Enterococcus and Streptococcusspp. associated with chronic and self-medicated urinary tract infections in Vietnam View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-12

AUTHORS

Louise Ladefoged Poulsen, Magne Bisgaard, Nguyen Thai Son, Nguyen Vu Trung, Hoang Manh An, Anders Dalsgaard

ABSTRACT

BACKGROUND: Urinary tract infections (UTI) are one of the most common infections among women worldwide. E. coli often causes more than 75% of acute uncomplicated UTI, however, little is known about how recurrent UTIs and indiscriminate use of antimicrobials affect the aetiology of UTIs. This study aimed to establish the aetiology of UTI in a population of recurrent and self-medicated patients referred from pharmacies to a hospital in Hanoi, Vietnam and to describe genotypes and antimicrobial susceptibility of the associated bacterial pathogens. The aetiology of bacterial pathogens associated with UTI (defined as ≥ 104 CFU/ml urine) was established by phenotypic and molecular methods. Enterococcus faecalis isolates were typed by Multi Locus Sequence Typing (MLST), Pulsed-Field Gel Electrophoresis (PFGE) and antimicrobial susceptibility testing. METHODS: Urine samples from 276 patients suffering symptoms of urinary tract infection were collected and cultured on Flexicult agar® allowing for detection of the most common urine pathogens. Patients were interviewed about underlying diseases, duration of symptoms, earlier episodes of UTI, number of episodes diagnosed by doctors and treatment in relation to UTI. All tentative E. faecalis and E. faecium isolates were identified to species level by PCR, 16S rRNA and partial sequencing of the groEL gene. E. faecalis isolates were further characterized by Multi Locus Sequence Typing and antimicrobial susceptibility testing. RESULTS: Mean age of 49 patients was 48 yrs (range was 11-86 yrs) and included 94% women. On average, patients reported to have suffered from UTI for 348 days (range 3 days-10 years, and experienced 2.7 UTIs during the previous year). Cephalosporins were reported the second drug of choice in treatment of UTI at the hospital. E. faecalis (55.1%), E. coli (12.2%) and Streptococcus gallolyticus subsp. pasteurianus (8.2%) were main bacterial pathogens. MIC testing of E. faecalis showed susceptibility to ampicillin, penicillin and vancomycin, but high-level resistance against gentamicin (48.1%). MLST revealed 12 Sequence Types (ST) of which ST 16 made up 44.5% and showed closely related PFGE types. CONCLUSION: The different aetiology of UTI compared with reports elsewhere, where E. coli dominates, may be a result of chronic and recurrent UTIs together with indiscriminate use of antimicrobials. The similar genotypes shown by epidemiologically unrelated ST 16 isolates in Vietnam and elsewhere, suggest that E. faecalis ST 16 might represent a globally distributed clone. Treatment of UTI with cephalosporins may select for E. faecalis as it is intrinsic resistant and further studies are needed to establish the source(s) and role of E. faecalis ST 16 in acute UTI. More... »

