Diagnostic performance of line-immunoassay based algorithms for incident HIV-1 infection View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-12

AUTHORS

Jörg Schüpbach, Leslie R Bisset, Martin D Gebhardt, Stephan Regenass, Philippe Bürgisser, Meri Gorgievski, Thomas Klimkait, Corinne Andreutti, Gladys Martinetti, Christoph Niederhauser, Sabine Yerly, Stefan Pfister, Detlev Schultze, Marcel Brandenberger, Franziska Schöni-Affolter, Alexandra U Scherrer, Huldrych F Günthard, Swiss HIV Cohort Study

ABSTRACT

BACKGROUND: Serologic testing algorithms for recent HIV seroconversion (STARHS) provide important information for HIV surveillance. We have previously demonstrated that a patient's antibody reaction pattern in a confirmatory line immunoassay (INNO-LIA™ HIV I/II Score) provides information on the duration of infection, which is unaffected by clinical, immunological and viral variables. In this report we have set out to determine the diagnostic performance of Inno-Lia algorithms for identifying incident infections in patients with known duration of infection and evaluated the algorithms in annual cohorts of HIV notifications. METHODS: Diagnostic sensitivity was determined in 527 treatment-naive patients infected for up to 12 months. Specificity was determined in 740 patients infected for longer than 12 months. Plasma was tested by Inno-Lia and classified as either incident (< = 12 m) or older infection by 26 different algorithms. Incident infection rates (IIR) were calculated based on diagnostic sensitivity and specificity of each algorithm and the rule that the total of incident results is the sum of true-incident and false-incident results, which can be calculated by means of the pre-determined sensitivity and specificity. RESULTS: The 10 best algorithms had a mean raw sensitivity of 59.4% and a mean specificity of 95.1%. Adjustment for overrepresentation of patients in the first quarter year of infection further reduced the sensitivity. In the preferred model, the mean adjusted sensitivity was 37.4%. Application of the 10 best algorithms to four annual cohorts of HIV-1 notifications totalling 2'595 patients yielded a mean IIR of 0.35 in 2005/6 (baseline) and of 0.45, 0.42 and 0.35 in 2008, 2009 and 2010, respectively. The increase between baseline and 2008 and the ensuing decreases were highly significant. Other adjustment models yielded different absolute IIR, although the relative changes between the cohorts were identical for all models. CONCLUSIONS: The method can be used for comparing IIR in annual cohorts of HIV notifications. The use of several different algorithms in combination, each with its own sensitivity and specificity to detect incident infection, is advisable as this reduces the impact of individual imperfections stemming primarily from relatively low sensitivities and sampling bias. More... »

