Seroprevalence of anti-hepatitis E virus (HEV) in a Korean population: comparison of two commercial anti-HEV assays View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-06-22

AUTHORS

Hyun Kyung Park, Sook-Hyang Jeong, Jin-Wook Kim, Byung-Hyun Woo, Dong Ho Lee, Hyun Young Kim, Soyeon Ahn

ABSTRACT

BackgroundHepatitis E virus (HEV) has emerged as an important cause of epidemic and sporadic acute viral hepatitis worldwide. This study investigated the seroprevalence of anti-HEV in a Korean population and compared the performance of two commercially available anti-HEV assays.MethodsA total 147 health-check examinees were randomly sampled as matched to the age- and sex- adjusted standard population based on the Korean National Census of 2007. Serum immunoglobulin G anti-HEV was determined by using the Genelabs assay (Genelabs, Singapore) and the Wantai assay (Wantai, Beijing, China).ResultsThe overall anti-HEV seroprevalence was 23.1% (95% CI, 16.1-30.1%) using the Wantai assay and 14.3% (95% CI, 8.3-20.3%) using the Genelabs assay. Only 12 samples (8.1%) were positive for anti-HEV as measured by both assays; agreement between the two assays was poor (kappa value of 0.315). The anti-HEV seroprevalence increased with age from 2% and 3% in the people younger than 20-years-of-age to 34.6% and 42.3% in those over 59-years-of-age by the Genelabs and Wantai assay, respectively.ConclusionsThe HEV seroprevalence in Korean population is about 20% overall, with seroprevalence increasing in this population with increasing age. There was poor concordance in the results of the Genelabs and Wantai assays, which warrants further study concerning a reliable diagnostic test for the diagnosis of hepatitis E. More... »

PAGES

142

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1471-2334-12-142

DOI

http://dx.doi.org/10.1186/1471-2334-12-142

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1001799408

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22726615


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