The association of CD81 with tetraspanin-enriched microdomains is not essential for Hepatitis C virus entry View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-12

AUTHORS

Vera Rocha-Perugini, Muriel Lavie, David Delgrange, Jonathan Canton, André Pillez, Julie Potel, Cécile Lecoeur, Eric Rubinstein, Jean Dubuisson, Czeslaw Wychowski, Laurence Cocquerel

ABSTRACT

BACKGROUND: Three percent of the world's population is chronically infected with hepatitis C virus (HCV) and thus at risk of developing liver cancer. Although precise mechanisms regulating HCV entry into hepatic cells are still unknown, several cell surface proteins have been identified as entry factors for this virus. Among these molecules, the tetraspanin CD81 is essential for HCV entry. Interestingly, CD81 is also required for Plasmodium infection. A major characteristic of tetraspanins is their ability to interact with each other and other transmembrane proteins to build tetraspanin-enriched microdomains (TEM). RESULTS: In our study, we describe a human hepatoma Huh-7 cell clone (Huh-7w7) which has lost CD81 expression and can be infected by HCV when human CD81 (hCD81) or mouse CD81 (mCD81) is ectopically expressed. We took advantage of these permissive cells expressing mCD81 and the previously described MT81/MT81w mAbs to analyze the role of TEM-associated CD81 in HCV infection. Importantly, MT81w antibody, which only recognizes TEM-associated mCD81, did not strongly affect HCV infection. Furthermore, cholesterol depletion, which inhibits HCV infection and reduces total cell surface expression of CD81, did not affect TEM-associated CD81 levels. In addition, sphingomyelinase treatment, which also reduces HCV infection and cell surface expression of total CD81, raised TEM-associated CD81 levels. CONCLUSION: In contrast to Plasmodium infection, our data show that association of CD81 with TEM is not essential for the early steps of HCV life cycle, indicating that these two pathogens, while using the same molecules, invade their host by different mechanisms. More... »

