The effect of environmental conditions on expression of Bacteroides fragilis and Bacteroides thetaiotaomicron C10 protease genes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-12

AUTHORS

Roibeard F Thornton, Elizabeth C Murphy, Todd F Kagawa, Paul W O’Toole, Jakki C Cooney

ABSTRACT

BACKGROUND: Bacteroides fragilis and Bacteroides thetaiotaomicron are members of the normal human intestinal microbiota. However, both organisms are capable of causing opportunistic infections, during which the environmental conditions to which the bacteria are exposed change dramatically. To further explore their potential for contributing to infection, we have characterized the expression in B. thetaiotaomicron of four homologues of the gene encoding the C10 cysteine protease SpeB, a potent extracellular virulence factor produced by Streptococcus pyogenes. RESULTS: We identified a paralogous set of genes (btp genes) in the B. thetaiotaomicron genome, that were related to C10 protease genes we recently identified in B. fragilis. Similar to C10 proteases found in B. fragilis, three of the B. thetaiotaomicron homologues were transcriptionally coupled to genes encoding small proteins that are similar in structural architecture to Staphostatins, protease inhibitors associated with Staphopains in Staphylococcus aureus. The expression of genes for these C10 proteases in both B. fragilis and B. thetaiotaomicron was found to be regulated by environmental stimuli, in particular by exposure to oxygen, which may be important for their contribution to the development of opportunistic infections. CONCLUSIONS: Genes encoding C10 proteases are increasingly identified in operons which also contain genes encoding proteins homologous to protease inhibitors. The Bacteroides C10 protease gene expression levels are responsive to different environmental stimuli suggesting they may have distinct roles in the bacterial-host interaction. More... »

