Genome-wide analysis of the interaction between the endosymbiotic bacterium Wolbachia and its Drosophila host View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-12

AUTHORS

Zhiyong Xi, Laurent Gavotte, Yan Xie, Stephen L Dobson

ABSTRACT

BACKGROUND: Intracellular Wolbachia bacteria are obligate, maternally-inherited, endosymbionts found frequently in insects and other invertebrates. The success of Wolbachia can be attributed in part to an ability to alter host reproduction via mechanisms including cytoplasmic incompatibility (CI), parthenogenesis, feminization and male killing. Despite substantial scientific effort, the molecular mechanisms underlying the Wolbachia/host interaction are unknown. RESULTS: Here, an in vitro Wolbachia infection was generated in the Drosophila S2 cell line, and transcription profiles of infected and uninfected cells were compared by microarray. Differentially-expressed patterns related to reproduction, immune response and heat stress response are observed, including multiple genes that have been previously reported to be involved in the Wolbachia/host interaction. Subsequent in vivo characterization of differentially-expressed products in gonads demonstrates that Angiotensin Converting Enzyme (Ance) varies between Wolbachia infected and uninfected flies and that the variation occurs in a sex-specific manner. Consistent with expectations for the conserved CI mechanism, the observed Ance expression pattern is repeatable in different Drosophila species and with different Wolbachia types. To examine Ance involvement in the CI phenotype, compatible and incompatible crosses of Ance mutant flies were conducted. Significant differences are observed in the egg hatch rate resulting from incompatible crosses, providing support for additional experiments examining for an interaction of Ance with the CI mechanism. CONCLUSION: Wolbachia infection is shown to affect the expression of multiple host genes, including Ance. Evidence for potential Ance involvement in the CI mechanism is described, including the prior report of Ance in spermatid differentiation, Wolbachia-induced sex-specific effects on Ance expression and an Ance mutation effect on CI levels. The results support the use of Wolbachia infected cell cultures as an appropriate model for predicting in vivo host/Wolbachia interactions. More... »

PAGES

1

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1471-2164-9-1

DOI

http://dx.doi.org/10.1186/1471-2164-9-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003504508

