Investigation of innate immunity genes CARD4, CARD8 and CARD15 as germline susceptibility factors for colorectal cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-12

AUTHORS

Nikolaus Möckelmann, Witigo von Schönfels, Stephan Buch, Oliver von Kampen, Bence Sipos, Jan Hendrik Egberts, Philip Rosenstiel, Andre Franke, Mario Brosch, Sebastian Hinz, Christian Röder, Holger Kalthoff, Ulrich R Fölsch, Michael Krawczak, Stefan Schreiber, Clemens Dieter Bröring, Jürgen Tepel, Clemens Schafmayer, Jochen Hampe

ABSTRACT

BACKGROUND: Variation in genes involved in the innate immune response may play a role in the predisposition to colorectal cancer (CRC). Several polymorphisms of the CARD15 gene (caspase activating recruitment domain, member 15) have been reported to be associated with an increased susceptibility to Crohn disease. Since the CARD15 gene product and other CARD proteins function in innate immunity, we investigated the impact of germline variation at the CARD4, CARD8 and CARD15 loci on the risk for sporadic CRC, using a large patient sample from Northern Germany. METHODS: A total of 1044 patients who had been operated with sporadic colorectal carcinoma (median age at diagnosis: 59 years) were recruited and compared to 724 sex-matched, population-based control individuals (median age: 68 years). Genetic investigation was carried out following both a coding SNP and haplotype tagging approach. Subgroup analyses for N = 143 patients with early manifestation of CRC ( More... »

PAGES

79

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/1471-230x-9-79

    DOI

    http://dx.doi.org/10.1186/1471-230x-9-79

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1021778499

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19843337


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