Efficacy of omeprazole, famotidine, mosapride and teprenone in patients with upper gastrointestinal symptoms: an omeprazole-controlled randomized study (J-FOCUS) View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-12

AUTHORS

Kouichi Sakurai, Akihito Nagahara, Kazuhiko Inoue, Junichi Akiyama, Katsuhiro Mabe, Junichi Suzuki, Yasuki Habu, Akihiro Araki, Tsuyoshi Suzuki, Katsuaki Satoh, Haruhiko Nagami, Ryosaku Harada, Nobuo Tano, Masayasu Kusaka, Yasuhiko Fujioka, Toshikatsu Fujimura, Nobuyuki Shigeto, Tsuneyo Oumi, Jun Miwa, Hiroto Miwa, Kazuma Fujimoto, Yoshikazu Kinoshita, Ken Haruma

ABSTRACT

BACKGROUND: In Japan, treatment guidelines are lacking for patients with upper gastrointestinal symptoms. We aimed to compare the efficacy of different drugs for the treatment of uninvestigated upper gastrointestinal symptoms. METHODS: This was a randomized, open-label, parallel-group multicenter study. Helicobacter pylori-negative, endoscopically uninvestigated patients ≥ 20 years of age with upper gastrointestinal symptoms of at least moderate severity (Global Overall Symptom score [GOS] ≥ 4 on a 7-point Likert scale) were randomized to treatment with omeprazole (10 mg once daily), famotidine (10 mg twice daily), mosapride (5 mg three times daily) or teprenone (50 mg three times daily). The primary endpoint was sufficient relief of upper gastrointestinal symptoms after 4 weeks of treatment (GOS ≤ 2). UMIN clinical trial registration number: UMIN000005399. RESULTS: Of 471 randomized patients, 454 were included in the full analysis set. After 4 weeks of treatment, sufficient symptom relief was achieved by 66.9% of patients in the omeprazole group, compared with 41.0%, 36.3% and 32.3% in the famotidine, mosapride and teprenone groups, respectively (all, p < 0.001 vs omeprazole). There were no treatment-related adverse events. CONCLUSIONS: The favorable efficacy and safety profiles of omeprazole in relieving uninvestigated upper gastrointestinal symptoms support its use as first-line treatment in this patient group in Japan. Patients who show no improvement in symptoms despite PPI use, and those with alarm symptoms (such as vomiting, GI bleeding or acute weight loss) should receive further investigation, including prompt referral for endoscopy. TRIAL REGISTRATION: UMIN000005399. More... »