PAGES

320

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1471-2334-12-320

DOI

http://dx.doi.org/10.1186/1471-2334-12-320

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1041130424

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23176582


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1108", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Microbiology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anti-Bacterial Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bacterial Infections", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Child", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Electrophoresis, Gel, Pulsed-Field", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enterococcus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Escherichia coli", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microbial Sensitivity Tests", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Multilocus Sequence Typing", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Self Medication", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Streptococcus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Urinary Tract Infections", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vietnam", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Young Adult", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Copenhagen", 
          "id": "https://www.grid.ac/institutes/grid.5254.6", 
          "name": [
            "Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Groennegaardsvej 15 DK-1870, Frederiksberg C, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Poulsen", 
        "givenName": "Louise Ladefoged", 
        "id": "sg:person.01301326113.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301326113.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Copenhagen", 
          "id": "https://www.grid.ac/institutes/grid.5254.6", 
          "name": [
            "Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Groennegaardsvej 15 DK-1870, Frederiksberg C, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bisgaard", 
        "givenName": "Magne", 
        "id": "sg:person.01331213470.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331213470.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Hospital 103, Military Medical University, Ha Dong, Hanoi, Vietnam"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Son", 
        "givenName": "Nguyen Thai", 
        "id": "sg:person.0756750663.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756750663.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hanoi Medical University", 
          "id": "https://www.grid.ac/institutes/grid.56046.31", 
          "name": [
            "Department of Medical Microbiology, Hanoi Medical University, Hanoi, Vietnam"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Trung", 
        "givenName": "Nguyen Vu", 
        "id": "sg:person.01165262733.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165262733.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Hospital 103, Military Medical University, Ha Dong, Hanoi, Vietnam"
          ], 
          "type": "Organization"
        }, 
        "familyName": "An", 
        "givenName": "Hoang Manh", 
        "id": "sg:person.0740263613.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740263613.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Copenhagen", 
          "id": "https://www.grid.ac/institutes/grid.5254.6", 
          "name": [
            "Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Groennegaardsvej 15 DK-1870, Frederiksberg C, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dalsgaard", 
        "givenName": "Anders", 
        "id": "sg:person.0602327062.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602327062.28"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1080/00365540110080601", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015941065"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.0000153812.64956.ef", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019465385"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/383029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020621768"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0378-1135(98)00222-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021706699"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jcm.02596-05", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025237349"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jac/dkg028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027901564"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1067/mda.2003.7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027947795"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1099/ijs.0.005488-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028176848"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jac/dkl082", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028926718"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.317.7159.647", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029165363"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.105.165564", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030420291"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.105.165564", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030420291"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3201/eid1604.090500", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031652276"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/13691050801932478", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032472869"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0277-9536(01)00155-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035329038"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jac/45.3.277", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040027598"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mpmed.2007.05.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040066544"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archinternmed.2008.603", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041107657"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/aac.47.4.1423-1426.2003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043687713"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/aac.35.6.1147", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051461457"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/clinids/15.2.295", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059472263"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1099/00207713-52-4-1247", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060350849"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1099/ijs.0.02044-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060383009"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1099/ijs.0.02361-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060383381"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/cmr.3.1.46", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062710814"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jb.174.6.2002-2013.1992", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062721394"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077961445", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082385007", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082470220", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/med/9780199204854.003.070203_update_001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1088887721"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-12", 
    "datePublishedReg": "2012-12-01", 
    "description": "BACKGROUND: Urinary tract infections (UTI) are one of the most common infections among women worldwide. E. coli often causes more than 75% of acute uncomplicated UTI, however, little is known about how recurrent UTIs and indiscriminate use of antimicrobials affect the aetiology of UTIs. This study aimed to establish the aetiology of UTI in a population of recurrent and self-medicated patients referred from pharmacies to a hospital in Hanoi, Vietnam and to describe genotypes and antimicrobial susceptibility of the associated bacterial pathogens. The aetiology of bacterial pathogens associated with UTI (defined as \u2265 104 CFU/ml urine) was established by phenotypic and molecular methods. Enterococcus faecalis isolates were typed by Multi Locus Sequence Typing (MLST), Pulsed-Field Gel Electrophoresis (PFGE) and antimicrobial susceptibility testing.\nMETHODS: Urine samples from 276 patients suffering symptoms of urinary tract infection were collected and cultured on Flexicult agar\u00ae allowing for detection of the most common urine pathogens. Patients were interviewed about underlying diseases, duration of symptoms, earlier episodes of UTI, number of episodes diagnosed by doctors and treatment in relation to UTI. All tentative E. faecalis and E. faecium isolates were identified to species level by PCR, 16S rRNA and partial sequencing of the groEL gene. E. faecalis isolates were further characterized by Multi Locus Sequence Typing and antimicrobial susceptibility testing.\nRESULTS: Mean age of 49 patients was 48 yrs (range was 11-86 yrs) and included 94% women. On average, patients reported to have suffered from UTI for 348 days (range 3 days-10 years, and experienced 2.7 UTIs during the previous year). Cephalosporins were reported the second drug of choice in treatment of UTI at the hospital. E. faecalis (55.1%), E. coli (12.2%) and Streptococcus gallolyticus subsp. pasteurianus (8.2%) were main bacterial pathogens. MIC testing of E. faecalis showed susceptibility to ampicillin, penicillin and vancomycin, but high-level resistance against gentamicin (48.1%). MLST revealed 12 Sequence Types (ST) of which ST 16 made up 44.5% and showed closely related PFGE types.\nCONCLUSION: The different aetiology of UTI compared with reports elsewhere, where E. coli dominates, may be a result of chronic and recurrent UTIs together with indiscriminate use of antimicrobials. The similar genotypes shown by epidemiologically unrelated ST 16 isolates in Vietnam and elsewhere, suggest that E. faecalis ST 16 might represent a globally distributed clone. Treatment of UTI with cephalosporins may select for E. faecalis as it is intrinsic resistant and further studies are needed to establish the source(s) and role of E. faecalis ST 16 in acute UTI.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/1471-2334-12-320", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1024946", 
        "issn": [
          "1471-2334"
        ], 
        "name": "BMC Infectious Diseases", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "12"
      }
    ], 
    "name": "Enterococcus and Streptococcusspp. associated with chronic and self-medicated urinary tract infections in Vietnam", 
    "pagination": "320", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "c3ee4cc9c733d46245a0bb419a76a62a5a7b2beea993054be86afc63ac0c0fa9"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23176582"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100968551"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1471-2334-12-320"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1041130424"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1471-2334-12-320", 
      "https://app.dimensions.ai/details/publication/pub.1041130424"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T23:23", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8693_00000507.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2F1471-2334-12-320"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1471-2334-12-320'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1471-2334-12-320'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1471-2334-12-320'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1471-2334-12-320'


