QTc interval prolongation in HIV-infected patients: a case–control study by 24-hour Holter ECG recording View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-12

AUTHORS

Alessandra Fiorentini, Nicola Petrosillo, Angelo Di Stefano, Stefania Cicalini, Laura Borgognoni, Evangelo Boumis, Luigi Tubani, Pierangelo Chinello

ABSTRACT

BACKGROUND: Aim of the study was to assess QTc interval by a 24-hour ECG recording in a group of HIV-infected individuals with a basal prolonged QTc. The risk factors associated with QTc prolongation and the indices of cardiovascular autonomic control were also evaluated. METHODS: A case-control study was performed using as cases 32 HIV-infected patients with prolonged (>440 msec) QTc interval as assessed by Holter ECG, and as controls 64 HIV-infected subjects with normal QTc interval. Autonomic function was evaluated by heart rate variability analysis during 24-hour recording. RESULTS: Duration of HIV disease was significantly longer among cases than among controls (p=0.04). Waist/hip ratio was also higher among cases than among controls (p=0.05). Frequency domain analysis showed the absence of physiologic decrease of low frequency (LF) in the night period in both cases and controls. The LF night in cases showed a statistically significant reduction when compared with controls (p=0.007). CONCLUSIONS: In our study group, QTc interval prolongation was associated with a longer duration of HIV infection and with a greater waist/hip ratio. HIV patients with QTc interval prolongation and with a longer duration of HIV infection were more likely to have an impairment of parasympathetic and sympathetic cardiac component. More... »

PAGES

124

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1471-2261-12-124

DOI

http://dx.doi.org/10.1186/1471-2261-12-124

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049632378

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23259665


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