Serum cortisol predicts death and critical disease independently of CRB-65 score in community-acquired pneumonia: a prospective observational cohort study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-12

AUTHORS

Martin Kolditz, Gert Höffken, Peter Martus, Gernot Rohde, Hartwig Schütte, Robert Bals, Norbert Suttorp, Mathias W Pletz, the CAPNETZ study group

ABSTRACT

BACKGROUND: Several biomarkers and prognostic scores have been evaluated to predict prognosis in community-acquired pneumonia (CAP). Optimal risk stratification remains to be evaluated. The aim of this study was to evaluate serum cortisol as biomarker for the prediction of adverse outcomes independently of the CRB-65 score und inflammatory biomarkers in a large cohort of hospitalised patients with CAP. METHODS: 984 hospitalised CAP-patients were included. Serum cortisol was measured and its prognostic accuracy compared to the CRB-65 score, leucocyte count and C-reactive protein. Predefined endpoints were 30-day mortality and the combined endpoint critical pneumonia, defined as presence of death occurring during antibiotic treatment, mechanical ventilation, catecholamine treatment or ICU admission. RESULTS: 64 patients died (6.5%) and 85 developed critical pneumonia (8.6%). Cortisol levels were significantly elevated in both adverse outcomes (p < 0.001) and predicted mortality (AUC 0.70, cut-off 795 nmol/L) and critical pneumonia (AUC 0.71) independently of all other measured variables after logistic regression analysis (p = 0.005 and 0.001, respectively). Prognostic accuracy of CRB-65 was significantly improved by adding cortisol levels (combined AUC 0.81 for both endpoints). In Kaplan-Meier analysis, cortisol predicted survival within different CRB-65 strata (p = 0.003). In subgroup analyses, cortisol independently predicted critical pneumonia when compared to procalcitonin, the CURB65 score and minor criteria for severe pneumonia according to the 2007 ATS/IDSA-guideline. CONCLUSION: Cortisol predicts mortality and critical disease in hospitalised CAP-patients independently of clinical scores and inflammatory biomarkers. It should be incorporated into trials assessing optimal combinations of clinical criteria and biomarkers to improve initial high risk prediction in CAP. More... »

