Ontology type: schema:ScholarlyArticle Open Access: True
2013-12
AUTHORSTaira Kuroda, Teru Kumagi, Tomoyuki Yokota, Hirotaka Seike, Mari Nishiyama, Yusuke Imai, Nobu Inada, Naozumi Shibata, Satoshi Imamine, Shin-ichi Okada, Mitsuhito Koizumi, Hirofumi Yamanishi, Nobuaki Azemoto, Jiro Miyaike, Yoshinori Tanaka, Haruka Tatsukawa, Hiroki Utsunomiya, Yoshinori Ohno, Teruki Miyake, Masashi Hirooka, Shinya Furukawa, Masanori Abe, Yoshiou Ikeda, Bunzo Matsuura, Yoichi Hiasa, Morikazu Onji
ABSTRACTBACKGROUND: Although the outcomes of pancreatic cancer have been improved by gemcitabine, the changes in its characteristics and long-term outcomes within the gemcitabine era remain unclear. This study was conducted to identify clinical characteristics of pancreatic cancer patients within the gemcitabine era. METHODS: A retrospective chart review was performed at 10 centers for 1,248 consecutive patients who were ever considered to have a diagnosis of pancreatic cancer between 2001 and 2010. Data collected included demographics, diagnosis date, clinical stage, treatment, and outcome 1,082 patients met the inclusion criteria and were analyzed further. The chi-square test, Student's t-test, and Mann-Whitney U-test were used for statistical analysis. Outcomes were analyzed using the Kaplan-Meier method and Cox proportional hazards regression. Differences in survival analyses were determined using the log-rank test. RESULTS: The distribution of clinical stages was: I, 2.2% II, 3.4% III, 13% IVa, 27% and IVb, 55%. Chemotherapy alone was administered to 42% of patients and 17% underwent resection. The 1-, 3-, and 5-year survival rates were 39%, 13%, and 6.9%, respectively. The median survival time was 257 days, but differed considerably among treatments and clinical stages. Demographics, distribution of clinical stage, and cause of death did not differ between groups A (2001-2005, n=406) and B (2006-2010, n=676). However, group B included more patients who underwent chemotherapy (P<0.0001) and fewer treated with best supportive care (P=0.0004), mirroring improvements in this group's long-term outcomes (P=0.0063). Finally, factors associated with long-term outcomes derived from multivariate analysis were clinical stage (P<0.0001), location of the tumor (P=0.0294) and treatments (surgery, chemotherapy) (<0.0001). CONCLUSIONS: Long-term outcomes in pancreatic cancer has improved even within the gemcitabine era, suggesting the importance of offering chemotherapy to patients previously only considered for best supportive care. Most patients are still diagnosed at an advanced stage, making clinical strategy development for diagnosing pancreatic cancer at earlier stages essential. More... »
PAGES134
http://scigraph.springernature.com/pub.10.1186/1471-230x-13-134
DOIhttp://dx.doi.org/10.1186/1471-230x-13-134
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1046584627
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/24256464
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adenocarcinoma",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adult",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged, 80 and over",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Antimetabolites, Antineoplastic",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Chemotherapy, Adjuvant",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Deoxycytidine",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Japan",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Kaplan-Meier Estimate",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Middle Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Multivariate Analysis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Pancreatectomy",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Pancreatic Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Prognosis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Proportional Hazards Models",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Retrospective Studies",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Survival Rate",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Treatment Outcome",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Ehime University",
"id": "https://www.grid.ac/institutes/grid.255464.4",
"name": [
"Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, 791-0295, Shitsukawa, To-on, Ehime, Japan",
"the EPOCH Study Group, Japan"
],
"type": "Organization"
},
"familyName": "Kuroda",
"givenName": "Taira",
"id": "sg:person.01114106051.53",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114106051.53"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Ehime University",
"id": "https://www.grid.ac/institutes/grid.255464.4",
"name": [
"Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, 791-0295, Shitsukawa, To-on, Ehime, Japan",
"Internal Medicine, Saiseikai Imabari Hospital, 799-1592, Imabari, Ehime, Japan"
],
"type": "Organization"
},
"familyName": "Kumagi",
"givenName": "Teru",
"id": "sg:person.01066054314.49",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066054314.49"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Matsuyama Red Cross Hospital",
