5-hydroxytryptamine (5-HT) reduces total peripheral resistance during chronic infusion: direct arterial mesenteric relaxation is not involved View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-05-06

AUTHORS

Robert Patrick Davis, Jill Pattison, Janice M Thompson, Ruslan Tiniakov, Karie E Scrogin, Stephanie W Watts

ABSTRACT

Serotonin (5-hydroxytryptamine; 5-HT) delivered over 1 week results in a sustained fall in blood pressure in the sham and deoxycorticosterone acetate (DOCA)-salt rat. We hypothesized 5-HT lowers blood pressure through direct receptor-mediated vascular relaxation. In vivo, 5-HT reduced mean arterial pressure (MAP), increased heart rate, stroke volume, cardiac index, and reduced total peripheral resistance during a 1 week infusion of 5-HT (25 µg/kg/min) in the normotensive Sprague Dawley rat. The mesenteric vasculature was chosen as an ideal candidate for the site of 5-HT receptor mediated vascular relaxation given the high percentage of cardiac output the site receives. Real-time RT-PCR demonstrated that mRNA transcripts for the 5-HT2B, 5-HT1B, and 5-HT7 receptors are present in sham and DOCA-salt superior mesenteric arteries. Immunohistochemistry and Western blot validated the presence of the 5-HT2B, 5- HT1B and 5-HT7 receptor protein in sham and DOCA-salt superior mesenteric artery. Isometric contractile force was measured in endothelium-intact superior mesenteric artery and mesenteric resistance arteries in which the contractile 5- HT2A receptor was antagonized. Maximum concentrations of BW-723C86 (5- HT2B agonist), CP 93129 (5-HT1B agonist) or LP-44 (5-HT7 agonist) did not relax the superior mesenteric artery from DOCA-salt rats vs. vehicle. Additionally, 5-HT (10–9 M to 10–5 M) did not cause relaxation in either contracted mesenteric resistance arteries or superior mesenteric arteries from normotensive Sprague- Dawley rats. Thus, although 5-HT receptors known to mediate vascular relaxation are present in the superior mesenteric artery, they are not functional, and are therefore not likely involved in a 5-HT-induced fall in total peripheral resistance and MAP. More... »

PAGES

4

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1471-2210-12-4

DOI

http://dx.doi.org/10.1186/1471-2210-12-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005458212

