Peptide binding characteristics of the non-classical class Ib MHC molecule HLA-E assessed by a recombinant random peptide approach View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2001-12

AUTHORS

James Stevens, Etienne Joly, John Trowsdale, Geoffrey W Butcher

ABSTRACT

BACKGROUND: Increasing evidence suggests that the effect of HLA-E on Natural Killer (NK) cell activity can be affected by the nature of the peptides bound to this non-classical, MHC class Ib molecule. However, its reduced cell surface expression, and until recently, the lack of specific monoclonal antibodies hinder studying the peptide-binding specificity HLA-E. RESULTS: An in vitro refolding system was used to assess binding of recombinant HLA-E to either specific peptides or a nonamer random peptide library. Peptides eluted from HLA-E molecules refolded around the nonamer library were then used to determine a binding motif for HLA-E. Hydrophobic and non-charged amino acids were found to predominate along the peptide motif, with a leucine anchor at P9, but surprisingly there was no methionine preference at P2, as suggested by previous studies. CONCLUSIONS: Compared to the results obtained with rat classical class Ia MHC molecules, RT1-A1c and RT1-Au, HLA-E appears to refold around a random peptide library to reduced but detectable levels, suggesting that this molecule's specificity is tight but probably not as exquisite as has been previously suggested. This, and a previous report that it can associate with synthetic peptides carrying a viral sequence, suggests that HLA-E, similar to its mouse counterpart (Qa-1b), could possibly bind peptides different from MHC class I leader peptides and present them to T lymphocytes. More... »

PAGES

5

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1471-2172-2-5

DOI

http://dx.doi.org/10.1186/1471-2172-2-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1035484834