PAGES

42

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1471-230x-12-42

DOI

http://dx.doi.org/10.1186/1471-230x-12-42

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1009108058

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22548767


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Algorithms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Benzamides", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diterpenes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dose-Response Relationship, Drug", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dyspepsia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Famotidine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gastroesophageal Reflux", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Guideline Adherence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Japan", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Morpholines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Omeprazole", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proton Pump Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Upper Gastrointestinal Tract", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Kumamoto University", 
          "id": "https://www.grid.ac/institutes/grid.274841.c", 
          "name": [
            "Department of Gastroenterology and Hepatology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, 860-8556, Kumamoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sakurai", 
        "givenName": "Kouichi", 
        "id": "sg:person.01305372746.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305372746.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Juntendo University", 
          "id": "https://www.grid.ac/institutes/grid.258269.2", 
          "name": [
            "Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nagahara", 
        "givenName": "Akihito", 
        "id": "sg:person.01205010513.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205010513.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kawasaki Medical School", 
          "id": "https://www.grid.ac/institutes/grid.415086.e", 
          "name": [
            "Internal Medicine, Matsue Red Cross Hospital, Matsue, Japan", 
            "Department of General Medicine, Kawasaki Medical School, Kurashiki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Inoue", 
        "givenName": "Kazuhiko", 
        "id": "sg:person.0626373475.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626373475.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Gastroenterology, International Medical Centre, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Akiyama", 
        "givenName": "Junichi", 
        "id": "sg:person.01052606132.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052606132.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hokkaido University", 
          "id": "https://www.grid.ac/institutes/grid.39158.36", 
          "name": [
            "Department of Internal Medicine, Yamagata Prefectural Central Hospital, Yamagata, Japan", 
            "Department of Gastroenterology, Hokkaido University, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mabe", 
        "givenName": "Katsuhiro", 
        "id": "sg:person.01141341200.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141341200.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Gastroenterology, KKR Sapporo Medical Center, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Suzuki", 
        "givenName": "Junichi", 
        "id": "sg:person.0612036127.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612036127.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Gastroenterology, Saiseikai Noe Hospital, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Habu", 
        "givenName": "Yasuki", 
        "id": "sg:person.01061765643.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061765643.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokyo Medical and Dental University", 
          "id": "https://www.grid.ac/institutes/grid.265073.5", 
          "name": [
            "Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Araki", 
        "givenName": "Akihiro", 
        "id": "sg:person.01231644665.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231644665.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokyo Metropolitan Police Hospital", 
          "id": "https://www.grid.ac/institutes/grid.417117.5", 
          "name": [
            "Department of Gastroenterology, Tokyo Metropolitan Police Hospital, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Suzuki", 
        "givenName": "Tsuyoshi", 
        "id": "sg:person.0774377727.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774377727.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Satoh Gastrointestinal Surgical Hospital, Kurashiki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Satoh", 
        "givenName": "Katsuaki", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Nagami Clinic, Unnan, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nagami", 
        "givenName": "Haruhiko", 
        "id": "sg:person.01277604147.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277604147.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Gastrointestinal Division, Harada Internal Medicine, Tosu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Harada", 
        "givenName": "Ryosaku", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Internal Medicine, Kyoritsu Hospital, Kawanishi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tano", 
        "givenName": "Nobuo", 
        "id": "sg:person.01225054727.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225054727.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Kusaka Hospital, Bizen, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kusaka", 
        "givenName": "Masayasu", 
        "id": "sg:person.0653567450.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653567450.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Fujioka Hospital, Saga, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fujioka", 
        "givenName": "Yasuhiko", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Yamaguchi Hospital, Imari, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fujimura", 
        "givenName": "Toshikatsu", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Internal Medicine, Tamano City Hospital, Tamano, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shigeto", 
        "givenName": "Nobuyuki", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Ooumi Clinic, Tsuyama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oumi", 
        "givenName": "Tsuneyo", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Toshiba General Hospital", 
          "id": "https://www.grid.ac/institutes/grid.417200.0", 
          "name": [
            "Department of Internal Medicine, Toshiba Hospital, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miwa", 
        "givenName": "Jun", 
        "id": "sg:person.0633561662.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0633561662.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hyogo College of Medicine", 
          "id": "https://www.grid.ac/institutes/grid.272264.7", 
          "name": [
            "Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miwa", 
        "givenName": "Hiroto", 
        "id": "sg:person.0611747536.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611747536.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Saga University", 
          "id": "https://www.grid.ac/institutes/grid.412339.e", 
          "name": [
            "Department of Internal Medicine, Gastrointestinal Endoscopy, Saga Medical School, Saga, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fujimoto", 
        "givenName": "Kazuma", 
        "id": "sg:person.01061721336.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061721336.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Shimane University", 
          "id": "https://www.grid.ac/institutes/grid.411621.1", 
          "name": [
            "Department of Gastroenterology and Hepatology, Shimane University School of Medicine, Izumo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kinoshita", 
        "givenName": "Yoshikazu", 
        "id": "sg:person.01126567733.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126567733.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kawasaki Medical School", 
          "id": "https://www.grid.ac/institutes/grid.415086.e", 
          "name": [
            "Division of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School, Kurashiki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Haruma", 
        "givenName": "Ken", 
        "id": "sg:person.01145465265.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145465265.82"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1111/j.1572-0241.2005.00225.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000091526", 
