Pierotti, Patrizia Schincaglia, Nereo Segnan, Manuel Zorzi, Paolo Giorgi-Rossi, Guglielmo Ronco

ABSTRACT

BackgroundAlthough among women a decreasing prevalence of human papillomavirus (HPV) infection with increasing age has been consistently observed in high-resource countries, different age profiles have been reported elsewhere.MethodsWe compared the age profile of high-risk (HR)-HPV prevalence in nine different areas of Northern and Central Italy by studying the women recruited in the intervention arm of the New Technologies in Cervical Cancer study and tested by Hybrid Capture 2. Differences in the age-distribution of HPV infection were investigated in each centre by the joinpoint approach in a logistic model. 46,900 women aged 25 to 60 years were included in the analysis.ResultsThe HR-HPV age-standardised (on Italian population) prevalence ranged from 5.7% (Trento) to 10.3% (Ravenna). HR-HPV prevalence decreased as a logistic function of increasing age in 6 of 9 centres (Trento, Verona, Florence, Bologna, Imola, and Viterbo). The effect of age on HR-HPV prevalence slopes did not differ significantly among these 6 centres, whereas significant heterogeneity in intercepts (p < 0.001) was found, reflecting different overall HR-HPV prevalence between centres. One significant joinpoint was observed in 2 centres (Padua and Ravenna), indicating that the decrease in HR-HPV prevalence by age was better described using a function composed with two logistic segments. In Padua HR-HPV prevalence decreased only slightly up to 39 years but showed a steep downturn thereafter. In Ravenna HR-HPV prevalence decreased steeply down to 45 years of age and then showed a plateau. Finally, in Turin two significant joinpoints were observed: prevalence decreased only after age 29 and showed a plateau after age 39.ConclusionsOur results showed substantial differences in overall and age-specific HR-HPV prevalence across Italian areas. These findings may be related to different timing of changes in sexual behaviours across regions. Age-specific HR-HPV prevalence in Italy does not support an influence of age per se. More... »

PAGES

238

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1471-2334-13-238

DOI

http://dx.doi.org/10.1186/1471-2334-13-238

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026843318

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23706168


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23 schema:description BackgroundAlthough among women a decreasing prevalence of human papillomavirus (HPV) infection with increasing age has been consistently observed in high-resource countries, different age profiles have been reported elsewhere.MethodsWe compared the age profile of high-risk (HR)-HPV prevalence in nine different areas of Northern and Central Italy by studying the women recruited in the intervention arm of the New Technologies in Cervical Cancer study and tested by Hybrid Capture 2. Differences in the age-distribution of HPV infection were investigated in each centre by the joinpoint approach in a logistic model. 46,900 women aged 25 to 60 years were included in the analysis.ResultsThe HR-HPV age-standardised (on Italian population) prevalence ranged from 5.7% (Trento) to 10.3% (Ravenna). HR-HPV prevalence decreased as a logistic function of increasing age in 6 of 9 centres (Trento, Verona, Florence, Bologna, Imola, and Viterbo). The effect of age on HR-HPV prevalence slopes did not differ significantly among these 6 centres, whereas significant heterogeneity in intercepts (p < 0.001) was found, reflecting different overall HR-HPV prevalence between centres. One significant joinpoint was observed in 2 centres (Padua and Ravenna), indicating that the decrease in HR-HPV prevalence by age was better described using a function composed with two logistic segments. In Padua HR-HPV prevalence decreased only slightly up to 39 years but showed a steep downturn thereafter. In Ravenna HR-HPV prevalence decreased steeply down to 45 years of age and then showed a plateau. Finally, in Turin two significant joinpoints were observed: prevalence decreased only after age 29 and showed a plateau after age 39.ConclusionsOur results showed substantial differences in overall and age-specific HR-HPV prevalence across Italian areas. These findings may be related to different timing of changes in sexual behaviours across regions. Age-specific HR-HPV prevalence in Italy does not support an influence of age per se.
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30 schema:keywords BackgroundAlthough
31 Capture 2
32 HPV infection
33 HPV prevalence
34 HR-HPV prevalence
35 Hybrid Capture 2
36 Italian areas
37 Italy
38 MethodsWe
39 age
40 age 29
41 age profile
42 age-specific prevalence
43 age-standardised prevalence
44 analysis
45 approach
46 area
47 arm
48 behavior
49 cancer studies
50 center
51 central Italy
52 cervical cancer study
53 changes
54 countries
55 decrease
56 differences
57 different age profiles
58 different areas
59 different timing
60 downturn
61 effect
62 effect of age
63 evidence
64 findings
65 function
66 heterogeneity
67 high-resource countries
68 high-risk human papillomavirus infection
69 human papillomavirus infection
70 infection
71 influence
72 influence of age
73 intercept
74 intervention arm
75 joinpoints
76 logistic function
77 logistic model
78 logistics segment
79 model
80 new technologies
81 overall HR-HPV prevalence
82 papillomavirus infection
83 plateau
84 prevalence
85 profile
86 region
87 results
88 segments
89 sexual behavior
90 significant heterogeneity
91 significant joinpoints
92 slope
93 steep downturn
94 study
95 substantial differences
96 technology
97 timing
98 trials
99 women
100 years
101 years of age
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