Anaesthesia in a patient with subarachanoidal haemorrhage and high oxygen affinity haemoglobinopathy (HB york): case report View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-08-08

AUTHORS

Enrico Monaca, Tobias Jüttner, Norbert Gattermann, Michael Winterhalter

ABSTRACT

BackgroundApproximately 90 haemoglobinopathies have been identified that result in abnormally high oxygen affinity. One of these is haemoglobinopathy York (HbY), first described in 1976. HbY causes an extreme leftward shift of the oxygen dissociation curve with the P50 value changing to 12.5 - 15.5 mmHg (normal value 26.7 mmHg), indicating that approximately half of the haemoglobin is not available as oxygen carrier. Patients with haemoglobinopathies with increased oxygen affinity could suffer from the risk developing ischaemic complications due to a lack of functional oxygen carriers. This is, to best of our knowledge, the first case report on a patient with HbY published in connection with anesthesia.Case PresentationA 42-year-old female with a severe headache and Glasgow coma scale (GCS) of 15 was admitted to the neurosurgical intensive care unit with a ruptured, right sided ICA aneurysm with consecutive subarachnoid haemorrhage [Fisher III, World Federation of Neurosurgical Societies (WFNS) I)]. The medical history of the patient included an erythrocytosis (Hb 17.5 g/dl) on the base of a high-oxygen-affinity haemoglobinopathy, called Hb York (HbY). With no time available to take special preoperative precautions, rapid blood loss occurred during the first attempt to clip the aneurysm. General transfusion procedures, according to the guidelines based on haemoglobin and haematocrit values, could not be applied due to the uncertainty in the oxygen carrier reduction. To maintain tissue oxygen supply, clinical indicators of ischaemia were instead utilized to gauge the appropriate required blood products, crystalloids and colloids replacements. Despite this, the patient survived the neurosurgical intervention without any neurological deficit.ConclusionsFamily members of patients with HbY (and other haemoglobinopathies with increased oxygen affinity) should undergo clinical assessment, particularly if they are polycythaemic. If the diagnosis of HbY is confirmed, they should carry an "emergency anaesthesiology card" in order to avert perioperative risks arising from their "hidden" anemia. More... »