          "https://doi.org/10.1111/j.1572-0241.2005.00225.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/j.1572-0241.2005.00225.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000091526", 
          "https://doi.org/10.1111/j.1572-0241.2005.00225.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1440-1746.1995.tb01362.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003318592"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2036.2007.03367.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004264049"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2036.2007.03367.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004264049"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00535-009-0095-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005257876", 
          "https://doi.org/10.1007/s00535-009-0095-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00535-009-0095-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005257876", 
          "https://doi.org/10.1007/s00535-009-0095-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00535-009-0095-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005257876", 
          "https://doi.org/10.1007/s00535-009-0095-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000167862", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005707072"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/003655299750025264", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007163434"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/j.1572-0241.2002.05421.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008796062", 
          "https://doi.org/10.1111/j.1572-0241.2002.05421.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/j.1572-0241.2005.40280.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008956874", 
          "https://doi.org/10.1111/j.1572-0241.2005.40280.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/j.1572-0241.2004.30822.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011118686", 
          "https://doi.org/10.1111/j.1572-0241.2004.30822.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/gast.2001.27180", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012549424"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2005.11.059", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013146576"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2011/940650", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014751294"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.50.suppl_4.iv72", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014851373"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000121351", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018932294"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3164/jcbn.39.46", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019666299"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/j.1572-0241.2005.41217.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020343522", 
          "https://doi.org/10.1111/j.1572-0241.2005.41217.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/gast.2002.36556", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021131824"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.318.7187.833", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026896783"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00535-006-1990-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029113764", 
          "https://doi.org/10.1007/s00535-006-1990-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00535-006-1990-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029113764", 
          "https://doi.org/10.1007/s00535-006-1990-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2036.2003.01646.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031665855"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00535-009-0003-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037783704", 
          "https://doi.org/10.1007/s00535-009-0003-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00535-009-0003-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037783704", 
          "https://doi.org/10.1007/s00535-009-0003-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00535-009-0003-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037783704", 
          "https://doi.org/10.1007/s00535-009-0003-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199812243392602", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042845761"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cgh.2005.10.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043602081"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/003655299750025237", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045692406"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcla.1019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047228882"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/j.1572-0241.2006.00630.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048337809", 
          "https://doi.org/10.1111/j.1572-0241.2006.00630.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpgi.00086.2003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051141199"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/11024159850191355", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058381278"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.a1400", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062799556"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.a1400", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062799556"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpgi.00242.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063192905"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075127201", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-12", 
    "datePublishedReg": "2012-12-01", 
    "description": "BACKGROUND: In Japan, treatment guidelines are lacking for patients with upper gastrointestinal symptoms. We aimed to compare the efficacy of different drugs for the treatment of uninvestigated upper gastrointestinal symptoms.\nMETHODS: This was a randomized, open-label, parallel-group multicenter study. Helicobacter pylori-negative, endoscopically uninvestigated patients \u2265 20 years of age with upper gastrointestinal symptoms of at least moderate severity (Global Overall Symptom score [GOS] \u2265 4 on a 7-point Likert scale) were randomized to treatment with omeprazole (10 mg once daily), famotidine (10 mg twice daily), mosapride (5 mg three times daily) or teprenone (50 mg three times daily). The primary endpoint was sufficient relief of upper gastrointestinal symptoms after 4 weeks of treatment (GOS \u2264 2). UMIN clinical trial registration number: UMIN000005399.\nRESULTS: Of 471 randomized patients, 454 were included in the full analysis set. After 4 weeks of treatment, sufficient symptom relief was achieved by 66.9% of patients in the omeprazole group, compared with 41.0%, 36.3% and 32.3% in the famotidine, mosapride and teprenone groups, respectively (all, p < 0.001 vs omeprazole). There were no treatment-related adverse events.\nCONCLUSIONS: The favorable efficacy and safety profiles of omeprazole in relieving uninvestigated upper gastrointestinal symptoms support its use as first-line treatment in this patient group in Japan. Patients who show no improvement in symptoms despite PPI use, and those with alarm symptoms (such as vomiting, GI bleeding or acute weight loss) should receive further investigation, including prompt referral for endoscopy.\nTRIAL REGISTRATION: UMIN000005399.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/1471-230x-12-42", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.6044446", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1024942", 
        "issn": [
          "1471-230X"
        ], 
        "name": "BMC Gastroenterology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "12"
      }
    ], 
    "name": "Efficacy of omeprazole, famotidine, mosapride and teprenone in patients with upper gastrointestinal symptoms: an omeprazole-controlled randomized study (J-FOCUS)", 
    "pagination": "42", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "2b645fad9d41e77c23883a6020e692eaf7a2369e91d9cff4732f0394575a8004"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "22548767"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100968547"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1471-230x-12-42"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1009108058"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1471-230x-12-42", 
      "https://app.dimensions.ai/details/publication/pub.1009108058"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T22:29", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8690_00000503.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2F1471-230X-12-42"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1471-230x-12-42'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1471-230x-12-42'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1471-230x-12-42'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1471-230x-12-42'