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11432755


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acid Motifs", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Binding Sites", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cloning, Molecular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HLA Antigens", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Histocompatibility Antigens Class I", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Peptide Library", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Peptides", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Binding", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Folding", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Cambridge", 
          "id": "https://www.grid.ac/institutes/grid.5335.0", 
          "name": [
            "Laboratory of Functional Immunogenetics, The Babraham Institute, CB2 4AT, Cambridge, UK", 
            "Department of Pathology, Division of Immunology, University of Cambridge, Tennis Court Road, CB2 1QP, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stevens", 
        "givenName": "James", 
        "id": "sg:person.01011733445.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011733445.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Babraham Institute", 
          "id": "https://www.grid.ac/institutes/grid.418195.0", 
          "name": [
            "Laboratory of Functional Immunogenetics, The Babraham Institute, CB2 4AT, Cambridge, UK", 
            "CNRS UPS, UPCM, 2163, 31300, CHU Purpan, Toulouse, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Joly", 
        "givenName": "Etienne", 
        "id": "sg:person.01245752150.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245752150.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Cambridge", 
          "id": "https://www.grid.ac/institutes/grid.5335.0", 
          "name": [
            "Department of Pathology, Division of Immunology, University of Cambridge, Tennis Court Road, CB2 1QP, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Trowsdale", 
        "givenName": "John", 
        "id": "sg:person.0751743111.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751743111.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Babraham Institute", 
          "id": "https://www.grid.ac/institutes/grid.418195.0", 
          "name": [
            "Laboratory of Functional Immunogenetics, The Babraham Institute, CB2 4AT, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Butcher", 
        "givenName": "Geoffrey W", 
        "id": "sg:person.01255606374.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255606374.96"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1093/emboj/18.15.4250", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001801848"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1074-7613(00)80099-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006188455"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.91.4.1534", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006194160"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1097-2765(00)80053-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006935877"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/356443a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007464108", 
          "https://doi.org/10.1038/356443a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0165-0378(99)00033-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012759086"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.89.8.3429", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013088552"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(94)90550-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018199473"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/351290a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022085395", 
          "https://doi.org/10.1038/351290a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0960-9822(98)70014-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022789763"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.189.5.797", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023338763"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.91.10.4145", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023361266"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/9783527614912.ch07", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025129049"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35869", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026463684", 
          "https://doi.org/10.1038/35869"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35869", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026463684", 
          "https://doi.org/10.1038/35869"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/abio.1994.1266", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027502012"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m002565200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028470865"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.273.5.2874", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030501160"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1074-7613(00)80680-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033028041"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1521-4141(199809)28:09<2854::aid-immu2854>3.0.co;2-w", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033705059"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1521-4141(199809)28:09<2854::aid-immu2854>3.0.co;2-w", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033705059"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.95.9.5199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036173895"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/360364a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037617338", 
          "https://doi.org/10.1038/360364a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0960-894x(01)80226-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040747020"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-5793(96)00226-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041727504"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.187.5.813", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043689356"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/eji.1830270517", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045995800"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.192.5.613", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047608813"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.287.5455.1031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062568265"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083072525", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083256094", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083262400", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083373726", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2001-12", 
    "datePublishedReg": "2001-12-01", 
    "description": "BACKGROUND: Increasing evidence suggests that the effect of HLA-E on Natural Killer (NK) cell activity can be affected by the nature of the peptides bound to this non-classical, MHC class Ib molecule. However, its reduced cell surface expression, and until recently, the lack of specific monoclonal antibodies hinder studying the peptide-binding specificity HLA-E.\nRESULTS: An in vitro refolding system was used to assess binding of recombinant HLA-E to either specific peptides or a nonamer random peptide library. Peptides eluted from HLA-E molecules refolded around the nonamer library were then used to determine a binding motif for HLA-E. Hydrophobic and non-charged amino acids were found to predominate along the peptide motif, with a leucine anchor at P9, but surprisingly there was no methionine preference at P2, as suggested by previous studies.\nCONCLUSIONS: Compared to the results obtained with rat classical class Ia MHC molecules, RT1-A1c and RT1-Au, HLA-E appears to refold around a random peptide library to reduced but detectable levels, suggesting that this molecule's specificity is tight but probably not as exquisite as has been previously suggested. This, and a previous report that it can associate with synthetic peptides carrying a viral sequence, suggests that HLA-E, similar to its mouse counterpart (Qa-1b), could possibly bind peptides different from MHC class I leader peptides and present them to T lymphocytes.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/1471-2172-2-5", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1024252", 
        "issn": [
          "1471-2172"
        ], 
        "name": "BMC Immunology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "2"
      }
    ], 
    "name": "Peptide binding characteristics of the non-classical class Ib MHC molecule HLA-E assessed by a recombinant random peptide approach", 
    "pagination": "5", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "a908f992f5651f4465ae3fb7931d58842b29bea08d168e77bae79a3e57991794"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "11432755"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100966980"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1471-2172-2-5"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1035484834"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1471-2172-2-5", 
      "https://app.dimensions.ai/details/publication/pub.1035484834"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T01:05", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000506.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2F1471-2172-2-5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1471-2172-2-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1471-2172-2-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1471-2172-2-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1471-2172-2-5'


 

This table displays all metadata directly associated to this object as RDF triples.

