5-hydroxytryptamine (5-HT) reduces total peripheral resistance during chronic infusion: direct arterial mesenteric relaxation is not involved View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-12

AUTHORS

Robert Patrick Davis, Jill Pattison, Janice M Thompson, Ruslan Tiniakov, Karie E Scrogin, Stephanie W Watts

ABSTRACT

Serotonin (5-hydroxytryptamine; 5-HT) delivered over 1 week results in a sustained fall in blood pressure in the sham and deoxycorticosterone acetate (DOCA)-salt rat. We hypothesized 5-HT lowers blood pressure through direct receptor-mediated vascular relaxation. In vivo, 5-HT reduced mean arterial pressure (MAP), increased heart rate, stroke volume, cardiac index, and reduced total peripheral resistance during a 1 week infusion of 5-HT (25 µg/kg/min) in the normotensive Sprague Dawley rat. The mesenteric vasculature was chosen as an ideal candidate for the site of 5-HT receptor mediated vascular relaxation given the high percentage of cardiac output the site receives. Real-time RT-PCR demonstrated that mRNA transcripts for the 5-HT2B, 5-HT1B, and 5-HT7 receptors are present in sham and DOCA-salt superior mesenteric arteries. Immunohistochemistry and Western blot validated the presence of the 5-HT2B, 5- HT1B and 5-HT7 receptor protein in sham and DOCA-salt superior mesenteric artery. Isometric contractile force was measured in endothelium-intact superior mesenteric artery and mesenteric resistance arteries in which the contractile 5- HT2A receptor was antagonized. Maximum concentrations of BW-723C86 (5- HT2B agonist), CP 93129 (5-HT1B agonist) or LP-44 (5-HT7 agonist) did not relax the superior mesenteric artery from DOCA-salt rats vs. vehicle. Additionally, 5-HT (10-9 M to 10-5 M) did not cause relaxation in either contracted mesenteric resistance arteries or superior mesenteric arteries from normotensive Sprague- Dawley rats. Thus, although 5-HT receptors known to mediate vascular relaxation are present in the superior mesenteric artery, they are not functional, and are therefore not likely involved in a 5-HT-induced fall in total peripheral resistance and MAP. More... »

PAGES

4

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1471-2210-12-4

DOI

http://dx.doi.org/10.1186/1471-2210-12-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005458212