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22559843


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blood Pressure", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Desoxycorticosterone", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "In Vitro Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Isometric Contraction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mesenteric Arteries", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mineralocorticoids", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Sprague-Dawley", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Serotonin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Serotonin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Serotonin Receptor Agonists", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vascular Resistance", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vasodilation", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Pharmacology and Toxicology, Michigan State University, 48824-1317, East Lansing, MI, USA", 
          "id": "http://www.grid.ac/institutes/grid.17088.36", 
          "name": [
            "Department of Pharmacology and Toxicology, Michigan State University, 48824-1317, East Lansing, MI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Davis", 
        "givenName": "Robert Patrick", 
        "id": "sg:person.0577713124.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577713124.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pharmacology and Toxicology, Michigan State University, 48824-1317, East Lansing, MI, USA", 
          "id": "http://www.grid.ac/institutes/grid.17088.36", 
          "name": [
            "Department of Pharmacology and Toxicology, Michigan State University, 48824-1317, East Lansing, MI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pattison", 
        "givenName": "Jill", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pharmacology and Toxicology, Michigan State University, 48824-1317, East Lansing, MI, USA", 
          "id": "http://www.grid.ac/institutes/grid.17088.36", 
          "name": [
            "Department of Pharmacology and Toxicology, Michigan State University, 48824-1317, East Lansing, MI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thompson", 
        "givenName": "Janice M", 
        "id": "sg:person.0736306175.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736306175.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pharmacology and Experimental Therapeutics, Loyola University, Chicago, Stritch School of Medicine, 60153, Maywood, IL, USA", 
          "id": "http://www.grid.ac/institutes/grid.164971.c", 
          "name": [
            "Department of Pharmacology and Experimental Therapeutics, Loyola University, Chicago, Stritch School of Medicine, 60153, Maywood, IL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tiniakov", 
        "givenName": "Ruslan", 
        "id": "sg:person.01120706127.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120706127.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pharmacology and Experimental Therapeutics, Loyola University, Chicago, Stritch School of Medicine, 60153, Maywood, IL, USA", 
          "id": "http://www.grid.ac/institutes/grid.164971.c", 
          "name": [
            "Department of Pharmacology and Experimental Therapeutics, Loyola University, Chicago, Stritch School of Medicine, 60153, Maywood, IL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Scrogin", 
        "givenName": "Karie E", 
        "id": "sg:person.01307764320.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307764320.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pharmacology and Toxicology, Michigan State University, 48824-1317, East Lansing, MI, USA", 
          "id": "http://www.grid.ac/institutes/grid.17088.36", 
          "name": [
            "Department of Pharmacology and Toxicology, Michigan State University, 48824-1317, East Lansing, MI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Watts", 
        "givenName": "Stephanie W", 
        "id": "sg:person.0611032321.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611032321.58"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/169800b0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021242644", 
          "https://doi.org/10.1038/169800b0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2210-3-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043739890", 
          "https://doi.org/10.1186/1471-2210-3-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00169451", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007079585", 
          "https://doi.org/10.1007/bf00169451"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/pl00005359", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034354135", 
          "https://doi.org/10.1007/pl00005359"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00210-004-1006-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048516570", 
          "https://doi.org/10.1007/s00210-004-1006-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2210-3-12", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039994735", 
          "https://doi.org/10.1186/1471-2210-3-12"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00053439", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050362470", 
