A multi-centre randomised double-blind placebo-controlled trial to evaluate the value of a single bolus intravenous alfentanil in CT colonography View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-12

AUTHORS

Thierry N Boellaard, Marije P van der Paardt, Markus W Hollmann, Susanne Eberl, Jan Peringa, Lex J Schouten, Giedre Kavaliauskiene, Jurgen H Runge, Jeroen AW Tielbeek, Jaap Stoker

ABSTRACT

BACKGROUND: Pain is common during colonic insufflation required for CT colonography. We therefore evaluate whether a single intravenous alfentanil bolus has a clinically relevant analgesic effect compared with placebo in patients undergoing CT colonography. METHODS: A prospective multi-centre randomised double-blind placebo-controlled trial was performed in patients scheduled for elective CT colonography. Patients were randomised to receive either a bolus of 7.5 μg/kg alfentanil (n = 45) or placebo (n = 45). The primary outcome was the difference in maximum pain during colonic insufflation on an 11-point numeric rating scale. We defined a clinically relevant effect as a maximum pain reduction of at least 1.3 points. Secondary outcomes included total pain and burden of CT colonography (5-point scale), the most burdensome aspect and side effects. Our primary outcome was tested using a one-sided independent samples t-test. RESULTS: Maximum pain scores during insufflation were lower with alfentanil as compared with placebo, 5.3 versus 3.0 (P < 0.001). Total CT colonography pain and burden were also lower with alfentanil (2.0 vs. 1.6; P = 0.014 and 2.1 vs. 1.7; P = 0.007, respectively). With alfentanil fewer patients rated the insufflation as most burdensome aspect (56.1% vs. 18.6%; P = 0.001). Episodes with desaturations < 90% SpO2 were more common with alfentanil (8.1% vs. 44.4%; P < 0.001, but no clinically relevant desaturations occurred. CONCLUSIONS: A low-dose intravenous alfentanil bolus provides a clinically relevant reduction of maximum pain during CT colonography and may improve the CT colonography acceptance, especially for patients with a low pain threshold. TRIAL REGISTRATION: Dutch Trial Register: NTR2902. More... »

PAGES

94

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1471-230x-13-94

DOI

http://dx.doi.org/10.1186/1471-230x-13-94

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034378112

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23706123


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