Coexistence of HBsAg and HBsAb in a difficult-to-treat chronic hepatitis B: loss of HBsAg with entecavir plus tenofovir combination View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-12

AUTHORS

Giovanni Galati, Antonio De Vincentis, Umberto Vespasiani-Gentilucci, Paolo Gallo, Donatella Vincenti, Maria Carmela Solmone, Chiara Dell’Unto, Antonio Picardi

ABSTRACT

BACKGROUND: Some reports have documented the coexistence of Hepatitis B surfage Antigen (HBsAg) and anti-HBsAg antibodies (HBsAb) in patients with chronic hepatitis B (CHB), often in the absence of amino acid substitutions in the HBsAg sequences of the Hepatitis B Virus (HBV) genome able to explain an immunological escape variant.HBV genome has a very compact coding organization, with four partially overlapping open reading frames (ORFs). Because the reverse transcriptase region (rt) of HBV polymerase overlaps the HBsAg ORF, it is possible that some mutations in the HBsAg region correspond to mutations in the rt ORF, conferring resistance to current antiviral therapies. This unique case explores the response to antiviral therapies of a CHB with concurrent HBsAg and HBsAb positivity, and analyse the clinical implications of possible mutations in rt and HBsAg ORFs. CASE PRESENTATION: Here we describe the case of a 59 year-old Italian man suffering from Hepatitis B envelope Antigen (HBeAg) positive CHB with concurrent HBsAb positivity. By ultra-deep pyro-sequencing (UDPS) technique, mutations conferring immunological escape or resistance to antiviral therapies were found neither in HBsAg nor in HBV rt ORFs, respectively. The patient was unsuccessfully treated with interferon, adefovir monotherapy and adefovir plus entecavir combination. Surprisingly, during entecavir plus tenofovir combination, anti-HBe seroconversion and HBsAg loss were observed, while the titer of HBsAb persisted. CONCLUSIONS: Concurrent HBsAg/HBsAb positivity in active CHB is a clinical and virological dilemma. In this setting, there are not consistent data about the response to conventional therapies and the immunological balance between host and virus remains so far unexplained. This is, to our knowledge, the first case described of a CHB with HBsAg/HBsAb positivity, wild type for clinically relevant mutations in HBsAg and rt ORFs, successfully treated with a combination of nucleot(s)ide analogues (NAs). More... »