PAGES

111

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1471-2180-9-111

DOI

http://dx.doi.org/10.1186/1471-2180-9-111

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1036309169

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19476617


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1108", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Microbiology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antigens, CD", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biotinylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Membrane", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ceramides", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cholesterol", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hepacivirus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hepatitis Antibodies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hepatitis C", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Microdomains", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neutralization Tests", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sphingomyelin Phosphodiesterase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tetraspanin 28", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Virus Internalization", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Lille Nord de France", 
          "id": "https://www.grid.ac/institutes/grid.412304.0", 
          "name": [
            "Institut de Biologie de Lille, CNRS-UMR8161, Universit\u00e9 Lille Nord de France, Institut Pasteur de Lille, Lille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rocha-Perugini", 
        "givenName": "Vera", 
        "id": "sg:person.0617720131.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617720131.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "German Cancer Research Center", 
          "id": "https://www.grid.ac/institutes/grid.7497.d", 
          "name": [
            "Institut de Biologie de Lille, CNRS-UMR8161, Universit\u00e9 Lille Nord de France, Institut Pasteur de Lille, Lille, France", 
            "DKFZ, Tumorvirologie, Virus-Produktion und Entwicklung, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lavie", 
        "givenName": "Muriel", 
        "id": "sg:person.01054637224.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054637224.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Lille Nord de France", 
          "id": "https://www.grid.ac/institutes/grid.412304.0", 
          "name": [
            "Institut de Biologie de Lille, CNRS-UMR8161, Universit\u00e9 Lille Nord de France, Institut Pasteur de Lille, Lille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Delgrange", 
        "givenName": "David", 
        "id": "sg:person.01300636227.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300636227.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Lille Nord de France", 
          "id": "https://www.grid.ac/institutes/grid.412304.0", 
          "name": [
            "Institut de Biologie de Lille, CNRS-UMR8161, Universit\u00e9 Lille Nord de France, Institut Pasteur de Lille, Lille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Canton", 
        "givenName": "Jonathan", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Lille Nord de France", 
          "id": "https://www.grid.ac/institutes/grid.412304.0", 
          "name": [
            "Institut de Biologie de Lille, CNRS-UMR8161, Universit\u00e9 Lille Nord de France, Institut Pasteur de Lille, Lille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pillez", 
        "givenName": "Andr\u00e9", 
        "id": "sg:person.015260547544.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015260547544.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "German Cancer Research Center", 
          "id": "https://www.grid.ac/institutes/grid.7497.d", 
          "name": [
            "Institut de Biologie de Lille, CNRS-UMR8161, Universit\u00e9 Lille Nord de France, Institut Pasteur de Lille, Lille, France", 
            "DKFZ, Tumorvirologie, Virus-Produktion und Entwicklung, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Potel", 
        "givenName": "Julie", 
        "id": "sg:person.01264667642.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264667642.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Lille Nord de France", 
          "id": "https://www.grid.ac/institutes/grid.412304.0", 
          "name": [
            "Institut de Biologie de Lille, CNRS-UMR8090, Universit\u00e9 Lille Nord de France, Institut Pasteur de Lille, Lille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lecoeur", 
        "givenName": "C\u00e9cile", 
        "id": "sg:person.01162054063.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162054063.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Paul Brousse", 
          "id": "https://www.grid.ac/institutes/grid.413133.7", 
          "name": [
            "INSERM-U602, Institut Andr\u00e9-Lwoff, Universit\u00e9 Paris XI, H\u00f4pital Paul Brousse, Villejuif, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rubinstein", 
        "givenName": "Eric", 
        "id": "sg:person.01213310172.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213310172.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Lille Nord de France", 
          "id": "https://www.grid.ac/institutes/grid.412304.0", 
          "name": [
            "Institut de Biologie de Lille, CNRS-UMR8161, Universit\u00e9 Lille Nord de France, Institut Pasteur de Lille, Lille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dubuisson", 
        "givenName": "Jean", 
        "id": "sg:person.01012365124.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012365124.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Lille Nord de France", 
          "id": "https://www.grid.ac/institutes/grid.412304.0", 
          "name": [
            "Institut de Biologie de Lille, CNRS-UMR8161, Universit\u00e9 Lille Nord de France, Institut Pasteur de Lille, Lille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wychowski", 
        "givenName": "Czeslaw", 
        "id": "sg:person.0660112131.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660112131.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Lille Nord de France", 
          "id": "https://www.grid.ac/institutes/grid.412304.0", 
          "name": [
            "Institut de Biologie de Lille, CNRS-UMR8161, Universit\u00e9 Lille Nord de France, Institut Pasteur de Lille, Lille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cocquerel", 
        "givenName": "Laurence", 
        "id": "sg:person.0630023324.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630023324.71"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0014-5793(02)02522-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000064724"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1194/jlr.m300461-jlr200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000192425"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.80.4.1734-1741.2006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000337310"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/09687680410001700517", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000524116"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.80.10.4940-4948.2006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000552272"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1114016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003059448"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.177.5.1287", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004207606"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m101866200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004553848"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1462-5822.2006.00697.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005555971"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1462-5822.2006.00697.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005555971"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.2005.076646", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006697632"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.chom.2008.07.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006710331"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m510617200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007889243"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.20542", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010688419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/b978-1-4831-9942-9.50008-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013593729"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.virol.2005.05.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014667613"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1091/mbc.01-05-0275", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016790857"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.ppat.1000010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017573677"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.117.6.1351", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017808240"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20030343", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019243785"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20030343", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019243785"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2001-11-0042", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019955154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbamcr.2005.09.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020124494"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbamcr.2005.09.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020124494"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-291x(03)00545-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020328867"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-291x(03)00545-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020328867"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/pl00000933", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021381332", 