PAGES

190

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1471-2180-12-190

DOI

http://dx.doi.org/10.1186/1471-2180-12-190

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1015063776

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22943521


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bacteroides", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cysteine Endopeptidases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Profiling", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oxygen", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Virulence Factors", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Limerick", 
          "id": "https://www.grid.ac/institutes/grid.10049.3c", 
          "name": [
            "Department of Life Sciences, University of Limerick, Limerick, Ireland", 
            "Materials and Surface Science Institute, University of Limerick, Limerick, Ireland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thornton", 
        "givenName": "Roibeard F", 
        "id": "sg:person.01212162343.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212162343.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Lund University", 
          "id": "https://www.grid.ac/institutes/grid.4514.4", 
          "name": [
            "Department of Life Sciences, University of Limerick, Limerick, Ireland", 
            "Materials and Surface Science Institute, University of Limerick, Limerick, Ireland", 
            "Department of Clinical Sciences, Lund University, Lund, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Murphy", 
        "givenName": "Elizabeth C", 
        "id": "sg:person.0770744204.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0770744204.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Limerick", 
          "id": "https://www.grid.ac/institutes/grid.10049.3c", 
          "name": [
            "Department of Life Sciences, University of Limerick, Limerick, Ireland", 
            "Materials and Surface Science Institute, University of Limerick, Limerick, Ireland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kagawa", 
        "givenName": "Todd F", 
        "id": "sg:person.01254363134.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254363134.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University College Cork", 
          "id": "https://www.grid.ac/institutes/grid.7872.a", 
          "name": [
            "Department of Microbiology, & Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "O\u2019Toole", 
        "givenName": "Paul W", 
        "id": "sg:person.01305242542.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305242542.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Limerick", 
          "id": "https://www.grid.ac/institutes/grid.10049.3c", 
          "name": [
            "Department of Life Sciences, University of Limerick, Limerick, Ireland", 
            "Materials and Surface Science Institute, University of Limerick, Limerick, Ireland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cooney", 
        "givenName": "Jakki C", 
        "id": "sg:person.01301362237.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301362237.34"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1073/pnas.0404172101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000351126"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2958.1999.01647.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001609059"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.micpath.2007.04.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001697882"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1099/jmm.0.46984-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002211480"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jcm.43.7.3380-3389.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004278855"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.184.2.665", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004486429"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jb.182.18.5059-5069.2000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006597900"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0076-6879(94)35179-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007256714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.040549997", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010552205"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m411792200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015275563"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2958.2009.06974.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015750118"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2958.2009.06974.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015750118"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/iai.69.1.159-169.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016226120"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/iai.70.12.6646-6651.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016793774"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1075-9964(03)00008-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021315096"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1075-9964(03)00008-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021315096"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/cmr.00008-07", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021409328"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0004769", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022261755"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/jmbi.2000.4042", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022575813"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m704821200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025943062"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.ppat.1000316", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027539697"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0076-6879(96)66034-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027814431"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2105-4-29", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028598747", 
          "https://doi.org/10.1186/1471-2105-4-29"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2105-4-29", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028598747", 
          "https://doi.org/10.1186/1471-2105-4-29"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/clinids/23.supplement_1.s97", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029055303"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/29.9.e45", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030834024"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/iai.74.4.2304-2316.2006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031220063"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1110/ps.0303703", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032600631"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m302926200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036132744"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jb.187.5.1751-1762.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036649715"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2958.1991.tb00723.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036704248"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1107008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036766924"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1110/ps.03247703", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036998336"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20090343", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037642093"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20090343", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037642093"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20090343", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037642093"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/mpat.1996.0018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041996885"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/22.22.4673", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042438223"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/iai.72.8.4836-4847.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044555612"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2958.2005.04714.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044981980"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2958.2005.04714.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044981980"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.micpath.2004.02.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046315387"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.micpath.2004.02.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046315387"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/25.17.3389", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047265454"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2958.2007.06031.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048962409"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2958.2007.06031.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048962409"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1399-302x.2007.00429.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050601325"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1399-302x.2007.00429.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050601325"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2180-10-122", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051816432", 
          "https://doi.org/10.1186/1471-2180-10-122"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2958.2005.04708.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052679971"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2958.2005.04708.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052679971"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/17.21.6263", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053147095"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi035310j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055197723"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi035310j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055197723"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi048661m", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055199283"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi048661m", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055199283"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/587525", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058800377"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1099/mic.0.26948-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060397010"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1080029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062447714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jb.176.7.1939-1943.1994", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062723567"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078060571", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079809979", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081654851", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082159538", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-12", 
    "datePublishedReg": "2012-12-01", 
    "description": "BACKGROUND: Bacteroides fragilis and Bacteroides thetaiotaomicron are members of the normal human intestinal microbiota. However, both organisms are capable of causing opportunistic infections, during which the environmental conditions to which the bacteria are exposed change dramatically. To further explore their potential for contributing to infection, we have characterized the expression in B. thetaiotaomicron of four homologues of the gene encoding the C10 cysteine protease SpeB, a potent extracellular virulence factor produced by Streptococcus pyogenes.\nRESULTS: We identified a paralogous set of genes (btp genes) in the B. thetaiotaomicron genome, that were related to C10 protease genes we recently identified in B. fragilis. Similar to C10 proteases found in B. fragilis, three of the B. thetaiotaomicron homologues were transcriptionally coupled to genes encoding small proteins that are similar in structural architecture to Staphostatins, protease inhibitors associated with Staphopains in Staphylococcus aureus. The expression of genes for these C10 proteases in both B. fragilis and B. thetaiotaomicron was found to be regulated by environmental stimuli, in particular by exposure to oxygen, which may be important for their contribution to the development of opportunistic infections.\nCONCLUSIONS: Genes encoding C10 proteases are increasingly identified in operons which also contain genes encoding proteins homologous to protease inhibitors. The Bacteroides C10 protease gene expression levels are responsive to different environmental stimuli suggesting they may have distinct roles in the bacterial-host interaction.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/1471-2180-12-190", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.3983386", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1024253", 
        "issn": [
          "1471-2180"
        ], 
        "name": "BMC Microbiology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "12"
      }
    ], 
    "name": "The effect of environmental conditions on expression of Bacteroides fragilis and Bacteroides thetaiotaomicron C10 protease genes", 
    "pagination": "190", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "47c4c021f5d4d3a57e122f934488498910945b8f8d93d3b3ae75f13b34f12414"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "22943521"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100966981"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1471-2180-12-190"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1015063776"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1471-2180-12-190", 
      "https://app.dimensions.ai/details/publication/pub.1015063776"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T14:07", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000504.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2F1471-2180-12-190"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1471-2180-12-190'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1471-2180-12-190'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1471-2180-12-190'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1471-2180-12-190'