PAGES

88

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1471-2334-12-88

DOI

http://dx.doi.org/10.1186/1471-2334-12-88

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1000075666

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22497961


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Algorithms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Clinical Laboratory Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HIV Antibodies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HIV Infections", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HIV-1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoassay", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Plasma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sensitivity and Specificity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Virology", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Zurich", 
          "id": "https://www.grid.ac/institutes/grid.7400.3", 
          "name": [
            "Swiss National Center for Retroviruses, Institute of Medical Virology, University of Zurich, Winterthurerstrasse 190, CH-8057, Zurich, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sch\u00fcpbach", 
        "givenName": "J\u00f6rg", 
        "id": "sg:person.01071627041.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071627041.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Zurich", 
          "id": "https://www.grid.ac/institutes/grid.7400.3", 
          "name": [
            "Swiss National Center for Retroviruses, Institute of Medical Virology, University of Zurich, Winterthurerstrasse 190, CH-8057, Zurich, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bisset", 
        "givenName": "Leslie R", 
        "id": "sg:person.01221345763.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221345763.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Federal Office of Public Health", 
          "id": "https://www.grid.ac/institutes/grid.414841.c", 
          "name": [
            "Swiss Federal Office of Public Health, CH-3003, Berne, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gebhardt", 
        "givenName": "Martin D", 
        "id": "sg:person.01206055441.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206055441.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Clinic for Immunology, University Hospital, CH-8044, Zurich, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Regenass", 
        "givenName": "Stephan", 
        "id": "sg:person.01137472127.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137472127.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital of Lausanne", 
          "id": "https://www.grid.ac/institutes/grid.8515.9", 
          "name": [
            "Service d'Immunologie et d'Allergie, University Hospital, CH-1011, Lausanne, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "B\u00fcrgisser", 
        "givenName": "Philippe", 
        "id": "sg:person.0645430202.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645430202.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Bern", 
          "id": "https://www.grid.ac/institutes/grid.5734.5", 
          "name": [
            "Institute of Infectious Diseases, University of Berne, CH-3010, Berne, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gorgievski", 
        "givenName": "Meri", 
        "id": "sg:person.0604441342.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604441342.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Basel", 
          "id": "https://www.grid.ac/institutes/grid.6612.3", 
          "name": [
            "Institute for Medical Microbiology, University of Basel, CH-4003, Basel, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Klimkait", 
        "givenName": "Thomas", 
        "id": "sg:person.0577203201.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577203201.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Clinique de La Source", 
          "id": "https://www.grid.ac/institutes/grid.483297.3", 
          "name": [
            "Clinique de la Source, Laboratoire, CH-1004, Lausanne, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Andreutti", 
        "givenName": "Corinne", 
        "id": "sg:person.01043364627.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043364627.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Istituto Cantonale di Microbiologia, CH-6501, Bellinzona, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Martinetti", 
        "givenName": "Gladys", 
        "id": "sg:person.0713431601.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713431601.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Swiss Red Cross", 
          "id": "https://www.grid.ac/institutes/grid.452284.d", 
          "name": [
            "Blood Transfusion Service, Swiss Red Cross Berne, CH-3001, Berne, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Niederhauser", 
        "givenName": "Christoph", 
        "id": "sg:person.01321110261.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321110261.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital of Geneva", 
          "id": "https://www.grid.ac/institutes/grid.150338.c", 
          "name": [
            "Laboratory of Virology, Geneva University Hospitals, 14 CH-1211, Gen\u00e8ve, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yerly", 
        "givenName": "Sabine", 
        "id": "sg:person.01354207002.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354207002.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Institut Dr. Viollier AG, CH-4002, Basel, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pfister", 
        "givenName": "Stefan", 
        "id": "sg:person.01075773401.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075773401.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Center of Laboratory Medicine, St. Gallen, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schultze", 
        "givenName": "Detlev", 
        "id": "sg:person.01261571600.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261571600.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Labor Dr. G\u00fcntert, CH-6002, Lucerne, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brandenberger", 
        "givenName": "Marcel", 
        "id": "sg:person.01212222001.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212222001.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital of Lausanne", 
          "id": "https://www.grid.ac/institutes/grid.8515.9", 
          "name": [
            "Swiss HIV Cohort Study (SHCS) Data Center, University Hospital, CH-1011, Lausanne, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sch\u00f6ni-Affolter", 
        "givenName": "Franziska", 
        "id": "sg:person.01351760121.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351760121.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Division of Infectious Diseases and and Hospital Epidemiology, University Hospital Zurich, University of Zurich, CH-8091, Zurich, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Scherrer", 
        "givenName": "Alexandra U", 
        "id": "sg:person.0714666627.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714666627.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Division of Infectious Diseases and and Hospital Epidemiology, University Hospital Zurich, University of Zurich, CH-8091, Zurich, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "G\u00fcnthard", 
        "givenName": "Huldrych F", 
        "id": "sg:person.013744766542.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013744766542.77"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Swiss HIV Cohort Study", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1371/journal.pmed.0040343", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000102317"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00126334-200307010-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000386251"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00126334-200307010-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000386251"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00126334-200307010-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000386251"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.79.13.8454-8469.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005586170"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0928-0197(94)00057-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005905351"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jcm.40.11.4015-4020.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008838825"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jmv.20600", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009097841"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ije/dyp321", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016432050"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ije/dyp321", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016432050"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00126334-200308150-00012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018065714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00126334-200308150-00012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018065714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0003640", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020462931"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/510683", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022301756"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0027211", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027044472"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0b013e328338e4de", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027422182"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0b013e328338e4de", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027422182"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0b013e328338e4de", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027422182"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1468-1293.2008.00566.