PAGES

90

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1471-2334-12-90

DOI

http://dx.doi.org/10.1186/1471-2334-12-90

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1043794271

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22501026


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "C-Reactive Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cohort Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Community-Acquired Infections", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hydrocortisone", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leukocyte Count", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pneumonia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Serum", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Analysis", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University Hospital Carl Gustav Carus", 
          "id": "https://www.grid.ac/institutes/grid.412282.f", 
          "name": [
            "Division of Pulmonology, Medical Department 1, University Hospital Carl Gustav Carus, Fetscherstr. 74, 01307, Dresden, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kolditz", 
        "givenName": "Martin", 
        "id": "sg:person.01330577317.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330577317.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Carl Gustav Carus", 
          "id": "https://www.grid.ac/institutes/grid.412282.f", 
          "name": [
            "Division of Pulmonology, Medical Department 1, University Hospital Carl Gustav Carus, Fetscherstr. 74, 01307, Dresden, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "H\u00f6ffken", 
        "givenName": "Gert", 
        "id": "sg:person.0703064461.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703064461.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Charit\u00e9", 
          "id": "https://www.grid.ac/institutes/grid.6363.0", 
          "name": [
            "Department of Biostatistics and Clinical Epidemiology, Charit\u00e9 Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Martus", 
        "givenName": "Peter", 
        "id": "sg:person.0614557272.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0614557272.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Maastricht University Medical Centre", 
          "id": "https://www.grid.ac/institutes/grid.412966.e", 
          "name": [
            "Department of Respiratory Medicine, Maastricht University Medical Center, Maastricht, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rohde", 
        "givenName": "Gernot", 
        "id": "sg:person.01053063160.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053063160.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Charit\u00e9", 
          "id": "https://www.grid.ac/institutes/grid.6363.0", 
          "name": [
            "Department of Internal Medicine, Infectious Diseases and Pulmonary Medicine, Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sch\u00fctte", 
        "givenName": "Hartwig", 
        "id": "sg:person.0722302133.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0722302133.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e4tsklinikum des Saarlandes", 
          "id": "https://www.grid.ac/institutes/grid.411937.9", 
          "name": [
            "Department of Internal Medicine V - Pulmonology, Allergology, Respiratory Intensive Care Medicine, Saarland University Hospital, Homburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bals", 
        "givenName": "Robert", 
        "id": "sg:person.01124232770.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124232770.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Charit\u00e9", 
          "id": "https://www.grid.ac/institutes/grid.6363.0", 
          "name": [
            "Department of Internal Medicine, Infectious Diseases and Pulmonary Medicine, Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Suttorp", 
        "givenName": "Norbert", 
        "id": "sg:person.0654166733.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0654166733.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Jena University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.275559.9", 
          "name": [
            "Division of Gastroenterology, Hepatology and Infectious Diseases, Department of Internal Medicine II, Jena University Hospital, Jena, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pletz", 
        "givenName": "Mathias W", 
        "id": "sg:person.01000344453.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000344453.00"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "the CAPNETZ study group", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1097/ccm.0b013e3181b02dbb", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001127548"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ccm.0b013e3181b02dbb", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001127548"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/thx.2008.099028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001683857"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/rccm.201003-0415oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002104283"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jac/dkp148", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003207015"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-0029-1215037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003897585"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/rccm.200702-307oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004240402"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/emj.2009.089383", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005809783"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/thx.2008.105312", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006180405"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/thx.2008.105312", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006180405"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/09031936.00021007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006376875"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.annemergmed.2008.01.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008005707"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/09031936.00054507", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008931628"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/511159", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011420673"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/cc9055", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012408311", 
          "https://doi.org/10.1186/cc9055"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/thx.2009.121178", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013238892"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/thx.2009.121178", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013238892"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s15010-004-3107-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016076154", 
          "https://doi.org/10.1007/s15010-004-3107-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/09031936.00135607", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016914748"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-011-2261-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017303346", 