 

This table displays all metadata directly associated to this object as RDF triples.

281 TRIPLES      21 PREDICATES      86 URIs      26 LITERALS      14 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1471-2180-12-190 schema:about N3433cb0a0cf84e52b4e64b19e73068a9
2 N444f7871af064d6a8b052bbe02004267
3 N6d3a8dc03894401e9c44c94958b5107e
4 N8ac378787ae04b7d9759058499f4734c
5 Na6523525e1cd4f71ab59fa5b6dd767b2
6 anzsrc-for:06
7 anzsrc-for:0604
8 schema:author Neb2ef0d847b245dab1de0a62f04d32f1
9 schema:citation sg:pub.10.1186/1471-2105-4-29
10 sg:pub.10.1186/1471-2180-10-122
11 https://app.dimensions.ai/details/publication/pub.1078060571
12 https://app.dimensions.ai/details/publication/pub.1079809979
13 https://app.dimensions.ai/details/publication/pub.1081654851
14 https://app.dimensions.ai/details/publication/pub.1082159538
15 https://doi.org/10.1006/jmbi.2000.4042
16 https://doi.org/10.1006/mpat.1996.0018
17 https://doi.org/10.1016/0076-6879(94)35179-1
18 https://doi.org/10.1016/j.micpath.2004.02.004
19 https://doi.org/10.1016/j.micpath.2007.04.002
20 https://doi.org/10.1016/s0076-6879(96)66034-0
21 https://doi.org/10.1016/s1075-9964(03)00008-8
22 https://doi.org/10.1021/bi035310j
23 https://doi.org/10.1021/bi048661m
24 https://doi.org/10.1042/bj20090343
25 https://doi.org/10.1046/j.1365-2958.1999.01647.x
26 https://doi.org/10.1073/pnas.0404172101
27 https://doi.org/10.1073/pnas.040549997
28 https://doi.org/10.1074/jbc.m302926200
29 https://doi.org/10.1074/jbc.m411792200
30 https://doi.org/10.1074/jbc.m704821200
31 https://doi.org/10.1084/jem.184.2.665
32 https://doi.org/10.1086/587525
33 https://doi.org/10.1093/clinids/23.supplement_1.s97
34 https://doi.org/10.1093/emboj/17.21.6263
35 https://doi.org/10.1093/nar/22.22.4673
36 https://doi.org/10.1093/nar/25.17.3389
37 https://doi.org/10.1093/nar/29.9.e45
38 https://doi.org/10.1099/jmm.0.46984-0
39 https://doi.org/10.1099/mic.0.26948-0
40 https://doi.org/10.1110/ps.0303703
41 https://doi.org/10.1110/ps.03247703
42 https://doi.org/10.1111/j.1365-2958.1991.tb00723.x
43 https://doi.org/10.1111/j.1365-2958.2005.04708.x
44 https://doi.org/10.1111/j.1365-2958.2005.04714.x
45 https://doi.org/10.1111/j.1365-2958.2007.06031.x
46 https://doi.org/10.1111/j.1365-2958.2009.06974.x
47 https://doi.org/10.1111/j.1399-302x.2007.00429.x
48 https://doi.org/10.1126/science.1080029
49 https://doi.org/10.1126/science.1107008
50 https://doi.org/10.1128/cmr.00008-07
51 https://doi.org/10.1128/iai.69.1.159-169.2001
52 https://doi.org/10.1128/iai.70.12.6646-6651.2002
53 https://doi.org/10.1128/iai.72.8.4836-4847.2004
54 https://doi.org/10.1128/iai.74.4.2304-2316.2006
55 https://doi.org/10.1128/jb.176.7.1939-1943.1994
56 https://doi.org/10.1128/jb.182.18.5059-5069.2000
57 https://doi.org/10.1128/jb.187.5.1751-1762.2005
58 https://doi.org/10.1128/jcm.43.7.3380-3389.2005
59 https://doi.org/10.1371/journal.pone.0004769
60 https://doi.org/10.1371/journal.ppat.1000316
61 schema:datePublished 2012-12
62 schema:datePublishedReg 2012-12-01
63 schema:description BACKGROUND: Bacteroides fragilis and Bacteroides thetaiotaomicron are members of the normal human intestinal microbiota. However, both organisms are capable of causing opportunistic infections, during which the environmental conditions to which the bacteria are exposed change dramatically. To further explore their potential for contributing to infection, we have characterized the expression in B. thetaiotaomicron of four homologues of the gene encoding the C10 cysteine protease SpeB, a potent extracellular virulence factor produced by Streptococcus pyogenes. RESULTS: We identified a paralogous set of genes (btp genes) in the B. thetaiotaomicron genome, that were related to C10 protease genes we recently identified in B. fragilis. Similar to C10 proteases found in B. fragilis, three of the B. thetaiotaomicron homologues were transcriptionally coupled to genes encoding small proteins that are similar in structural architecture to Staphostatins, protease inhibitors associated with Staphopains in Staphylococcus aureus. The expression of genes for these C10 proteases in both B. fragilis and B. thetaiotaomicron was found to be regulated by environmental stimuli, in particular by exposure to oxygen, which may be important for their contribution to the development of opportunistic infections. CONCLUSIONS: Genes encoding C10 proteases are increasingly identified in operons which also contain genes encoding proteins homologous to protease inhibitors. The Bacteroides C10 protease gene expression levels are responsive to different environmental stimuli suggesting they may have distinct roles in the bacterial-host interaction.