          "https://doi.org/10.1007/pl00000933"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m205265200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021404188"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.ppat.0030108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022322879"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m509747200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022974952"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/eji.1830261117", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024004304"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/physiol.00015.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025071747"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/physiol.00015.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025071747"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/eji.200424887", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025621394"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0014-5793(03)00635-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027013132"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20060259", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027735293"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20060259", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027735293"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/viro.2000.0617", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027950501"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jmv.20842", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028038213"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m107338200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028146809"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.01748-06", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029470019"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.02622-06", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029647786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0001866", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030756654"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/viro.2002.1631", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032187005"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/viro.2002.1631", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032187005"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.02460-05", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032319454"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.00941-06", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033519649"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1462-5822.2007.01107.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033743398"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0800422105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034577250"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1462-5822.2007.01070.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034636303"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.01134-06", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035779955"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.01307-06", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037805467"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1206540", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038089782", 
          "https://doi.org/10.1038/sj.onc.1206540"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1206540", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038089782", 
          "https://doi.org/10.1038/sj.onc.1206540"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.01573-06", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038335568"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.78.6.2994-3002.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038965551"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m011297200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039052671"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jcs.02911", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040006605"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0503596102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040408551"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.74.13.5933-5938.2000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041452859"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1268", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042875201", 
          "https://doi.org/10.1038/nm1268"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1268", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042875201", 
          "https://doi.org/10.1038/nm1268"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.271.27.16026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043388629"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0832180100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047658060"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm808", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047718927", 
          "https://doi.org/10.1038/nm808"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm808", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047718927", 
          "https://doi.org/10.1038/nm808"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20041377", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047727315"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20041377", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047727315"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.00104-06", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047927323"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.01534-06", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048524297"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri1548", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048655836", 
          "https://doi.org/10.1038/nri1548"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri1548", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048655836", 
          "https://doi.org/10.1038/nri1548"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00018-007-7291-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049215470", 
          "https://doi.org/10.1007/s00018-007-7291-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbamem.2004.05.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049948011"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20021756", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052202585"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.74.8.3642-3649.2000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052486718"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000107533", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053146162"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1099/vir.0.82872-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060401479"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074365867", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074489127", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074529399", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083182330", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2009-12", 
    "datePublishedReg": "2009-12-01", 
    "description": "BACKGROUND: Three percent of the world's population is chronically infected with hepatitis C virus (HCV) and thus at risk of developing liver cancer. Although precise mechanisms regulating HCV entry into hepatic cells are still unknown, several cell surface proteins have been identified as entry factors for this virus. Among these molecules, the tetraspanin CD81 is essential for HCV entry. Interestingly, CD81 is also required for Plasmodium infection. A major characteristic of tetraspanins is their ability to interact with each other and other transmembrane proteins to build tetraspanin-enriched microdomains (TEM).\nRESULTS: In our study, we describe a human hepatoma Huh-7 cell clone (Huh-7w7) which has lost CD81 expression and can be infected by HCV when human CD81 (hCD81) or mouse CD81 (mCD81) is ectopically expressed. We took advantage of these permissive cells expressing mCD81 and the previously described MT81/MT81w mAbs to analyze the role of TEM-associated CD81 in HCV infection. Importantly, MT81w antibody, which only recognizes TEM-associated mCD81, did not strongly affect HCV infection. Furthermore, cholesterol depletion, which inhibits HCV infection and reduces total cell surface expression of CD81, did not affect TEM-associated CD81 levels. In addition, sphingomyelinase treatment, which also reduces HCV infection and cell surface expression of total CD81, raised TEM-associated CD81 levels.\nCONCLUSION: In contrast to Plasmodium infection, our data show that association of CD81 with TEM is not essential for the early steps of HCV life cycle, indicating that these two pathogens, while using the same molecules, invade their host by different mechanisms.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/1471-2180-9-111", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1024253", 
        "issn": [
          "1471-2180"
        ], 
        "name": "BMC Microbiology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "name": "The association of CD81 with tetraspanin-enriched microdomains is not essential for Hepatitis C virus entry", 
    "pagination": "111", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "acf64bcfaefadcffa47018b2a06585c8f9419ccf605979a2fd748a7ee55866c8"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "19476617"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100966981"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1471-2180-9-111"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1036309169"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1471-2180-9-111", 
      "https://app.dimensions.ai/details/publication/pub.1036309169"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T23:23", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8693_00000506.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2F1471-2180-9-111"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1471-2180-9-111'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1471-2180-9-111'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1471-2180-9-111'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1471-2180-9-111'


