Effect of thymol on kinetic properties of Ca and K currents in rat skeletal muscle View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2003-07-15

AUTHORS

Norbert Szentandrássy, Péter Szentesi, János Magyar, Péter P Nánási, László Csernoch

ABSTRACT

BackgroundThymol is widely used as a general antiseptic and antioxidant compound in the medical practice and industry, and also as a stabilizer to several therapeutic agents, including halothane. Thus intoxication with thymol may occur in case of ingestion or improper anesthesia. In the present study, therefore, concentration-dependent effects of thymol (30–600 micro-grams) were studied on calcium and potassium currents in enzymatically isolated rat skeletal muscle fibers using the double vaseline gap voltage clamp technique.ResultsThymol suppressed both Ca and K currents in a concentration-dependent manner, the EC50 values were 193 ± 26 and 93 ± 11 μM, with Hill coefficients of 2.52 ± 0.29 and 1.51 ± 0.18, respectively. Thymol had a biphasic effect on Ca current kinetics: time to peak current and the time constant for inactivation increased at lower (100–200 μM) but decreased below their control values at higher (600 μM) concentrations. Inactivation of K current was also significantly accelerated by thymol (200–300 μM). These effects of thymol developed rapidly and were partially reversible. In spite of the marked effects on the time-dependent properties, thymol caused no change in the current-voltage relationship of Ca and K peak currents.ConclusionsPresent results revealed marked suppression of Ca and K currents in skeletal muscle, similar to results obtained previously in cardiac cells. Furthermore, it is possible that part of the suppressive effects of halothane on Ca and K currents, observed experimentally, may be attributed to the concomitant presence of thymol in the superfusate. More... »

PAGES

9

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1471-2210-3-9

DOI

http://dx.doi.org/10.1186/1471-2210-3-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014045601

