Multicenter comparison of PEG-IFN α2a or α2b plus ribavirin for treatment-naïve HCV patient in Korean population View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-04-29

AUTHORS

Young-Joo Jin, Jin-Woo Lee, Jung il Lee, Sang Hoon Park, Choong Kee Park, Young Seok Kim, Sook-Hyang Jeong, Yun Soo Kim, Ju Hyun Kim, Seong Gyu Hwang, Kyu Sung Rim, Hyung Joon Yim, Jae Youn Cheong, Sung Won Cho, June Sung Lee, Young Min Park, Jeong Won Jang, Chun Kyon Lee, Joo Hyun Sohn, Jin Mo Yang, Seungbong Han

ABSTRACT

BACKGROUND: Two recent Italian studies suggested that Pegylated-interferon (PEG-IFN) alfa-2a achieves a higher sustained virological response (SVR) rate than PEG-IFN alfa-2b. We intended to compare the efficacy and safety of PEG-IFN alfa-2a with those of PEG-IFN alfa-2b in Korean patients with chronic hepatitis C virus (HCV). METHODS: This retrospective, multi-center trial was conducted on 661 treatment-naïve chronic HCV patients. Patients received PEG-IFN alfa-2a (180 μg/week; n=402) or PEG-IFN alfa-2b (1.5 μg/kg/week; n=259) with ribavirin (800-1200 mg/day) for 24 or 48 weeks according to HCV genotypes. RESULTS: Early virologic response and sustained virologic response (SVR) rates were not significantly different between two PEG-IFN groups both in patients with HCV genotype 1 (all P-values>0.05) and 2/3 (all P-values>0.05). SVR rates were not different between two groups in each categorized baseline characteristics: age (years) (≤ 50 and >50), HCV viral load (IU/mL) (≤ 7 × 10(5) and >7 × 10(5)), and hepatic fibrosis (F0-2 and F3-4) (all P-values >0.05). In additional analysis for 480 patients who sufficiently complied with treatment doses and duration (80/80/80 rule) and propensity-score matched analysis, SVR rates were not different between two groups both in patients with HCV genotype 1 and 2/3 (all P-values >0.05). Adverse event rates were similar between two groups. CONCLUSIONS: Unlike the Western data, efficacy and safety of PEG-IFN alfa-2a were similar to those of PEG-IFN alfa-2b in chronically HCV-infected Korean patients regardless of age, HCV viral load, and hepatic fibrosis. More... »

PAGES

74-74

Journal

TITLE

BMC Gastroenterology

ISSUE

1

VOLUME

13

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1471-230x-13-74

DOI

http://dx.doi.org/10.1186/1471-230x-13-74

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022971234

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23627926


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366 grid-institutes:grid.413967.e schema:alternateName Department of Biostatistics and Clinical Epidemiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
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369 grid-institutes:grid.416665.6 schema:alternateName National Health Insurance Corporation Ilsan Hospital, Goyang, Suwon, Republic of Korea
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378 grid-institutes:grid.477505.4 schema:alternateName Hallym University Kangnam Sacred Heart Hospital, Seoul, South Korea
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381 grid-institutes:grid.488421.3 schema:alternateName Hallym University Sacred Heart Hospital, Anyang, South Korea
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384 grid-institutes:grid.49606.3d schema:alternateName Guri Hospital, Hanyang University College of Medicine, Guri, St.Vincent Hospital, The Catholic University College of Medicine, Suwon, Republic of Korea
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387 grid-institutes:grid.508282.5 schema:alternateName Department of Internal Medicine, Incheon, South Korea
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