 

This table displays all metadata directly associated to this object as RDF triples.

429 TRIPLES      21 PREDICATES      117 URIs      39 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1471-2180-9-111 schema:about N065a5c6848544873bba06ba6c9cbb705
2 N12432d4ce6664daa87faedef479981f2
3 N17ed420c327a4aea817d53349a1279bf
4 N181e596316bf4c4a901de0c3a0ac1526
5 N5d60798cbda24f55988e47fbb506d4bc
6 N6269c15489894e28b9a05406ea2b8747
7 N7c3d5fd9616346bd8812d079a19225c2
8 N86ad0514539d4ca9bfb0b39891a2b029
9 Na7502915654541af99bac3f852198bab
10 Nac5756a00afd401b8617a129254638ae
11 Nb5c2096e84724423b09f7adc1bbaa7dc
12 Nbb083c253a7f4383b604f9643aa888d4
13 Nbf3840327b234baeb220217ff9db9adb
14 Nc15eda2cda914e94992467b57ee20170
15 Nc50b346db7ff4b45b65569b94e127fbb
16 Nc54d9099c506426f8eda7049a9ad2606
17 Nca33e24c54524811b0a21328750ce8ab
18 Nf364d88239e9438489cb7e1975cfae74
19 anzsrc-for:11
20 anzsrc-for:1108
21 schema:author Nbfd7c743165045428ddbe804496ed5ce
22 schema:citation sg:pub.10.1007/pl00000933
23 sg:pub.10.1007/s00018-007-7291-8
24 sg:pub.10.1038/nm1268
25 sg:pub.10.1038/nm808
26 sg:pub.10.1038/nri1548
27 sg:pub.10.1038/sj.onc.1206540
28 https://app.dimensions.ai/details/publication/pub.1074365867
29 https://app.dimensions.ai/details/publication/pub.1074489127
30 https://app.dimensions.ai/details/publication/pub.1074529399
31 https://app.dimensions.ai/details/publication/pub.1083182330
32 https://doi.org/10.1002/eji.1830261117
33 https://doi.org/10.1002/eji.200424887
34 https://doi.org/10.1002/hep.20542
35 https://doi.org/10.1002/jmv.20842
36 https://doi.org/10.1006/viro.2000.0617
37 https://doi.org/10.1006/viro.2002.1631
38 https://doi.org/10.1016/b978-1-4831-9942-9.50008-5
39 https://doi.org/10.1016/j.bbamcr.2005.09.001
40 https://doi.org/10.1016/j.bbamem.2004.05.011
41 https://doi.org/10.1016/j.chom.2008.07.012
42 https://doi.org/10.1016/j.virol.2005.05.006
43 https://doi.org/10.1016/s0006-291x(03)00545-x
44 https://doi.org/10.1016/s0014-5793(02)02522-x
45 https://doi.org/10.1016/s0014-5793(03)00635-5
46 https://doi.org/10.1042/bj20030343
47 https://doi.org/10.1042/bj20041377
48 https://doi.org/10.1042/bj20060259
49 https://doi.org/10.1073/pnas.0503596102
50 https://doi.org/10.1073/pnas.0800422105
51 https://doi.org/10.1073/pnas.0832180100
52 https://doi.org/10.1074/jbc.271.27.16026
53 https://doi.org/10.1074/jbc.m011297200
54 https://doi.org/10.1074/jbc.m101866200
55 https://doi.org/10.1074/jbc.m107338200
56 https://doi.org/10.1074/jbc.m205265200
57 https://doi.org/10.1074/jbc.m509747200
58 https://doi.org/10.1074/jbc.m510617200
59 https://doi.org/10.1080/09687680410001700517
60 https://doi.org/10.1083/jcb.117.6.1351
61 https://doi.org/10.1084/jem.177.5.1287
62 https://doi.org/10.1084/jem.20021756
63 https://doi.org/10.1091/mbc.01-05-0275
64 https://doi.org/10.1099/vir.0.82872-0
65 https://doi.org/10.1111/j.1462-5822.2006.00697.x
66 https://doi.org/10.1111/j.1462-5822.2007.01070.x
67 https://doi.org/10.1111/j.1462-5822.2007.01107.x
68 https://doi.org/10.1126/science.1114016
69 https://doi.org/10.1128/jvi.00104-06
70 https://doi.org/10.1128/jvi.00941-06
71 https://doi.org/10.1128/jvi.01134-06
72 https://doi.org/10.1128/jvi.01307-06
73 https://doi.org/10.1128/jvi.01534-06
74 https://doi.org/10.1128/jvi.01573-06
75 https://doi.org/10.1128/jvi.01748-06
76 https://doi.org/10.1128/jvi.02460-05
77 https://doi.org/10.1128/jvi.02622-06
78 https://doi.org/10.1128/jvi.74.13.5933-5938.2000
79 https://doi.org/10.1128/jvi.74.8.3642-3649.2000
80 https://doi.org/10.1128/jvi.78.6.2994-3002.2004
81 https://doi.org/10.1128/jvi.80.10.4940-4948.2006
82 https://doi.org/10.1128/jvi.80.4.1734-1741.2006
83 https://doi.org/10.1136/gut.2005.076646
84 https://doi.org/10.1152/physiol.00015.2005
85 https://doi.org/10.1159/000107533
86 https://doi.org/10.1182/blood-2001-11-0042
87 https://doi.org/10.1194/jlr.m300461-jlr200
88 https://doi.org/10.1242/jcs.02911
89 https://doi.org/10.1371/journal.pone.0001866
90 https://doi.org/10.1371/journal.ppat.0030108
91 https://doi.org/10.1371/journal.ppat.1000010
92 schema:datePublished 2009-12
93 schema:datePublishedReg 2009-12-01
94 schema:description BACKGROUND: Three percent of the world's population is chronically infected with hepatitis C virus (HCV) and thus at risk of developing liver cancer. Although precise mechanisms regulating HCV entry into hepatic cells are still unknown, several cell surface proteins have been identified as entry factors for this virus. Among these molecules, the tetraspanin CD81 is essential for HCV entry. Interestingly, CD81 is also required for Plasmodium infection. A major characteristic of tetraspanins is their ability to interact with each other and other transmembrane proteins to build tetraspanin-enriched microdomains (TEM). RESULTS: In our study, we describe a human hepatoma Huh-7 cell clone (Huh-7w7) which has lost CD81 expression and can be infected by HCV when human CD81 (hCD81) or mouse CD81 (mCD81) is ectopically expressed. We took advantage of these permissive cells expressing mCD81 and the previously