64 schema:genre research_article
65 schema:inLanguage en
66 schema:isAccessibleForFree true
67 schema:isPartOf N1fd7ad28c66340a5b35ed2b74015f670
68 N673f146a82dd4254b9304093229c8b9c
69 sg:journal.1024253
70 schema:name The effect of environmental conditions on expression of Bacteroides fragilis and Bacteroides thetaiotaomicron C10 protease genes
71 schema:pagination 190
72 schema:productId N1624e25b65ad4bb3999f2af525f21fdf
73 N30b626356a6945f7a74a551b6bc13466
74 N34b651ee4aaf4e3fa97f83cba9b4664a
75 N9c274e97c3924f6092dd04acba975df5
76 Nb2821d0239394318a1b1b7f7cf95685c
77 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015063776
78 https://doi.org/10.1186/1471-2180-12-190
79 schema:sdDatePublished 2019-04-10T14:07
80 schema:sdLicense https://scigraph.springernature.com/explorer/license/
81 schema:sdPublisher N363dba68b4e94bebacbbe04f5f1a5cc7
82 schema:url http://link.springer.com/10.1186%2F1471-2180-12-190
83 sgo:license sg:explorer/license/
84 sgo:sdDataset articles
85 rdf:type schema:ScholarlyArticle
86 N1624e25b65ad4bb3999f2af525f21fdf schema:name readcube_id
87 schema:value 47c4c021f5d4d3a57e122f934488498910945b8f8d93d3b3ae75f13b34f12414
88 rdf:type schema:PropertyValue
89 N1fd7ad28c66340a5b35ed2b74015f670 schema:issueNumber 1
90 rdf:type schema:PublicationIssue
91 N3094f1875b054e5aa677a1e907a54aa1 rdf:first sg:person.0770744204.97
92 rdf:rest N850d0c5b85aa4eeb9325e7045be49083
93 N30b626356a6945f7a74a551b6bc13466 schema:name dimensions_id
94 schema:value pub.1015063776
95 rdf:type schema:PropertyValue
96 N3433cb0a0cf84e52b4e64b19e73068a9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Bacteroides
98 rdf:type schema:DefinedTerm
99 N34b651ee4aaf4e3fa97f83cba9b4664a schema:name nlm_unique_id
100 schema:value 100966981
101 rdf:type schema:PropertyValue
102 N363dba68b4e94bebacbbe04f5f1a5cc7 schema:name Springer Nature - SN SciGraph project
103 rdf:type schema:Organization
104 N444f7871af064d6a8b052bbe02004267 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Virulence Factors
106 rdf:type schema:DefinedTerm
107 N673f146a82dd4254b9304093229c8b9c schema:volumeNumber 12
108 rdf:type schema:PublicationVolume
109 N6d3a8dc03894401e9c44c94958b5107e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Oxygen
111 rdf:type schema:DefinedTerm
112 N850d0c5b85aa4eeb9325e7045be49083 rdf:first sg:person.01254363134.31
113 rdf:rest Nc29fb09701b243938e6977d2badf49ca
114 N8ac378787ae04b7d9759058499f4734c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Gene Expression Profiling
116 rdf:type schema:DefinedTerm
117 N9c274e97c3924f6092dd04acba975df5 schema:name pubmed_id
118 schema:value 22943521
119 rdf:type schema:PropertyValue
120 Na6523525e1cd4f71ab59fa5b6dd767b2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Cysteine Endopeptidases
122 rdf:type schema:DefinedTerm
123 Nb2821d0239394318a1b1b7f7cf95685c schema:name doi
124 schema:value 10.1186/1471-2180-12-190
125 rdf:type schema:PropertyValue
126 Nc29fb09701b243938e6977d2badf49ca rdf:first sg:person.01305242542.02
127 rdf:rest Ne07c11f817cf457a954e5567a752f5c5
128 Ne07c11f817cf457a954e5567a752f5c5 rdf:first sg:person.01301362237.34
129 rdf:rest rdf:nil
130 Neb2ef0d847b245dab1de0a62f04d32f1 rdf:first sg:person.01212162343.01
131 rdf:rest N3094f1875b054e5aa677a1e907a54aa1
132 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
133 schema:name Biological Sciences
134 rdf:type schema:DefinedTerm
135 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
136 schema:name Genetics
137 rdf:type schema:DefinedTerm
138 sg:grant.3983386 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2180-12-190
139 rdf:type schema:MonetaryGrant
140 sg:journal.1024253 schema:issn 1471-2180
141 schema:name BMC Microbiology
142 rdf:type schema:Periodical
143 sg:person.01212162343.01 schema:affiliation https://www.grid.ac/institutes/grid.10049.3c
144 schema:familyName Thornton
145 schema:givenName Roibeard F
146 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212162343.01
147 rdf:type schema:Person
148 sg:person.01254363134.31 schema:affiliation https://www.grid.ac/institutes/grid.10049.3c
149 schema:familyName Kagawa
150 schema:givenName Todd F