 

This table displays all metadata directly associated to this object as RDF triples.

278 TRIPLES      21 PREDICATES      79 URIs      42 LITERALS      30 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1471-2334-12-320 schema:about N1f8f2736370b499180ba260a8489bf24
2 N22b45a04d42342f7b16c7621706a2c22
3 N39c51d1440704572b443b8372a675fdf
4 N3f51c04b9e08450c84e63f73da5d3581
5 N442c30032e654e929609681043d40e19
6 N57d86d19cf294bc9be42478f2f28d5db
7 N5bbc0eaab31644a5916d0b8993355c5e
8 N6e8ff81240964232961bbc2c05a1b803
9 N73222f36de1a4712a4ded8ea19ea8fc3
10 N7c6e398be95340f08c40602d79bebbf2
11 N9bef1201627a47a9814f37d1f8d38c64
12 Na5e9efb2ac464bcfa46f849d0fe62b65
13 Na7e4ab2f1c24438ea7244ca39960480c
14 Na9ecdf59a0a14d159e2f206d7ced939e
15 Nbbc7da73c8ea41abb492e6db73cd31f3
16 Nd65b2bae654e4b888c47ecb61eef0bc6
17 Nd66897df59294e35931907d29a13de95
18 Nddc392e2e4bd45c98b17feb6a8bab0bd
19 Ne7d9d8c60c3142a5acd0cd4170c2256d
20 Nf3a22a5c8a1e4b2090dc95a4e11a82b1
21 Nf853071db76940a0a521b8dcf4d16951
22 anzsrc-for:11
23 anzsrc-for:1108
24 schema:author N250e1975ca7f42dc9b187c7d37a2f482
25 schema:citation https://app.dimensions.ai/details/publication/pub.1077961445
26 https://app.dimensions.ai/details/publication/pub.1082385007
27 https://app.dimensions.ai/details/publication/pub.1082470220
28 https://doi.org/10.1001/archinternmed.2008.603
29 https://doi.org/10.1016/j.mpmed.2007.05.009
30 https://doi.org/10.1016/s0277-9536(01)00155-1
31 https://doi.org/10.1016/s0378-1135(98)00222-3
32 https://doi.org/10.1067/mda.2003.7
33 https://doi.org/10.1080/00365540110080601
34 https://doi.org/10.1080/13691050801932478
35 https://doi.org/10.1086/383029
36 https://doi.org/10.1093/clinids/15.2.295
37 https://doi.org/10.1093/jac/45.3.277
38 https://doi.org/10.1093/jac/dkg028
39 https://doi.org/10.1093/jac/dkl082
40 https://doi.org/10.1093/med/9780199204854.003.070203_update_001
41 https://doi.org/10.1099/00207713-52-4-1247
42 https://doi.org/10.1099/ijs.0.005488-0
43 https://doi.org/10.1099/ijs.0.02044-0
44 https://doi.org/10.1099/ijs.0.02361-0
45 https://doi.org/10.1128/aac.35.6.1147
46 https://doi.org/10.1128/aac.47.4.1423-1426.2003
47 https://doi.org/10.1128/cmr.3.1.46
48 https://doi.org/10.1128/jb.174.6.2002-2013.1992
49 https://doi.org/10.1128/jcm.02596-05
50 https://doi.org/10.1136/bmj.317.7159.647
51 https://doi.org/10.1161/01.cir.0000153812.64956.ef
52 https://doi.org/10.1161/circulationaha.105.165564
53 https://doi.org/10.3201/eid1604.090500
54 schema:datePublished 2012-12
55 schema:datePublishedReg 2012-12-01
56 schema:description BACKGROUND: Urinary tract infections (UTI) are one of the most common infections among women worldwide. E. coli often causes more than 75% of acute uncomplicated UTI, however, little is known about how recurrent UTIs and indiscriminate use of antimicrobials affect the aetiology of UTIs. This study aimed to establish the aetiology of UTI in a population of recurrent and self-medicated patients referred from pharmacies to a hospital in Hanoi, Vietnam and to describe genotypes and antimicrobial susceptibility of the associated bacterial pathogens. The aetiology of bacterial pathogens associated with UTI (defined as ≥ 104 CFU/ml urine) was established by phenotypic and molecular methods. Enterococcus faecalis isolates were typed by Multi Locus Sequence Typing (MLST), Pulsed-Field Gel Electrophoresis (PFGE) and antimicrobial susceptibility testing. METHODS: Urine samples from 276 patients suffering symptoms of urinary tract infection were collected and cultured on Flexicult agar® allowing for detection of the most common urine pathogens. Patients were interviewed about underlying diseases, duration of symptoms, earlier episodes of UTI, number of episodes diagnosed by doctors and treatment in relation to UTI. All tentative E. faecalis and E. faecium isolates were identified to species level by PCR, 16S rRNA and partial sequencing of the groEL gene. E. faecalis isolates were further characterized by Multi Locus Sequence Typing and antimicrobial susceptibility testing. RESULTS: Mean age of 49 patients was 48 yrs (range was 11-86 yrs) and included 94% women. On average, patients reported to have suffered from UTI for 348 days (range 3 days-10 years, and experienced 2.7 UTIs during the previous year). Cephalosporins were reported the second drug of choice in