          "https://doi.org/10.1007/s00134-011-2261-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-011-2208-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017774860", 
          "https://doi.org/10.1007/s00134-011-2208-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199701233360402", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018073258"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/ajrccm.158.4.9803114", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020202179"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/09031936.00092507", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022257927"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-010-2077-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023621060", 
          "https://doi.org/10.1007/s00134-010-2077-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/09031936.00191709", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025058086"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/cc7751", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025985061", 
          "https://doi.org/10.1186/cc7751"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.126.4.1087", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027228967"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.09-1547", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028973442"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/589754", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029079720"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2796.2006.01657.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029798513"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199505183322008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031448544"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/thx.2009.134072", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038532826"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/thx.2009.134072", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038532826"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/596307", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043173674"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/thorax.58.5.377", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044558168"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/thorax.58.5.377", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044558168"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cca.2010.08.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046003219"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(11)60607-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046248474"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/rccm.200512-1922oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050138013"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/thx.2009.133280", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050330108"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/thx.2009.133280", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050330108"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmra020529", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051351930"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/rccm.200905-0808oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052132142"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2006-0674", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064289237"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.83.6.1827", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064300228"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-12", 
    "datePublishedReg": "2012-12-01", 
    "description": "BACKGROUND: Several biomarkers and prognostic scores have been evaluated to predict prognosis in community-acquired pneumonia (CAP). Optimal risk stratification remains to be evaluated. The aim of this study was to evaluate serum cortisol as biomarker for the prediction of adverse outcomes independently of the CRB-65 score und inflammatory biomarkers in a large cohort of hospitalised patients with CAP.\nMETHODS: 984 hospitalised CAP-patients were included. Serum cortisol was measured and its prognostic accuracy compared to the CRB-65 score, leucocyte count and C-reactive protein. Predefined endpoints were 30-day mortality and the combined endpoint critical pneumonia, defined as presence of death occurring during antibiotic treatment, mechanical ventilation, catecholamine treatment or ICU admission.\nRESULTS: 64 patients died (6.5%) and 85 developed critical pneumonia (8.6%). Cortisol levels were significantly elevated in both adverse outcomes (p < 0.001) and predicted mortality (AUC 0.70, cut-off 795 nmol/L) and critical pneumonia (AUC 0.71) independently of all other measured variables after logistic regression analysis (p = 0.005 and 0.001, respectively). Prognostic accuracy of CRB-65 was significantly improved by adding cortisol levels (combined AUC 0.81 for both endpoints). In Kaplan-Meier analysis, cortisol predicted survival within different CRB-65 strata (p = 0.003). In subgroup analyses, cortisol independently predicted critical pneumonia when compared to procalcitonin, the CURB65 score and minor criteria for severe pneumonia according to the 2007 ATS/IDSA-guideline.\nCONCLUSION: Cortisol predicts mortality and critical disease in hospitalised CAP-patients independently of clinical scores and inflammatory biomarkers. It should be incorporated into trials assessing optimal combinations of clinical criteria and biomarkers to improve initial high risk prediction in CAP.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/1471-2334-12-90", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1024946", 
        "issn": [
          "1471-2334"
        ], 
        "name": "BMC Infectious Diseases", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "12"
      }
    ], 
    "name": "Serum cortisol predicts death and critical disease independently of CRB-65 score in community-acquired pneumonia: a prospective observational cohort study", 
    "pagination": "90", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "d09c09fedd3f61b3f0a105f6f55808f122797fe58faa7e01eb6d5479706d24e6"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "22501026"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100968551"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1471-2334-12-90"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1043794271"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1471-2334-12-90", 
      "https://app.dimensions.ai/details/publication/pub.1043794271"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T14:59", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8663_00000507.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2F1471-2334-12-90"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1471-2334-12-90'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1471-2334-12-90'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1471-2334-12-90'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1471-2334-12-90'