227 TRIPLES      21 PREDICATES      70 URIs      31 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1471-2172-2-5 schema:about N2e3894f0f390443696f57b64c15e389e
2 N3828be31d90c46bd851d04b147c94579
3 N509af96dc32045d5881ed1a9525535ac
4 N5dbbce49376e4d19a3216ecab4a085bd
5 Na44a217b4aa04dddbb07666651613a2b
6 Nba0ab65dcfea4e1bb6850e9252d9ccc6
7 Nc6c7945366014c339cace5f164a63bca
8 Neef718001d76493a8b3c41218567d403
9 Nf4d16f5eb39941b0ad9232aad9303165
10 Nf665c70946574a88ae7cf16c18e56760
11 anzsrc-for:11
12 anzsrc-for:1107
13 schema:author Nf88e674051974658aba61d79ec82a916
14 schema:citation sg:pub.10.1038/351290a0
15 sg:pub.10.1038/356443a0
16 sg:pub.10.1038/35869
17 sg:pub.10.1038/360364a0
18 https://app.dimensions.ai/details/publication/pub.1083072525
19 https://app.dimensions.ai/details/publication/pub.1083256094
20 https://app.dimensions.ai/details/publication/pub.1083262400
21 https://app.dimensions.ai/details/publication/pub.1083373726
22 https://doi.org/10.1002/(sici)1521-4141(199809)28:09<2854::aid-immu2854>3.0.co;2-w
23 https://doi.org/10.1002/9783527614912.ch07
24 https://doi.org/10.1002/eji.1830270517
25 https://doi.org/10.1006/abio.1994.1266
26 https://doi.org/10.1016/0014-5793(96)00226-8
27 https://doi.org/10.1016/0092-8674(94)90550-9
28 https://doi.org/10.1016/s0165-0378(99)00033-9
29 https://doi.org/10.1016/s0960-894x(01)80226-2
30 https://doi.org/10.1016/s0960-9822(98)70014-4
31 https://doi.org/10.1016/s1074-7613(00)80099-0
32 https://doi.org/10.1016/s1074-7613(00)80680-9
33 https://doi.org/10.1016/s1097-2765(00)80053-2
34 https://doi.org/10.1073/pnas.89.8.3429
35 https://doi.org/10.1073/pnas.91.10.4145
36 https://doi.org/10.1073/pnas.91.4.1534
37 https://doi.org/10.1073/pnas.95.9.5199
38 https://doi.org/10.1074/jbc.273.5.2874
39 https://doi.org/10.1074/jbc.m002565200
40 https://doi.org/10.1084/jem.187.5.813
41 https://doi.org/10.1084/jem.189.5.797
42 https://doi.org/10.1084/jem.192.5.613
43 https://doi.org/10.1093/emboj/18.15.4250
44 https://doi.org/10.1126/science.287.5455.1031
45 schema:datePublished 2001-12
46 schema:datePublishedReg 2001-12-01
47 schema:description BACKGROUND: Increasing evidence suggests that the effect of HLA-E on Natural Killer (NK) cell activity can be affected by the nature of the peptides bound to this non-classical, MHC class Ib molecule. However, its reduced cell surface expression, and until recently, the lack of specific monoclonal antibodies hinder studying the peptide-binding specificity HLA-E. RESULTS: An in vitro refolding system was used to assess binding of recombinant HLA-E to either specific peptides or a nonamer random peptide library. Peptides eluted from HLA-E molecules refolded around the nonamer library were then used to determine a binding motif for HLA-E. Hydrophobic and non-charged amino acids were found to predominate along the peptide motif, with a leucine anchor at P9, but surprisingly there was no methionine preference at P2, as suggested by previous studies. CONCLUSIONS: Compared to the results obtained with rat classical class Ia MHC molecules, RT1-A1c and RT1-Au, HLA-E appears to refold around a random peptide library to reduced but detectable levels, suggesting that this molecule's specificity is tight but probably not as exquisite as has been previously suggested. This, and a previous report that it can associate with synthetic peptides carrying a viral sequence, suggests that HLA-E, similar to its mouse counterpart (Qa-1b), could possibly bind peptides different from MHC class I leader peptides and present them to T lymphocytes.
48 schema:genre research_article
49 schema:inLanguage en
50 schema:isAccessibleForFree true
51 schema:isPartOf N00c198b26e374149874acdb9c8c06fe8
52 Ncf21f5e44bdd4a2c9e9b3932b6844c1c
53 sg:journal.1024252
54 schema:name Peptide binding characteristics of the non-classical class Ib MHC molecule HLA-E assessed by a recombinant random peptide approach
55 schema:pagination 5
56 schema:productId N8ad8ea7601dd45da9bf610125e48b706
57 N9007c97d29c44c40be3dd867649f9c3e
58 N96e70a8f8f39406dbd2f23a89ab190ff
59 Nc1a68a8a264b46b99f61c029f762749f
60 Ne7439619383541328ba853151a57f963
61 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035484834
62 https://doi.org/10.1186/1471-2172-2-5
63 schema:sdDatePublished 2019-04-11T01:05
64 schema:sdLicense https://scigraph.springernature.com/explorer/license/
65 schema:sdPublisher Ne4b3cc8856f844aab36c9e587314fd88
66 schema:url http://link.springer.com/10.1186%2F1471-2172-2-5
67 sgo:license sg:explorer/license/
68 sgo:sdDataset articles