PAGES

94

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1471-230x-14-94

DOI

http://dx.doi.org/10.1186/1471-230x-14-94

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042212885

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24885182


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1108", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Microbiology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antiviral Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Therapy, Combination", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Guanine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hepatitis B Antibodies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hepatitis B Surface Antigens", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hepatitis B e Antigens", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hepatitis B, Chronic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interferon-alpha", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Organophosphonates", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Recombinant Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tenofovir", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Failure", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Viral Load", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Universit\u00e0 Campus Bio-Medico", 
          "id": "https://www.grid.ac/institutes/grid.9657.d", 
          "name": [
            "Clinical Medicine and Hepatology Unit, Campus Bio Medico University of Rome, 200, Alvaro Del Portillo Street, 00128, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Galati", 
        "givenName": "Giovanni", 
        "id": "sg:person.01020754724.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01020754724.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e0 Campus Bio-Medico", 
          "id": "https://www.grid.ac/institutes/grid.9657.d", 
          "name": [
            "Clinical Medicine and Hepatology Unit, Campus Bio Medico University of Rome, 200, Alvaro Del Portillo Street, 00128, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "De Vincentis", 
        "givenName": "Antonio", 
        "id": "sg:person.0755456160.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755456160.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e0 Campus Bio-Medico", 
          "id": "https://www.grid.ac/institutes/grid.9657.d", 
          "name": [
            "Clinical Medicine and Hepatology Unit, Campus Bio Medico University of Rome, 200, Alvaro Del Portillo Street, 00128, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vespasiani-Gentilucci", 
        "givenName": "Umberto", 
        "id": "sg:person.0736357351.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736357351.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e0 Campus Bio-Medico", 
          "id": "https://www.grid.ac/institutes/grid.9657.d", 
          "name": [
            "Clinical Medicine and Hepatology Unit, Campus Bio Medico University of Rome, 200, Alvaro Del Portillo Street, 00128, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gallo", 
        "givenName": "Paolo", 
        "id": "sg:person.01004120050.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004120050.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani", 
          "id": "https://www.grid.ac/institutes/grid.419423.9", 
          "name": [
            "National Institute for Infectious Diseases \u201cLazzaro Spallanzani\u201d, 292 Portuense Street, 00149, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vincenti", 
        "givenName": "Donatella", 
        "id": "sg:person.01174604772.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174604772.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani", 
          "id": "https://www.grid.ac/institutes/grid.419423.9", 
          "name": [
            "National Institute for Infectious Diseases \u201cLazzaro Spallanzani\u201d, 292 Portuense Street, 00149, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Solmone", 
        "givenName": "Maria Carmela", 
        "id": "sg:person.01320704465.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320704465.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e0 Campus Bio-Medico", 
          "id": "https://www.grid.ac/institutes/grid.9657.d", 
          "name": [
            "Clinical Medicine and Hepatology Unit, Campus Bio Medico University of Rome, 200, Alvaro Del Portillo Street, 00128, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dell\u2019Unto", 
        "givenName": "Chiara", 
        "id": "sg:person.01272064356.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272064356.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e0 Campus Bio-Medico", 
          "id": "https://www.grid.ac/institutes/grid.9657.d", 
          "name": [
            "Clinical Medicine and Hepatology Unit, Campus Bio Medico University of Rome, 200, Alvaro Del Portillo Street, 00128, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Picardi", 
        "givenName": "Antonio", 