 

This table displays all metadata directly associated to this object as RDF triples.

433 TRIPLES      21 PREDICATES      75 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1471-230x-12-42 schema:about N107782dae4434eee88b48670c77e41d7
2 N1f11d7cda7f94400b3f7138be95ccb8b
3 N22d65a9472ad4964a5b43e50b476423a
4 N65dddadf4a924f0eb6a8e0275dbb465c
5 N6e8a61cbda424eee934d9518ea957708
6 N7d9853247dbb4fdd873ee6a4f796dc7b
7 Na8a39cc358d14275a47ac3ccea6f95fb
8 Nb886d00925204d1ea05aaf13ffa555ea
9 Nb8b40ccf8cd6442d8c7e1005ee0dc591
10 Nbb834457bdee438ca58458f9064b9fe6
11 Nbccaa28d91f94be2b97a8b12d25cb326
12 Ncf69f28f308e42ed9fa7c483ebeae273
13 Nd634bef44aed47ee8d52414d2d3f3cc4
14 Ndc93017430fd42e8b31fbf4c5706f71f
15 Ndeb947b076f74207ad9dc992557b1131
16 anzsrc-for:11
17 anzsrc-for:1103
18 schema:author N5a2a235664e04b8180dfcc8ca9df73d5
19 schema:citation sg:pub.10.1007/s00535-006-1990-z
20 sg:pub.10.1007/s00535-009-0003-4
21 sg:pub.10.1007/s00535-009-0095-x
22 sg:pub.10.1111/j.1572-0241.2002.05421.x
23 sg:pub.10.1111/j.1572-0241.2004.30822.x
24 sg:pub.10.1111/j.1572-0241.2005.00225.x
25 sg:pub.10.1111/j.1572-0241.2005.40280.x
26 sg:pub.10.1111/j.1572-0241.2005.41217.x
27 sg:pub.10.1111/j.1572-0241.2006.00630.x
28 https://app.dimensions.ai/details/publication/pub.1075127201
29 https://doi.org/10.1002/jcla.1019
30 https://doi.org/10.1016/j.cgh.2005.10.011
31 https://doi.org/10.1046/j.1365-2036.2003.01646.x
32 https://doi.org/10.1053/gast.2001.27180
33 https://doi.org/10.1053/gast.2002.36556
34 https://doi.org/10.1053/j.gastro.2005.11.059
35 https://doi.org/10.1056/nejm199812243392602
36 https://doi.org/10.1080/003655299750025237
37 https://doi.org/10.1080/003655299750025264
38 https://doi.org/10.1080/11024159850191355
39 https://doi.org/10.1111/j.1365-2036.2007.03367.x
40 https://doi.org/10.1111/j.1440-1746.1995.tb01362.x
41 https://doi.org/10.1136/bmj.318.7187.833
42 https://doi.org/10.1136/bmj.a1400
43 https://doi.org/10.1136/gut.50.suppl_4.iv72
44 https://doi.org/10.1152/ajpgi.00086.2003
45 https://doi.org/10.1152/ajpgi.00242.2002
46 https://doi.org/10.1155/2011/940650
47 https://doi.org/10.1159/000121351
48 https://doi.org/10.1159/000167862
49 https://doi.org/10.3164/jcbn.39.46
50 schema:datePublished 2012-12
51 schema:datePublishedReg 2012-12-01
52 schema:description BACKGROUND: In Japan, treatment guidelines are lacking for patients with upper gastrointestinal symptoms. We aimed to compare the efficacy of different drugs for the treatment of uninvestigated upper gastrointestinal symptoms. METHODS: This was a randomized, open-label, parallel-group multicenter study. Helicobacter pylori-negative, endoscopically uninvestigated patients ≥ 20 years of age with upper gastrointestinal symptoms of at least moderate severity (Global Overall Symptom score [GOS] ≥ 4 on a 7-point Likert scale) were randomized to treatment with omeprazole (10 mg once daily), famotidine (10 mg twice daily), mosapride (5 mg three times daily) or teprenone (50 mg three times daily). The primary endpoint was sufficient relief of upper gastrointestinal symptoms after 4 weeks of treatment (GOS ≤ 2). UMIN clinical trial registration number: UMIN000005399. RESULTS: Of 471 randomized patients, 454 were included in the full analysis set. After 4 weeks of treatment, sufficient symptom relief was achieved by 66.9% of patients in the omeprazole group, compared with 41.0%, 36.3% and 32.3% in the famotidine, mosapride and teprenone groups, respectively (all, p < 0.001 vs omeprazole). There were no treatment-related adverse events. CONCLUSIONS: The favorable efficacy and safety profiles of omeprazole in relieving uninvestigated upper gastrointestinal symptoms support its use as first-line treatment in this patient group in Japan. Patients who show no improvement in symptoms despite PPI use, and those with alarm symptoms (such as vomiting, GI bleeding or acute weight loss) should receive further investigation, including prompt referral for endoscopy. TRIAL REGISTRATION: UMIN000005399.
53 schema:genre research_article
54 schema:inLanguage en
55 schema:isAccessibleForFree true
56 schema:isPartOf N0e41069142cc4dd1a8f2ba5f6ae01290
57 N19ebee5fd76f4fd4948d78f6e22b3766
58 sg:journal.1024942
59 schema:name Efficacy of omeprazole, famotidine, mosapride and teprenone in patients with upper gastrointestinal symptoms: an omeprazole-controlled randomized study (J-FOCUS)
60 schema:pagination 42
61 schema:productId N48fd2249fca846038845c4854fbd3248
62 N4df1ef7f7bd64873949fd4c79b212e0c
63 N5bb4a30309834ed8a2f046e49d3d8269
64 Nb905bb43885a4efeaa2ca13d19679565
65 Nd9a5c8d0e57644518acbf4d8f7942631
66 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009108058
67 https://doi.org/10.1186/1471-230x-12-42
68 schema:sdDatePublished 2019-04-10T22:29
69 schema:sdLicense https://scigraph.springernature.com/explorer/license/
70 schema:sdPublisher N82eb77de1253483a8ed9237f25c2fc60
71 schema:url http://link.springer.com/10.1186%2F1471-230X-12-42
72 sgo:license sg:explorer/license/
73 sgo:sdDataset articles
74 rdf:type schema:ScholarlyArticle