treatment of UTI at the hospital. E. faecalis (55.1%), E. coli (12.2%) and Streptococcus gallolyticus subsp. pasteurianus (8.2%) were main bacterial pathogens. MIC testing of E. faecalis showed susceptibility to ampicillin, penicillin and vancomycin, but high-level resistance against gentamicin (48.1%). MLST revealed 12 Sequence Types (ST) of which ST 16 made up 44.5% and showed closely related PFGE types. CONCLUSION: The different aetiology of UTI compared with reports elsewhere, where E. coli dominates, may be a result of chronic and recurrent UTIs together with indiscriminate use of antimicrobials. The similar genotypes shown by epidemiologically unrelated ST 16 isolates in Vietnam and elsewhere, suggest that E. faecalis ST 16 might represent a globally distributed clone. Treatment of UTI with cephalosporins may select for E. faecalis as it is intrinsic resistant and further studies are needed to establish the source(s) and role of E. faecalis ST 16 in acute UTI.
57 schema:genre research_article
58 schema:inLanguage en
59 schema:isAccessibleForFree true
60 schema:isPartOf N3837685702024478bf258b21545371a4
61 Nf5584422b34e4d929fff48d6decbcf27
62 sg:journal.1024946
63 schema:name Enterococcus and Streptococcusspp. associated with chronic and self-medicated urinary tract infections in Vietnam
64 schema:pagination 320
65 schema:productId N5dec709727544d2b8b79d171671fe699
66 N5f8891ed860b46f6a50c44b3d333f2e7
67 N66719da56a6a475c8065ab6f7de4ec52
68 N79dbbdf575db40048e9db3876f650223
69 N9b32ef2420ee4320a3f18aea0df838e5
70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041130424
71 https://doi.org/10.1186/1471-2334-12-320
72 schema:sdDatePublished 2019-04-10T23:23
73 schema:sdLicense https://scigraph.springernature.com/explorer/license/
74 schema:sdPublisher N4d84e36236264ef2aa074cbba7848060
75 schema:url http://link.springer.com/10.1186%2F1471-2334-12-320
76 sgo:license sg:explorer/license/
77 sgo:sdDataset articles
78 rdf:type schema:ScholarlyArticle
79 N0c2ed09ce54245618e382399a4995767 rdf:first sg:person.01165262733.50
80 rdf:rest Nf224611cf2a64685a726d00b2de6cd44
81 N1821c26ca5c044dea490a81ace836307 rdf:first sg:person.01331213470.28
82 rdf:rest Ne3eba52ffa57460f8509f11aa34ae603
83 N1f8f2736370b499180ba260a8489bf24 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Vietnam
85 rdf:type schema:DefinedTerm
86 N22b45a04d42342f7b16c7621706a2c22 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Microbial Sensitivity Tests
88 rdf:type schema:DefinedTerm
89 N250e1975ca7f42dc9b187c7d37a2f482 rdf:first sg:person.01301326113.42
90 rdf:rest N1821c26ca5c044dea490a81ace836307
91 N3837685702024478bf258b21545371a4 schema:volumeNumber 12
92 rdf:type schema:PublicationVolume
93 N39c51d1440704572b443b8372a675fdf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Enterococcus
95 rdf:type schema:DefinedTerm
96 N3f51c04b9e08450c84e63f73da5d3581 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Streptococcus
98 rdf:type schema:DefinedTerm
99 N4028fa9240004f918eaab24e2315e792 schema:name Hospital 103, Military Medical University, Ha Dong, Hanoi, Vietnam
100 rdf:type schema:Organization
101 N442c30032e654e929609681043d40e19 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Electrophoresis, Gel, Pulsed-Field
103 rdf:type schema:DefinedTerm
104 N4d84e36236264ef2aa074cbba7848060 schema:name Springer Nature - SN SciGraph project
105 rdf:type schema:Organization
106 N57d86d19cf294bc9be42478f2f28d5db schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Anti-Bacterial Agents
108 rdf:type schema:DefinedTerm
109 N5bbc0eaab31644a5916d0b8993355c5e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Bacterial Infections
111 rdf:type schema:DefinedTerm
112 N5dec709727544d2b8b79d171671fe699 schema:name doi
113 schema:value 10.1186/1471-2334-12-320
114 rdf:type schema:PropertyValue
115 N5f8891ed860b46f6a50c44b3d333f2e7 schema:name readcube_id
116 schema:value c3ee4cc9c733d46245a0bb419a76a62a5a7b2beea993054be86afc63ac0c0fa9
117 rdf:type schema:PropertyValue
118 N5feb553b9c7143658b1c2bfb03436b0a schema:name Hospital 103, Military Medical University, Ha Dong, Hanoi, Vietnam
119 rdf:type schema:Organization
120 N66719da56a6a475c8065ab6f7de4ec52 schema:name nlm_unique_id
121 schema:value 100968551
122 rdf:type schema:PropertyValue
123 N6e8ff81240964232961bbc2c05a1b803 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Child