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029415937"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.virol.2005.03.030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031460015"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/aac.00870-06", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031708717"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ede.0b013e3181e9e978", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034082129"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ede.0b013e3181e9e978", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034082129"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ede.0b013e3181e9e978", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034082129"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.280.1.42", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035592771"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.aids.0000172874.90133.7a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035837457"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.aids.0000172874.90133.7a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035837457"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.aids.0000172874.90133.7a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035837457"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0b013e328349f089", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036521258"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0b013e328349f089", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036521258"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0140-6736(93)91884-o", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036969937"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0140-6736(93)91884-o", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036969937"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00002030-200411190-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037969404"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00002030-200411190-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037969404"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00002030-200309050-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038488929"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00002030-200309050-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038488929"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0007368", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039608042"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0014748", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042302169"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cid/cir725", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043341146"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0b013e32801481b7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043644534"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0b013e32801481b7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043644534"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00002030-198911000-00010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045704652"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00002030-198911000-00010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045704652"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0013310", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048857905"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cid/ciq164", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048905029"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00126334-200412150-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048945945"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00126334-200412150-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048945945"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qai.0b013e3181b61938", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050950623"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qai.0b013e3181b61938", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050950623"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qai.0b013e3181b61938", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050950623"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2334-11-254", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050959899", 
          "https://doi.org/10.1186/1471-2334-11-254"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00002030-200205240-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051067001"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00002030-200205240-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051067001"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/088922202753472874", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059199883"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/aid.2006.22.1178", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059225246"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/aid.2006.22.945", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059225395"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/aid.2009.0218", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059225959"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/aid.2010.0009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059226026"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/aid.2010.0347", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059226210"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3851/imp1776", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071479324"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077035491", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077232644", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077722781", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077722782", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077834374", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078179817", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/oxfordjournals.aje.a117404", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082521761"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-12", 
    "datePublishedReg": "2012-12-01", 
    "description": "BACKGROUND: Serologic testing algorithms for recent HIV seroconversion (STARHS) provide important information for HIV surveillance. We have previously demonstrated that a patient's antibody reaction pattern in a confirmatory line immunoassay (INNO-LIA\u2122 HIV I/II Score) provides information on the duration of infection, which is unaffected by clinical, immunological and viral variables. In this report we have set out to determine the diagnostic performance of Inno-Lia algorithms for identifying incident infections in patients with known duration of infection and evaluated the algorithms in annual cohorts of HIV notifications.\nMETHODS: Diagnostic sensitivity was determined in 527 treatment-naive patients infected for up to 12 months. Specificity was determined in 740 patients infected for longer than 12 months. Plasma was tested by Inno-Lia and classified as either incident (< = 12 m) or older infection by 26 different algorithms. Incident infection rates (IIR) were calculated based on diagnostic sensitivity and specificity of each algorithm and the rule that the total of incident results is the sum of true-incident and false-incident results, which can be calculated by means of the pre-determined sensitivity and specificity.\nRESULTS: The 10 best algorithms had a mean raw sensitivity of 59.4% and a mean specificity of 95.1%. Adjustment for overrepresentation of patients in the first quarter year of infection further reduced the sensitivity. In the preferred model, the mean adjusted sensitivity was 37.4%. Application of the 10 best algorithms to four annual cohorts of HIV-1 notifications totalling 2'595 patients yielded a mean IIR of 0.35 in 2005/6 (baseline) and of 0.45, 0.42 and 0.35 in 2008, 2009 and 2010, respectively. The increase between baseline and 2008 and the ensuing decreases were highly significant. Other adjustment models yielded different absolute IIR, although the relative changes between the cohorts were identical for all models.\nCONCLUSIONS: The method can be used for comparing IIR in annual cohorts of HIV notifications. The use of several different algorithms in combination, each with its own sensitivity and specificity to detect incident infection, is advisable as this reduces the impact of individual imperfections stemming primarily from relatively low sensitivities and sampling bias.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/1471-2334-12-88", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1024946", 
        "issn": [
          "1471-2334"
        ], 
        "name": "BMC Infectious Diseases", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "12"
      }
    ], 
    "name": "Diagnostic performance of line-immunoassay based algorithms for incident HIV-1 infection", 
    "pagination": "88", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "005c2d43ab27a431c0b3df6b53868918bd36dbd9377f18ffc78bf6cc4f60c9fd"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "22497961"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100968551"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1471-2334-12-88"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1000075666"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1471-2334-12-88", 
      "https://app.dimensions.ai/details/publication/pub.1000075666"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T16:48", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8669_00000548.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2F1471-2334-12-88"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1471-2334-12-88'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1471-2334-12-88'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1471-2334-12-88'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1471-2334-12-88'