 

This table displays all metadata directly associated to this object as RDF triples.

328 TRIPLES      21 PREDICATES      86 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1471-2334-12-90 schema:about N03e9ca3dfd774d2e8347a15c009fc2f4
2 N05eb9783f0244a7fb3e45f509b8e05b7
3 N0bbc2da447074985a8f8ce16266cefa8
4 N2ddddb27c4c34110a0c0a49284f48c96
5 N377eda7eda704c248a635ce3cd7d2dac
6 N3a1996286a7e491f8ce05358af6dfde6
7 N4806e388cf5d48baa68c9f34d3c76615
8 N51cd8634bb194a9182fefe5e348f92bc
9 N67a4ac26dd4d4e488bc5f8bfec571806
10 N80695d4f9ad94041869f308f6d6aa97c
11 N98bb5904fb3f499abb5d50c47934124b
12 Nabe4321686fc4af6a29b4b6a1057e98c
13 Nc17c93d51f5d47ec88cb2a05017383f8
14 Nc6fe8caa5e10442a8e811d885fa8296e
15 Nd1ac3fd8a26c4985a192ad10c60134b7
16 Nd7fe0f4f69db4845b3b065791d47e029
17 Nec663669355242b9be86f2e5ab712569
18 anzsrc-for:11
19 anzsrc-for:1103
20 schema:author Nf6f3adac5e2a442fb616f19895dd50c2
21 schema:citation sg:pub.10.1007/s00134-010-2077-0
22 sg:pub.10.1007/s00134-011-2208-2
23 sg:pub.10.1007/s00134-011-2261-x
24 sg:pub.10.1007/s15010-004-3107-z
25 sg:pub.10.1186/cc7751
26 sg:pub.10.1186/cc9055
27 https://doi.org/10.1016/j.annemergmed.2008.01.003
28 https://doi.org/10.1016/j.cca.2010.08.004
29 https://doi.org/10.1016/s0140-6736(11)60607-7
30 https://doi.org/10.1055/s-0029-1215037
31 https://doi.org/10.1056/nejm199505183322008
32 https://doi.org/10.1056/nejm199701233360402
33 https://doi.org/10.1056/nejmra020529
34 https://doi.org/10.1086/511159
35 https://doi.org/10.1086/589754
36 https://doi.org/10.1086/596307
37 https://doi.org/10.1093/jac/dkp148
38 https://doi.org/10.1097/ccm.0b013e3181b02dbb
39 https://doi.org/10.1111/j.1365-2796.2006.01657.x
40 https://doi.org/10.1136/emj.2009.089383
41 https://doi.org/10.1136/thorax.58.5.377
42 https://doi.org/10.1136/thx.2008.099028
43 https://doi.org/10.1136/thx.2008.105312
44 https://doi.org/10.1136/thx.2009.121178
45 https://doi.org/10.1136/thx.2009.133280
46 https://doi.org/10.1136/thx.2009.134072
47 https://doi.org/10.1164/ajrccm.158.4.9803114
48 https://doi.org/10.1164/rccm.200512-1922oc
49 https://doi.org/10.1164/rccm.200702-307oc
50 https://doi.org/10.1164/rccm.200905-0808oc
51 https://doi.org/10.1164/rccm.201003-0415oc
52 https://doi.org/10.1183/09031936.00021007
53 https://doi.org/10.1183/09031936.00054507
54 https://doi.org/10.1183/09031936.00092507
55 https://doi.org/10.1183/09031936.00135607
56 https://doi.org/10.1183/09031936.00191709
57 https://doi.org/10.1210/jc.2006-0674
58 https://doi.org/10.1210/jc.83.6.1827
59 https://doi.org/10.1378/chest.09-1547
60 https://doi.org/10.1378/chest.126.4.1087
61 schema:datePublished 2012-12
62 schema:datePublishedReg 2012-12-01
63 schema:description BACKGROUND: Several biomarkers and prognostic scores have been evaluated to predict prognosis in community-acquired pneumonia (CAP). Optimal risk stratification remains to be evaluated. The aim of this study was to evaluate serum cortisol as biomarker for the prediction of adverse outcomes independently of the CRB-65 score und inflammatory biomarkers in a large cohort of hospitalised patients with CAP. METHODS: 984 hospitalised CAP-patients were included. Serum cortisol was measured and its prognostic accuracy compared to the CRB-65 score, leucocyte count and C-reactive protein. Predefined endpoints were 30-day mortality and the combined endpoint critical pneumonia, defined as presence of death occurring during antibiotic treatment, mechanical ventilation, catecholamine treatment or ICU admission. RESULTS: 64 patients died (6.5%) and 85 developed critical pneumonia (8.6%). Cortisol levels were significantly elevated in both adverse outcomes (p < 0.001) and predicted mortality (AUC 0.70, cut-off 795 nmol/L) and critical pneumonia (AUC 0.71) independently of all other measured variables after logistic regression analysis (p = 0.005 and 0.001, respectively). Prognostic accuracy of CRB-65 was significantly improved by adding cortisol levels (combined AUC 0.81 for both endpoints). In Kaplan-Meier analysis, cortisol predicted survival within different CRB-65 strata (p = 0.003). In subgroup analyses, cortisol independently predicted critical pneumonia when compared to procalcitonin, the CURB65 score and minor criteria for severe pneumonia according to the 2007 ATS/IDSA-guideline. CONCLUSION: Cortisol predicts mortality and critical disease in hospitalised CAP-patients independently of clinical scores and inflammatory biomarkers. It should be incorporated into trials assessing optimal combinations of clinical criteria and biomarkers to improve initial high risk prediction in CAP.
64 schema:genre research_article
65 schema:inLanguage en
66 schema:isAccessibleForFree true
67 schema:isPartOf N3489e52b20a9402c9f463dac45dfee15
68 Nf0585778063d4d0e8a19e05f89e7c863
69 sg:journal.1024946
70 schema:name Serum cortisol predicts death and critical disease independently of CRB-65 score in community-acquired pneumonia: a prospective observational cohort study