75 N01fe8fe9ad9841ad89319fb17806dcf2 schema:name Department of Gastroenterology, International Medical Centre, Tokyo, Japan
76 rdf:type schema:Organization
77 N0a517227fb4446358b65434924cabc68 rdf:first sg:person.01126567733.70
78 rdf:rest N3a64295d95a84157aced051e8a0af273
79 N0e41069142cc4dd1a8f2ba5f6ae01290 schema:issueNumber 1
80 rdf:type schema:PublicationIssue
81 N107782dae4434eee88b48670c77e41d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Humans
83 rdf:type schema:DefinedTerm
84 N1662f492d44e4392afa6e1eb51f4c53e schema:name Yamaguchi Hospital, Imari, Japan
85 rdf:type schema:Organization
86 N187a8226b0b84ef4a3612a417b4ff3dc schema:name Satoh Gastrointestinal Surgical Hospital, Kurashiki, Japan
87 rdf:type schema:Organization
88 N19ebee5fd76f4fd4948d78f6e22b3766 schema:volumeNumber 12
89 rdf:type schema:PublicationVolume
90 N1abee8f4622843f2a1d97d1dc3ca8e0f schema:affiliation Nb0548dcf88544a4f91eeab65d8fdb694
91 schema:familyName Harada
92 schema:givenName Ryosaku
93 rdf:type schema:Person
94 N1f11d7cda7f94400b3f7138be95ccb8b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Algorithms
96 rdf:type schema:DefinedTerm
97 N22d65a9472ad4964a5b43e50b476423a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Upper Gastrointestinal Tract
99 rdf:type schema:DefinedTerm
100 N268b78e153904a4d8aadceed85ab571f rdf:first sg:person.01231644665.28
101 rdf:rest N89d88bb581c9466facd130624d77f9c2
102 N36be6c59ce2b4c5c91e4122b389226e2 rdf:first sg:person.0653567450.43
103 rdf:rest N78e35610a0b24c0d9d7185994b394203
104 N38560d97f0124aca8be96f7876cb9d5e schema:name Department of Internal Medicine, Kyoritsu Hospital, Kawanishi, Japan
105 rdf:type schema:Organization
106 N38a4ec87affb4eaabe8278c96b0394a5 schema:name Nagami Clinic, Unnan, Japan
107 rdf:type schema:Organization
108 N3a64295d95a84157aced051e8a0af273 rdf:first sg:person.01145465265.82
109 rdf:rest rdf:nil
110 N3d810b92f6924b02b2624a9729c93e22 rdf:first Naffe212762a74f5394214908c9fc1858
111 rdf:rest Naaca65e1c33949fd9fa2a1f26d33c4b9
112 N40370898ec07435e999eedc4b68fc81f rdf:first sg:person.01205010513.10
113 rdf:rest Nca1062c7439e4f8497fc57c69cdaa0c3
114 N4600b5b27b454bc985d194c9a8923e03 rdf:first sg:person.01225054727.86
115 rdf:rest N36be6c59ce2b4c5c91e4122b389226e2
116 N48fd2249fca846038845c4854fbd3248 schema:name doi
117 schema:value 10.1186/1471-230x-12-42
118 rdf:type schema:PropertyValue
119 N4df1ef7f7bd64873949fd4c79b212e0c schema:name dimensions_id
120 schema:value pub.1009108058
121 rdf:type schema:PropertyValue
122 N4eec62134a8c49aa8a87cbc011ab25fb schema:name Kusaka Hospital, Bizen, Japan
123 rdf:type schema:Organization
124 N59d6c49666a9479689d25b04376c25ed rdf:first N1abee8f4622843f2a1d97d1dc3ca8e0f
125 rdf:rest N4600b5b27b454bc985d194c9a8923e03
126 N5a2a235664e04b8180dfcc8ca9df73d5 rdf:first sg:person.01305372746.81
127 rdf:rest N40370898ec07435e999eedc4b68fc81f
128 N5bb4a30309834ed8a2f046e49d3d8269 schema:name readcube_id
129 schema:value 2b645fad9d41e77c23883a6020e692eaf7a2369e91d9cff4732f0394575a8004
130 rdf:type schema:PropertyValue
131 N5f361cfaa70b4eb8a5f139824674a4fb schema:affiliation Nb29855543f8445678b30ecbcf596f2cc
132 schema:familyName Oumi
133 schema:givenName Tsuneyo
134 rdf:type schema:Person
135 N610c7d392a09477e9bc13a68450e6195 rdf:first sg:person.0611747536.16
136 rdf:rest Nb62955b0dc5f4299be7c3eb39bc2439e
137 N65dddadf4a924f0eb6a8e0275dbb465c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Treatment Outcome
139 rdf:type schema:DefinedTerm
140 N66baa8262cfc48188142666a481f7450 schema:affiliation Nc840b17ce6b44976adcf40809c14509d
141 schema:familyName Fujioka
142 schema:givenName Yasuhiko
143 rdf:type schema:Person
144 N6e8a61cbda424eee934d9518ea957708 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Famotidine
146 rdf:type schema:DefinedTerm
147 N7253b1c90ad04552a5b2b636e99baf37 rdf:first sg:person.01052606132.14
148 rdf:rest N9af1f847d60b4f45b84ba79e741af9c8
149 N78e35610a0b24c0d9d7185994b394203 rdf:first N66baa8262cfc48188142666a481f7450
150 rdf:rest Nd08037a6900f414eb613767b98ae528c
151 N7d9853247dbb4fdd873ee6a4f796dc7b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Omeprazole
153 rdf:type schema:DefinedTerm
154 N7f615a454d044fb88cafdead1ac095d8 schema:affiliation Nf807fa9eb24f43c4856e3478f3f0b143
155 schema:familyName Shigeto
156 schema:givenName Nobuyuki
157 rdf:type schema:Person
158 N82eb77de1253483a8ed9237f25c2fc60 schema:name Springer Nature - SN SciGraph project
159 rdf:type schema:Organization
160 N89d88bb581c9466facd130624d77f9c2 rdf:first sg:person.0774377727.52
161 rdf:rest N3d810b92f6924b02b2624a9729c93e22
162 N9a0abd50028f41daa8cd84930cfa76d3 rdf:first N5f361cfaa70b4eb8a5f139824674a4fb
163 rdf:rest Nb0cd3a693115487b82eb264497325651
164 N9a92bc182a9745fdb5dcb65aceff488c rdf:first sg:person.01061765643.11
165 rdf:rest N268b78e153904a4d8aadceed85ab571f
166 N9af1f847d60b4f45b84ba79e741af9c8 rdf:first sg:person.01141341200.31
167 rdf:rest Naf3c3d347554430da81578c25c420d99
168 Na0e9a16aa62b4e6094b92b912329e112 schema:affiliation N1662f492d44e4392afa6e1eb51f4c53e
169 schema:familyName Fujimura
170 schema:givenName Toshikatsu