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12864924


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1116", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Physiology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antioxidants", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Calcium Channels", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Culture Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dose-Response Relationship, Drug", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Electric Conductivity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kinetics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Muscle, Skeletal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Patch-Clamp Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Potassium Channels", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thymol", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Physiology, University Medical School of Debrecen, P.O.Box 22, H-4012, Debrecen, Hungary", 
          "id": "http://www.grid.ac/institutes/grid.7122.6", 
          "name": [
            "Department of Physiology, University Medical School of Debrecen, P.O.Box 22, H-4012, Debrecen, Hungary"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Szentandr\u00e1ssy", 
        "givenName": "Norbert", 
        "id": "sg:person.0741603700.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0741603700.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Physiology, University Medical School of Debrecen, P.O.Box 22, H-4012, Debrecen, Hungary", 
          "id": "http://www.grid.ac/institutes/grid.7122.6", 
          "name": [
            "Department of Physiology, University Medical School of Debrecen, P.O.Box 22, H-4012, Debrecen, Hungary"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Szentesi", 
        "givenName": "P\u00e9ter", 
        "id": "sg:person.0626475330.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626475330.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Physiology, University Medical School of Debrecen, P.O.Box 22, H-4012, Debrecen, Hungary", 
          "id": "http://www.grid.ac/institutes/grid.7122.6", 
          "name": [
            "Department of Physiology, University Medical School of Debrecen, P.O.Box 22, H-4012, Debrecen, Hungary"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Magyar", 
        "givenName": "J\u00e1nos", 
        "id": "sg:person.01206027354.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206027354.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Physiology, University Medical School of Debrecen, P.O.Box 22, H-4012, Debrecen, Hungary", 
          "id": "http://www.grid.ac/institutes/grid.7122.6", 
          "name": [
            "Department of Physiology, University Medical School of Debrecen, P.O.Box 22, H-4012, Debrecen, Hungary"
          ], 
          "type": "Organization"
        }, 
        "familyName": "N\u00e1n\u00e1si", 
        "givenName": "P\u00e9ter P", 
        "id": "sg:person.0724365203.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724365203.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Physiology, University Medical School of Debrecen, P.O.Box 22, H-4012, Debrecen, Hungary", 
          "id": "http://www.grid.ac/institutes/grid.7122.6", 
          "name": [
            "Department of Physiology, University Medical School of Debrecen, P.O.Box 22, H-4012, Debrecen, Hungary"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Csernoch", 
        "givenName": "L\u00e1szl\u00f3", 
        "id": "sg:person.01205301115.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205301115.74"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf02679961", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006912447", 
          "https://doi.org/10.1007/bf02679961"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2003-07-15", 
    "datePublishedReg": "2003-07-15", 
    "description": "BackgroundThymol is widely used as a general antiseptic and antioxidant compound in the medical practice and industry, and also as a stabilizer to several therapeutic agents, including halothane. Thus intoxication with thymol may occur in case of ingestion or improper anesthesia. In the present study, therefore, concentration-dependent effects of thymol (30\u2013600 micro-grams) were studied on calcium and potassium currents in enzymatically isolated rat skeletal muscle fibers using the double vaseline gap voltage clamp technique.ResultsThymol suppressed both Ca and K currents in a concentration-dependent manner, the EC50 values were 193 \u00b1 26 and 93 \u00b1 11 \u03bcM, with Hill coefficients of 2.52 \u00b1 0.29 and 1.51 \u00b1 0.18, respectively. Thymol had a biphasic effect on Ca current kinetics: time to peak current and the time constant for inactivation increased at lower (100\u2013200 \u03bcM) but decreased below their control values at higher (600 \u03bcM) concentrations. Inactivation of K current was also significantly accelerated by thymol (200\u2013300 \u03bcM). These effects of thymol developed rapidly and were partially reversible. In spite of the marked effects on the time-dependent properties, thymol caused no change in the current-voltage relationship of Ca and K peak currents.ConclusionsPresent results revealed marked suppression of Ca and K currents in skeletal muscle, similar to results obtained previously in cardiac cells. Furthermore, it is possible that part of the suppressive effects of halothane on Ca and K currents, observed experimentally, may be attributed to the concomitant presence of thymol in the superfusate.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/1471-2210-3-9", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1024637", 
        "issn": [
          "1471-2210"
        ], 
        "name": "BMC Pharmacology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "3"
      }
    ], 
    "keywords": [
      "K currents", 
      "effect of thymol", 
      "skeletal muscle", 
      "case of ingestion", 
      "rat skeletal muscle fibers", 
      "voltage-clamp technique", 
      "concentration-dependent manner", 
      "ConclusionsPresent results", 
      "rat skeletal muscle", 
      "concentration-dependent effects", 
      "biphasic effect", 
      "marked suppression", 
      "skeletal muscle fibers", 
      "potassium current", 
      "suppressive effect", 
      "clamp technique", 
      "concomitant presence", 
      "therapeutic agents", 
      "control values", 
      "muscle fibers", 
      "current-voltage relationship", 
      "cardiac cells", 
      "double Vaseline-gap voltage-clamp technique", 
      "halothane", 
      "medical practice", 
      "Vaseline-gap voltage-clamp technique", 
      "current kinetics", 
      "muscle", 
      "present study", 
      "EC50 values", 
      "antioxidant compounds", 
      "Hill coefficient", 
      "anesthesia", 
      "superfusate", 
      "intoxication", 
      "ingestion", 
      "high concentrations", 
      "effect", 
      "inactivation", 
      "thymol", 
      "calcium", 
      "cells", 
      "suppression", 
      "agents", 
      "cases", 
      "study", 
      "time", 
      "changes", 
      "presence", 
      "manner", 
      "concentration", 
      "results", 
      "practice", 
      "spite", 
      "values", 
      "kinetic properties", 
      "relationship", 
      "Ca", 
      "fibers", 
      "compounds", 
      "part", 
      "stabilizer", 
      "technique", 
      "current", 
      "kinetics", 
      "properties", 
      "time-dependent properties", 
      "coefficient", 
      "peak current", 
      "industry"
    ], 
    "name": "Effect of thymol on kinetic properties of Ca and K currents in rat skeletal muscle", 
    "pagination": "9", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1014045601"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1471-2210-3-9"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "12864924"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1471-2210-3-9", 
      "https://app.dimensions.ai/details/publication/pub.1014045601"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-05-20T07:22", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_363.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/1471-2210-3-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1471-2210-3-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1471-2210-3-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1471-2210-3-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1471-2210-3-9'


 

This table displays all metadata directly associated to this object as RDF triples.