        "id": "sg:person.01046155143.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046155143.25"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.4065/82.8.967", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001585719"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1386-6532(02)00049-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016035813"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.virol.2007.05.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016357280"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.88.10.4186", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019592616"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.02011-08", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021168978"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/513200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022757619"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.510300511", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026634474"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa020681", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027660106"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0168-8278(95)80226-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037903619"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.80.6.2968-2975.2006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037926878"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1478-3231.2007.01480.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042066104"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2893.1999.00160.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051062831"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2893.1999.00160.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051062831"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2012.05.037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053089951"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7326/0003-4819-119-4-199308150-00011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073697674"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077654954", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081694921", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-12", 
    "datePublishedReg": "2014-12-01", 
    "description": "BACKGROUND: Some reports have documented the coexistence of Hepatitis B surfage Antigen (HBsAg) and anti-HBsAg antibodies (HBsAb) in patients with chronic hepatitis B (CHB), often in the absence of amino acid substitutions in the HBsAg sequences of the Hepatitis B Virus (HBV) genome able to explain an immunological escape variant.HBV genome has a very compact coding organization, with four partially overlapping open reading frames (ORFs). Because the reverse transcriptase region (rt) of HBV polymerase overlaps the HBsAg ORF, it is possible that some mutations in the HBsAg region correspond to mutations in the rt ORF, conferring resistance to current antiviral therapies. This unique case explores the response to antiviral therapies of a CHB with concurrent HBsAg and HBsAb positivity, and analyse the clinical implications of possible mutations in rt and HBsAg ORFs.\nCASE PRESENTATION: Here we describe the case of a 59 year-old Italian man suffering from Hepatitis B envelope Antigen (HBeAg) positive CHB with concurrent HBsAb positivity. By ultra-deep pyro-sequencing (UDPS) technique, mutations conferring immunological escape or resistance to antiviral therapies were found neither in HBsAg nor in HBV rt ORFs, respectively. The patient was unsuccessfully treated with interferon, adefovir monotherapy and adefovir plus entecavir combination. Surprisingly, during entecavir plus tenofovir combination, anti-HBe seroconversion and HBsAg loss were observed, while the titer of HBsAb persisted.\nCONCLUSIONS: Concurrent HBsAg/HBsAb positivity in active CHB is a clinical and virological dilemma. In this setting, there are not consistent data about the response to conventional therapies and the immunological balance between host and virus remains so far unexplained. This is, to our knowledge, the first case described of a CHB with HBsAg/HBsAb positivity, wild type for clinically relevant mutations in HBsAg and rt ORFs, successfully treated with a combination of nucleot(s)ide analogues (NAs).", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/1471-230x-14-94", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1024942", 
        "issn": [
          "1471-230X"
        ], 
        "name": "BMC Gastroenterology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "14"
      }
    ], 
    "name": "Coexistence of HBsAg and HBsAb in a difficult-to-treat chronic hepatitis B: loss of HBsAg with entecavir plus tenofovir combination", 
    "pagination": "94", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "c914dccf7b5d1a64d33cc06edf7dff28d195601d7d3835e187c1bf8d1984db86"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "24885182"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100968547"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1471-230x-14-94"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1042212885"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1471-230x-14-94", 
      "https://app.dimensions.ai/details/publication/pub.1042212885"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T02:20", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8700_00000551.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2F1471-230X-14-94"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1471-230x-14-94'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1471-230x-14-94'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1471-230x-14-94'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1471-230x-14-94'