"id": "https://www.grid.ac/institutes/grid.416592.d",
"name": [
"Center for Liver-Biliary-Pancreatic Disease, Matsuyama Red Cross Hospital, 790-8524, Matsuyama, Ehime, Japan"
],
"type": "Organization"
},
"familyName": "Yokota",
"givenName": "Tomoyuki",
"id": "sg:person.01076555574.95",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076555574.95"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Gastroenterology, Uwajima Municipal Hospital, 798-8510, Uwajima, Ehime, Japan"
],
"type": "Organization"
},
"familyName": "Seike",
"givenName": "Hirotaka",
"type": "Person"
},
{
"affiliation": {
"name": [
"Gastroenterology, Matsuyama Municipal Hospital, 790-0067, Matsuyama, Ehime, Japan"
],
"type": "Organization"
},
"familyName": "Nishiyama",
"givenName": "Mari",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Ehime Prefectural Central Hospital",
"id": "https://www.grid.ac/institutes/grid.414413.7",
"name": [
"Gastroenterology, Ehime Prefectural Central Hospital, 790-0024, Matsuyama, Ehime, Japan"
],
"type": "Organization"
},
"familyName": "Imai",
"givenName": "Yusuke",
"id": "sg:person.0706406515.30",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706406515.30"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Saiseikai Matsuyama Hospital",
"id": "https://www.grid.ac/institutes/grid.459909.8",
"name": [
"Internal Medicine, Saiseikai Matsuyama Hospital, 791-8026, Matsuyama, Ehime, Japan"
],
"type": "Organization"
},
"familyName": "Inada",
"givenName": "Nobu",
"id": "sg:person.01270360631.84",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270360631.84"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Gastroenterology, Ehime Prefectural Niihama Hospital, 792-0042, Niihama, Ehime, Japan"
],
"type": "Organization"
},
"familyName": "Shibata",
"givenName": "Naozumi",
"type": "Person"
},
{
"affiliation": {
"name": [
"Internal Medicine, Ohzu Municipal Hospital, 795-0013, Ohzu, Ehime, Japan"
],
"type": "Organization"
},
"familyName": "Imamine",
"givenName": "Satoshi",
"type": "Person"
},
{
"affiliation": {
"name": [
"Internal Medicine, Saiseikai Saijo Hospital, 793-0027, Saijo, Ehime, Japan"
],
"type": "Organization"
},
"familyName": "Okada",
"givenName": "Shin-ichi",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Ehime University",
"id": "https://www.grid.ac/institutes/grid.255464.4",
"name": [
"Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, 791-0295, Shitsukawa, To-on, Ehime, Japan"
],
"type": "Organization"
},
"familyName": "Koizumi",
"givenName": "Mitsuhito",
"id": "sg:person.01327232574.06",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01327232574.06"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Ehime University",
"id": "https://www.grid.ac/institutes/grid.255464.4",
"name": [
"Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, 791-0295, Shitsukawa, To-on, Ehime, Japan"
],
"type": "Organization"
},
"familyName": "Yamanishi",
"givenName": "Hirofumi",
"id": "sg:person.01074670411.32",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074670411.32"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Ehime University",
"id": "https://www.grid.ac/institutes/grid.255464.4",
"name": [
"Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, 791-0295, Shitsukawa, To-on, Ehime, Japan"
],
"type": "Organization"
},
"familyName": "Azemoto",
"givenName": "Nobuaki",
"id": "sg:person.01346462503.70",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346462503.70"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Internal Medicine, Saiseikai Imabari Hospital, 799-1592, Imabari, Ehime, Japan"
],
"type": "Organization"
},
"familyName": "Miyaike",
"givenName": "Jiro",
"id": "sg:person.01331160504.57",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331160504.57"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Gastroenterology, Matsuyama Municipal Hospital, 790-0067, Matsuyama, Ehime, Japan"
],
"type": "Organization"
},
"familyName": "Tanaka",
"givenName": "Yoshinori",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Ehime Prefectural Central Hospital",
"id": "https://www.grid.ac/institutes/grid.414413.7",
"name": [
"Gastroenterology, Ehime Prefectural Central Hospital, 790-0024, Matsuyama, Ehime, Japan"
],
"type": "Organization"
},
"familyName": "Tatsukawa",
"givenName": "Haruka",
"id": "sg:person.01022635115.78",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022635115.78"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Ehime Prefectural Central Hospital",
"id": "https://www.grid.ac/institutes/grid.414413.7",
"name": [
"Gastroenterology, Ehime Prefectural Central Hospital, 790-0024, Matsuyama, Ehime, Japan"
],
"type": "Organization"
},
"familyName": "Utsunomiya",
"givenName": "Hiroki",
"id": "sg:person.01065537704.94",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065537704.94"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Matsuyama Red Cross Hospital",
"id": "https://www.grid.ac/institutes/grid.416592.d",
"name": [