71 schema:pagination 90
72 schema:productId Na83dd9bc708f41658687dca9ca596b9e
73 Naf438810b692463da6aa7f378e6574b1
74 Nd2b3303125b64d56823444fe6218a8fd
75 Nddbcc22d156a49c6933b5ee0229b6cb5
76 Nef99c8880d304bd0a15080c88491551b
77 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043794271
78 https://doi.org/10.1186/1471-2334-12-90
79 schema:sdDatePublished 2019-04-10T14:59
80 schema:sdLicense https://scigraph.springernature.com/explorer/license/
81 schema:sdPublisher Nad1a98a4324a480fac621160d3c7dbdb
82 schema:url http://link.springer.com/10.1186%2F1471-2334-12-90
83 sgo:license sg:explorer/license/
84 sgo:sdDataset articles
85 rdf:type schema:ScholarlyArticle
86 N03e9ca3dfd774d2e8347a15c009fc2f4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Cohort Studies
88 rdf:type schema:DefinedTerm
89 N05eb9783f0244a7fb3e45f509b8e05b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Serum
91 rdf:type schema:DefinedTerm
92 N0bbc2da447074985a8f8ce16266cefa8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Male
94 rdf:type schema:DefinedTerm
95 N2075db15c29347a9b4bf2f27c95b3688 rdf:first sg:person.0654166733.58
96 rdf:rest N2421fe4cdbbb48118d909e7de2d2f886
97 N2421fe4cdbbb48118d909e7de2d2f886 rdf:first sg:person.01000344453.00
98 rdf:rest Ne3dbedc01bb24d39a304118040f34f61
99 N2ddddb27c4c34110a0c0a49284f48c96 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name C-Reactive Protein
101 rdf:type schema:DefinedTerm
102 N3489e52b20a9402c9f463dac45dfee15 schema:issueNumber 1
103 rdf:type schema:PublicationIssue
104 N360873a6f80f46718015c33124cfda26 rdf:first sg:person.01053063160.74
105 rdf:rest N5c7563b655634d338718b4d20bf702ff
106 N377eda7eda704c248a635ce3cd7d2dac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Biomarkers
108 rdf:type schema:DefinedTerm
109 N3a1996286a7e491f8ce05358af6dfde6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Female
111 rdf:type schema:DefinedTerm
112 N4806e388cf5d48baa68c9f34d3c76615 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Leukocyte Count
114 rdf:type schema:DefinedTerm
115 N51cd8634bb194a9182fefe5e348f92bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Middle Aged
117 rdf:type schema:DefinedTerm
118 N5c7563b655634d338718b4d20bf702ff rdf:first sg:person.0722302133.88
119 rdf:rest Naa7e47902bf8488b8fe91e5656a54b1e
120 N67a4ac26dd4d4e488bc5f8bfec571806 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Prospective Studies
122 rdf:type schema:DefinedTerm
123 N80695d4f9ad94041869f308f6d6aa97c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Hydrocortisone
125 rdf:type schema:DefinedTerm
126 N98bb5904fb3f499abb5d50c47934124b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Aged
128 rdf:type schema:DefinedTerm
129 N99c7e0fb8f5e40c69b57778c8f25d155 schema:familyName the CAPNETZ study group
130 rdf:type schema:Person
131 Na83dd9bc708f41658687dca9ca596b9e schema:name nlm_unique_id
132 schema:value 100968551
133 rdf:type schema:PropertyValue
134 Naa7e47902bf8488b8fe91e5656a54b1e rdf:first sg:person.01124232770.20
135 rdf:rest N2075db15c29347a9b4bf2f27c95b3688
136 Nabe4321686fc4af6a29b4b6a1057e98c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Survival Analysis
138 rdf:type schema:DefinedTerm
139 Nad1a98a4324a480fac621160d3c7dbdb schema:name Springer Nature - SN SciGraph project
140 rdf:type schema:Organization
141 Naf438810b692463da6aa7f378e6574b1 schema:name dimensions_id
142 schema:value pub.1043794271
143 rdf:type schema:PropertyValue
144 Nc17c93d51f5d47ec88cb2a05017383f8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Pneumonia
146 rdf:type schema:DefinedTerm
147 Nc6fe8caa5e10442a8e811d885fa8296e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Prognosis
149 rdf:type schema:DefinedTerm
150 Nd1ac3fd8a26c4985a192ad10c60134b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Community-Acquired Infections
152 rdf:type schema:DefinedTerm
153 Nd2b3303125b64d56823444fe6218a8fd schema:name pubmed_id
154 schema:value 22501026
155 rdf:type schema:PropertyValue
156 Nd7fe0f4f69db4845b3b065791d47e029 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Adult
158 rdf:type schema:DefinedTerm
159 Nddbcc22d156a49c6933b5ee0229b6cb5 schema:name doi
160 schema:value 10.1186/1471-2334-12-90
161 rdf:type schema:PropertyValue
162 Ne0c1e6498f1842dcb70a8caf4af0068a rdf:first sg:person.0614557272.47
163 rdf:rest N360873a6f80f46718015c33124cfda26
164 Ne3dbedc01bb24d39a304118040f34f61 rdf:first N99c7e0fb8f5e40c69b57778c8f25d155
165 rdf:rest rdf:nil
166 Nec663669355242b9be86f2e5ab712569 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Humans
168 rdf:type schema:DefinedTerm
169 Nef99c8880d304bd0a15080c88491551b schema:name readcube_id
170 schema:value d09c09fedd3f61b3f0a105f6f55808f122797fe58faa7e01eb6d5479706d24e6
171 rdf:type schema:PropertyValue
172 Nf0585778063d4d0e8a19e05f89e7c863 schema:volumeNumber 12