PAGES

19

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1471-2253-12-19

DOI

http://dx.doi.org/10.1186/1471-2253-12-19

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1016895515

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22870883


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Anaesthesiology, Heinrich-Heine-University, Moorenstrasse 5, D-40225, D\u00fcsseldorf, Germany", 
          "id": "http://www.grid.ac/institutes/grid.411327.2", 
          "name": [
            "Department of Anaesthesiology, Heinrich-Heine-University, Moorenstrasse 5, D-40225, D\u00fcsseldorf, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Monaca", 
        "givenName": "Enrico", 
        "id": "sg:person.0765374711.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765374711.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Anaesthesiology, Heinrich-Heine-University, Moorenstrasse 5, D-40225, D\u00fcsseldorf, Germany", 
          "id": "http://www.grid.ac/institutes/grid.411327.2", 
          "name": [
            "Department of Anaesthesiology, Heinrich-Heine-University, Moorenstrasse 5, D-40225, D\u00fcsseldorf, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "J\u00fcttner", 
        "givenName": "Tobias", 
        "id": "sg:person.01164156215.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164156215.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department Of Haematology, Oncology and Clinical Immunology, Heinrich-Heine-University, Moorenstrasse 5, D-40225, D\u00fcsseldorf, Germany", 
          "id": "http://www.grid.ac/institutes/grid.411327.2", 
          "name": [
            "Department Of Haematology, Oncology and Clinical Immunology, Heinrich-Heine-University, Moorenstrasse 5, D-40225, D\u00fcsseldorf, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gattermann", 
        "givenName": "Norbert", 
        "id": "sg:person.01273447501.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273447501.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Anaesthesiology, Heinrich-Heine-University, Moorenstrasse 5, D-40225, D\u00fcsseldorf, Germany", 
          "id": "http://www.grid.ac/institutes/grid.411327.2", 
          "name": [
            "Department of Anaesthesiology, Heinrich-Heine-University, Moorenstrasse 5, D-40225, D\u00fcsseldorf, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Winterhalter", 
        "givenName": "Michael", 
        "id": "sg:person.01300234354.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300234354.49"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s002770100299", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033732985", 
          "https://doi.org/10.1007/s002770100299"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/259155a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036216989", 
          "https://doi.org/10.1038/259155a0"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-08-08", 
    "datePublishedReg": "2012-08-08", 
    "description": "BackgroundApproximately 90 haemoglobinopathies have been identified that result in abnormally high oxygen affinity. One of these is haemoglobinopathy York (HbY), first described in 1976. HbY causes an extreme leftward shift of the oxygen dissociation curve with the P50 value changing to 12.5 - 15.5 mmHg (normal value 26.7 mmHg), indicating that approximately half of the haemoglobin is not available as oxygen carrier. Patients with haemoglobinopathies with increased oxygen affinity could suffer from the risk developing ischaemic complications due to a lack of functional oxygen carriers. This is, to best of our knowledge, the first case report on a patient with HbY published in connection with anesthesia.Case PresentationA 42-year-old female with a severe headache and Glasgow coma scale (GCS) of 15 was admitted to the neurosurgical intensive care unit with a ruptured, right sided ICA aneurysm with consecutive subarachnoid haemorrhage [Fisher III, World Federation of Neurosurgical Societies (WFNS) I)]. The medical history of the patient included an erythrocytosis (Hb 17.5\u2009g/dl) on the base of a high-oxygen-affinity haemoglobinopathy, called Hb York (HbY). With no time available to take special preoperative precautions, rapid blood loss occurred during the first attempt to clip the aneurysm. General transfusion procedures, according to the guidelines based on haemoglobin and haematocrit values, could not be applied due to the uncertainty in the oxygen carrier reduction. To maintain tissue oxygen supply, clinical indicators of ischaemia were instead utilized to gauge the appropriate required blood products, crystalloids and colloids replacements. Despite this, the patient survived the neurosurgical intervention without any neurological deficit.ConclusionsFamily members of patients with HbY (and other haemoglobinopathies with increased oxygen affinity) should undergo clinical assessment, particularly if they are polycythaemic. If the diagnosis of HbY is confirmed, they should carry an \"emergency anaesthesiology card\" in order to avert perioperative risks arising from their \"hidden\" anemia.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/1471-2253-12-19", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1024933", 
        "issn": [
          "1471-2253"
        ], 
        "name": "BMC Anesthesiology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "12"
      }
    ], 
    "keywords": [
      "Glasgow Coma Scale", 
      "case report", 
      "neurosurgical intensive care unit", 
      "consecutive subarachnoid hemorrhage", 
      "intensive care unit", 
      "first case report", 
      "rapid blood loss", 
      "tissue oxygen supply", 
      "ischemic complications", 
      "neurological deficits", 
      "perioperative risk", 
      "blood loss", 
      "severe headache", 
      "Coma Scale", 
      "care unit", 
      "subarachnoid hemorrhage", 
      "medical history", 
      "colloid replacement", 
      "clinical indicators", 
      "neurosurgical intervention", 
      "blood products", 
      "clinical assessment", 
      "transfusion procedures", 
      "oxygen dissociation curve", 
      "leftward shift", 
      "patients", 
      "ConclusionsFamily members", 
      "haematocrit values", 
      "haemoglobinopathies", 
      "oxygen affinity", 
      "hemorrhage", 
      "anesthesia", 
      "hemoglobin", 
      "dissociation curve", 
      "oxygen supply", 
      "P50 values", 
      "risk", 
      "Hb York", 
      "report", 
      "complications", 
      "ischaemia", 
      "headache", 
      "mmHg", 
      "anemia", 
      "aneurysms", 
      "high oxygen affinity", 
      "erythrocytosis", 
      "crystalloids", 
      "diagnosis", 
      "intervention", 
      "HbY", 
      "deficits", 
      "females", 
      "guidelines", 
      "oxygen carrier", 
      "ICA", 
      "precautions", 
      "affinity", 
      "assessment", 
      "replacement", 
      "half", 
      "carriers", 
      "history", 
      "lack", 
      "reduction", 
      "loss", 
      "procedure", 
      "indicators", 
      "York", 
      "values", 
      "first attempt", 
      "members", 
      "knowledge", 
      "units", 
      "time", 
      "curves", 
      "scale", 
      "results", 
      "attempt", 
      "cards", 
      "base", 
      "supply", 
      "products", 
      "connection", 
      "shift", 
      "order", 
      "uncertainty", 
      "oxygen carrier reduction", 
      "carrier reduction"
    ], 
    "name": "Anaesthesia in a patient with subarachanoidal haemorrhage and high oxygen affinity haemoglobinopathy (HB york): case report", 
    "pagination": "19", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1016895515"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1471-2253-12-19"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "22870883"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1471-2253-12-19", 
      "https://app.dimensions.ai/details/publication/pub.1016895515"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-09-02T15:56", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_559.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/1471-2253-12-19"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1471-2253-12-19'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1471-2253-12-19'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1471-2253-12-19'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1471-2253-12-19'


 

This table displays all metadata directly associated to this object as RDF triples.