          "https://doi.org/10.1007/bf00053439"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00508342", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031656352", 
          "https://doi.org/10.1007/bf00508342"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-05-06", 
    "datePublishedReg": "2012-05-06", 
    "description": "Serotonin (5-hydroxytryptamine; 5-HT) delivered over 1\u2009week results in a sustained fall in blood pressure in the sham and deoxycorticosterone acetate (DOCA)-salt rat. We hypothesized 5-HT lowers blood pressure through direct receptor-mediated vascular relaxation. In vivo, 5-HT reduced mean arterial pressure (MAP), increased heart rate, stroke volume, cardiac index, and reduced total peripheral resistance during a 1\u2009week infusion of 5-HT (25 \u00b5g/kg/min) in the normotensive Sprague Dawley rat. The mesenteric vasculature was chosen as an ideal candidate for the site of 5-HT receptor mediated vascular relaxation given the high percentage of cardiac output the site receives. Real-time RT-PCR demonstrated that mRNA transcripts for the 5-HT2B, 5-HT1B, and 5-HT7 receptors are present in sham and DOCA-salt superior mesenteric arteries. Immunohistochemistry and Western blot validated the presence of the 5-HT2B, 5- HT1B and 5-HT7 receptor protein in sham and DOCA-salt superior mesenteric artery. Isometric contractile force was measured in endothelium-intact superior mesenteric artery and mesenteric resistance arteries in which the contractile 5- HT2A receptor was antagonized. Maximum concentrations of BW-723C86 (5- HT2B agonist), CP 93129 (5-HT1B agonist) or LP-44 (5-HT7 agonist) did not relax the superior mesenteric artery from DOCA-salt rats vs. vehicle. Additionally, 5-HT (10\u20139\u2009M to 10\u20135\u2009M) did not cause relaxation in either contracted mesenteric resistance arteries or superior mesenteric arteries from normotensive Sprague- Dawley rats. Thus, although 5-HT receptors known to mediate vascular relaxation are present in the superior mesenteric artery, they are not functional, and are therefore not likely involved in a 5-HT-induced fall in total peripheral resistance and MAP.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/1471-2210-12-4", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2543232", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2539114", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2358600", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1024637", 
        "issn": [
          "1471-2210"
        ], 
        "name": "BMC Pharmacology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "12"
      }
    ], 
    "keywords": [
      "superior mesenteric artery", 
      "total peripheral resistance", 
      "normotensive Sprague-Dawley rats", 
      "mesenteric resistance arteries", 
      "mean arterial pressure", 
      "mesenteric artery", 
      "Sprague-Dawley rats", 
      "vascular relaxation", 
      "peripheral resistance", 
      "blood pressure", 
      "resistance arteries", 
      "DOCA-salt rats", 
      "isometric contractile force", 
      "real-time RT-PCR", 
      "BW 723C86", 
      "LP-44", 
      "deoxycorticosterone acetate", 
      "cardiac index", 
      "salt rats", 
      "CP 93129", 
      "arterial pressure", 
      "chronic infusion", 
      "week infusion", 
      "cardiac output", 
      "sustained fall", 
      "mesenteric vasculature", 
      "stroke volume", 
      "Dawley rats", 
      "heart rate", 
      "weeks results", 
      "artery", 
      "Western blot", 
      "rats", 
      "contractile force", 
      "sham", 
      "RT-PCR", 
      "receptors", 
      "infusion", 
      "receptor protein", 
      "high percentage", 
      "serotonin", 
      "maximum concentration", 
      "fall", 
      "vasculature", 
      "blot", 
      "vivo", 
      "resistance", 
      "pressure", 
      "mRNA", 
      "percentage", 
      "index", 
      "ideal candidate", 
      "protein", 
      "sites", 
      "rate", 
      "volume", 
      "relaxation", 
      "presence", 
      "concentration", 
      "acetate", 
      "candidates", 
      "results", 
      "output", 
      "force"
    ], 
    "name": "5-hydroxytryptamine (5-HT) reduces total peripheral resistance during chronic infusion: direct arterial mesenteric relaxation is not involved", 
    "pagination": "4", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1005458212"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1471-2210-12-4"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "22559843"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1471-2210-12-4", 
      "https://app.dimensions.ai/details/publication/pub.1005458212"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-11-24T20:56", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221124/entities/gbq_results/article/article_574.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/1471-2210-12-4"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1471-2210-12-4'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1471-2210-12-4'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1471-2210-12-4'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1471-2210-12-4'