 

This table displays all metadata directly associated to this object as RDF triples.

412 TRIPLES      21 PREDICATES      90 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1471-2334-12-88 schema:about N0ba0642e640147a18818d9b75bdd60b8
2 N216e504a62404cf19ff87ecda7e8cc36
3 N311db4c5f885427a8b841a316d166e63
4 N4462c9695377450bb9a23898b1e6d28a
5 N548fbeafbaa44055bf29a24de4e21600
6 N56c5d053d8ed461e8db11f89330f3245
7 N60d5404375bc4b83bddec52ce15e3ed0
8 N8fc215e33f924f71b653ad3ed0f0f1d2
9 N9483253f833b4d98a18d9d42fc78297b
10 N9fee12b19de949c78f1853c30348b0fd
11 Na4cfa407cb3b4cf3a2efe2bf5b8af21f
12 Nbf6f7f79cebb46f0a7ece7527885652b
13 Ncb43ace9df534deeb339a26d6ea3f8f4
14 Nef1baceb613d4278809da2976241b695
15 anzsrc-for:11
16 anzsrc-for:1103
17 schema:author Ned43712d1d9942c3b2446bad065b15f2
18 schema:citation sg:pub.10.1186/1471-2334-11-254
19 https://app.dimensions.ai/details/publication/pub.1077035491
20 https://app.dimensions.ai/details/publication/pub.1077232644
21 https://app.dimensions.ai/details/publication/pub.1077722781
22 https://app.dimensions.ai/details/publication/pub.1077722782
23 https://app.dimensions.ai/details/publication/pub.1077834374
24 https://app.dimensions.ai/details/publication/pub.1078179817
25 https://doi.org/10.1001/jama.280.1.42
26 https://doi.org/10.1002/jmv.20600
27 https://doi.org/10.1016/0140-6736(93)91884-o
28 https://doi.org/10.1016/0928-0197(94)00057-2
29 https://doi.org/10.1016/j.virol.2005.03.030
30 https://doi.org/10.1086/510683
31 https://doi.org/10.1089/088922202753472874
32 https://doi.org/10.1089/aid.2006.22.1178
33 https://doi.org/10.1089/aid.2006.22.945
34 https://doi.org/10.1089/aid.2009.0218
35 https://doi.org/10.1089/aid.2010.0009
36 https://doi.org/10.1089/aid.2010.0347
37 https://doi.org/10.1093/cid/ciq164
38 https://doi.org/10.1093/cid/cir725
39 https://doi.org/10.1093/ije/dyp321
40 https://doi.org/10.1093/oxfordjournals.aje.a117404
41 https://doi.org/10.1097/00002030-198911000-00010
42 https://doi.org/10.1097/00002030-200205240-00005
43 https://doi.org/10.1097/00002030-200309050-00005
44 https://doi.org/10.1097/00002030-200411190-00005
45 https://doi.org/10.1097/00126334-200307010-00009
46 https://doi.org/10.1097/00126334-200308150-00012
47 https://doi.org/10.1097/00126334-200412150-00001
48 https://doi.org/10.1097/01.aids.0000172874.90133.7a
49 https://doi.org/10.1097/ede.0b013e3181e9e978
50 https://doi.org/10.1097/qad.0b013e32801481b7
51 https://doi.org/10.1097/qad.0b013e328338e4de
52 https://doi.org/10.1097/qad.0b013e328349f089
53 https://doi.org/10.1097/qai.0b013e3181b61938
54 https://doi.org/10.1111/j.1468-1293.2008.00566.x
55 https://doi.org/10.1128/aac.00870-06
56 https://doi.org/10.1128/jcm.40.11.4015-4020.2002
57 https://doi.org/10.1128/jvi.79.13.8454-8469.2005
58 https://doi.org/10.1371/journal.pmed.0040343
59 https://doi.org/10.1371/journal.pone.0003640
60 https://doi.org/10.1371/journal.pone.0007368
61 https://doi.org/10.1371/journal.pone.0013310
62 https://doi.org/10.1371/journal.pone.0014748
63 https://doi.org/10.1371/journal.pone.0027211
64 https://doi.org/10.3851/imp1776
65 schema:datePublished 2012-12
66 schema:datePublishedReg 2012-12-01
67 schema:description BACKGROUND: Serologic testing algorithms for recent HIV seroconversion (STARHS) provide important information for HIV surveillance. We have previously demonstrated that a patient's antibody reaction pattern in a confirmatory line immunoassay (INNO-LIA™ HIV I/II Score) provides information on the duration of infection, which is unaffected by clinical, immunological and viral variables. In this report we have set out to determine the diagnostic performance of Inno-Lia algorithms for identifying incident infections in patients with known duration of infection and evaluated the algorithms in annual cohorts of HIV notifications. METHODS: Diagnostic sensitivity was determined in 527 treatment-naive patients infected for up to 12 months. Specificity was determined in 740 patients infected for longer than 12 months. Plasma was tested by Inno-Lia and classified as either incident (< = 12 m) or older infection by 26 different algorithms. Incident infection rates (IIR) were calculated based on diagnostic sensitivity and specificity of each algorithm and the rule that the total of incident results is the sum of true-incident and false-incident results, which can be calculated by means of the pre-determined sensitivity and specificity. RESULTS: The 10 best algorithms had a mean raw sensitivity of 59.4% and a mean specificity of 95.1%. Adjustment for overrepresentation of patients in the first quarter year of infection further reduced the sensitivity. In the preferred model, the mean adjusted sensitivity was 37.4%. Application of the 10 best algorithms to four annual cohorts of HIV-1 notifications totalling 2'595 patients yielded a mean IIR of 0.35 in 2005/6 (baseline) and of 0.45, 0.42 and 0.35 in 2008, 2009 and 2010, respectively. The increase between baseline and 2008 and the ensuing decreases were highly significant. Other adjustment models yielded different absolute IIR, although the relative changes between the cohorts were identical for all models. CONCLUSIONS: The method can be used for comparing IIR in annual cohorts of HIV notifications. The use of several different algorithms in combination, each with its own sensitivity and specificity to detect incident infection, is advisable as this reduces the impact of individual imperfections stemming primarily from relatively low sensitivities and sampling bias.