180 TRIPLES      21 PREDICATES      116 URIs      106 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1471-2253-12-19 schema:about anzsrc-for:11
2 anzsrc-for:1103
3 schema:author Nad98ae4919094424817713c53f22d6c0
4 schema:citation sg:pub.10.1007/s002770100299
5 sg:pub.10.1038/259155a0
6 schema:datePublished 2012-08-08
7 schema:datePublishedReg 2012-08-08
8 schema:description BackgroundApproximately 90 haemoglobinopathies have been identified that result in abnormally high oxygen affinity. One of these is haemoglobinopathy York (HbY), first described in 1976. HbY causes an extreme leftward shift of the oxygen dissociation curve with the P50 value changing to 12.5 - 15.5 mmHg (normal value 26.7 mmHg), indicating that approximately half of the haemoglobin is not available as oxygen carrier. Patients with haemoglobinopathies with increased oxygen affinity could suffer from the risk developing ischaemic complications due to a lack of functional oxygen carriers. This is, to best of our knowledge, the first case report on a patient with HbY published in connection with anesthesia.Case PresentationA 42-year-old female with a severe headache and Glasgow coma scale (GCS) of 15 was admitted to the neurosurgical intensive care unit with a ruptured, right sided ICA aneurysm with consecutive subarachnoid haemorrhage [Fisher III, World Federation of Neurosurgical Societies (WFNS) I)]. The medical history of the patient included an erythrocytosis (Hb 17.5 g/dl) on the base of a high-oxygen-affinity haemoglobinopathy, called Hb York (HbY). With no time available to take special preoperative precautions, rapid blood loss occurred during the first attempt to clip the aneurysm. General transfusion procedures, according to the guidelines based on haemoglobin and haematocrit values, could not be applied due to the uncertainty in the oxygen carrier reduction. To maintain tissue oxygen supply, clinical indicators of ischaemia were instead utilized to gauge the appropriate required blood products, crystalloids and colloids replacements. Despite this, the patient survived the neurosurgical intervention without any neurological deficit.ConclusionsFamily members of patients with HbY (and other haemoglobinopathies with increased oxygen affinity) should undergo clinical assessment, particularly if they are polycythaemic. If the diagnosis of HbY is confirmed, they should carry an "emergency anaesthesiology card" in order to avert perioperative risks arising from their "hidden" anemia.
9 schema:genre article
10 schema:isAccessibleForFree true
11 schema:isPartOf N58f5da63d3704d04b5ad43b52747e7a0
12 Ncbd6e2552001477b94578e386e27ca6b
13 sg:journal.1024933
14 schema:keywords Coma Scale
15 ConclusionsFamily members
16 Glasgow Coma Scale
17 Hb York
18 HbY
19 ICA
20 P50 values
21 York
22 affinity
23 anemia
24 anesthesia
25 aneurysms
26 assessment
27 attempt
28 base
29 blood loss
30 blood products
31 cards
32 care unit
33 carrier reduction
34 carriers
35 case report
36 clinical assessment
37 clinical indicators
38 colloid replacement
39 complications
40 connection
41 consecutive subarachnoid hemorrhage
42 crystalloids
43 curves
44 deficits
45 diagnosis
46 dissociation curve
47 erythrocytosis
48 females
49 first attempt
50 first case report
51 guidelines
52 haematocrit values
53 haemoglobinopathies
54 half
55 headache
56 hemoglobin
57 hemorrhage
58 high oxygen affinity
59 history
60 indicators
61 intensive care unit
62 intervention
63 ischaemia
64 ischemic complications
65 knowledge
66 lack
67 leftward shift
68 loss
69 medical history
70 members
71 mmHg
72 neurological deficits
73 neurosurgical intensive care unit
74 neurosurgical intervention
75 order
76 oxygen affinity
77 oxygen carrier
78 oxygen carrier reduction
79 oxygen dissociation curve
80 oxygen supply
81 patients
82 perioperative risk
83 precautions
84 procedure
85 products
86 rapid blood loss
87 reduction
88 replacement
89 report
90 results
91 risk
92 scale
93 severe headache
94 shift
95 subarachnoid hemorrhage
96 supply
97 time
98 tissue oxygen supply
99 transfusion procedures
100 uncertainty
101 units
102 values