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22559843


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blood Pressure", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Desoxycorticosterone", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "In Vitro Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Isometric Contraction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mesenteric Arteries", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mineralocorticoids", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Sprague-Dawley", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Serotonin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Serotonin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Serotonin Receptor Agonists", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vascular Resistance", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vasodilation", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Michigan State University", 
          "id": "https://www.grid.ac/institutes/grid.17088.36", 
          "name": [
            "Department of Pharmacology and Toxicology, Michigan State University, 48824-1317, East Lansing, MI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Davis", 
        "givenName": "Robert Patrick", 
        "id": "sg:person.0577713124.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577713124.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Michigan State University", 
          "id": "https://www.grid.ac/institutes/grid.17088.36", 
          "name": [
            "Department of Pharmacology and Toxicology, Michigan State University, 48824-1317, East Lansing, MI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pattison", 
        "givenName": "Jill", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Michigan State University", 
          "id": "https://www.grid.ac/institutes/grid.17088.36", 
          "name": [
            "Department of Pharmacology and Toxicology, Michigan State University, 48824-1317, East Lansing, MI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thompson", 
        "givenName": "Janice M", 
        "id": "sg:person.0736306175.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736306175.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Loyola University Chicago", 
          "id": "https://www.grid.ac/institutes/grid.164971.c", 
          "name": [
            "Department of Pharmacology and Experimental Therapeutics, Loyola University, Chicago, Stritch School of Medicine, 60153, Maywood, IL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tiniakov", 
        "givenName": "Ruslan", 
        "id": "sg:person.01120706127.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120706127.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Loyola University Chicago", 
          "id": "https://www.grid.ac/institutes/grid.164971.c", 
          "name": [
            "Department of Pharmacology and Experimental Therapeutics, Loyola University, Chicago, Stritch School of Medicine, 60153, Maywood, IL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Scrogin", 
        "givenName": "Karie E", 
        "id": "sg:person.01307764320.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307764320.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Michigan State University", 
          "id": "https://www.grid.ac/institutes/grid.17088.36", 
          "name": [
            "Department of Pharmacology and Toxicology, Michigan State University, 48824-1317, East Lansing, MI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Watts", 
        "givenName": "Stephanie W", 
        "id": "sg:person.0611032321.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611032321.58"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.pbb.2003.11.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003320718"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.bjp.0701134", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003689593"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/10739680600618967", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006069187"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1211/0022357021837", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006228711"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00169451", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007079585", 
          "https://doi.org/10.1007/bf00169451"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00169451", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007079585", 
          "https://doi.org/10.1007/bf00169451"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/jpet.108.136226", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008399224"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.0000036082.04708.83", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009280704"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1476-5381.1996.tb15990.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011103338"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1476-5381.1995.tb13240.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011113035"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.bjp.0701509", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011262909"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005344-200302000-00021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011310316"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005344-200302000-00021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011310316"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1755-5922.2010.00173.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011811079"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/169800b0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021242644", 
          "https://doi.org/10.1038/169800b0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-2999(92)90488-p", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021268260"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-2999(92)90488-p", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021268260"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1460-9568.2008.06201.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021550070"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hy1001.091779", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022382894"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1440-1681.1994.tb02530.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027626885"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005344-199000157-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028159814"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005344-199000157-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028159814"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1113/jphysiol.2007.144642", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029524095"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-4159.2007.04542.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029570248"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00508342", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031656352", 
          "https://doi.org/10.1007/bf00508342"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00508342", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031656352", 
          "https://doi.org/10.1007/bf00508342"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/jpet.106.114355", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032093588"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/pl00005359", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034354135", 
          "https://doi.org/10.1007/pl00005359"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2210-3-12", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039994735", 
          "https://doi.org/10.1186/1471-2210-3-12"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0014-2999(99)00114-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042928699"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2210-3-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043739890", 
          "https://doi.org/10.1186/1471-2210-3-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0024-3205(97)01166-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044455181"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005344-199102000-00019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048354487"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005344-199102000-00019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048354487"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00210-004-1006-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048516570", 
          "https://doi.org/10.1007/s00210-004-1006-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0378-3782(96)01778-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050242339"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00053439", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050362470", 
          "https://doi.org/10.1007/bf00053439"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00053439", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050362470", 
          "https://doi.org/10.1007/bf00053439"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0028-3908(92)90032-k", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052696317"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0028-3908(92)90032-k", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052696317"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.bjp.0702571", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052796031"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-2999(92)90544-e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053505232"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-2999(92)90544-e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053505232"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074255072", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076354950", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077539044", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpheart.1991.261.5.h1487", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077912849"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-12", 
    "datePublishedReg": "2012-12-01", 
    "description": "Serotonin (5-hydroxytryptamine; 5-HT) delivered over 1 week results in a sustained fall in blood pressure in the sham and deoxycorticosterone acetate (DOCA)-salt rat. We hypothesized 5-HT lowers blood pressure through direct receptor-mediated vascular relaxation. In vivo, 5-HT reduced mean arterial pressure (MAP), increased heart rate, stroke volume, cardiac index, and reduced total peripheral resistance during a 1 week infusion of 5-HT (25 \u00b5g/kg/min) in the normotensive Sprague Dawley rat. The mesenteric vasculature was chosen as an ideal candidate for the site of 5-HT receptor mediated vascular relaxation given the high percentage of cardiac output the site receives. Real-time RT-PCR demonstrated that mRNA transcripts for the 5-HT2B, 5-HT1B, and 5-HT7 receptors are present in sham and DOCA-salt superior mesenteric arteries. Immunohistochemistry and Western blot validated the presence of the 5-HT2B, 5- HT1B and 5-HT7 receptor protein in sham and DOCA-salt superior mesenteric artery. Isometric contractile force was measured in endothelium-intact superior mesenteric artery and mesenteric resistance arteries in which the contractile 5- HT2A receptor was antagonized. Maximum concentrations of BW-723C86 (5- HT2B agonist), CP 93129 (5-HT1B agonist) or LP-44 (5-HT7 agonist) did not relax the superior mesenteric artery from DOCA-salt rats vs. vehicle. Additionally, 5-HT (10-9 M to 10-5 M) did not cause relaxation in either contracted mesenteric resistance arteries or superior mesenteric arteries from normotensive Sprague- Dawley rats. Thus, although 5-HT receptors known to mediate vascular relaxation are present in the superior mesenteric artery, they are not functional, and are therefore not likely involved in a 5-HT-induced fall in total peripheral resistance and MAP.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/1471-2210-12-4", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2543232", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2539114", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2358600", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1024637", 
        "issn": [
          "1471-2210"
        ], 
        "name": "BMC Pharmacology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "12"
      }
    ], 
    "name": "5-hydroxytryptamine (5-HT) reduces total peripheral resistance during chronic infusion: direct arterial mesenteric relaxation is not involved", 
    "pagination": "4", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "1a01bfbb0778cb3d5014acf1a879405f8bbd82f390f4551453cd8a0676a352cf"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "22559843"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100967806"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1471-2210-12-4"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1005458212"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1471-2210-12-4", 
      "https://app.dimensions.ai/details/publication/pub.1005458212"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T15:58", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8664_00000549.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2F1471-2210-12-4"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1471-2210-12-4'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1471-2210-12-4'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1471-2210-12-4'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1471-2210-12-4'