68 schema:genre research_article
69 schema:inLanguage en
70 schema:isAccessibleForFree true
71 schema:isPartOf N3be025285b11406995dbba3298982411
72 Na2bc55572de043c1bd51f6cc5f1575bc
73 sg:journal.1024946
74 schema:name Diagnostic performance of line-immunoassay based algorithms for incident HIV-1 infection
75 schema:pagination 88
76 schema:productId N02276b88a98c4968842b5743bd798390
77 N2d37a318703a4cbbb4884bc376528dd0
78 Na2eb42b01693488e9c693c18e8ec81d3
79 Ne035bf96aaf64dc089984ff24e95f5f4
80 Nf42b5ee7f70241fe82d1d3cf6655a5ae
81 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000075666
82 https://doi.org/10.1186/1471-2334-12-88
83 schema:sdDatePublished 2019-04-10T16:48
84 schema:sdLicense https://scigraph.springernature.com/explorer/license/
85 schema:sdPublisher Nbe4b593e2af1474fab4628bfef9f9633
86 schema:url http://link.springer.com/10.1186%2F1471-2334-12-88
87 sgo:license sg:explorer/license/
88 sgo:sdDataset articles
89 rdf:type schema:ScholarlyArticle
90 N02276b88a98c4968842b5743bd798390 schema:name dimensions_id
91 schema:value pub.1000075666
92 rdf:type schema:PropertyValue
93 N0aa8389a41a346a28ea6b5022c30f3cd rdf:first sg:person.0577203201.99
94 rdf:rest N7dc801412bb04a1aa7425d54508076e4
95 N0ba0642e640147a18818d9b75bdd60b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Sensitivity and Specificity
97 rdf:type schema:DefinedTerm
98 N0c0e8933efc34e17ab77d4930049407d rdf:first sg:person.01206055441.03
99 rdf:rest N3b8b2625b2de41e184dea9091be2624e
100 N0f8a1f6b3e1d42fbb2210883899d0b27 rdf:first sg:person.01212222001.30
101 rdf:rest N48876e48038542c4b4d3842b1d1b7132
102 N184d0677644d447d8d533d2d87964273 rdf:first sg:person.013744766542.77
103 rdf:rest N380a1e4539c94218a2e5cb5410346c78
104 N216e504a62404cf19ff87ecda7e8cc36 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Algorithms
106 rdf:type schema:DefinedTerm
107 N2d37a318703a4cbbb4884bc376528dd0 schema:name nlm_unique_id
108 schema:value 100968551
109 rdf:type schema:PropertyValue
110 N2f59ed3c79ae4de4b76a0d6b0bd26754 schema:name Institut Dr. Viollier AG, CH-4002, Basel, Switzerland
111 rdf:type schema:Organization
112 N311db4c5f885427a8b841a316d166e63 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Middle Aged
114 rdf:type schema:DefinedTerm
115 N380a1e4539c94218a2e5cb5410346c78 rdf:first N88cc3e844bc14a4ebc18c2e48a03c893
116 rdf:rest rdf:nil
117 N3b8b2625b2de41e184dea9091be2624e rdf:first sg:person.01137472127.54
118 rdf:rest N9ef23d2809b6490686232814cff24c19
119 N3be025285b11406995dbba3298982411 schema:volumeNumber 12
120 rdf:type schema:PublicationVolume
121 N3c9cf6c35d384e44b7c294425eb1e298 schema:name Division of Infectious Diseases and and Hospital Epidemiology, University Hospital Zurich, University of Zurich, CH-8091, Zurich, Switzerland
122 rdf:type schema:Organization
123 N4462c9695377450bb9a23898b1e6d28a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Humans
125 rdf:type schema:DefinedTerm
126 N48876e48038542c4b4d3842b1d1b7132 rdf:first sg:person.01351760121.63
127 rdf:rest Nf6a34c66088648dd91b53ed0699d40e6
128 N548fbeafbaa44055bf29a24de4e21600 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Immunoassay
130 rdf:type schema:DefinedTerm
131 N56c5d053d8ed461e8db11f89330f3245 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Virology
133 rdf:type schema:DefinedTerm
134 N60d5404375bc4b83bddec52ce15e3ed0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Female
136 rdf:type schema:DefinedTerm
137 N6a12883a20994ec99e7c054fc21eb623 rdf:first sg:person.01075773401.12
138 rdf:rest N97a8b4a8ff1d49378bf6395cc3050d78
139 N6a43b79ab17d4a75825640ef56932b96 rdf:first sg:person.0604441342.66
140 rdf:rest N0aa8389a41a346a28ea6b5022c30f3cd
141 N7dc801412bb04a1aa7425d54508076e4 rdf:first sg:person.01043364627.51
142 rdf:rest Nc5c0f00792d14261ad8e5024d484a8f5
143 N87271932eef3420c8069e324e5cc057c rdf:first sg:person.01321110261.22
144 rdf:rest Nfd1b9e6b36bb43938c6e2d0b15d064bf
145 N88cc3e844bc14a4ebc18c2e48a03c893 schema:familyName Swiss HIV Cohort Study
146 rdf:type schema:Person
147 N8fc215e33f924f71b653ad3ed0f0f1d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Clinical Laboratory Techniques
149 rdf:type schema:DefinedTerm
150 N9483253f833b4d98a18d9d42fc78297b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Male
152 rdf:type schema:DefinedTerm
153 N97a8b4a8ff1d49378bf6395cc3050d78 rdf:first sg:person.01261571600.01
154 rdf:rest N0f8a1f6b3e1d42fbb2210883899d0b27
155 N9ef23d2809b6490686232814cff24c19 rdf:first sg:person.0645430202.23
156 rdf:rest N6a43b79ab17d4a75825640ef56932b96
157 N9fee12b19de949c78f1853c30348b0fd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name HIV-1
159 rdf:type schema:DefinedTerm
160 Na2bc55572de043c1bd51f6cc5f1575bc schema:issueNumber 1