 

This table displays all metadata directly associated to this object as RDF triples.

238 TRIPLES      21 PREDICATES      63 URIs      39 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1471-230x-14-94 schema:about N1d612ae398cf485faba841cec2cf77ea
2 N206d3039f4a94fce9eca02e8831be12f
3 N213395938f7942d19875659b4d69388f
4 N22aba8721f8142f98ea8ec2a4b0ea71d
5 N2c83850e9a3e4379a9577861d3aed21c
6 N3543ed9f857643d990323ef7c90cb241
7 N4510c805879e4c5f9696a444085c5e97
8 N877cc734f5d743768320008933b08a89
9 N8958c9f23bf041c088a648ecfff206a5
10 N8c76be2d90344f168ded04dc29da0ce2
11 N9f09c303f37a436a9aaadec8c5699afb
12 Na59b78d9aa384a51936fa5e3e6709dcc
13 Nc6f26f8d98b341f3bedf4405c514f3dc
14 Nc8ae698faee04370b8ec66c5cbba1701
15 Nc9ef85a795e74facb9d8083e6ada80b9
16 Nd03e6226b99e498ba36e0b1590b75d09
17 Nd04c379751c346998397f98469daed8e
18 Nd2bc04a47e724853bafeafd23517a891
19 anzsrc-for:11
20 anzsrc-for:1108
21 schema:author N1e8cecfa29c54819b66c42249dd66e9b
22 schema:citation https://app.dimensions.ai/details/publication/pub.1077654954
23 https://app.dimensions.ai/details/publication/pub.1081694921
24 https://doi.org/10.1002/hep.510300511
25 https://doi.org/10.1016/0168-8278(95)80226-6
26 https://doi.org/10.1016/j.virol.2007.05.012
27 https://doi.org/10.1016/s1386-6532(02)00049-5
28 https://doi.org/10.1046/j.1365-2893.1999.00160.x
29 https://doi.org/10.1053/j.gastro.2012.05.037
30 https://doi.org/10.1056/nejmoa020681
31 https://doi.org/10.1073/pnas.88.10.4186
32 https://doi.org/10.1086/513200
33 https://doi.org/10.1111/j.1478-3231.2007.01480.x
34 https://doi.org/10.1128/jvi.02011-08
35 https://doi.org/10.1128/jvi.80.6.2968-2975.2006
36 https://doi.org/10.4065/82.8.967
37 https://doi.org/10.7326/0003-4819-119-4-199308150-00011
38 schema:datePublished 2014-12
39 schema:datePublishedReg 2014-12-01
40 schema:description BACKGROUND: Some reports have documented the coexistence of Hepatitis B surfage Antigen (HBsAg) and anti-HBsAg antibodies (HBsAb) in patients with chronic hepatitis B (CHB), often in the absence of amino acid substitutions in the HBsAg sequences of the Hepatitis B Virus (HBV) genome able to explain an immunological escape variant.HBV genome has a very compact coding organization, with four partially overlapping open reading frames (ORFs). Because the reverse transcriptase region (rt) of HBV polymerase overlaps the HBsAg ORF, it is possible that some mutations in the HBsAg region correspond to mutations in the rt ORF, conferring resistance to current antiviral therapies. This unique case explores the response to antiviral therapies of a CHB with concurrent HBsAg and HBsAb positivity, and analyse the clinical implications of possible mutations in rt and HBsAg ORFs. CASE PRESENTATION: Here we describe the case of a 59 year-old Italian man suffering from Hepatitis B envelope Antigen (HBeAg) positive CHB with concurrent HBsAb positivity. By ultra-deep pyro-sequencing (UDPS) technique, mutations conferring immunological escape or resistance to antiviral therapies were found neither in HBsAg nor in HBV rt ORFs, respectively. The patient was unsuccessfully treated with interferon, adefovir monotherapy and adefovir plus entecavir combination. Surprisingly, during entecavir plus tenofovir combination, anti-HBe seroconversion and HBsAg loss were observed, while the titer of HBsAb persisted. CONCLUSIONS: Concurrent HBsAg/HBsAb positivity in active CHB is a clinical and virological dilemma. In this setting, there are not consistent data about the response to conventional therapies and the immunological balance between host and virus remains so far unexplained. This is, to our knowledge, the first case described of a CHB with HBsAg/HBsAb positivity, wild type for clinically relevant mutations in HBsAg and rt ORFs, successfully treated with a combination of nucleot(s)ide analogues (NAs).
41 schema:genre research_article
42 schema:inLanguage en
43 schema:isAccessibleForFree true
44 schema:isPartOf Nb736eba258834294a8fc3ba30a86cc45
45 Ndc2c06efffae4478af50766ec3b25e87
46 sg:journal.1024942
47 schema:name Coexistence of HBsAg and HBsAb in a difficult-to-treat chronic hepatitis B: loss of HBsAg with entecavir plus tenofovir combination
48 schema:pagination 94
49 schema:productId Nb105bc46690247cbb3299d4ba45e71ba
50 Nc4696585196f4e44a118936fb55918df
51 Ncc472fb36a394c9b876c1313a239dec8
52 Nf0d2662aa1464f3a803a9aca98e26a85
53 Nf8b3afb127a646548d4f1a77f886431e
54 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042212885
55 https://doi.org/10.1186/1471-230x-14-94
56 schema:sdDatePublished 2019-04-11T02:20
57 schema:sdLicense https://scigraph.springernature.com/explorer/license/
58 schema:sdPublisher Na375a5b83e90480eb8f3728fbeaba02e
59 schema:url http://link.springer.com/10.1186%2F1471-230X-14-94