69 rdf:type schema:ScholarlyArticle
70 N00c198b26e374149874acdb9c8c06fe8 schema:volumeNumber 2
71 rdf:type schema:PublicationVolume
72 N2e3894f0f390443696f57b64c15e389e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
73 schema:name Humans
74 rdf:type schema:DefinedTerm
75 N3828be31d90c46bd851d04b147c94579 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name HLA Antigens
77 rdf:type schema:DefinedTerm
78 N4df0297162484f4783dab4617a2e3f83 rdf:first sg:person.01255606374.96
79 rdf:rest rdf:nil
80 N509af96dc32045d5881ed1a9525535ac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Protein Folding
82 rdf:type schema:DefinedTerm
83 N5dbbce49376e4d19a3216ecab4a085bd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Histocompatibility Antigens Class I
85 rdf:type schema:DefinedTerm
86 N8ad8ea7601dd45da9bf610125e48b706 schema:name pubmed_id
87 schema:value 11432755
88 rdf:type schema:PropertyValue
89 N9007c97d29c44c40be3dd867649f9c3e schema:name readcube_id
90 schema:value a908f992f5651f4465ae3fb7931d58842b29bea08d168e77bae79a3e57991794
91 rdf:type schema:PropertyValue
92 N96e70a8f8f39406dbd2f23a89ab190ff schema:name doi
93 schema:value 10.1186/1471-2172-2-5
94 rdf:type schema:PropertyValue
95 Na44a217b4aa04dddbb07666651613a2b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Cloning, Molecular
97 rdf:type schema:DefinedTerm
98 Nba0ab65dcfea4e1bb6850e9252d9ccc6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Peptides
100 rdf:type schema:DefinedTerm
101 Nbe65d94375f24192a620a2f40ab2631a rdf:first sg:person.01245752150.57
102 rdf:rest Nc86ed41bfb4f4c659b6197ba0cfc52ad
103 Nc1a68a8a264b46b99f61c029f762749f schema:name dimensions_id
104 schema:value pub.1035484834
105 rdf:type schema:PropertyValue
106 Nc6c7945366014c339cace5f164a63bca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Peptide Library
108 rdf:type schema:DefinedTerm
109 Nc86ed41bfb4f4c659b6197ba0cfc52ad rdf:first sg:person.0751743111.42
110 rdf:rest N4df0297162484f4783dab4617a2e3f83
111 Ncf21f5e44bdd4a2c9e9b3932b6844c1c schema:issueNumber 1
112 rdf:type schema:PublicationIssue
113 Ne4b3cc8856f844aab36c9e587314fd88 schema:name Springer Nature - SN SciGraph project
114 rdf:type schema:Organization
115 Ne7439619383541328ba853151a57f963 schema:name nlm_unique_id
116 schema:value 100966980
117 rdf:type schema:PropertyValue
118 Neef718001d76493a8b3c41218567d403 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Protein Binding
120 rdf:type schema:DefinedTerm
121 Nf4d16f5eb39941b0ad9232aad9303165 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Binding Sites
123 rdf:type schema:DefinedTerm
124 Nf665c70946574a88ae7cf16c18e56760 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Amino Acid Motifs
126 rdf:type schema:DefinedTerm
127 Nf88e674051974658aba61d79ec82a916 rdf:first sg:person.01011733445.89
128 rdf:rest Nbe65d94375f24192a620a2f40ab2631a
129 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
130 schema:name Medical and Health Sciences
131 rdf:type schema:DefinedTerm
132 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
133 schema:name Immunology
134 rdf:type schema:DefinedTerm
135 sg:journal.1024252 schema:issn 1471-2172
136 schema:name BMC Immunology
137 rdf:type schema:Periodical
138 sg:person.01011733445.89 schema:affiliation https://www.grid.ac/institutes/grid.5335.0
139 schema:familyName Stevens
140 schema:givenName James
141 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011733445.89
142 rdf:type schema:Person
143 sg:person.01245752150.57 schema:affiliation https://www.grid.ac/institutes/grid.418195.0
144 schema:familyName Joly
145 schema:givenName Etienne
146 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245752150.57
147 rdf:type schema:Person
148 sg:person.01255606374.96 schema:affiliation https://www.grid.ac/institutes/grid.418195.0
149 schema:familyName Butcher
150 schema:givenName Geoffrey W
151 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255606374.96
152 rdf:type schema:Person
153 sg:person.0751743111.42 schema:affiliation https://www.grid.ac/institutes/grid.5335.0
154 schema:familyName Trowsdale
155 schema:givenName John
156 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751743111.42
157 rdf:type schema:Person
158 sg:pub.10.1038/351290a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022085395
159 https://doi.org/10.1038/351290a0
160 rdf:type schema:CreativeWork
161 sg:pub.10.1038/356443a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007464108
162 https://doi.org/10.1038/356443a0
163 rdf:type schema:CreativeWork