161 rdf:type schema:PublicationIssue
162 Na2eb42b01693488e9c693c18e8ec81d3 schema:name doi
163 schema:value 10.1186/1471-2334-12-88
164 rdf:type schema:PropertyValue
165 Na4cfa407cb3b4cf3a2efe2bf5b8af21f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Adult
167 rdf:type schema:DefinedTerm
168 Nbe3637b36e1d4d44ac6e587faa247689 rdf:first sg:person.01221345763.25
169 rdf:rest N0c0e8933efc34e17ab77d4930049407d
170 Nbe4b593e2af1474fab4628bfef9f9633 schema:name Springer Nature - SN SciGraph project
171 rdf:type schema:Organization
172 Nbf6f7f79cebb46f0a7ece7527885652b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Plasma
174 rdf:type schema:DefinedTerm
175 Nc5c0f00792d14261ad8e5024d484a8f5 rdf:first sg:person.0713431601.30
176 rdf:rest N87271932eef3420c8069e324e5cc057c
177 Ncb43ace9df534deeb339a26d6ea3f8f4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name HIV Infections
179 rdf:type schema:DefinedTerm
180 Nce5ef13fd34a4544931368835dd55744 schema:name Labor Dr. Güntert, CH-6002, Lucerne, Switzerland
181 rdf:type schema:Organization
182 Ne035bf96aaf64dc089984ff24e95f5f4 schema:name readcube_id
183 schema:value 005c2d43ab27a431c0b3df6b53868918bd36dbd9377f18ffc78bf6cc4f60c9fd
184 rdf:type schema:PropertyValue
185 Ne517ad76a10e4e9885e0fd432022e4e6 schema:name Clinic for Immunology, University Hospital, CH-8044, Zurich, Switzerland
186 rdf:type schema:Organization
187 Ned43712d1d9942c3b2446bad065b15f2 rdf:first sg:person.01071627041.43
188 rdf:rest Nbe3637b36e1d4d44ac6e587faa247689
189 Nee36e0782a7748979d8b7c90de08880b schema:name Istituto Cantonale di Microbiologia, CH-6501, Bellinzona, Switzerland
190 rdf:type schema:Organization
191 Nef1baceb613d4278809da2976241b695 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name HIV Antibodies
193 rdf:type schema:DefinedTerm
194 Nefc41a200fbd43328ad6006183648a35 schema:name Center of Laboratory Medicine, St. Gallen, Switzerland
195 rdf:type schema:Organization
196 Nf3f83ca703a047f98ed6fb07fb2e98d6 schema:name Division of Infectious Diseases and and Hospital Epidemiology, University Hospital Zurich, University of Zurich, CH-8091, Zurich, Switzerland
197 rdf:type schema:Organization
198 Nf42b5ee7f70241fe82d1d3cf6655a5ae schema:name pubmed_id
199 schema:value 22497961
200 rdf:type schema:PropertyValue
201 Nf6a34c66088648dd91b53ed0699d40e6 rdf:first sg:person.0714666627.89
202 rdf:rest N184d0677644d447d8d533d2d87964273
203 Nfd1b9e6b36bb43938c6e2d0b15d064bf rdf:first sg:person.01354207002.08
204 rdf:rest N6a12883a20994ec99e7c054fc21eb623
205 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
206 schema:name Medical and Health Sciences
207 rdf:type schema:DefinedTerm
208 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
209 schema:name Clinical Sciences
210 rdf:type schema:DefinedTerm
211 sg:journal.1024946 schema:issn 1471-2334
212 schema:name BMC Infectious Diseases
213 rdf:type schema:Periodical
214 sg:person.01043364627.51 schema:affiliation https://www.grid.ac/institutes/grid.483297.3
215 schema:familyName Andreutti
216 schema:givenName Corinne
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043364627.51
218 rdf:type schema:Person
219 sg:person.01071627041.43 schema:affiliation https://www.grid.ac/institutes/grid.7400.3
220 schema:familyName Schüpbach
221 schema:givenName Jörg
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071627041.43
223 rdf:type schema:Person
224 sg:person.01075773401.12 schema:affiliation N2f59ed3c79ae4de4b76a0d6b0bd26754
225 schema:familyName Pfister
226 schema:givenName Stefan
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075773401.12
228 rdf:type schema:Person
229 sg:person.01137472127.54 schema:affiliation Ne517ad76a10e4e9885e0fd432022e4e6
230 schema:familyName Regenass
231 schema:givenName Stephan
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137472127.54
233 rdf:type schema:Person
234 sg:person.01206055441.03 schema:affiliation https://www.grid.ac/institutes/grid.414841.c
235 schema:familyName Gebhardt
236 schema:givenName Martin D
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206055441.03
238 rdf:type schema:Person
239 sg:person.01212222001.30 schema:affiliation Nce5ef13fd34a4544931368835dd55744
240 schema:familyName Brandenberger
241 schema:givenName Marcel
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212222001.30
243 rdf:type schema:Person
244 sg:person.01221345763.25 schema:affiliation https://www.grid.ac/institutes/grid.7400.3
245 schema:familyName Bisset
246 schema:givenName Leslie R
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221345763.25
248 rdf:type schema:Person
249 sg:person.01261571600.01 schema:affiliation Nefc41a200fbd43328ad6006183648a35
250 schema:familyName Schultze
251 schema:givenName Detlev
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261571600.01
253 rdf:type schema:Person
254 sg:person.01321110261.22 schema:affiliation https://www.grid.ac/institutes/grid.452284.d
255 schema:familyName Niederhauser
256 schema:givenName Christoph
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321110261.22
258 rdf:type schema:Person