60 sgo:license sg:explorer/license/
61 sgo:sdDataset articles
62 rdf:type schema:ScholarlyArticle
63 N0bde5989f3a64b2b818510c6375c8588 rdf:first sg:person.01272064356.26
64 rdf:rest Ne4dd56bc6c314723a8e90c57e46449ab
65 N1ac0022861b04598bfa2af8788aa951d rdf:first sg:person.01320704465.59
66 rdf:rest N0bde5989f3a64b2b818510c6375c8588
67 N1d612ae398cf485faba841cec2cf77ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
68 schema:name Antiviral Agents
69 rdf:type schema:DefinedTerm
70 N1e8cecfa29c54819b66c42249dd66e9b rdf:first sg:person.01020754724.52
71 rdf:rest Ndacfbe08bba648bcba30b4e5b4acf341
72 N206d3039f4a94fce9eca02e8831be12f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
73 schema:name Hepatitis B Antibodies
74 rdf:type schema:DefinedTerm
75 N213395938f7942d19875659b4d69388f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name Middle Aged
77 rdf:type schema:DefinedTerm
78 N22aba8721f8142f98ea8ec2a4b0ea71d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Organophosphonates
80 rdf:type schema:DefinedTerm
81 N2c83850e9a3e4379a9577861d3aed21c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Tenofovir
83 rdf:type schema:DefinedTerm
84 N3543ed9f857643d990323ef7c90cb241 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Humans
86 rdf:type schema:DefinedTerm
87 N4510c805879e4c5f9696a444085c5e97 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Hepatitis B Surface Antigens
89 rdf:type schema:DefinedTerm
90 N7ecd777c77d24d58b6e392b6250636fa rdf:first sg:person.01004120050.35
91 rdf:rest N8d76acaa3c33436aa3071c1c293e0be7
92 N877cc734f5d743768320008933b08a89 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Recombinant Proteins
94 rdf:type schema:DefinedTerm
95 N8958c9f23bf041c088a648ecfff206a5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Treatment Outcome
97 rdf:type schema:DefinedTerm
98 N8c54af2a89ec4178b354ad1a187b6281 rdf:first sg:person.0736357351.35
99 rdf:rest N7ecd777c77d24d58b6e392b6250636fa
100 N8c76be2d90344f168ded04dc29da0ce2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Drug Therapy, Combination
102 rdf:type schema:DefinedTerm
103 N8d76acaa3c33436aa3071c1c293e0be7 rdf:first sg:person.01174604772.21
104 rdf:rest N1ac0022861b04598bfa2af8788aa951d
105 N9f09c303f37a436a9aaadec8c5699afb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Hepatitis B, Chronic
107 rdf:type schema:DefinedTerm
108 Na375a5b83e90480eb8f3728fbeaba02e schema:name Springer Nature - SN SciGraph project
109 rdf:type schema:Organization
110 Na59b78d9aa384a51936fa5e3e6709dcc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Guanine
112 rdf:type schema:DefinedTerm
113 Nb105bc46690247cbb3299d4ba45e71ba schema:name readcube_id
114 schema:value c914dccf7b5d1a64d33cc06edf7dff28d195601d7d3835e187c1bf8d1984db86
115 rdf:type schema:PropertyValue
116 Nb736eba258834294a8fc3ba30a86cc45 schema:volumeNumber 14
117 rdf:type schema:PublicationVolume
118 Nc4696585196f4e44a118936fb55918df schema:name doi
119 schema:value 10.1186/1471-230x-14-94
120 rdf:type schema:PropertyValue
121 Nc6f26f8d98b341f3bedf4405c514f3dc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Interferon-alpha
123 rdf:type schema:DefinedTerm
124 Nc8ae698faee04370b8ec66c5cbba1701 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Adenine
126 rdf:type schema:DefinedTerm
127 Nc9ef85a795e74facb9d8083e6ada80b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Male
129 rdf:type schema:DefinedTerm
130 Ncc472fb36a394c9b876c1313a239dec8 schema:name nlm_unique_id
131 schema:value 100968547
132 rdf:type schema:PropertyValue
133 Nd03e6226b99e498ba36e0b1590b75d09 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Hepatitis B e Antigens
135 rdf:type schema:DefinedTerm
136 Nd04c379751c346998397f98469daed8e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Viral Load
138 rdf:type schema:DefinedTerm
139 Nd2bc04a47e724853bafeafd23517a891 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Treatment Failure
141 rdf:type schema:DefinedTerm
142 Ndacfbe08bba648bcba30b4e5b4acf341 rdf:first sg:person.0755456160.25
143 rdf:rest N8c54af2a89ec4178b354ad1a187b6281
144 Ndc2c06efffae4478af50766ec3b25e87 schema:issueNumber 1
145 rdf:type schema:PublicationIssue
146 Ne4dd56bc6c314723a8e90c57e46449ab rdf:first sg:person.01046155143.25
147 rdf:rest rdf:nil
148 Nf0d2662aa1464f3a803a9aca98e26a85 schema:name pubmed_id
149 schema:value 24885182
150 rdf:type schema:PropertyValue
151 Nf8b3afb127a646548d4f1a77f886431e schema:name dimensions_id
152 schema:value pub.1042212885
153 rdf:type schema:PropertyValue
154 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
155 schema:name Medical and Health Sciences
156 rdf:type schema:DefinedTerm
157 anzsrc-for:1108 schema:inDefinedTermSet anzsrc-for:
158 schema:name Medical Microbiology
159 rdf:type schema:DefinedTerm