"Center for Liver-Biliary-Pancreatic Disease, Matsuyama Red Cross Hospital, 790-8524, Matsuyama, Ehime, Japan"
],
"type": "Organization"
},
"familyName": "Ohno",
"givenName": "Yoshinori",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Ehime University",
"id": "https://www.grid.ac/institutes/grid.255464.4",
"name": [
"Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, 791-0295, Shitsukawa, To-on, Ehime, Japan"
],
"type": "Organization"
},
"familyName": "Miyake",
"givenName": "Teruki",
"id": "sg:person.01322775103.66",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322775103.66"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Ehime University",
"id": "https://www.grid.ac/institutes/grid.255464.4",
"name": [
"Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, 791-0295, Shitsukawa, To-on, Ehime, Japan"
],
"type": "Organization"
},
"familyName": "Hirooka",
"givenName": "Masashi",
"id": "sg:person.01264716052.47",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264716052.47"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Ehime University",
"id": "https://www.grid.ac/institutes/grid.255464.4",
"name": [
"Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, 791-0295, Shitsukawa, To-on, Ehime, Japan"
],
"type": "Organization"
},
"familyName": "Furukawa",
"givenName": "Shinya",
"id": "sg:person.0644725370.29",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644725370.29"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Ehime University",
"id": "https://www.grid.ac/institutes/grid.255464.4",
"name": [
"Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, 791-0295, Shitsukawa, To-on, Ehime, Japan"
],
"type": "Organization"
},
"familyName": "Abe",
"givenName": "Masanori",
"id": "sg:person.014763264214.31",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014763264214.31"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Ehime University Hospital",
"id": "https://www.grid.ac/institutes/grid.452478.8",
"name": [
"Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, 791-0295, Shitsukawa, To-on, Ehime, Japan",
"Endoscopy Center, Ehime University Hospital, 791-0295, Ehime, Ehime, Japan"
],
"type": "Organization"
},
"familyName": "Ikeda",
"givenName": "Yoshiou",
"id": "sg:person.013054256427.30",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013054256427.30"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Ehime University",
"id": "https://www.grid.ac/institutes/grid.255464.4",
"name": [
"Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, 791-0295, Shitsukawa, To-on, Ehime, Japan"
],
"type": "Organization"
},
"familyName": "Matsuura",
"givenName": "Bunzo",
"id": "sg:person.0607425152.67",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607425152.67"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Ehime University",
"id": "https://www.grid.ac/institutes/grid.255464.4",
"name": [
"Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, 791-0295, Shitsukawa, To-on, Ehime, Japan"
],
"type": "Organization"
},
"familyName": "Hiasa",
"givenName": "Yoichi",
"id": "sg:person.01333031252.69",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333031252.69"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Ehime University",
"id": "https://www.grid.ac/institutes/grid.255464.4",
"name": [
"Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, 791-0295, Shitsukawa, To-on, Ehime, Japan"
],
"type": "Organization"
},
"familyName": "Onji",
"givenName": "Morikazu",
"id": "sg:person.0723653552.71",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723653552.71"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1038/nrgastro.2009.177",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005232580",
"https://doi.org/10.1038/nrgastro.2009.177"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrgastro.2009.177",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005232580",
"https://doi.org/10.1038/nrgastro.2009.177"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2958/suizo.22.e1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007323251"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00595-007-3745-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010670926",
"https://doi.org/10.1007/s00595-007-3745-8"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00595-007-3745-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010670926",
"https://doi.org/10.1007/s00595-007-3745-8"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s11864-002-0045-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012985433",
"https://doi.org/10.1007/s11864-002-0045-9"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-09-4227",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018425043"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0039-6060(97)90264-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019038679"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/mpa.0b013e318258055c",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028870348"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/mpa.0b013e318258055c",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028870348"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.surg.2004.04.030",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036543344"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1373/clinchem.2008.109603",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046765518"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.5833/jjgs.29.2043",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049112646"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00535-010-0258-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051322279",