171 rdf:type schema:Person
172 Na8a39cc358d14275a47ac3ccea6f95fb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Diterpenes
174 rdf:type schema:DefinedTerm
175 Naaca65e1c33949fd9fa2a1f26d33c4b9 rdf:first sg:person.01277604147.21
176 rdf:rest N59d6c49666a9479689d25b04376c25ed
177 Naf3c3d347554430da81578c25c420d99 rdf:first sg:person.0612036127.14
178 rdf:rest N9a92bc182a9745fdb5dcb65aceff488c
179 Naffe212762a74f5394214908c9fc1858 schema:affiliation N187a8226b0b84ef4a3612a417b4ff3dc
180 schema:familyName Satoh
181 schema:givenName Katsuaki
182 rdf:type schema:Person
183 Nb0548dcf88544a4f91eeab65d8fdb694 schema:name Gastrointestinal Division, Harada Internal Medicine, Tosu, Japan
184 rdf:type schema:Organization
185 Nb0cd3a693115487b82eb264497325651 rdf:first sg:person.0633561662.26
186 rdf:rest N610c7d392a09477e9bc13a68450e6195
187 Nb29855543f8445678b30ecbcf596f2cc schema:name Ooumi Clinic, Tsuyama, Japan
188 rdf:type schema:Organization
189 Nb62955b0dc5f4299be7c3eb39bc2439e rdf:first sg:person.01061721336.92
190 rdf:rest N0a517227fb4446358b65434924cabc68
191 Nb886d00925204d1ea05aaf13ffa555ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Morpholines
193 rdf:type schema:DefinedTerm
194 Nb8b40ccf8cd6442d8c7e1005ee0dc591 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Proton Pump Inhibitors
196 rdf:type schema:DefinedTerm
197 Nb905bb43885a4efeaa2ca13d19679565 schema:name pubmed_id
198 schema:value 22548767
199 rdf:type schema:PropertyValue
200 Nbb834457bdee438ca58458f9064b9fe6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
201 schema:name Japan
202 rdf:type schema:DefinedTerm
203 Nbccaa28d91f94be2b97a8b12d25cb326 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
204 schema:name Guideline Adherence
205 rdf:type schema:DefinedTerm
206 Nc5b127aa8cbe458c8536d86360eaffb1 rdf:first N7f615a454d044fb88cafdead1ac095d8
207 rdf:rest N9a0abd50028f41daa8cd84930cfa76d3
208 Nc840b17ce6b44976adcf40809c14509d schema:name Fujioka Hospital, Saga, Japan
209 rdf:type schema:Organization
210 Nca1062c7439e4f8497fc57c69cdaa0c3 rdf:first sg:person.0626373475.84
211 rdf:rest N7253b1c90ad04552a5b2b636e99baf37
212 Ncf69f28f308e42ed9fa7c483ebeae273 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
213 schema:name Dose-Response Relationship, Drug
214 rdf:type schema:DefinedTerm
215 Nd08037a6900f414eb613767b98ae528c rdf:first Na0e9a16aa62b4e6094b92b912329e112
216 rdf:rest Nc5b127aa8cbe458c8536d86360eaffb1
217 Nd5f412ec4c164590bd0ffd83fa1e2c97 schema:name Department of Gastroenterology, KKR Sapporo Medical Center, Sapporo, Japan
218 rdf:type schema:Organization
219 Nd634bef44aed47ee8d52414d2d3f3cc4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
220 schema:name Benzamides
221 rdf:type schema:DefinedTerm
222 Nd9a5c8d0e57644518acbf4d8f7942631 schema:name nlm_unique_id
223 schema:value 100968547
224 rdf:type schema:PropertyValue
225 Ndc93017430fd42e8b31fbf4c5706f71f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
226 schema:name Gastroesophageal Reflux
227 rdf:type schema:DefinedTerm
228 Ndd2b4482b3584ac1af1d7db1ff67c02e schema:name Department of Gastroenterology, Saiseikai Noe Hospital, Osaka, Japan
229 rdf:type schema:Organization
230 Ndeb947b076f74207ad9dc992557b1131 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
231 schema:name Dyspepsia
232 rdf:type schema:DefinedTerm
233 Nf807fa9eb24f43c4856e3478f3f0b143 schema:name Department of Internal Medicine, Tamano City Hospital, Tamano, Japan
234 rdf:type schema:Organization
235 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
236 schema:name Medical and Health Sciences
237 rdf:type schema:DefinedTerm
238 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
239 schema:name Clinical Sciences
240 rdf:type schema:DefinedTerm
241 sg:grant.6044446 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-230x-12-42
242 rdf:type schema:MonetaryGrant
243 sg:journal.1024942 schema:issn 1471-230X
244 schema:name BMC Gastroenterology
245 rdf:type schema:Periodical
246 sg:person.01052606132.14 schema:affiliation N01fe8fe9ad9841ad89319fb17806dcf2
247 schema:familyName Akiyama
248 schema:givenName Junichi
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052606132.14
250 rdf:type schema:Person
251 sg:person.01061721336.92 schema:affiliation https://www.grid.ac/institutes/grid.412339.e
252 schema:familyName Fujimoto
253 schema:givenName Kazuma
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061721336.92
255 rdf:type schema:Person
256 sg:person.01061765643.11 schema:affiliation Ndd2b4482b3584ac1af1d7db1ff67c02e
257 schema:familyName Habu
258 schema:givenName Yasuki
259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061765643.11
260 rdf:type schema:Person
261 sg:person.01126567733.70 schema:affiliation https://www.grid.ac/institutes/grid.411621.1
262 schema:familyName Kinoshita
263 schema:givenName Yoshikazu
264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126567733.70
265 rdf:type schema:Person
266 sg:person.01141341200.31 schema:affiliation https://www.grid.ac/institutes/grid.39158.36
267 schema:familyName Mabe
268 schema:givenName Katsuhiro