125 rdf:type schema:DefinedTerm
126 N73222f36de1a4712a4ded8ea19ea8fc3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Self Medication
128 rdf:type schema:DefinedTerm
129 N79dbbdf575db40048e9db3876f650223 schema:name pubmed_id
130 schema:value 23176582
131 rdf:type schema:PropertyValue
132 N7c6e398be95340f08c40602d79bebbf2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Aged
134 rdf:type schema:DefinedTerm
135 N9b32ef2420ee4320a3f18aea0df838e5 schema:name dimensions_id
136 schema:value pub.1041130424
137 rdf:type schema:PropertyValue
138 N9bef1201627a47a9814f37d1f8d38c64 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Male
140 rdf:type schema:DefinedTerm
141 Na5e9efb2ac464bcfa46f849d0fe62b65 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Urinary Tract Infections
143 rdf:type schema:DefinedTerm
144 Na7e4ab2f1c24438ea7244ca39960480c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Adolescent
146 rdf:type schema:DefinedTerm
147 Na9ecdf59a0a14d159e2f206d7ced939e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Adult
149 rdf:type schema:DefinedTerm
150 Nbbc7da73c8ea41abb492e6db73cd31f3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Multilocus Sequence Typing
152 rdf:type schema:DefinedTerm
153 Nd65b2bae654e4b888c47ecb61eef0bc6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Middle Aged
155 rdf:type schema:DefinedTerm
156 Nd66897df59294e35931907d29a13de95 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Escherichia coli
158 rdf:type schema:DefinedTerm
159 Nddc392e2e4bd45c98b17feb6a8bab0bd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Young Adult
161 rdf:type schema:DefinedTerm
162 Ne3eba52ffa57460f8509f11aa34ae603 rdf:first sg:person.0756750663.64
163 rdf:rest N0c2ed09ce54245618e382399a4995767
164 Ne7d9d8c60c3142a5acd0cd4170c2256d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Humans
166 rdf:type schema:DefinedTerm
167 Nf224611cf2a64685a726d00b2de6cd44 rdf:first sg:person.0740263613.29
168 rdf:rest Nf626f15a14b1420586b939047d8125fc
169 Nf3a22a5c8a1e4b2090dc95a4e11a82b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Aged, 80 and over
171 rdf:type schema:DefinedTerm
172 Nf5584422b34e4d929fff48d6decbcf27 schema:issueNumber 1
173 rdf:type schema:PublicationIssue
174 Nf626f15a14b1420586b939047d8125fc rdf:first sg:person.0602327062.28
175 rdf:rest rdf:nil
176 Nf853071db76940a0a521b8dcf4d16951 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Female
178 rdf:type schema:DefinedTerm
179 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
180 schema:name Medical and Health Sciences
181 rdf:type schema:DefinedTerm
182 anzsrc-for:1108 schema:inDefinedTermSet anzsrc-for:
183 schema:name Medical Microbiology
184 rdf:type schema:DefinedTerm
185 sg:journal.1024946 schema:issn 1471-2334
186 schema:name BMC Infectious Diseases
187 rdf:type schema:Periodical
188 sg:person.01165262733.50 schema:affiliation https://www.grid.ac/institutes/grid.56046.31
189 schema:familyName Trung
190 schema:givenName Nguyen Vu
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165262733.50
192 rdf:type schema:Person
193 sg:person.01301326113.42 schema:affiliation https://www.grid.ac/institutes/grid.5254.6
194 schema:familyName Poulsen
195 schema:givenName Louise Ladefoged
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301326113.42
197 rdf:type schema:Person
198 sg:person.01331213470.28 schema:affiliation https://www.grid.ac/institutes/grid.5254.6
199 schema:familyName Bisgaard
200 schema:givenName Magne
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331213470.28
202 rdf:type schema:Person
203 sg:person.0602327062.28 schema:affiliation https://www.grid.ac/institutes/grid.5254.6
204 schema:familyName Dalsgaard
205 schema:givenName Anders
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602327062.28
207 rdf:type schema:Person
208 sg:person.0740263613.29 schema:affiliation N5feb553b9c7143658b1c2bfb03436b0a
209 schema:familyName An
210 schema:givenName Hoang Manh
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740263613.29
212 rdf:type schema:Person
213 sg:person.0756750663.64 schema:affiliation N4028fa9240004f918eaab24e2315e792
214 schema:familyName Son
215 schema:givenName Nguyen Thai
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756750663.64
217 rdf:type schema:Person