 

This table displays all metadata directly associated to this object as RDF triples.

290 TRIPLES      21 PREDICATES      82 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1471-2210-12-4 schema:about N15e2fb37293a4556996422b979d85019
2 N38f145e4a2b34fa7aa7e5076645717ec
3 N5769175eed734e3c8602d0a24db6412c
4 N637a4ac88b9d403dae647a2f2160f6bf
5 N6d752d6aecda48098a505c495ff2d15f
6 N759129ce232c40538b5e5408cc42c3d6
7 N86c947a690624c18adc7b05272c4d070
8 N921664d1e48b4811854925d5769ef52f
9 N95a9266f1f52425db692d09cb0ccc5f5
10 N98bb7fd143df48fc8f7a369615060905
11 Nbf6fa620e8924b4f9766d1d522df9185
12 Nc1e5e637787c4469bec3a49aefd5547f
13 Nc3898ea1936742779342326ae84f8c8d
14 Nc61d9c401832425da97d8cbb7f45a141
15 Ne91df833d141483fa9e7b1d1416de8eb
16 anzsrc-for:11
17 anzsrc-for:1102
18 schema:author N4956b1a909744858bb44ed7ad4d044ba
19 schema:citation sg:pub.10.1007/bf00053439
20 sg:pub.10.1007/bf00169451
21 sg:pub.10.1007/bf00508342
22 sg:pub.10.1007/pl00005359
23 sg:pub.10.1007/s00210-004-1006-6
24 sg:pub.10.1038/169800b0
25 sg:pub.10.1186/1471-2210-3-1
26 sg:pub.10.1186/1471-2210-3-12
27 https://app.dimensions.ai/details/publication/pub.1074255072
28 https://app.dimensions.ai/details/publication/pub.1076354950
29 https://app.dimensions.ai/details/publication/pub.1077539044
30 https://doi.org/10.1016/0014-2999(92)90488-p
31 https://doi.org/10.1016/0014-2999(92)90544-e
32 https://doi.org/10.1016/0028-3908(92)90032-k
33 https://doi.org/10.1016/j.pbb.2003.11.009
34 https://doi.org/10.1016/s0014-2999(99)00114-4
35 https://doi.org/10.1016/s0024-3205(97)01166-1
36 https://doi.org/10.1016/s0378-3782(96)01778-1
37 https://doi.org/10.1038/sj.bjp.0701134
38 https://doi.org/10.1038/sj.bjp.0701509
39 https://doi.org/10.1038/sj.bjp.0702571
40 https://doi.org/10.1080/10739680600618967
41 https://doi.org/10.1097/00005344-199000157-00004
42 https://doi.org/10.1097/00005344-199102000-00019
43 https://doi.org/10.1097/00005344-200302000-00021
44 https://doi.org/10.1111/j.1440-1681.1994.tb02530.x
45 https://doi.org/10.1111/j.1460-9568.2008.06201.x
46 https://doi.org/10.1111/j.1471-4159.2007.04542.x
47 https://doi.org/10.1111/j.1476-5381.1995.tb13240.x
48 https://doi.org/10.1111/j.1476-5381.1996.tb15990.x
49 https://doi.org/10.1111/j.1755-5922.2010.00173.x
50 https://doi.org/10.1113/jphysiol.2007.144642
51 https://doi.org/10.1124/jpet.106.114355
52 https://doi.org/10.1124/jpet.108.136226
53 https://doi.org/10.1152/ajpheart.1991.261.5.h1487
54 https://doi.org/10.1161/01.cir.0000036082.04708.83
55 https://doi.org/10.1161/hy1001.091779
56 https://doi.org/10.1211/0022357021837
57 schema:datePublished 2012-12
58 schema:datePublishedReg 2012-12-01
59 schema:description Serotonin (5-hydroxytryptamine; 5-HT) delivered over 1 week results in a sustained fall in blood pressure in the sham and deoxycorticosterone acetate (DOCA)-salt rat. We hypothesized 5-HT lowers blood pressure through direct receptor-mediated vascular relaxation. In vivo, 5-HT reduced mean arterial pressure (MAP), increased heart rate, stroke volume, cardiac index, and reduced total peripheral resistance during a 1 week infusion of 5-HT (25 µg/kg/min) in the normotensive Sprague Dawley rat. The mesenteric vasculature was chosen as an ideal candidate for the site of 5-HT receptor mediated vascular relaxation given the high percentage of cardiac output the site receives. Real-time RT-PCR demonstrated that mRNA transcripts for the 5-HT2B, 5-HT1B, and 5-HT7 receptors are present in sham and DOCA-salt superior mesenteric arteries. Immunohistochemistry and Western blot validated the presence of the 5-HT2B, 5- HT1B and 5-HT7 receptor protein in sham and DOCA-salt superior mesenteric artery. Isometric contractile force was measured in endothelium-intact superior mesenteric artery and mesenteric resistance arteries in which the contractile 5- HT2A receptor was antagonized. Maximum concentrations of BW-723C86 (5- HT2B agonist), CP 93129 (5-HT1B agonist) or LP-44 (5-HT7 agonist) did not relax the superior mesenteric artery from DOCA-salt rats vs. vehicle. Additionally, 5-HT (10-9 M to 10-5 M) did not cause relaxation in either contracted mesenteric resistance arteries or superior mesenteric arteries from normotensive Sprague- Dawley rats. Thus, although 5-HT receptors known to mediate vascular relaxation are present in the superior mesenteric artery, they are not functional, and are therefore not likely involved in a 5-HT-induced fall in total peripheral resistance and MAP.