 

This table displays all metadata directly associated to this object as RDF triples.

259 TRIPLES      21 PREDICATES      112 URIs      96 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1471-2210-12-4 schema:about N195d9f36be194b34b7ae9f2e13016131
2 N297641b5b301481994166aecf34ddd51
3 N2d7a0755318e44b3abff8f998c46e8ac
4 N365fe7bf151448fe9ef77dc7772b8d98
5 N489d342f3c6c4793bcad7345c02455b2
6 N5dee578174034be78b39ec8f3d36221c
7 N6cf80413a8b34ffb9bbe146d65b3dabc
8 N8578cbcb456646ab9e25f7ab07be897c
9 Nb1c07471795243a3a43d048f01a64669
10 Nc0e491cfd37146e988b6899f8b71d712
11 Ndb956534b3d1449b8c26ca34ec3f1f6a
12 Ne039aa269a42479b8990e825fb6ce797
13 Ne1052abfb159423bbc46c9a09f1860e4
14 Ne861ee9027b745669907f5bf6987438f
15 Nfcff525bd0c9488ea5e891b133d37338
16 anzsrc-for:11
17 anzsrc-for:1102
18 schema:author N1f754be049054a09a63ed5264ceb28ce
19 schema:citation sg:pub.10.1007/bf00053439
20 sg:pub.10.1007/bf00169451
21 sg:pub.10.1007/bf00508342
22 sg:pub.10.1007/pl00005359
23 sg:pub.10.1007/s00210-004-1006-6
24 sg:pub.10.1038/169800b0
25 sg:pub.10.1186/1471-2210-3-1
26 sg:pub.10.1186/1471-2210-3-12
27 schema:datePublished 2012-05-06
28 schema:datePublishedReg 2012-05-06
29 schema:description Serotonin (5-hydroxytryptamine; 5-HT) delivered over 1 week results in a sustained fall in blood pressure in the sham and deoxycorticosterone acetate (DOCA)-salt rat. We hypothesized 5-HT lowers blood pressure through direct receptor-mediated vascular relaxation. In vivo, 5-HT reduced mean arterial pressure (MAP), increased heart rate, stroke volume, cardiac index, and reduced total peripheral resistance during a 1 week infusion of 5-HT (25 µg/kg/min) in the normotensive Sprague Dawley rat. The mesenteric vasculature was chosen as an ideal candidate for the site of 5-HT receptor mediated vascular relaxation given the high percentage of cardiac output the site receives. Real-time RT-PCR demonstrated that mRNA transcripts for the 5-HT2B, 5-HT1B, and 5-HT7 receptors are present in sham and DOCA-salt superior mesenteric arteries. Immunohistochemistry and Western blot validated the presence of the 5-HT2B, 5- HT1B and 5-HT7 receptor protein in sham and DOCA-salt superior mesenteric artery. Isometric contractile force was measured in endothelium-intact superior mesenteric artery and mesenteric resistance arteries in which the contractile 5- HT2A receptor was antagonized. Maximum concentrations of BW-723C86 (5- HT2B agonist), CP 93129 (5-HT1B agonist) or LP-44 (5-HT7 agonist) did not relax the superior mesenteric artery from DOCA-salt rats vs. vehicle. Additionally, 5-HT (10–9 M to 10–5 M) did not cause relaxation in either contracted mesenteric resistance arteries or superior mesenteric arteries from normotensive Sprague- Dawley rats. Thus, although 5-HT receptors known to mediate vascular relaxation are present in the superior mesenteric artery, they are not functional, and are therefore not likely involved in a 5-HT-induced fall in total peripheral resistance and MAP.
30 schema:genre article
31 schema:isAccessibleForFree true
32 schema:isPartOf Ne9b6aedb9f34454faee5392f3690e1f2
33 Nef6c7918754f4b56bd5f4c50fbb40a08
34 sg:journal.1024637
35 schema:keywords BW 723C86
36 CP 93129
37 DOCA-salt rats
38 Dawley rats
39 LP-44
40 RT-PCR
41 Sprague-Dawley rats
42 Western blot
43 acetate
44 arterial pressure
45 artery
46 blood pressure
47 blot
48 candidates
49 cardiac index
50 cardiac output
51 chronic infusion
52 concentration
53 contractile force
54 deoxycorticosterone acetate
55 fall
56 force
57 heart rate
58 high percentage
59 ideal candidate
60 index
61 infusion
62 isometric contractile force
63 mRNA
64 maximum concentration
65 mean arterial pressure
66 mesenteric artery
67 mesenteric resistance arteries
68 mesenteric vasculature
69 normotensive Sprague-Dawley rats
70 output
71 percentage
72 peripheral resistance
73 presence
74 pressure
75 protein
76 rate
77 rats
78 real-time RT-PCR
79 receptor protein
80 receptors
81 relaxation
82 resistance
83 resistance arteries
84 results
85 salt rats
86 serotonin
87 sham
88 sites
89 stroke volume
90 superior mesenteric artery
91 sustained fall
92 total peripheral resistance
93 vascular relaxation
94 vasculature
95 vivo
96 volume