219 TRIPLES      22 PREDICATES      111 URIs      102 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1471-2210-3-9 schema:about N0aaf9f7e095048a6924a44f8559ca868
2 N218ca43a3f9e4ef9954510248ad5aee8
3 N44b62dd440c3422e9d2e2efd493134e1
4 N44bb5d4a40294d669bda962ff1e66fef
5 N50653e04d824473694ffa132d9142c22
6 N5ab8115b5e3b49ca9c1e5149a198be89
7 N71a82b40aa514f89b3a9b522f07d7883
8 N94e3f4958cc44b958576c216832f7c28
9 Na3e2d06e336e47d28273c832e85f486a
10 Na701e72ac7e04a17b49c62c32fb7c20a
11 Nbb4f53499d254551b5a55d9a9a833c87
12 Nc41f21268a1a4bd18e096a835ef6f057
13 Nfa88c63fe71e4dc0952c76acfc99840a
14 Nff0d7a277c734b759be0bd9f3d9a1da3
15 anzsrc-for:11
16 anzsrc-for:1116
17 schema:author N49e3b003ec6d4afebc27c9a022593428
18 schema:citation sg:pub.10.1007/bf02679961
19 schema:datePublished 2003-07-15
20 schema:datePublishedReg 2003-07-15
21 schema:description BackgroundThymol is widely used as a general antiseptic and antioxidant compound in the medical practice and industry, and also as a stabilizer to several therapeutic agents, including halothane. Thus intoxication with thymol may occur in case of ingestion or improper anesthesia. In the present study, therefore, concentration-dependent effects of thymol (30–600 micro-grams) were studied on calcium and potassium currents in enzymatically isolated rat skeletal muscle fibers using the double vaseline gap voltage clamp technique.ResultsThymol suppressed both Ca and K currents in a concentration-dependent manner, the EC50 values were 193 ± 26 and 93 ± 11 μM, with Hill coefficients of 2.52 ± 0.29 and 1.51 ± 0.18, respectively. Thymol had a biphasic effect on Ca current kinetics: time to peak current and the time constant for inactivation increased at lower (100–200 μM) but decreased below their control values at higher (600 μM) concentrations. Inactivation of K current was also significantly accelerated by thymol (200–300 μM). These effects of thymol developed rapidly and were partially reversible. In spite of the marked effects on the time-dependent properties, thymol caused no change in the current-voltage relationship of Ca and K peak currents.ConclusionsPresent results revealed marked suppression of Ca and K currents in skeletal muscle, similar to results obtained previously in cardiac cells. Furthermore, it is possible that part of the suppressive effects of halothane on Ca and K currents, observed experimentally, may be attributed to the concomitant presence of thymol in the superfusate.
22 schema:genre article
23 schema:inLanguage en
24 schema:isAccessibleForFree true
25 schema:isPartOf N4a047d1ea1f747b387a0a615bb58eb2b
26 Nc67789b1a4ac47a4873f2b13d444bf9c
27 sg:journal.1024637
28 schema:keywords Ca
29 ConclusionsPresent results
30 EC50 values
31 Hill coefficient
32 K currents
33 Vaseline-gap voltage-clamp technique
34 agents
35 anesthesia
36 antioxidant compounds
37 biphasic effect
38 calcium
39 cardiac cells
40 case of ingestion
41 cases
42 cells
43 changes
44 clamp technique
45 coefficient
46 compounds
47 concentration
48 concentration-dependent effects
49 concentration-dependent manner
50 concomitant presence
51 control values
52 current
53 current kinetics
54 current-voltage relationship
55 double Vaseline-gap voltage-clamp technique
56 effect
57 effect of thymol
58 fibers
59 halothane
60 high concentrations
61 inactivation
62 industry
63 ingestion
64 intoxication
65 kinetic properties
66 kinetics
67 manner
68 marked suppression
69 medical practice
70 muscle
71 muscle fibers
72 part
73 peak current
74 potassium current
75 practice
76 presence
77 present study
78 properties
79 rat skeletal muscle
80 rat skeletal muscle fibers
81 relationship
82 results
83 skeletal muscle
84 skeletal muscle fibers
85 spite
86 stabilizer
87 study
88 superfusate
89 suppression
90 suppressive effect
91 technique
92 therapeutic agents
93 thymol
94 time
95 time-dependent properties
96 values
97 voltage-clamp technique
98 schema:name Effect of thymol on kinetic properties of Ca and K currents in rat skeletal muscle
99 schema:pagination 9
100 schema:productId N59877bf37f3248beaacff6e979dd88d4
101 N84e42ee2e3a846f7a585ef8a29bcbb8e
102 Nd6378bdee12d42db9993b5f821ae175b
103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014045601
104 https://doi.org/10.1186/1471-2210-3-9
105 schema:sdDatePublished 2022-05-20T07:22
106 schema:sdLicense https://scigraph.springernature.com/explorer/license/
107 schema:sdPublisher Nd21399d37d494fa7a41101d1f2e8ae88
108 schema:url https://doi.org/10.1186/1471-2210-3-9
109 sgo:license sg:explorer/license/
110 sgo:sdDataset articles
111 rdf:type schema:ScholarlyArticle
112 N0551ff38ed94484fa692e4e8eed13101 rdf:first sg:person.0724365203.35
113 rdf:rest N8e55545e9181494eaa94a5b3368fb357
114 N0aaf9f7e095048a6924a44f8559ca868 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Calcium Channels
116 rdf:type schema:DefinedTerm