60 schema:genre research_article
61 schema:inLanguage en
62 schema:isAccessibleForFree true
63 schema:isPartOf N74e4edaa764240379e1d32012e558fd6
64 N7f0061bf56424bf89c0cdc1adf98007e
65 sg:journal.1024637
66 schema:name 5-hydroxytryptamine (5-HT) reduces total peripheral resistance during chronic infusion: direct arterial mesenteric relaxation is not involved
67 schema:pagination 4
68 schema:productId N11b6781c33aa405685e5cbe3b0cb2d1c
69 N4bd509823e1e4d2789c52e6bc6b97ffe
70 N573078ebe1504bc6ab031ac615d6bf1f
71 N88fbc4a5aed748b5ab6129e040f41877
72 Nf600fbab272c4f2b93072f3fe04dd580
73 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005458212
74 https://doi.org/10.1186/1471-2210-12-4
75 schema:sdDatePublished 2019-04-10T15:58
76 schema:sdLicense https://scigraph.springernature.com/explorer/license/
77 schema:sdPublisher N84783c776bd242b8ba5be6fbd092b417
78 schema:url http://link.springer.com/10.1186%2F1471-2210-12-4
79 sgo:license sg:explorer/license/
80 sgo:sdDataset articles
81 rdf:type schema:ScholarlyArticle
82 N119b235bb77341ccbff5d8b5f701fdd4 schema:affiliation https://www.grid.ac/institutes/grid.17088.36
83 schema:familyName Pattison
84 schema:givenName Jill
85 rdf:type schema:Person
86 N11b6781c33aa405685e5cbe3b0cb2d1c schema:name doi
87 schema:value 10.1186/1471-2210-12-4
88 rdf:type schema:PropertyValue
89 N15e2fb37293a4556996422b979d85019 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Serotonin
91 rdf:type schema:DefinedTerm
92 N34c9c97de0a343ed86f5790cb35bafe1 rdf:first sg:person.0736306175.24
93 rdf:rest N3cbe7b87940747e4b217171d89c88c48
94 N38f145e4a2b34fa7aa7e5076645717ec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name In Vitro Techniques
96 rdf:type schema:DefinedTerm
97 N3cbe7b87940747e4b217171d89c88c48 rdf:first sg:person.01120706127.29
98 rdf:rest N559f4839bbfe4576bcf6227486fbd147
99 N45b8a8c7ecca4161b2a6e6f7323b0336 rdf:first N119b235bb77341ccbff5d8b5f701fdd4
100 rdf:rest N34c9c97de0a343ed86f5790cb35bafe1
101 N4956b1a909744858bb44ed7ad4d044ba rdf:first sg:person.0577713124.01
102 rdf:rest N45b8a8c7ecca4161b2a6e6f7323b0336
103 N4bd509823e1e4d2789c52e6bc6b97ffe schema:name pubmed_id
104 schema:value 22559843
105 rdf:type schema:PropertyValue
106 N559f4839bbfe4576bcf6227486fbd147 rdf:first sg:person.01307764320.24
107 rdf:rest N8548aea145b64f27905087f96a6ffa5e
108 N573078ebe1504bc6ab031ac615d6bf1f schema:name nlm_unique_id
109 schema:value 100967806
110 rdf:type schema:PropertyValue
111 N5769175eed734e3c8602d0a24db6412c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Mesenteric Arteries
113 rdf:type schema:DefinedTerm
114 N637a4ac88b9d403dae647a2f2160f6bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Isometric Contraction
116 rdf:type schema:DefinedTerm
117 N6d752d6aecda48098a505c495ff2d15f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Vasodilation
119 rdf:type schema:DefinedTerm
120 N74e4edaa764240379e1d32012e558fd6 schema:volumeNumber 12
121 rdf:type schema:PublicationVolume
122 N759129ce232c40538b5e5408cc42c3d6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Serotonin Receptor Agonists
124 rdf:type schema:DefinedTerm
125 N7f0061bf56424bf89c0cdc1adf98007e schema:issueNumber 1
126 rdf:type schema:PublicationIssue
127 N84783c776bd242b8ba5be6fbd092b417 schema:name Springer Nature - SN SciGraph project
128 rdf:type schema:Organization
129 N8548aea145b64f27905087f96a6ffa5e rdf:first sg:person.0611032321.58
130 rdf:rest rdf:nil
131 N86c947a690624c18adc7b05272c4d070 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Rats, Sprague-Dawley
133 rdf:type schema:DefinedTerm
134 N88fbc4a5aed748b5ab6129e040f41877 schema:name readcube_id
135 schema:value 1a01bfbb0778cb3d5014acf1a879405f8bbd82f390f4551453cd8a0676a352cf
136 rdf:type schema:PropertyValue
137 N921664d1e48b4811854925d5769ef52f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Mineralocorticoids
139 rdf:type schema:DefinedTerm
140 N95a9266f1f52425db692d09cb0ccc5f5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Receptors, Serotonin
142 rdf:type schema:DefinedTerm
143 N98bb7fd143df48fc8f7a369615060905 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Male
145 rdf:type schema:DefinedTerm
146 Nbf6fa620e8924b4f9766d1d522df9185 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Vascular Resistance