described MT81/MT81w mAbs to analyze the role of TEM-associated CD81 in HCV infection. Importantly, MT81w antibody, which only recognizes TEM-associated mCD81, did not strongly affect HCV infection. Furthermore, cholesterol depletion, which inhibits HCV infection and reduces total cell surface expression of CD81, did not affect TEM-associated CD81 levels. In addition, sphingomyelinase treatment, which also reduces HCV infection and cell surface expression of total CD81, raised TEM-associated CD81 levels. CONCLUSION: In contrast to Plasmodium infection, our data show that association of CD81 with TEM is not essential for the early steps of HCV life cycle, indicating that these two pathogens, while using the same molecules, invade their host by different mechanisms.
95 schema:genre research_article
96 schema:inLanguage en
97 schema:isAccessibleForFree true
98 schema:isPartOf N508dd83a6c9c4c73b0764fa5bdfeaaed
99 N79f262f9cde74ae2a9c8a449ef13d638
100 sg:journal.1024253
101 schema:name The association of CD81 with tetraspanin-enriched microdomains is not essential for Hepatitis C virus entry
102 schema:pagination 111
103 schema:productId N0d6a23a5af8d45dea25d430e7ff97c14
104 N16a51859ab2c4c5b8b2d16ffa56be18f
105 N47c72a22385440ab9d6a89bf0668d509
106 N52d28066f58142b2a2062d7dae8177b9
107 N71ec8583e5a14fc188b5806d3679bf6b
108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036309169
109 https://doi.org/10.1186/1471-2180-9-111
110 schema:sdDatePublished 2019-04-10T23:23
111 schema:sdLicense https://scigraph.springernature.com/explorer/license/
112 schema:sdPublisher Ndab30b3631d84069a0a33c3c7dcf777a
113 schema:url http://link.springer.com/10.1186%2F1471-2180-9-111
114 sgo:license sg:explorer/license/
115 sgo:sdDataset articles
116 rdf:type schema:ScholarlyArticle
117 N065a5c6848544873bba06ba6c9cbb705 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Virus Internalization
119 rdf:type schema:DefinedTerm
120 N0d6a23a5af8d45dea25d430e7ff97c14 schema:name pubmed_id
121 schema:value 19476617
122 rdf:type schema:PropertyValue
123 N12432d4ce6664daa87faedef479981f2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Cell Line, Tumor
125 rdf:type schema:DefinedTerm
126 N16a51859ab2c4c5b8b2d16ffa56be18f schema:name doi
127 schema:value 10.1186/1471-2180-9-111
128 rdf:type schema:PropertyValue
129 N17e29c658c8d42d8b95e316b825c5e47 rdf:first sg:person.01012365124.90
130 rdf:rest N2bfb3ed7efca42018f787fe890766531
131 N17ed420c327a4aea817d53349a1279bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Cell Membrane
133 rdf:type schema:DefinedTerm
134 N181e596316bf4c4a901de0c3a0ac1526 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Membrane Microdomains
136 rdf:type schema:DefinedTerm
137 N2bfb3ed7efca42018f787fe890766531 rdf:first sg:person.0660112131.25
138 rdf:rest Nbe08f7efd0cb405a83786bf960201c8e
139 N3948c9c537294ea29a57f112fa406add rdf:first sg:person.01264667642.09
140 rdf:rest Neef1c1698b744d8fa59f0bea79669908
141 N47c72a22385440ab9d6a89bf0668d509 schema:name nlm_unique_id
142 schema:value 100966981
143 rdf:type schema:PropertyValue
144 N508dd83a6c9c4c73b0764fa5bdfeaaed schema:volumeNumber 9
145 rdf:type schema:PublicationVolume
146 N52d28066f58142b2a2062d7dae8177b9 schema:name dimensions_id
147 schema:value pub.1036309169
148 rdf:type schema:PropertyValue
149 N5d60798cbda24f55988e47fbb506d4bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Animals
151 rdf:type schema:DefinedTerm
152 N5d6c7498ad954db5a5ad18cbc6105d3c rdf:first sg:person.01213310172.88
153 rdf:rest N17e29c658c8d42d8b95e316b825c5e47
154 N6269c15489894e28b9a05406ea2b8747 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Cholesterol
156 rdf:type schema:DefinedTerm
157 N71ec8583e5a14fc188b5806d3679bf6b schema:name readcube_id
158 schema:value acf64bcfaefadcffa47018b2a06585c8f9419ccf605979a2fd748a7ee55866c8
159 rdf:type schema:PropertyValue
160 N7714fa9f67804221bccc78f559621590 rdf:first sg:person.01054637224.45
161 rdf:rest Ned75c6d0180b4d6c9ba1f7df656b3b3d
162 N79f262f9cde74ae2a9c8a449ef13d638 schema:issueNumber 1
163 rdf:type schema:PublicationIssue
164 N7c3d5fd9616346bd8812d079a19225c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Hepatitis Antibodies
166 rdf:type schema:DefinedTerm
167 N86ad0514539d4ca9bfb0b39891a2b029 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Biotinylation
169 rdf:type schema:DefinedTerm
170 N97f40c7193f64a41b2337030ea68846e rdf:first sg:person.015260547544.47
171 rdf:rest N3948c9c537294ea29a57f112fa406add
172 Na7502915654541af99bac3f852198bab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Antigens, CD
174 rdf:type schema:DefinedTerm
175 Nac5756a00afd401b8617a129254638ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Mice
177 rdf:type schema:DefinedTerm
178 Nb5c2096e84724423b09f7adc1bbaa7dc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Tetraspanin 28
180 rdf:type schema:DefinedTerm
181 Nbb083c253a7f4383b604f9643aa888d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Hepacivirus
183 rdf:type schema:DefinedTerm
184 Nbe08f7efd0cb405a83786bf960201c8e rdf:first sg:person.0630023324.71