259 sg:person.01351760121.63 schema:affiliation https://www.grid.ac/institutes/grid.8515.9
260 schema:familyName Schöni-Affolter
261 schema:givenName Franziska
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351760121.63
263 rdf:type schema:Person
264 sg:person.01354207002.08 schema:affiliation https://www.grid.ac/institutes/grid.150338.c
265 schema:familyName Yerly
266 schema:givenName Sabine
267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354207002.08
268 rdf:type schema:Person
269 sg:person.013744766542.77 schema:affiliation Nf3f83ca703a047f98ed6fb07fb2e98d6
270 schema:familyName Günthard
271 schema:givenName Huldrych F
272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013744766542.77
273 rdf:type schema:Person
274 sg:person.0577203201.99 schema:affiliation https://www.grid.ac/institutes/grid.6612.3
275 schema:familyName Klimkait
276 schema:givenName Thomas
277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577203201.99
278 rdf:type schema:Person
279 sg:person.0604441342.66 schema:affiliation https://www.grid.ac/institutes/grid.5734.5
280 schema:familyName Gorgievski
281 schema:givenName Meri
282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604441342.66
283 rdf:type schema:Person
284 sg:person.0645430202.23 schema:affiliation https://www.grid.ac/institutes/grid.8515.9
285 schema:familyName Bürgisser
286 schema:givenName Philippe
287 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645430202.23
288 rdf:type schema:Person
289 sg:person.0713431601.30 schema:affiliation Nee36e0782a7748979d8b7c90de08880b
290 schema:familyName Martinetti
291 schema:givenName Gladys
292 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713431601.30
293 rdf:type schema:Person
294 sg:person.0714666627.89 schema:affiliation N3c9cf6c35d384e44b7c294425eb1e298
295 schema:familyName Scherrer
296 schema:givenName Alexandra U
297 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714666627.89
298 rdf:type schema:Person
299 sg:pub.10.1186/1471-2334-11-254 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050959899
300 https://doi.org/10.1186/1471-2334-11-254
301 rdf:type schema:CreativeWork
302 https://app.dimensions.ai/details/publication/pub.1077035491 schema:CreativeWork
303 https://app.dimensions.ai/details/publication/pub.1077232644 schema:CreativeWork
304 https://app.dimensions.ai/details/publication/pub.1077722781 schema:CreativeWork
305 https://app.dimensions.ai/details/publication/pub.1077722782 schema:CreativeWork
306 https://app.dimensions.ai/details/publication/pub.1077834374 schema:CreativeWork
307 https://app.dimensions.ai/details/publication/pub.1078179817 schema:CreativeWork
308 https://doi.org/10.1001/jama.280.1.42 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035592771
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1002/jmv.20600 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009097841
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1016/0140-6736(93)91884-o schema:sameAs https://app.dimensions.ai/details/publication/pub.1036969937
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1016/0928-0197(94)00057-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005905351
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1016/j.virol.2005.03.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031460015
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1086/510683 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022301756
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1089/088922202753472874 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059199883
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1089/aid.2006.22.1178 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059225246
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1089/aid.2006.22.945 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059225395
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1089/aid.2009.0218 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059225959
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1089/aid.2010.0009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059226026
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1089/aid.2010.0347 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059226210
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1093/cid/ciq164 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048905029
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1093/cid/cir725 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043341146
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1093/ije/dyp321 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016432050
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1093/oxfordjournals.aje.a117404 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082521761
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1097/00002030-198911000-00010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045704652
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1097/00002030-200205240-00005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051067001