218 https://app.dimensions.ai/details/publication/pub.1077961445 schema:CreativeWork
219 https://app.dimensions.ai/details/publication/pub.1082385007 schema:CreativeWork
220 https://app.dimensions.ai/details/publication/pub.1082470220 schema:CreativeWork
221 https://doi.org/10.1001/archinternmed.2008.603 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041107657
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1016/j.mpmed.2007.05.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040066544
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1016/s0277-9536(01)00155-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035329038
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1016/s0378-1135(98)00222-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021706699
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1067/mda.2003.7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027947795
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1080/00365540110080601 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015941065
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1080/13691050801932478 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032472869
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1086/383029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020621768
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1093/clinids/15.2.295 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059472263
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1093/jac/45.3.277 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040027598
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1093/jac/dkg028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027901564
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1093/jac/dkl082 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028926718
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1093/med/9780199204854.003.070203_update_001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1088887721
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1099/00207713-52-4-1247 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060350849
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1099/ijs.0.005488-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028176848
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1099/ijs.0.02044-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060383009
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1099/ijs.0.02361-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060383381
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1128/aac.35.6.1147 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051461457
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1128/aac.47.4.1423-1426.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043687713
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1128/cmr.3.1.46 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062710814
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1128/jb.174.6.2002-2013.1992 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062721394
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1128/jcm.02596-05 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025237349
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1136/bmj.317.7159.647 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029165363
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1161/01.cir.0000153812.64956.ef schema:sameAs https://app.dimensions.ai/details/publication/pub.1019465385
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1161/circulationaha.105.165564 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030420291
270 rdf:type schema:CreativeWork
271 https://doi.org/10.3201/eid1604.090500 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031652276
272 rdf:type schema:CreativeWork
273 https://www.grid.ac/institutes/grid.5254.6 schema:alternateName University of Copenhagen
274 schema:name Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Groennegaardsvej 15 DK-1870, Frederiksberg C, Denmark
275 rdf:type schema:Organization
276 https://www.grid.ac/institutes/grid.56046.31 schema:alternateName Hanoi Medical University
277 schema:name Department of Medical Microbiology, Hanoi Medical University, Hanoi, Vietnam
278 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...