173 rdf:type schema:PublicationVolume
174 Nf6f3adac5e2a442fb616f19895dd50c2 rdf:first sg:person.01330577317.65
175 rdf:rest Nfce51f0d41624c09b5f6ff8ecffa0678
176 Nfce51f0d41624c09b5f6ff8ecffa0678 rdf:first sg:person.0703064461.15
177 rdf:rest Ne0c1e6498f1842dcb70a8caf4af0068a
178 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
179 schema:name Medical and Health Sciences
180 rdf:type schema:DefinedTerm
181 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
182 schema:name Clinical Sciences
183 rdf:type schema:DefinedTerm
184 sg:journal.1024946 schema:issn 1471-2334
185 schema:name BMC Infectious Diseases
186 rdf:type schema:Periodical
187 sg:person.01000344453.00 schema:affiliation https://www.grid.ac/institutes/grid.275559.9
188 schema:familyName Pletz
189 schema:givenName Mathias W
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000344453.00
191 rdf:type schema:Person
192 sg:person.01053063160.74 schema:affiliation https://www.grid.ac/institutes/grid.412966.e
193 schema:familyName Rohde
194 schema:givenName Gernot
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053063160.74
196 rdf:type schema:Person
197 sg:person.01124232770.20 schema:affiliation https://www.grid.ac/institutes/grid.411937.9
198 schema:familyName Bals
199 schema:givenName Robert
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124232770.20
201 rdf:type schema:Person
202 sg:person.01330577317.65 schema:affiliation https://www.grid.ac/institutes/grid.412282.f
203 schema:familyName Kolditz
204 schema:givenName Martin
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330577317.65
206 rdf:type schema:Person
207 sg:person.0614557272.47 schema:affiliation https://www.grid.ac/institutes/grid.6363.0
208 schema:familyName Martus
209 schema:givenName Peter
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0614557272.47
211 rdf:type schema:Person
212 sg:person.0654166733.58 schema:affiliation https://www.grid.ac/institutes/grid.6363.0
213 schema:familyName Suttorp
214 schema:givenName Norbert
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0654166733.58
216 rdf:type schema:Person
217 sg:person.0703064461.15 schema:affiliation https://www.grid.ac/institutes/grid.412282.f
218 schema:familyName Höffken
219 schema:givenName Gert
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703064461.15
221 rdf:type schema:Person
222 sg:person.0722302133.88 schema:affiliation https://www.grid.ac/institutes/grid.6363.0
223 schema:familyName Schütte
224 schema:givenName Hartwig
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0722302133.88
226 rdf:type schema:Person
227 sg:pub.10.1007/s00134-010-2077-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023621060
228 https://doi.org/10.1007/s00134-010-2077-0
229 rdf:type schema:CreativeWork
230 sg:pub.10.1007/s00134-011-2208-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017774860
231 https://doi.org/10.1007/s00134-011-2208-2
232 rdf:type schema:CreativeWork
233 sg:pub.10.1007/s00134-011-2261-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1017303346
234 https://doi.org/10.1007/s00134-011-2261-x
235 rdf:type schema:CreativeWork
236 sg:pub.10.1007/s15010-004-3107-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1016076154
237 https://doi.org/10.1007/s15010-004-3107-z
238 rdf:type schema:CreativeWork
239 sg:pub.10.1186/cc7751 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025985061
240 https://doi.org/10.1186/cc7751
241 rdf:type schema:CreativeWork
242 sg:pub.10.1186/cc9055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012408311
243 https://doi.org/10.1186/cc9055
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1016/j.annemergmed.2008.01.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008005707
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1016/j.cca.2010.08.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046003219
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1016/s0140-6736(11)60607-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046248474
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1055/s-0029-1215037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003897585
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1056/nejm199505183322008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031448544
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1056/nejm199701233360402 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018073258
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1056/nejmra020529 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051351930
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1086/511159 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011420673
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1086/589754 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029079720
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1086/596307 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043173674