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1097/00002030-200309050-00005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038488929
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1097/00002030-200411190-00005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037969404
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1097/00126334-200307010-00009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000386251
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1097/00126334-200308150-00012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018065714
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1097/00126334-200412150-00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048945945
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1097/01.aids.0000172874.90133.7a schema:sameAs https://app.dimensions.ai/details/publication/pub.1035837457
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1097/ede.0b013e3181e9e978 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034082129
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1097/qad.0b013e32801481b7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043644534
359 rdf:type schema:CreativeWork
360 https://doi.org/10.1097/qad.0b013e328338e4de schema:sameAs https://app.dimensions.ai/details/publication/pub.1027422182
361 rdf:type schema:CreativeWork
362 https://doi.org/10.1097/qad.0b013e328349f089 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036521258
363 rdf:type schema:CreativeWork
364 https://doi.org/10.1097/qai.0b013e3181b61938 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050950623
365 rdf:type schema:CreativeWork
366 https://doi.org/10.1111/j.1468-1293.2008.00566.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1029415937
367 rdf:type schema:CreativeWork
368 https://doi.org/10.1128/aac.00870-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031708717
369 rdf:type schema:CreativeWork
370 https://doi.org/10.1128/jcm.40.11.4015-4020.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008838825
371 rdf:type schema:CreativeWork
372 https://doi.org/10.1128/jvi.79.13.8454-8469.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005586170
373 rdf:type schema:CreativeWork
374 https://doi.org/10.1371/journal.pmed.0040343 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000102317
375 rdf:type schema:CreativeWork
376 https://doi.org/10.1371/journal.pone.0003640 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020462931
377 rdf:type schema:CreativeWork
378 https://doi.org/10.1371/journal.pone.0007368 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039608042
379 rdf:type schema:CreativeWork
380 https://doi.org/10.1371/journal.pone.0013310 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048857905
381 rdf:type schema:CreativeWork
382 https://doi.org/10.1371/journal.pone.0014748 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042302169
383 rdf:type schema:CreativeWork
384 https://doi.org/10.1371/journal.pone.0027211 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027044472
385 rdf:type schema:CreativeWork
386 https://doi.org/10.3851/imp1776 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071479324
387 rdf:type schema:CreativeWork
388 https://www.grid.ac/institutes/grid.150338.c schema:alternateName University Hospital of Geneva
389 schema:name Laboratory of Virology, Geneva University Hospitals, 14 CH-1211, Genève, Switzerland
390 rdf:type schema:Organization
391 https://www.grid.ac/institutes/grid.414841.c schema:alternateName Federal Office of Public Health
392 schema:name Swiss Federal Office of Public Health, CH-3003, Berne, Switzerland
393 rdf:type schema:Organization
394 https://www.grid.ac/institutes/grid.452284.d schema:alternateName Swiss Red Cross
395 schema:name Blood Transfusion Service, Swiss Red Cross Berne, CH-3001, Berne, Switzerland
396 rdf:type schema:Organization
397 https://www.grid.ac/institutes/grid.483297.3 schema:alternateName Clinique de La Source
398 schema:name Clinique de la Source, Laboratoire, CH-1004, Lausanne, Switzerland
399 rdf:type schema:Organization
400 https://www.grid.ac/institutes/grid.5734.5 schema:alternateName University of Bern
401 schema:name Institute of Infectious Diseases, University of Berne, CH-3010, Berne, Switzerland
402 rdf:type schema:Organization
403 https://www.grid.ac/institutes/grid.6612.3 schema:alternateName University of Basel
404 schema:name Institute for Medical Microbiology, University of Basel, CH-4003, Basel, Switzerland
405 rdf:type schema:Organization
406 https://www.grid.ac/institutes/grid.7400.3 schema:alternateName University of Zurich
407 schema:name Swiss National Center for Retroviruses, Institute of Medical Virology, University of Zurich, Winterthurerstrasse 190, CH-8057, Zurich, Switzerland
408 rdf:type schema:Organization
409 https://www.grid.ac/institutes/grid.8515.9 schema:alternateName University Hospital of Lausanne
410 schema:name Service d'Immunologie et d'Allergie, University Hospital, CH-1011, Lausanne, Switzerland
411 Swiss HIV Cohort Study (SHCS) Data Center, University Hospital, CH-1011, Lausanne, Switzerland
412 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...