117 N218ca43a3f9e4ef9954510248ad5aee8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Kinetics
119 rdf:type schema:DefinedTerm
120 N44b62dd440c3422e9d2e2efd493134e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Culture Techniques
122 rdf:type schema:DefinedTerm
123 N44bb5d4a40294d669bda962ff1e66fef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Animals
125 rdf:type schema:DefinedTerm
126 N49e3b003ec6d4afebc27c9a022593428 rdf:first sg:person.0741603700.70
127 rdf:rest Nc4f0a5a4c0f94a878b5a6bb057d48612
128 N4a047d1ea1f747b387a0a615bb58eb2b schema:volumeNumber 3
129 rdf:type schema:PublicationVolume
130 N50653e04d824473694ffa132d9142c22 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Potassium Channels
132 rdf:type schema:DefinedTerm
133 N59877bf37f3248beaacff6e979dd88d4 schema:name doi
134 schema:value 10.1186/1471-2210-3-9
135 rdf:type schema:PropertyValue
136 N5ab8115b5e3b49ca9c1e5149a198be89 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Muscle, Skeletal
138 rdf:type schema:DefinedTerm
139 N71a82b40aa514f89b3a9b522f07d7883 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Electric Conductivity
141 rdf:type schema:DefinedTerm
142 N84e42ee2e3a846f7a585ef8a29bcbb8e schema:name pubmed_id
143 schema:value 12864924
144 rdf:type schema:PropertyValue
145 N8e55545e9181494eaa94a5b3368fb357 rdf:first sg:person.01205301115.74
146 rdf:rest rdf:nil
147 N94e3f4958cc44b958576c216832f7c28 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Rats
149 rdf:type schema:DefinedTerm
150 Na3e2d06e336e47d28273c832e85f486a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Antioxidants
152 rdf:type schema:DefinedTerm
153 Na701e72ac7e04a17b49c62c32fb7c20a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Thymol
155 rdf:type schema:DefinedTerm
156 Na834e452bb0d4fe38fd44541c9df80d0 rdf:first sg:person.01206027354.83
157 rdf:rest N0551ff38ed94484fa692e4e8eed13101
158 Nbb4f53499d254551b5a55d9a9a833c87 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Male
160 rdf:type schema:DefinedTerm
161 Nc41f21268a1a4bd18e096a835ef6f057 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Patch-Clamp Techniques
163 rdf:type schema:DefinedTerm
164 Nc4f0a5a4c0f94a878b5a6bb057d48612 rdf:first sg:person.0626475330.83
165 rdf:rest Na834e452bb0d4fe38fd44541c9df80d0
166 Nc67789b1a4ac47a4873f2b13d444bf9c schema:issueNumber 1
167 rdf:type schema:PublicationIssue
168 Nd21399d37d494fa7a41101d1f2e8ae88 schema:name Springer Nature - SN SciGraph project
169 rdf:type schema:Organization
170 Nd6378bdee12d42db9993b5f821ae175b schema:name dimensions_id
171 schema:value pub.1014045601
172 rdf:type schema:PropertyValue
173 Nfa88c63fe71e4dc0952c76acfc99840a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Dose-Response Relationship, Drug
175 rdf:type schema:DefinedTerm
176 Nff0d7a277c734b759be0bd9f3d9a1da3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Female
178 rdf:type schema:DefinedTerm
179 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
180 schema:name Medical and Health Sciences
181 rdf:type schema:DefinedTerm
182 anzsrc-for:1116 schema:inDefinedTermSet anzsrc-for:
183 schema:name Medical Physiology
184 rdf:type schema:DefinedTerm
185 sg:journal.1024637 schema:issn 1471-2210
186 schema:name BMC Pharmacology
187 schema:publisher Springer Nature
188 rdf:type schema:Periodical
189 sg:person.01205301115.74 schema:affiliation grid-institutes:grid.7122.6
190 schema:familyName Csernoch
191 schema:givenName László
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205301115.74
193 rdf:type schema:Person
194 sg:person.01206027354.83 schema:affiliation grid-institutes:grid.7122.6
195 schema:familyName Magyar
196 schema:givenName János
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206027354.83
198 rdf:type schema:Person
199 sg:person.0626475330.83 schema:affiliation grid-institutes:grid.7122.6
200 schema:familyName Szentesi
201 schema:givenName Péter
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626475330.83
203 rdf:type schema:Person
204 sg:person.0724365203.35 schema:affiliation grid-institutes:grid.7122.6
205 schema:familyName Nánási
206 schema:givenName Péter P
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724365203.35
208 rdf:type schema:Person
209 sg:person.0741603700.70 schema:affiliation grid-institutes:grid.7122.6
210 schema:familyName Szentandrássy
211 schema:givenName Norbert
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0741603700.70
213 rdf:type schema:Person
214 sg:pub.10.1007/bf02679961 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006912447
215 https://doi.org/10.1007/bf02679961
216 rdf:type schema:CreativeWork
217 grid-institutes:grid.7122.6 schema:alternateName Department of Physiology, University Medical School of Debrecen, P.O.Box 22, H-4012, Debrecen, Hungary
218 schema:name Department of Physiology, University Medical School of Debrecen, P.O.Box 22, H-4012, Debrecen, Hungary
219 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...