148 rdf:type schema:DefinedTerm
149 Nc1e5e637787c4469bec3a49aefd5547f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Rats
151 rdf:type schema:DefinedTerm
152 Nc3898ea1936742779342326ae84f8c8d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Animals
154 rdf:type schema:DefinedTerm
155 Nc61d9c401832425da97d8cbb7f45a141 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Desoxycorticosterone
157 rdf:type schema:DefinedTerm
158 Ne91df833d141483fa9e7b1d1416de8eb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Blood Pressure
160 rdf:type schema:DefinedTerm
161 Nf600fbab272c4f2b93072f3fe04dd580 schema:name dimensions_id
162 schema:value pub.1005458212
163 rdf:type schema:PropertyValue
164 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
165 schema:name Medical and Health Sciences
166 rdf:type schema:DefinedTerm
167 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
168 schema:name Cardiorespiratory Medicine and Haematology
169 rdf:type schema:DefinedTerm
170 sg:grant.2358600 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2210-12-4
171 rdf:type schema:MonetaryGrant
172 sg:grant.2539114 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2210-12-4
173 rdf:type schema:MonetaryGrant
174 sg:grant.2543232 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2210-12-4
175 rdf:type schema:MonetaryGrant
176 sg:journal.1024637 schema:issn 1471-2210
177 schema:name BMC Pharmacology
178 rdf:type schema:Periodical
179 sg:person.01120706127.29 schema:affiliation https://www.grid.ac/institutes/grid.164971.c
180 schema:familyName Tiniakov
181 schema:givenName Ruslan
182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120706127.29
183 rdf:type schema:Person
184 sg:person.01307764320.24 schema:affiliation https://www.grid.ac/institutes/grid.164971.c
185 schema:familyName Scrogin
186 schema:givenName Karie E
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307764320.24
188 rdf:type schema:Person
189 sg:person.0577713124.01 schema:affiliation https://www.grid.ac/institutes/grid.17088.36
190 schema:familyName Davis
191 schema:givenName Robert Patrick
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577713124.01
193 rdf:type schema:Person
194 sg:person.0611032321.58 schema:affiliation https://www.grid.ac/institutes/grid.17088.36
195 schema:familyName Watts
196 schema:givenName Stephanie W
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611032321.58
198 rdf:type schema:Person
199 sg:person.0736306175.24 schema:affiliation https://www.grid.ac/institutes/grid.17088.36
200 schema:familyName Thompson
201 schema:givenName Janice M
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736306175.24
203 rdf:type schema:Person
204 sg:pub.10.1007/bf00053439 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050362470
205 https://doi.org/10.1007/bf00053439
206 rdf:type schema:CreativeWork
207 sg:pub.10.1007/bf00169451 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007079585
208 https://doi.org/10.1007/bf00169451
209 rdf:type schema:CreativeWork
210 sg:pub.10.1007/bf00508342 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031656352
211 https://doi.org/10.1007/bf00508342
212 rdf:type schema:CreativeWork
213 sg:pub.10.1007/pl00005359 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034354135
214 https://doi.org/10.1007/pl00005359
215 rdf:type schema:CreativeWork
216 sg:pub.10.1007/s00210-004-1006-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048516570
217 https://doi.org/10.1007/s00210-004-1006-6
218 rdf:type schema:CreativeWork
219 sg:pub.10.1038/169800b0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021242644
220 https://doi.org/10.1038/169800b0
221 rdf:type schema:CreativeWork
222 sg:pub.10.1186/1471-2210-3-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043739890
223 https://doi.org/10.1186/1471-2210-3-1
224 rdf:type schema:CreativeWork
225 sg:pub.10.1186/1471-2210-3-12 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039994735
226 https://doi.org/10.1186/1471-2210-3-12
227 rdf:type schema:CreativeWork
228 https://app.dimensions.ai/details/publication/pub.1074255072 schema:CreativeWork
229 https://app.dimensions.ai/details/publication/pub.1076354950 schema:CreativeWork
230 https://app.dimensions.ai/details/publication/pub.1077539044 schema:CreativeWork