185 rdf:rest rdf:nil
186 Nbf3840327b234baeb220217ff9db9adb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Ceramides
188 rdf:type schema:DefinedTerm
189 Nbfd7c743165045428ddbe804496ed5ce rdf:first sg:person.0617720131.70
190 rdf:rest N7714fa9f67804221bccc78f559621590
191 Nc15e619017604a8eb700156a8b9ccbbb schema:affiliation https://www.grid.ac/institutes/grid.412304.0
192 schema:familyName Canton
193 schema:givenName Jonathan
194 rdf:type schema:Person
195 Nc15eda2cda914e94992467b57ee20170 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
196 schema:name Hepatitis C
197 rdf:type schema:DefinedTerm
198 Nc50b346db7ff4b45b65569b94e127fbb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
199 schema:name Humans
200 rdf:type schema:DefinedTerm
201 Nc54d9099c506426f8eda7049a9ad2606 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
202 schema:name Membrane Proteins
203 rdf:type schema:DefinedTerm
204 Nca33e24c54524811b0a21328750ce8ab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
205 schema:name Neutralization Tests
206 rdf:type schema:DefinedTerm
207 Ndab30b3631d84069a0a33c3c7dcf777a schema:name Springer Nature - SN SciGraph project
208 rdf:type schema:Organization
209 Nebdb50bfbc044422938cd6a2cd2f08a0 rdf:first Nc15e619017604a8eb700156a8b9ccbbb
210 rdf:rest N97f40c7193f64a41b2337030ea68846e
211 Ned75c6d0180b4d6c9ba1f7df656b3b3d rdf:first sg:person.01300636227.18
212 rdf:rest Nebdb50bfbc044422938cd6a2cd2f08a0
213 Neef1c1698b744d8fa59f0bea79669908 rdf:first sg:person.01162054063.86
214 rdf:rest N5d6c7498ad954db5a5ad18cbc6105d3c
215 Nf364d88239e9438489cb7e1975cfae74 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
216 schema:name Sphingomyelin Phosphodiesterase
217 rdf:type schema:DefinedTerm
218 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
219 schema:name Medical and Health Sciences
220 rdf:type schema:DefinedTerm
221 anzsrc-for:1108 schema:inDefinedTermSet anzsrc-for:
222 schema:name Medical Microbiology
223 rdf:type schema:DefinedTerm
224 sg:journal.1024253 schema:issn 1471-2180
225 schema:name BMC Microbiology
226 rdf:type schema:Periodical
227 sg:person.01012365124.90 schema:affiliation https://www.grid.ac/institutes/grid.412304.0
228 schema:familyName Dubuisson
229 schema:givenName Jean
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012365124.90
231 rdf:type schema:Person
232 sg:person.01054637224.45 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
233 schema:familyName Lavie
234 schema:givenName Muriel
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054637224.45
236 rdf:type schema:Person
237 sg:person.01162054063.86 schema:affiliation https://www.grid.ac/institutes/grid.412304.0
238 schema:familyName Lecoeur
239 schema:givenName Cécile
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162054063.86
241 rdf:type schema:Person
242 sg:person.01213310172.88 schema:affiliation https://www.grid.ac/institutes/grid.413133.7
243 schema:familyName Rubinstein
244 schema:givenName Eric
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213310172.88
246 rdf:type schema:Person
247 sg:person.01264667642.09 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
248 schema:familyName Potel
249 schema:givenName Julie
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264667642.09
251 rdf:type schema:Person
252 sg:person.01300636227.18 schema:affiliation https://www.grid.ac/institutes/grid.412304.0
253 schema:familyName Delgrange
254 schema:givenName David
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300636227.18
256 rdf:type schema:Person
257 sg:person.015260547544.47 schema:affiliation https://www.grid.ac/institutes/grid.412304.0
258 schema:familyName Pillez
259 schema:givenName André
260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015260547544.47
261 rdf:type schema:Person
262 sg:person.0617720131.70 schema:affiliation https://www.grid.ac/institutes/grid.412304.0
263 schema:familyName Rocha-Perugini
264 schema:givenName Vera
265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617720131.70
266 rdf:type schema:Person
267 sg:person.0630023324.71 schema:affiliation https://www.grid.ac/institutes/grid.412304.0
268 schema:familyName Cocquerel
269 schema:givenName Laurence
270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630023324.71
271 rdf:type schema:Person
272 sg:person.0660112131.25 schema:affiliation https://www.grid.ac/institutes/grid.412304.0
273 schema:familyName Wychowski
274 schema:givenName Czeslaw
275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660112131.25
276 rdf:type schema:Person
277 sg:pub.10.1007/pl00000933 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021381332
278 https://doi.org/10.1007/pl00000933
279 rdf:type schema:CreativeWork
280 sg:pub.10.1007/s00018-007-7291-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049215470
281 https://doi.org/10.1007/s00018-007-7291-8
282 rdf:type schema:CreativeWork
283 sg:pub.10.1038/nm1268 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042875201
284 https://doi.org/10.1038/nm1268
