Anastrozole-related acute hepatitis with autoimmune features: a case report View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-12

AUTHORS

Alessandro Inno, Michele Basso, Fabio M Vecchio, Valentina A Marsico, Eleonora Cerchiaro, Ettore D'Argento, Cinzia Bagalà, Carlo Barone

ABSTRACT

BACKGROUND: Two cases of acute hepatitis occurring during treatment with anastrozole have previously been reported, but the underlying mechanisms of liver injury are still uncertain. We report the case of anastrozole-related acute hepatitis with some autoimmune features. CASE PRESENTATION: A 70-year-old woman developed acute hepatitis associated with serum antinuclear antibodies during anastrozole treatment; after drug withdrawal, liver function parameters rapidly improved and serum auto-antibodies were no longer detectable. CONCLUSIONS: Anastrozole-induced hepatotoxicity is a very rare event. Drug-drug interactions or metabolically-mediated damage might be involved, with a possible role of individual susceptibility. Our report suggests that an immune-mediated mechanism may also be considered in anastrozole-related liver injury. More... »

PAGES

32

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1471-230x-11-32

DOI

http://dx.doi.org/10.1186/1471-230x-11-32

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1018807660

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21453541


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