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1093/jac/dkp148 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003207015
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1097/ccm.0b013e3181b02dbb schema:sameAs https://app.dimensions.ai/details/publication/pub.1001127548
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1111/j.1365-2796.2006.01657.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1029798513
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1136/emj.2009.089383 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005809783
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1136/thorax.58.5.377 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044558168
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1136/thx.2008.099028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001683857
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1136/thx.2008.105312 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006180405
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1136/thx.2009.121178 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013238892
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1136/thx.2009.133280 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050330108
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1136/thx.2009.134072 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038532826
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1164/ajrccm.158.4.9803114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020202179
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1164/rccm.200512-1922oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1050138013
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1164/rccm.200702-307oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1004240402
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1164/rccm.200905-0808oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1052132142
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1164/rccm.201003-0415oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1002104283
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1183/09031936.00021007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006376875
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1183/09031936.00054507 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008931628
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1183/09031936.00092507 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022257927
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1183/09031936.00135607 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016914748
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1183/09031936.00191709 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025058086
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1210/jc.2006-0674 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064289237
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1210/jc.83.6.1827 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064300228
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1378/chest.09-1547 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028973442
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1378/chest.126.4.1087 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027228967
312 rdf:type schema:CreativeWork
313 https://www.grid.ac/institutes/grid.275559.9 schema:alternateName Jena University Hospital
314 schema:name Division of Gastroenterology, Hepatology and Infectious Diseases, Department of Internal Medicine II, Jena University Hospital, Jena, Germany
315 rdf:type schema:Organization
316 https://www.grid.ac/institutes/grid.411937.9 schema:alternateName Universitätsklinikum des Saarlandes
317 schema:name Department of Internal Medicine V - Pulmonology, Allergology, Respiratory Intensive Care Medicine, Saarland University Hospital, Homburg, Germany
318 rdf:type schema:Organization
319 https://www.grid.ac/institutes/grid.412282.f schema:alternateName University Hospital Carl Gustav Carus
320 schema:name Division of Pulmonology, Medical Department 1, University Hospital Carl Gustav Carus, Fetscherstr. 74, 01307, Dresden, Germany
321 rdf:type schema:Organization
322 https://www.grid.ac/institutes/grid.412966.e schema:alternateName Maastricht University Medical Centre
323 schema:name Department of Respiratory Medicine, Maastricht University Medical Center, Maastricht, The Netherlands
324 rdf:type schema:Organization
325 https://www.grid.ac/institutes/grid.6363.0 schema:alternateName Charité
326 schema:name Department of Biostatistics and Clinical Epidemiology, Charité Berlin, Germany
327 Department of Internal Medicine, Infectious Diseases and Pulmonary Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany
328 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...