285 rdf:type schema:CreativeWork
286 sg:pub.10.1038/nm808 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047718927
287 https://doi.org/10.1038/nm808
288 rdf:type schema:CreativeWork
289 sg:pub.10.1038/nri1548 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048655836
290 https://doi.org/10.1038/nri1548
291 rdf:type schema:CreativeWork
292 sg:pub.10.1038/sj.onc.1206540 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038089782
293 https://doi.org/10.1038/sj.onc.1206540
294 rdf:type schema:CreativeWork
295 https://app.dimensions.ai/details/publication/pub.1074365867 schema:CreativeWork
296 https://app.dimensions.ai/details/publication/pub.1074489127 schema:CreativeWork
297 https://app.dimensions.ai/details/publication/pub.1074529399 schema:CreativeWork
298 https://app.dimensions.ai/details/publication/pub.1083182330 schema:CreativeWork
299 https://doi.org/10.1002/eji.1830261117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024004304
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1002/eji.200424887 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025621394
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1002/hep.20542 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010688419
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1002/jmv.20842 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028038213
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1006/viro.2000.0617 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027950501
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1006/viro.2002.1631 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032187005
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1016/b978-1-4831-9942-9.50008-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013593729
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1016/j.bbamcr.2005.09.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020124494
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1016/j.bbamem.2004.05.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049948011
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1016/j.chom.2008.07.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006710331
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1016/j.virol.2005.05.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014667613
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1016/s0006-291x(03)00545-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1020328867
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1016/s0014-5793(02)02522-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1000064724
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1016/s0014-5793(03)00635-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027013132
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1042/bj20030343 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019243785
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1042/bj20041377 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047727315
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1042/bj20060259 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027735293
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1073/pnas.0503596102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040408551
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1073/pnas.0800422105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034577250
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1073/pnas.0832180100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047658060
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1074/jbc.271.27.16026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043388629
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1074/jbc.m011297200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039052671
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1074/jbc.m101866200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004553848
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1074/jbc.m107338200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028146809
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1074/jbc.m205265200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021404188
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1074/jbc.m509747200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022974952
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1074/jbc.m510617200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007889243
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1080/09687680410001700517 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000524116
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1083/jcb.117.6.1351 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017808240
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1084/jem.177.5.1287 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004207606
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1084/jem.20021756 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052202585