164 sg:pub.10.1038/35869 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026463684
165 https://doi.org/10.1038/35869
166 rdf:type schema:CreativeWork
167 sg:pub.10.1038/360364a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037617338
168 https://doi.org/10.1038/360364a0
169 rdf:type schema:CreativeWork
170 https://app.dimensions.ai/details/publication/pub.1083072525 schema:CreativeWork
171 https://app.dimensions.ai/details/publication/pub.1083256094 schema:CreativeWork
172 https://app.dimensions.ai/details/publication/pub.1083262400 schema:CreativeWork
173 https://app.dimensions.ai/details/publication/pub.1083373726 schema:CreativeWork
174 https://doi.org/10.1002/(sici)1521-4141(199809)28:09<2854::aid-immu2854>3.0.co;2-w schema:sameAs https://app.dimensions.ai/details/publication/pub.1033705059
175 rdf:type schema:CreativeWork
176 https://doi.org/10.1002/9783527614912.ch07 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025129049
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1002/eji.1830270517 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045995800
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1006/abio.1994.1266 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027502012
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1016/0014-5793(96)00226-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041727504
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1016/0092-8674(94)90550-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018199473
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1016/s0165-0378(99)00033-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012759086
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1016/s0960-894x(01)80226-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040747020
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1016/s0960-9822(98)70014-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022789763
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1016/s1074-7613(00)80099-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006188455
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1016/s1074-7613(00)80680-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033028041
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1016/s1097-2765(00)80053-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006935877
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1073/pnas.89.8.3429 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013088552
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1073/pnas.91.10.4145 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023361266
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1073/pnas.91.4.1534 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006194160
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1073/pnas.95.9.5199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036173895
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1074/jbc.273.5.2874 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030501160
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1074/jbc.m002565200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028470865
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1084/jem.187.5.813 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043689356
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1084/jem.189.5.797 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023338763
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1084/jem.192.5.613 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047608813
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1093/emboj/18.15.4250 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001801848
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1126/science.287.5455.1031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062568265
219 rdf:type schema:CreativeWork
220 https://www.grid.ac/institutes/grid.418195.0 schema:alternateName Babraham Institute
221 schema:name CNRS UPS, UPCM, 2163, 31300, CHU Purpan, Toulouse, France
222 Laboratory of Functional Immunogenetics, The Babraham Institute, CB2 4AT, Cambridge, UK
223 rdf:type schema:Organization
224 https://www.grid.ac/institutes/grid.5335.0 schema:alternateName University of Cambridge
225 schema:name Department of Pathology, Division of Immunology, University of Cambridge, Tennis Court Road, CB2 1QP, Cambridge, UK
226 Laboratory of Functional Immunogenetics, The Babraham Institute, CB2 4AT, Cambridge, UK
227 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...