Dominance of multidrug resistant CC271 clones in macrolide-resistant streptococcus pneumoniae in Arizona View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-01-18

AUTHORS

Jolene R Bowers, Elizabeth M Driebe, Jennifer L Nibecker, Bette R Wojack, Derek S Sarovich, Ada H Wong, Pius M Brzoska, Nathaniel Hubert, Andrew Knadler, Lindsey M Watson, David M Wagner, Manohar R Furtado, Michael Saubolle, David M Engelthaler, Paul S Keim

ABSTRACT

BACKGROUND: Rates of resistance to macrolide antibiotics in Streptococcus pneumoniae are rising around the world due to the spread of mobile genetic elements harboring mef(E) and erm(B) genes and post-vaccine clonal expansion of strains that carry them. RESULTS: Characterization of 592 clinical isolates collected in Arizona over a 10 year period shows 23.6% are macrolide resistant. The largest portion of the macrolide-resistant population, 52%, is dual mef(E)/erm(B)-positive. All dual-positive isolates are multidrug-resistant clonal lineages of Taiwan19F-14, mostly multilocus sequence type 320, carrying the recently described transposon Tn2010. The remainder of the macrolide resistant S. pneumoniae collection includes 31% mef(E)-positive, and 9% erm(B)-positive strains. CONCLUSIONS: The dual-positive, multidrug-resistant S. pneumoniae clones have likely expanded by switching to non-vaccine serotypes after the heptavalent pneumococcal conjugate vaccine release, and their success limits therapy options. This upsurge could have a considerable clinical impact in Arizona. More... »

PAGES

12-12

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1471-2180-12-12

DOI

http://dx.doi.org/10.1186/1471-2180-12-12

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013175272

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22251616


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41 CC271 clones
42 Streptococcus pneumoniae
43 Taiwan19F-14
44 Tn2010
45 antibiotics
46 characterization
47 clinical impact
48 clinical isolates
49 clonal expansion
50 clonal lineages
51 clones
52 collection
53 conjugate vaccine release
54 considerable clinical impact
55 dominance
56 dual-positive isolates
57 elements
58 expansion
59 genes
60 genetic elements
61 heptavalent pneumococcal conjugate vaccine release
62 impact
63 isolates
64 large portion
65 lineages
66 macrolide-resistant Streptococcus pneumoniae
67 macrolide-resistant population
68 macrolides
69 mobile genetic elements
70 multidrug resistant CC271 clones
71 non-vaccine serotypes
72 options
73 period
74 pneumococcal conjugate vaccine release
75 pneumoniae
76 pneumoniae clones
77 pneumoniae collection
78 population
79 portion
80 positive strains
81 post-vaccine clonal expansion
82 rate
83 rate of resistance
84 release
85 remainder
86 resistance
87 resistant CC271 clones
88 resistant clonal lineages
89 sequence type 320
90 serotypes
91 spread
92 strains
93 success
94 therapy options
95 transposon Tn2010
96 type 320
97 upsurge
98 vaccine release
99 world
100 year period
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