Placental malaria is associated with attenuated CD4 T-cell responses to tuberculin PPD 12 months after BCG vaccination View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-12

AUTHORS

Brigitte Walther, David JC Miles, Pauline Waight, Melba S Palmero, Olubukola Ojuola, Ebrima S Touray, Hilton Whittle, Marianne van der Sande, Sarah Crozier, Katie L Flanagan

ABSTRACT

BACKGROUND: Placental malaria (PM) is associated with prenatal malaise, but many PM+ infants are born without symptoms. As malaria has powerful immunomodulatory effects, we tested the hypothesis that PM predicts reduced T-cell responses to vaccine challenge. METHODS: We recruited healthy PM+ and PM- infants at birth. At six and 12 months, we stimulated PBMCs with tuberculin purified protein derivative (PPD) and compared expression of CD154, IL-2 and IFNγ by CD4 T-cells to a negative control using flow cytometry.We measured the length, weight and head circumference at birth and 12 months. RESULTS: IL-2 and CD154 expression were low in both groups at both timepoints, without discernable differences. Expression of IFNγ was similarly low at 6 months but by 12 months, the median response was higher in PM- than PM + infants (p = 0.026). The PM+ infants also had a lower weight (p = 0.032) and head circumference (p = 0.041) at 12 months, indicating lower growth rates.At birth, the size and weight of the PM+ and PM- infants were equivalent. By 12 months, the PM+ infants had a lower weight and head circumference than the PM- infants. CONCLUSIONS: Placental malaria was associated with reduced immune responses 12 months after immune challenge in infants apparently healthy at birth. More... »

PAGES

6

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1471-2334-12-6

DOI

http://dx.doi.org/10.1186/1471-2334-12-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034737584

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22243970


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