160 sg:journal.1024942 schema:issn 1471-230X
161 schema:name BMC Gastroenterology
162 rdf:type schema:Periodical
163 sg:person.01004120050.35 schema:affiliation https://www.grid.ac/institutes/grid.9657.d
164 schema:familyName Gallo
165 schema:givenName Paolo
166 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004120050.35
167 rdf:type schema:Person
168 sg:person.01020754724.52 schema:affiliation https://www.grid.ac/institutes/grid.9657.d
169 schema:familyName Galati
170 schema:givenName Giovanni
171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01020754724.52
172 rdf:type schema:Person
173 sg:person.01046155143.25 schema:affiliation https://www.grid.ac/institutes/grid.9657.d
174 schema:familyName Picardi
175 schema:givenName Antonio
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046155143.25
177 rdf:type schema:Person
178 sg:person.01174604772.21 schema:affiliation https://www.grid.ac/institutes/grid.419423.9
179 schema:familyName Vincenti
180 schema:givenName Donatella
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174604772.21
182 rdf:type schema:Person
183 sg:person.01272064356.26 schema:affiliation https://www.grid.ac/institutes/grid.9657.d
184 schema:familyName Dell’Unto
185 schema:givenName Chiara
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272064356.26
187 rdf:type schema:Person
188 sg:person.01320704465.59 schema:affiliation https://www.grid.ac/institutes/grid.419423.9
189 schema:familyName Solmone
190 schema:givenName Maria Carmela
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320704465.59
192 rdf:type schema:Person
193 sg:person.0736357351.35 schema:affiliation https://www.grid.ac/institutes/grid.9657.d
194 schema:familyName Vespasiani-Gentilucci
195 schema:givenName Umberto
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736357351.35
197 rdf:type schema:Person
198 sg:person.0755456160.25 schema:affiliation https://www.grid.ac/institutes/grid.9657.d
199 schema:familyName De Vincentis
200 schema:givenName Antonio
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755456160.25
202 rdf:type schema:Person
203 https://app.dimensions.ai/details/publication/pub.1077654954 schema:CreativeWork
204 https://app.dimensions.ai/details/publication/pub.1081694921 schema:CreativeWork
205 https://doi.org/10.1002/hep.510300511 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026634474
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1016/0168-8278(95)80226-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037903619
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1016/j.virol.2007.05.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016357280
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1016/s1386-6532(02)00049-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016035813
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1046/j.1365-2893.1999.00160.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1051062831
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1053/j.gastro.2012.05.037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053089951
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1056/nejmoa020681 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027660106
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1073/pnas.88.10.4186 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019592616
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1086/513200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022757619
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1111/j.1478-3231.2007.01480.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1042066104
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1128/jvi.02011-08 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021168978
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1128/jvi.80.6.2968-2975.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037926878
228 rdf:type schema:CreativeWork
229 https://doi.org/10.4065/82.8.967 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001585719
230 rdf:type schema:CreativeWork
231 https://doi.org/10.7326/0003-4819-119-4-199308150-00011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073697674
232 rdf:type schema:CreativeWork
233 https://www.grid.ac/institutes/grid.419423.9 schema:alternateName Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani
234 schema:name National Institute for Infectious Diseases “Lazzaro Spallanzani”, 292 Portuense Street, 00149, Rome, Italy
235 rdf:type schema:Organization
236 https://www.grid.ac/institutes/grid.9657.d schema:alternateName Università Campus Bio-Medico
237 schema:name Clinical Medicine and Hepatology Unit, Campus Bio Medico University of Rome, 200, Alvaro Del Portillo Street, 00128, Rome, Italy
238 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...