151 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254363134.31
152 rdf:type schema:Person
153 sg:person.01301362237.34 schema:affiliation https://www.grid.ac/institutes/grid.10049.3c
154 schema:familyName Cooney
155 schema:givenName Jakki C
156 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301362237.34
157 rdf:type schema:Person
158 sg:person.01305242542.02 schema:affiliation https://www.grid.ac/institutes/grid.7872.a
159 schema:familyName O’Toole
160 schema:givenName Paul W
161 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305242542.02
162 rdf:type schema:Person
163 sg:person.0770744204.97 schema:affiliation https://www.grid.ac/institutes/grid.4514.4
164 schema:familyName Murphy
165 schema:givenName Elizabeth C
166 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0770744204.97
167 rdf:type schema:Person
168 sg:pub.10.1186/1471-2105-4-29 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028598747
169 https://doi.org/10.1186/1471-2105-4-29
170 rdf:type schema:CreativeWork
171 sg:pub.10.1186/1471-2180-10-122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051816432
172 https://doi.org/10.1186/1471-2180-10-122
173 rdf:type schema:CreativeWork
174 https://app.dimensions.ai/details/publication/pub.1078060571 schema:CreativeWork
175 https://app.dimensions.ai/details/publication/pub.1079809979 schema:CreativeWork
176 https://app.dimensions.ai/details/publication/pub.1081654851 schema:CreativeWork
177 https://app.dimensions.ai/details/publication/pub.1082159538 schema:CreativeWork
178 https://doi.org/10.1006/jmbi.2000.4042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022575813
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1006/mpat.1996.0018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041996885
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1016/0076-6879(94)35179-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007256714
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1016/j.micpath.2004.02.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046315387
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1016/j.micpath.2007.04.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001697882
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1016/s0076-6879(96)66034-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027814431
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1016/s1075-9964(03)00008-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021315096
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1021/bi035310j schema:sameAs https://app.dimensions.ai/details/publication/pub.1055197723
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1021/bi048661m schema:sameAs https://app.dimensions.ai/details/publication/pub.1055199283
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1042/bj20090343 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037642093
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1046/j.1365-2958.1999.01647.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1001609059
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1073/pnas.0404172101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000351126
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1073/pnas.040549997 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010552205
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1074/jbc.m302926200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036132744
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1074/jbc.m411792200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015275563
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1074/jbc.m704821200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025943062
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1084/jem.184.2.665 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004486429
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1086/587525 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058800377
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1093/clinids/23.supplement_1.s97 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029055303
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1093/emboj/17.21.6263 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053147095
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1093/nar/22.22.4673 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042438223