97 week infusion
98 weeks results
99 schema:name 5-hydroxytryptamine (5-HT) reduces total peripheral resistance during chronic infusion: direct arterial mesenteric relaxation is not involved
100 schema:pagination 4
101 schema:productId N22cd326d9743455aa0c41eafdeabb0f9
102 N60fc01bf0fa24a42abb812fa8c472397
103 N92256f19c4b94a97a193215f4f8750ac
104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005458212
105 https://doi.org/10.1186/1471-2210-12-4
106 schema:sdDatePublished 2022-11-24T20:56
107 schema:sdLicense https://scigraph.springernature.com/explorer/license/
108 schema:sdPublisher N849ec96fca6d4982a1148c9280599b9f
109 schema:url https://doi.org/10.1186/1471-2210-12-4
110 sgo:license sg:explorer/license/
111 sgo:sdDataset articles
112 rdf:type schema:ScholarlyArticle
113 N195d9f36be194b34b7ae9f2e13016131 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Serotonin Receptor Agonists
115 rdf:type schema:DefinedTerm
116 N1f754be049054a09a63ed5264ceb28ce rdf:first sg:person.0577713124.01
117 rdf:rest Ne10c07f9242844869a3e8244a100eada
118 N22cd326d9743455aa0c41eafdeabb0f9 schema:name dimensions_id
119 schema:value pub.1005458212
120 rdf:type schema:PropertyValue
121 N297641b5b301481994166aecf34ddd51 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Vasodilation
123 rdf:type schema:DefinedTerm
124 N2d7a0755318e44b3abff8f998c46e8ac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name In Vitro Techniques
126 rdf:type schema:DefinedTerm
127 N349c81913fa54dfeaa19a9e43372d8c5 rdf:first sg:person.01120706127.29
128 rdf:rest Nd15fe3843e5e4a7d9e8d5c5efa78d38c
129 N365fe7bf151448fe9ef77dc7772b8d98 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Male
131 rdf:type schema:DefinedTerm
132 N36beb7691d01469297a3d2f71598be78 rdf:first sg:person.0736306175.24
133 rdf:rest N349c81913fa54dfeaa19a9e43372d8c5
134 N489d342f3c6c4793bcad7345c02455b2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Blood Pressure
136 rdf:type schema:DefinedTerm
137 N5dee578174034be78b39ec8f3d36221c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Mesenteric Arteries
139 rdf:type schema:DefinedTerm
140 N60fc01bf0fa24a42abb812fa8c472397 schema:name pubmed_id
141 schema:value 22559843
142 rdf:type schema:PropertyValue
143 N6cf80413a8b34ffb9bbe146d65b3dabc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Isometric Contraction
145 rdf:type schema:DefinedTerm
146 N7bd498a43efa40c5ba78e568182a48e7 rdf:first sg:person.0611032321.58
147 rdf:rest rdf:nil
148 N849ec96fca6d4982a1148c9280599b9f schema:name Springer Nature - SN SciGraph project
149 rdf:type schema:Organization
150 N8578cbcb456646ab9e25f7ab07be897c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Rats, Sprague-Dawley
152 rdf:type schema:DefinedTerm
153 N92256f19c4b94a97a193215f4f8750ac schema:name doi
154 schema:value 10.1186/1471-2210-12-4
155 rdf:type schema:PropertyValue
156 N98c8c5c25c8e42a69a4c62c38d8fd430 schema:affiliation grid-institutes:grid.17088.36
157 schema:familyName Pattison
158 schema:givenName Jill
159 rdf:type schema:Person
160 Nb1c07471795243a3a43d048f01a64669 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Rats
162 rdf:type schema:DefinedTerm
163 Nc0e491cfd37146e988b6899f8b71d712 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Mineralocorticoids
165 rdf:type schema:DefinedTerm
166 Nd15fe3843e5e4a7d9e8d5c5efa78d38c rdf:first sg:person.01307764320.24
167 rdf:rest N7bd498a43efa40c5ba78e568182a48e7
168 Ndb956534b3d1449b8c26ca34ec3f1f6a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Desoxycorticosterone
170 rdf:type schema:DefinedTerm
171 Ne039aa269a42479b8990e825fb6ce797 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Serotonin
173 rdf:type schema:DefinedTerm
174 Ne1052abfb159423bbc46c9a09f1860e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Vascular Resistance
176 rdf:type schema:DefinedTerm
177 Ne10c07f9242844869a3e8244a100eada rdf:first N98c8c5c25c8e42a69a4c62c38d8fd430
178 rdf:rest N36beb7691d01469297a3d2f71598be78
179 Ne861ee9027b745669907f5bf6987438f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Receptors, Serotonin
181 rdf:type schema:DefinedTerm
182 Ne9b6aedb9f34454faee5392f3690e1f2 schema:issueNumber 1
183 rdf:type schema:PublicationIssue