269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141341200.31
270 rdf:type schema:Person
271 sg:person.01145465265.82 schema:affiliation https://www.grid.ac/institutes/grid.415086.e
272 schema:familyName Haruma
273 schema:givenName Ken
274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145465265.82
275 rdf:type schema:Person
276 sg:person.01205010513.10 schema:affiliation https://www.grid.ac/institutes/grid.258269.2
277 schema:familyName Nagahara
278 schema:givenName Akihito
279 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205010513.10
280 rdf:type schema:Person
281 sg:person.01225054727.86 schema:affiliation N38560d97f0124aca8be96f7876cb9d5e
282 schema:familyName Tano
283 schema:givenName Nobuo
284 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225054727.86
285 rdf:type schema:Person
286 sg:person.01231644665.28 schema:affiliation https://www.grid.ac/institutes/grid.265073.5
287 schema:familyName Araki
288 schema:givenName Akihiro
289 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231644665.28
290 rdf:type schema:Person
291 sg:person.01277604147.21 schema:affiliation N38a4ec87affb4eaabe8278c96b0394a5
292 schema:familyName Nagami
293 schema:givenName Haruhiko
294 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277604147.21
295 rdf:type schema:Person
296 sg:person.01305372746.81 schema:affiliation https://www.grid.ac/institutes/grid.274841.c
297 schema:familyName Sakurai
298 schema:givenName Kouichi
299 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305372746.81
300 rdf:type schema:Person
301 sg:person.0611747536.16 schema:affiliation https://www.grid.ac/institutes/grid.272264.7
302 schema:familyName Miwa
303 schema:givenName Hiroto
304 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611747536.16
305 rdf:type schema:Person
306 sg:person.0612036127.14 schema:affiliation Nd5f412ec4c164590bd0ffd83fa1e2c97
307 schema:familyName Suzuki
308 schema:givenName Junichi
309 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612036127.14
310 rdf:type schema:Person
311 sg:person.0626373475.84 schema:affiliation https://www.grid.ac/institutes/grid.415086.e
312 schema:familyName Inoue
313 schema:givenName Kazuhiko
314 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626373475.84
315 rdf:type schema:Person
316 sg:person.0633561662.26 schema:affiliation https://www.grid.ac/institutes/grid.417200.0
317 schema:familyName Miwa
318 schema:givenName Jun
319 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0633561662.26
320 rdf:type schema:Person
321 sg:person.0653567450.43 schema:affiliation N4eec62134a8c49aa8a87cbc011ab25fb
322 schema:familyName Kusaka
323 schema:givenName Masayasu
324 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653567450.43
325 rdf:type schema:Person
326 sg:person.0774377727.52 schema:affiliation https://www.grid.ac/institutes/grid.417117.5
327 schema:familyName Suzuki
328 schema:givenName Tsuyoshi
329 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774377727.52
330 rdf:type schema:Person
331 sg:pub.10.1007/s00535-006-1990-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1029113764
332 https://doi.org/10.1007/s00535-006-1990-z
333 rdf:type schema:CreativeWork
334 sg:pub.10.1007/s00535-009-0003-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037783704
335 https://doi.org/10.1007/s00535-009-0003-4
336 rdf:type schema:CreativeWork
337 sg:pub.10.1007/s00535-009-0095-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1005257876
338 https://doi.org/10.1007/s00535-009-0095-x
339 rdf:type schema:CreativeWork
340 sg:pub.10.1111/j.1572-0241.2002.05421.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1008796062
341 https://doi.org/10.1111/j.1572-0241.2002.05421.x
342 rdf:type schema:CreativeWork
343 sg:pub.10.1111/j.1572-0241.2004.30822.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011118686
344 https://doi.org/10.1111/j.1572-0241.2004.30822.x
345 rdf:type schema:CreativeWork
346 sg:pub.10.1111/j.1572-0241.2005.00225.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1000091526
347 https://doi.org/10.1111/j.1572-0241.2005.00225.x
348 rdf:type schema:CreativeWork
349 sg:pub.10.1111/j.1572-0241.2005.40280.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1008956874
350 https://doi.org/10.1111/j.1572-0241.2005.40280.x
351 rdf:type schema:CreativeWork
352 sg:pub.10.1111/j.1572-0241.2005.41217.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1020343522
353 https://doi.org/10.1111/j.1572-0241.2005.41217.x
354 rdf:type schema:CreativeWork
355 sg:pub.10.1111/j.1572-0241.2006.00630.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1048337809
356 https://doi.org/10.1111/j.1572-0241.2006.00630.x
357 rdf:type schema:CreativeWork
358 https://app.dimensions.ai/details/publication/pub.1075127201 schema:CreativeWork
359 https://doi.org/10.1002/jcla.1019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047228882
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1016/j.cgh.2005.10.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043602081
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1046/j.1365-2036.2003.01646.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1031665855