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1093/nar/25.17.3389 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047265454
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1093/nar/29.9.e45 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030834024
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1099/jmm.0.46984-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002211480
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1099/mic.0.26948-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060397010
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1110/ps.0303703 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032600631
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1110/ps.03247703 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036998336
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1111/j.1365-2958.1991.tb00723.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036704248
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1111/j.1365-2958.2005.04708.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1052679971
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1111/j.1365-2958.2005.04714.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044981980
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1111/j.1365-2958.2007.06031.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1048962409
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1111/j.1365-2958.2009.06974.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1015750118
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1111/j.1399-302x.2007.00429.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1050601325
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1126/science.1080029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062447714
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1126/science.1107008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036766924
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1128/cmr.00008-07 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021409328
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1128/iai.69.1.159-169.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016226120
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1128/iai.70.12.6646-6651.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016793774
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1128/iai.72.8.4836-4847.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044555612
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1128/iai.74.4.2304-2316.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031220063
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1128/jb.176.7.1939-1943.1994 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062723567
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1128/jb.182.18.5059-5069.2000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006597900
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1128/jb.187.5.1751-1762.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036649715
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1128/jcm.43.7.3380-3389.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004278855
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1371/journal.pone.0004769 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022261755
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1371/journal.ppat.1000316 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027539697
269 rdf:type schema:CreativeWork
270 https://www.grid.ac/institutes/grid.10049.3c schema:alternateName University of Limerick
271 schema:name Department of Life Sciences, University of Limerick, Limerick, Ireland
272 Materials and Surface Science Institute, University of Limerick, Limerick, Ireland
273 rdf:type schema:Organization
274 https://www.grid.ac/institutes/grid.4514.4 schema:alternateName Lund University
275 schema:name Department of Clinical Sciences, Lund University, Lund, Sweden
276 Department of Life Sciences, University of Limerick, Limerick, Ireland
277 Materials and Surface Science Institute, University of Limerick, Limerick, Ireland
278 rdf:type schema:Organization
279 https://www.grid.ac/institutes/grid.7872.a schema:alternateName University College Cork
280 schema:name Department of Microbiology, & Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
281 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...