184 Nef6c7918754f4b56bd5f4c50fbb40a08 schema:volumeNumber 12
185 rdf:type schema:PublicationVolume
186 Nfcff525bd0c9488ea5e891b133d37338 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Animals
188 rdf:type schema:DefinedTerm
189 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
190 schema:name Medical and Health Sciences
191 rdf:type schema:DefinedTerm
192 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
193 schema:name Cardiorespiratory Medicine and Haematology
194 rdf:type schema:DefinedTerm
195 sg:grant.2358600 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2210-12-4
196 rdf:type schema:MonetaryGrant
197 sg:grant.2539114 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2210-12-4
198 rdf:type schema:MonetaryGrant
199 sg:grant.2543232 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2210-12-4
200 rdf:type schema:MonetaryGrant
201 sg:journal.1024637 schema:issn 1471-2210
202 schema:name BMC Pharmacology
203 schema:publisher Springer Nature
204 rdf:type schema:Periodical
205 sg:person.01120706127.29 schema:affiliation grid-institutes:grid.164971.c
206 schema:familyName Tiniakov
207 schema:givenName Ruslan
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120706127.29
209 rdf:type schema:Person
210 sg:person.01307764320.24 schema:affiliation grid-institutes:grid.164971.c
211 schema:familyName Scrogin
212 schema:givenName Karie E
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307764320.24
214 rdf:type schema:Person
215 sg:person.0577713124.01 schema:affiliation grid-institutes:grid.17088.36
216 schema:familyName Davis
217 schema:givenName Robert Patrick
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577713124.01
219 rdf:type schema:Person
220 sg:person.0611032321.58 schema:affiliation grid-institutes:grid.17088.36
221 schema:familyName Watts
222 schema:givenName Stephanie W
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611032321.58
224 rdf:type schema:Person
225 sg:person.0736306175.24 schema:affiliation grid-institutes:grid.17088.36
226 schema:familyName Thompson
227 schema:givenName Janice M
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736306175.24
229 rdf:type schema:Person
230 sg:pub.10.1007/bf00053439 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050362470
231 https://doi.org/10.1007/bf00053439
232 rdf:type schema:CreativeWork
233 sg:pub.10.1007/bf00169451 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007079585
234 https://doi.org/10.1007/bf00169451
235 rdf:type schema:CreativeWork
236 sg:pub.10.1007/bf00508342 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031656352
237 https://doi.org/10.1007/bf00508342
238 rdf:type schema:CreativeWork
239 sg:pub.10.1007/pl00005359 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034354135
240 https://doi.org/10.1007/pl00005359
241 rdf:type schema:CreativeWork
242 sg:pub.10.1007/s00210-004-1006-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048516570
243 https://doi.org/10.1007/s00210-004-1006-6
244 rdf:type schema:CreativeWork
245 sg:pub.10.1038/169800b0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021242644
246 https://doi.org/10.1038/169800b0
247 rdf:type schema:CreativeWork
248 sg:pub.10.1186/1471-2210-3-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043739890
249 https://doi.org/10.1186/1471-2210-3-1
250 rdf:type schema:CreativeWork
251 sg:pub.10.1186/1471-2210-3-12 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039994735
252 https://doi.org/10.1186/1471-2210-3-12
253 rdf:type schema:CreativeWork
254 grid-institutes:grid.164971.c schema:alternateName Department of Pharmacology and Experimental Therapeutics, Loyola University, Chicago, Stritch School of Medicine, 60153, Maywood, IL, USA
255 schema:name Department of Pharmacology and Experimental Therapeutics, Loyola University, Chicago, Stritch School of Medicine, 60153, Maywood, IL, USA
256 rdf:type schema:Organization
257 grid-institutes:grid.17088.36 schema:alternateName Department of Pharmacology and Toxicology, Michigan State University, 48824-1317, East Lansing, MI, USA
258 schema:name Department of Pharmacology and Toxicology, Michigan State University, 48824-1317, East Lansing, MI, USA
259 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...