231 https://doi.org/10.1016/0014-2999(92)90488-p schema:sameAs https://app.dimensions.ai/details/publication/pub.1021268260
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1016/0014-2999(92)90544-e schema:sameAs https://app.dimensions.ai/details/publication/pub.1053505232
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1016/0028-3908(92)90032-k schema:sameAs https://app.dimensions.ai/details/publication/pub.1052696317
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1016/j.pbb.2003.11.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003320718
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1016/s0014-2999(99)00114-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042928699
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1016/s0024-3205(97)01166-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044455181
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1016/s0378-3782(96)01778-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050242339
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1038/sj.bjp.0701134 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003689593
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1038/sj.bjp.0701509 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011262909
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1038/sj.bjp.0702571 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052796031
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1080/10739680600618967 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006069187
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1097/00005344-199000157-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028159814
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1097/00005344-199102000-00019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048354487
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1097/00005344-200302000-00021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011310316
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1111/j.1440-1681.1994.tb02530.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1027626885
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1111/j.1460-9568.2008.06201.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1021550070
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1111/j.1471-4159.2007.04542.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1029570248
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1111/j.1476-5381.1995.tb13240.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011113035
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1111/j.1476-5381.1996.tb15990.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011103338
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1111/j.1755-5922.2010.00173.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011811079
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1113/jphysiol.2007.144642 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029524095
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1124/jpet.106.114355 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032093588
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1124/jpet.108.136226 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008399224
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1152/ajpheart.1991.261.5.h1487 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077912849
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1161/01.cir.0000036082.04708.83 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009280704
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1161/hy1001.091779 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022382894
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1211/0022357021837 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006228711
284 rdf:type schema:CreativeWork
285 https://www.grid.ac/institutes/grid.164971.c schema:alternateName Loyola University Chicago
286 schema:name Department of Pharmacology and Experimental Therapeutics, Loyola University, Chicago, Stritch School of Medicine, 60153, Maywood, IL, USA
287 rdf:type schema:Organization
288 https://www.grid.ac/institutes/grid.17088.36 schema:alternateName Michigan State University
289 schema:name Department of Pharmacology and Toxicology, Michigan State University, 48824-1317, East Lansing, MI, USA
290 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...