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1091/mbc.01-05-0275 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016790857
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1099/vir.0.82872-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060401479
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1111/j.1462-5822.2006.00697.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1005555971
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1111/j.1462-5822.2007.01070.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1034636303
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1111/j.1462-5822.2007.01107.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1033743398
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1126/science.1114016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003059448
372 rdf:type schema:CreativeWork
373 https://doi.org/10.1128/jvi.00104-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047927323
374 rdf:type schema:CreativeWork
375 https://doi.org/10.1128/jvi.00941-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033519649
376 rdf:type schema:CreativeWork
377 https://doi.org/10.1128/jvi.01134-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035779955
378 rdf:type schema:CreativeWork
379 https://doi.org/10.1128/jvi.01307-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037805467
380 rdf:type schema:CreativeWork
381 https://doi.org/10.1128/jvi.01534-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048524297
382 rdf:type schema:CreativeWork
383 https://doi.org/10.1128/jvi.01573-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038335568
384 rdf:type schema:CreativeWork
385 https://doi.org/10.1128/jvi.01748-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029470019
386 rdf:type schema:CreativeWork
387 https://doi.org/10.1128/jvi.02460-05 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032319454
388 rdf:type schema:CreativeWork
389 https://doi.org/10.1128/jvi.02622-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029647786
390 rdf:type schema:CreativeWork
391 https://doi.org/10.1128/jvi.74.13.5933-5938.2000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041452859
392 rdf:type schema:CreativeWork
393 https://doi.org/10.1128/jvi.74.8.3642-3649.2000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052486718
394 rdf:type schema:CreativeWork
395 https://doi.org/10.1128/jvi.78.6.2994-3002.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038965551
396 rdf:type schema:CreativeWork
397 https://doi.org/10.1128/jvi.80.10.4940-4948.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000552272
398 rdf:type schema:CreativeWork
399 https://doi.org/10.1128/jvi.80.4.1734-1741.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000337310
400 rdf:type schema:CreativeWork
401 https://doi.org/10.1136/gut.2005.076646 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006697632
402 rdf:type schema:CreativeWork
403 https://doi.org/10.1152/physiol.00015.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025071747
404 rdf:type schema:CreativeWork
405 https://doi.org/10.1159/000107533 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053146162
406 rdf:type schema:CreativeWork
407 https://doi.org/10.1182/blood-2001-11-0042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019955154
408 rdf:type schema:CreativeWork
409 https://doi.org/10.1194/jlr.m300461-jlr200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000192425
410 rdf:type schema:CreativeWork
411 https://doi.org/10.1242/jcs.02911 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040006605
412 rdf:type schema:CreativeWork
413 https://doi.org/10.1371/journal.pone.0001866 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030756654
414 rdf:type schema:CreativeWork
415 https://doi.org/10.1371/journal.ppat.0030108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022322879
416 rdf:type schema:CreativeWork
417 https://doi.org/10.1371/journal.ppat.1000010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017573677
418 rdf:type schema:CreativeWork
419 https://www.grid.ac/institutes/grid.412304.0 schema:alternateName University of Lille Nord de France
420 schema:name Institut de Biologie de Lille, CNRS-UMR8090, Université Lille Nord de France, Institut Pasteur de Lille, Lille, France
421 Institut de Biologie de Lille, CNRS-UMR8161, Université Lille Nord de France, Institut Pasteur de Lille, Lille, France
422 rdf:type schema:Organization
423 https://www.grid.ac/institutes/grid.413133.7 schema:alternateName Hospital Paul Brousse
424 schema:name INSERM-U602, Institut André-Lwoff, Université Paris XI, Hôpital Paul Brousse, Villejuif, France
425 rdf:type schema:Organization
426 https://www.grid.ac/institutes/grid.7497.d schema:alternateName German Cancer Research Center
427 schema:name DKFZ, Tumorvirologie, Virus-Produktion und Entwicklung, Heidelberg, Germany
428 Institut de Biologie de Lille, CNRS-UMR8161, Université Lille Nord de France, Institut Pasteur de Lille, Lille, France
429 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...