"https://doi.org/10.1007/s00535-010-0258-9"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00535-010-0258-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051322279",
"https://doi.org/10.1007/s00535-010-0258-9"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1074610834",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1076887663",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.1997.15.6.2338",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1083106807"
],
"type": "CreativeWork"
}
],
"datePublished": "2013-12",
"datePublishedReg": "2013-12-01",
"description": "BACKGROUND: Although the outcomes of pancreatic cancer have been improved by gemcitabine, the changes in its characteristics and long-term outcomes within the gemcitabine era remain unclear. This study was conducted to identify clinical characteristics of pancreatic cancer patients within the gemcitabine era.\nMETHODS: A retrospective chart review was performed at 10 centers for 1,248 consecutive patients who were ever considered to have a diagnosis of pancreatic cancer between 2001 and 2010. Data collected included demographics, diagnosis date, clinical stage, treatment, and outcome 1,082 patients met the inclusion criteria and were analyzed further. The chi-square test, Student's t-test, and Mann-Whitney U-test were used for statistical analysis. Outcomes were analyzed using the Kaplan-Meier method and Cox proportional hazards regression. Differences in survival analyses were determined using the log-rank test.\nRESULTS: The distribution of clinical stages was: I, 2.2% II, 3.4% III, 13% IVa, 27% and IVb, 55%. Chemotherapy alone was administered to 42% of patients and 17% underwent resection. The 1-, 3-, and 5-year survival rates were 39%, 13%, and 6.9%, respectively. The median survival time was 257 days, but differed considerably among treatments and clinical stages. Demographics, distribution of clinical stage, and cause of death did not differ between groups A (2001-2005, n=406) and B (2006-2010, n=676). However, group B included more patients who underwent chemotherapy (P<0.0001) and fewer treated with best supportive care (P=0.0004), mirroring improvements in this group's long-term outcomes (P=0.0063). Finally, factors associated with long-term outcomes derived from multivariate analysis were clinical stage (P<0.0001), location of the tumor (P=0.0294) and treatments (surgery, chemotherapy) (<0.0001).\nCONCLUSIONS: Long-term outcomes in pancreatic cancer has improved even within the gemcitabine era, suggesting the importance of offering chemotherapy to patients previously only considered for best supportive care. Most patients are still diagnosed at an advanced stage, making clinical strategy development for diagnosing pancreatic cancer at earlier stages essential.",
"genre": "research_article",
"id": "sg:pub.10.1186/1471-230x-13-134",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isFundedItemOf": [
{
"id": "sg:grant.6068567",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1024942",
"issn": [
"1471-230X"
],
"name": "BMC Gastroenterology",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "13"
}
],
"name": "Improvement of long-term outcomes in pancreatic cancer and its associated factors within the gemcitabine era: a collaborative retrospective multicenter clinical review of 1,082 patients",
"pagination": "134",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"dde921271e756ab562a1862d9bacb1b7211bffc869d41b1a5db6cf4c406f0ce4"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"24256464"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"100968547"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1186/1471-230x-13-134"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1046584627"
]
}
],
"sameAs": [
"https://doi.org/10.1186/1471-230x-13-134",
"https://app.dimensions.ai/details/publication/pub.1046584627"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T01:06",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000507.jsonl",
"type": "ScholarlyArticle",
"url": "http://link.springer.com/10.1186%2F1471-230X-13-134"
}
]
Download the RDF metadata as:Â json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1471-230x-13-134'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1471-230x-13-134'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1471-230x-13-134'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1471-230x-13-134'
This table displays all metadata directly associated to this object as RDF triples.
395 TRIPLES
21 PREDICATES
64 URIs
42 LITERALS
30 BLANK NODES