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18171476


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Down-Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drosophila", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Profiling", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genome, Insect", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gonads", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gram-Negative Bacterial Infections", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heat-Shock Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Host-Pathogen Interactions", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oligonucleotide Array Sequence Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Peptidyl-Dipeptidase A", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phenotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reproduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sex Characteristics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Symbiosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Up-Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Wolbachia", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Michigan State University", 
          "id": "https://www.grid.ac/institutes/grid.17088.36", 
          "name": [
            "Department of Entomology, University of Kentucky, KY 40546, Lexington, USA", 
            "Department of Entomology, Michigan State University, 48824, East Lansing, MI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xi", 
        "givenName": "Zhiyong", 
        "id": "sg:person.0703426612.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703426612.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Montpellier", 
          "id": "https://www.grid.ac/institutes/grid.121334.6", 
          "name": [
            "Department of Entomology, University of Kentucky, KY 40546, Lexington, USA", 
            "Institut des Sciences de l'Evolution. UMR-CNRS 5554, Bat 24, CC063, Universit\u00e9 Montpellier II, Place Eug\u00e8ne Bataillon, 34095, Montpellier Cedex 5, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gavotte", 
        "givenName": "Laurent", 
        "id": "sg:person.0710455343.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710455343.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Kentucky", 
          "id": "https://www.grid.ac/institutes/grid.266539.d", 
          "name": [
            "Department of Statistics, University of Kentucky, KY 40546, Lexington, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xie", 
        "givenName": "Yan", 
        "id": "sg:person.01365001613.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365001613.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Kentucky", 
          "id": "https://www.grid.ac/institutes/grid.266539.d", 
          "name": [
            "Department of Entomology, University of Kentucky, KY 40546, Lexington, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dobson", 
        "givenName": "Stephen L", 
        "id": "sg:person.0773170272.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773170272.87"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1534/genetics.105.052431", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003329740"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1534/genetics.105.052431", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003329740"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/aem.70.9.5366-5372.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003728102"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tim.2006.01.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004207708"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1098/rspb.2001.1839", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004564911"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0400580101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005108107"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bies.10234", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005877403"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0506461102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006446064"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jac/47.5.659", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006519058"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1462-5822.2005.00508.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006569622"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006930818", 
          "https://doi.org/10.1038/ng1032"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006930818", 
          "https://doi.org/10.1038/ng1032"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0378-1119(96)00503-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009991463"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.101304298", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010050086"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1168104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012106152"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mmbr.67.3.343-359.2003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012498586"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.ento.42.1.587", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013372740"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1098/rspb.2006.3478", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013625793"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0403853101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016431264"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/1467-9868.00346", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018285816"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pbio.0030121", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020703803"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jb.182.22.6529-6531.2000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021217256"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0952-7915(02)00005-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021412234"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0952-7915(02)00005-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021412234"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature02021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022282224", 
          "https://doi.org/10.1038/nature02021"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature02021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022282224", 
          "https://doi.org/10.1038/nature02021"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1098/rspb.1995.0117", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022453191"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0502-19", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022919343", 
          "https://doi.org/10.1038/ng0502-19"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0502-19", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022919343", 
          "https://doi.org/10.1038/ng0502-19"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2583.2000.00224.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023223258"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/aem.68.2.656-660.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023297799"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04756", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023497716", 
          "https://doi.org/10.1038/nature04756"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04756", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023497716", 
          "https://doi.org/10.1038/nature04756"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04756", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023497716", 
          "https://doi.org/10.1038/nature04756"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.93.19.10343", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023920716"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0925-4773(02)00424-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024587838"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0925-4773(02)00424-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024587838"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/icb/39.2.363", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026027533"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature00843", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026150449", 
          "https://doi.org/10.1038/nature00843"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature00843", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026150449", 
          "https://doi.org/10.1038/nature00843"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0925-4773(95)00349-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026410539"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1046/j.1365-2540.1999.00501.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027523279", 
          "https://doi.org/10.1046/j.1365-2540.1999.00501.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/meth.2001.1262", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027621591"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/meth.2001.1262", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027621591"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1475-2883-5-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029480245", 
          "https://doi.org/10.1186/1475-2883-5-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.89.7.2699", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029781764"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature735", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032740616", 
          "https://doi.org/10.1038/nature735"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature735", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032740616", 
          "https://doi.org/10.1038/nature735"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/aem.71.6.3199-3204.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032884384"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.97.3.1263", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033714331"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/3-540-29623-9_7146", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037739161", 
          "https://doi.org/10.1007/3-540-29623-9_7146"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcb.20123", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037787028"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.222549199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037853812"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.856901", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038830468"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0012-1606(02)00082-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038988728"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0012-1606(02)00082-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038988728"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.161273698", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040273064"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1645/0022-3395(2002)088[0605:iveoao]2.0.co;2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041327260"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2004-5-6-r40", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044612502", 
          "https://doi.org/10.1186/gb-2004-5-6-r40"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1079190", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044897060"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.ppat.0020034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046313760"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ibmb.2004.03.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049743382"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4020-6754-9_6552", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051155383", 
          "https://doi.org/10.1007/978-1-4020-6754-9_6552"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.it.2005.02.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052226951"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5483/bmbrep.2005.38.2.121", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053665896"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s0016672302005827", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053964071"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1117607", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062452579"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.8511587", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062656415"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.169.12.7009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075200960"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075301127", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077441919", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080484930", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083255178", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2008-12", 
    "datePublishedReg": "2008-12-01", 
    "description": "BACKGROUND: Intracellular Wolbachia bacteria are obligate, maternally-inherited, endosymbionts found frequently in insects and other invertebrates. The success of Wolbachia can be attributed in part to an ability to alter host reproduction via mechanisms including cytoplasmic incompatibility (CI), parthenogenesis, feminization and male killing. Despite substantial scientific effort, the molecular mechanisms underlying the Wolbachia/host interaction are unknown.\nRESULTS: Here, an in vitro Wolbachia infection was generated in the Drosophila S2 cell line, and transcription profiles of infected and uninfected cells were compared by microarray. Differentially-expressed patterns related to reproduction, immune response and heat stress response are observed, including multiple genes that have been previously reported to be involved in the Wolbachia/host interaction. Subsequent in vivo characterization of differentially-expressed products in gonads demonstrates that Angiotensin Converting Enzyme (Ance) varies between Wolbachia infected and uninfected flies and that the variation occurs in a sex-specific manner. Consistent with expectations for the conserved CI mechanism, the observed Ance expression pattern is repeatable in different Drosophila species and with different Wolbachia types. To examine Ance involvement in the CI phenotype, compatible and incompatible crosses of Ance mutant flies were conducted. Significant differences are observed in the egg hatch rate resulting from incompatible crosses, providing support for additional experiments examining for an interaction of Ance with the CI mechanism.\nCONCLUSION: Wolbachia infection is shown to affect the expression of multiple host genes, including Ance. Evidence for potential Ance involvement in the CI mechanism is described, including the prior report of Ance in spermatid differentiation, Wolbachia-induced sex-specific effects on Ance expression and an Ance mutation effect on CI levels. The results support the use of Wolbachia infected cell cultures as an appropriate model for predicting in vivo host/Wolbachia interactions.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/1471-2164-9-1", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2455792", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1023790", 
        "issn": [
          "1471-2164"
        ], 
        "name": "BMC Genomics", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "name": "Genome-wide analysis of the interaction between the endosymbiotic bacterium Wolbachia and its Drosophila host", 
    "pagination": "1", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "10b1f319675a901a22c796b9a6a8416d1d80bace23a0205351dab470a8f661c6"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "18171476"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100965258"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1471-2164-9-1"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1003504508"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1471-2164-9-1", 
      "https://app.dimensions.ai/details/publication/pub.1003504508"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T14:07", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000503.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2F1471-2164-9-1"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1471-2164-9-1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1471-2164-9-1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1471-2164-9-1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1471-2164-9-1'