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1053/gast.2001.27180 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012549424
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1053/gast.2002.36556 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021131824
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1053/j.gastro.2005.11.059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013146576
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1056/nejm199812243392602 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042845761
372 rdf:type schema:CreativeWork
373 https://doi.org/10.1080/003655299750025237 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045692406
374 rdf:type schema:CreativeWork
375 https://doi.org/10.1080/003655299750025264 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007163434
376 rdf:type schema:CreativeWork
377 https://doi.org/10.1080/11024159850191355 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058381278
378 rdf:type schema:CreativeWork
379 https://doi.org/10.1111/j.1365-2036.2007.03367.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004264049
380 rdf:type schema:CreativeWork
381 https://doi.org/10.1111/j.1440-1746.1995.tb01362.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1003318592
382 rdf:type schema:CreativeWork
383 https://doi.org/10.1136/bmj.318.7187.833 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026896783
384 rdf:type schema:CreativeWork
385 https://doi.org/10.1136/bmj.a1400 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062799556
386 rdf:type schema:CreativeWork
387 https://doi.org/10.1136/gut.50.suppl_4.iv72 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014851373
388 rdf:type schema:CreativeWork
389 https://doi.org/10.1152/ajpgi.00086.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051141199
390 rdf:type schema:CreativeWork
391 https://doi.org/10.1152/ajpgi.00242.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063192905
392 rdf:type schema:CreativeWork
393 https://doi.org/10.1155/2011/940650 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014751294
394 rdf:type schema:CreativeWork
395 https://doi.org/10.1159/000121351 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018932294
396 rdf:type schema:CreativeWork
397 https://doi.org/10.1159/000167862 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005707072
398 rdf:type schema:CreativeWork
399 https://doi.org/10.3164/jcbn.39.46 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019666299
400 rdf:type schema:CreativeWork
401 https://www.grid.ac/institutes/grid.258269.2 schema:alternateName Juntendo University
402 schema:name Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, Japan
403 rdf:type schema:Organization
404 https://www.grid.ac/institutes/grid.265073.5 schema:alternateName Tokyo Medical and Dental University
405 schema:name Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan
406 rdf:type schema:Organization
407 https://www.grid.ac/institutes/grid.272264.7 schema:alternateName Hyogo College of Medicine
408 schema:name Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan
409 rdf:type schema:Organization
410 https://www.grid.ac/institutes/grid.274841.c schema:alternateName Kumamoto University
411 schema:name Department of Gastroenterology and Hepatology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, 860-8556, Kumamoto, Japan
412 rdf:type schema:Organization
413 https://www.grid.ac/institutes/grid.39158.36 schema:alternateName Hokkaido University
414 schema:name Department of Gastroenterology, Hokkaido University, Sapporo, Japan
415 Department of Internal Medicine, Yamagata Prefectural Central Hospital, Yamagata, Japan
416 rdf:type schema:Organization
417 https://www.grid.ac/institutes/grid.411621.1 schema:alternateName Shimane University
418 schema:name Department of Gastroenterology and Hepatology, Shimane University School of Medicine, Izumo, Japan
419 rdf:type schema:Organization
420 https://www.grid.ac/institutes/grid.412339.e schema:alternateName Saga University
421 schema:name Department of Internal Medicine, Gastrointestinal Endoscopy, Saga Medical School, Saga, Japan
422 rdf:type schema:Organization
423 https://www.grid.ac/institutes/grid.415086.e schema:alternateName Kawasaki Medical School
424 schema:name Department of General Medicine, Kawasaki Medical School, Kurashiki, Japan
425 Division of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School, Kurashiki, Japan
426 Internal Medicine, Matsue Red Cross Hospital, Matsue, Japan
427 rdf:type schema:Organization
428 https://www.grid.ac/institutes/grid.417117.5 schema:alternateName Tokyo Metropolitan Police Hospital
429 schema:name Department of Gastroenterology, Tokyo Metropolitan Police Hospital, Tokyo, Japan
430 rdf:type schema:Organization
431 https://www.grid.ac/institutes/grid.417200.0 schema:alternateName Toshiba General Hospital
432 schema:name Department of Internal Medicine, Toshiba Hospital, Tokyo, Japan
433 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...