103 schema:name Anaesthesia in a patient with subarachanoidal haemorrhage and high oxygen affinity haemoglobinopathy (HB york): case report
104 schema:pagination 19
105 schema:productId N04b0b33ec6b24da4a71a9b7d45c2e76b
106 Nac1065b1ebd14c5f906b2194f72db196
107 Ne06456d8aae248d5b4ddf9d96df4c0f0
108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016895515
109 https://doi.org/10.1186/1471-2253-12-19
110 schema:sdDatePublished 2022-09-02T15:56
111 schema:sdLicense https://scigraph.springernature.com/explorer/license/
112 schema:sdPublisher N7d1da851c57344efa8f6692ad3874df4
113 schema:url https://doi.org/10.1186/1471-2253-12-19
114 sgo:license sg:explorer/license/
115 sgo:sdDataset articles
116 rdf:type schema:ScholarlyArticle
117 N04b0b33ec6b24da4a71a9b7d45c2e76b schema:name pubmed_id
118 schema:value 22870883
119 rdf:type schema:PropertyValue
120 N407c7caa45e24e4098cf276fe6bd997c rdf:first sg:person.01300234354.49
121 rdf:rest rdf:nil
122 N58f5da63d3704d04b5ad43b52747e7a0 schema:volumeNumber 12
123 rdf:type schema:PublicationVolume
124 N7d1da851c57344efa8f6692ad3874df4 schema:name Springer Nature - SN SciGraph project
125 rdf:type schema:Organization
126 N8b7d6ec1a04b4f60a4756361179a5c1e rdf:first sg:person.01164156215.55
127 rdf:rest Na702949f785e4e4888d4b34e7574e440
128 Na702949f785e4e4888d4b34e7574e440 rdf:first sg:person.01273447501.34
129 rdf:rest N407c7caa45e24e4098cf276fe6bd997c
130 Nac1065b1ebd14c5f906b2194f72db196 schema:name dimensions_id
131 schema:value pub.1016895515
132 rdf:type schema:PropertyValue
133 Nad98ae4919094424817713c53f22d6c0 rdf:first sg:person.0765374711.76
134 rdf:rest N8b7d6ec1a04b4f60a4756361179a5c1e
135 Ncbd6e2552001477b94578e386e27ca6b schema:issueNumber 1
136 rdf:type schema:PublicationIssue
137 Ne06456d8aae248d5b4ddf9d96df4c0f0 schema:name doi
138 schema:value 10.1186/1471-2253-12-19
139 rdf:type schema:PropertyValue
140 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
141 schema:name Medical and Health Sciences
142 rdf:type schema:DefinedTerm
143 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
144 schema:name Clinical Sciences
145 rdf:type schema:DefinedTerm
146 sg:journal.1024933 schema:issn 1471-2253
147 schema:name BMC Anesthesiology
148 schema:publisher Springer Nature
149 rdf:type schema:Periodical
150 sg:person.01164156215.55 schema:affiliation grid-institutes:grid.411327.2
151 schema:familyName Jüttner
152 schema:givenName Tobias
153 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164156215.55
154 rdf:type schema:Person
155 sg:person.01273447501.34 schema:affiliation grid-institutes:grid.411327.2
156 schema:familyName Gattermann
157 schema:givenName Norbert
158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273447501.34
159 rdf:type schema:Person
160 sg:person.01300234354.49 schema:affiliation grid-institutes:grid.411327.2
161 schema:familyName Winterhalter
162 schema:givenName Michael
163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300234354.49
164 rdf:type schema:Person
165 sg:person.0765374711.76 schema:affiliation grid-institutes:grid.411327.2
166 schema:familyName Monaca
167 schema:givenName Enrico
168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765374711.76
169 rdf:type schema:Person
170 sg:pub.10.1007/s002770100299 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033732985
171 https://doi.org/10.1007/s002770100299
172 rdf:type schema:CreativeWork
173 sg:pub.10.1038/259155a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036216989
174 https://doi.org/10.1038/259155a0
175 rdf:type schema:CreativeWork
176 grid-institutes:grid.411327.2 schema:alternateName Department Of Haematology, Oncology and Clinical Immunology, Heinrich-Heine-University, Moorenstrasse 5, D-40225, Düsseldorf, Germany
177 Department of Anaesthesiology, Heinrich-Heine-University, Moorenstrasse 5, D-40225, Düsseldorf, Germany
178 schema:name Department Of Haematology, Oncology and Clinical Immunology, Heinrich-Heine-University, Moorenstrasse 5, D-40225, Düsseldorf, Germany
179 Department of Anaesthesiology, Heinrich-Heine-University, Moorenstrasse 5, D-40225, Düsseldorf, Germany
180 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...