 

This table displays all metadata directly associated to this object as RDF triples.

370 TRIPLES      21 PREDICATES      110 URIs      41 LITERALS      29 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1471-2164-9-1 schema:about N020b1708368c4e30a0a047ba82b1afe1
2 N1d057ad0f11e4673870b4d6325c61911
3 N3608994fe41b49c587cabc61dd864296
4 N471cf4929a164092b94e1743de5f8141
5 N66cbcecfaa8e438b9cd941db79ee1324
6 N7a990b90fd474ad9827ab65f3c0eec21
7 N8b8b22e78d974365801e536be70935be
8 N8c51efbd6b09451d911081f8f319ca39
9 N90f8e09c62754437ae75e4cd8aa27a42
10 N950fdeb7d1b84e76aebf0ac730d14d2f
11 N97ac56a8d4f74ec5950df60620480e3e
12 Nb062ce229a1d4c94891a9bff48be7ca0
13 Nb8d7ad9c1b59431dbe624e3a240d5162
14 Nbb610b6e771143cc9ebcedd35774800f
15 Nc5c2f4093eac4181bff4d32f3a894b45
16 Nd89791d0a56d400c825d7fd020d858e6
17 Ne88dffbcd2ac4f5987d2258ed858abb0
18 Nee150e09ebfa4d5d9dfcefde41bf1da1
19 Nf597583712234aaf837e4b228464d411
20 Nfbec633f92f446078878462ed08ed2ec
21 anzsrc-for:06
22 anzsrc-for:0604
23 schema:author Nb2b6dd0d38d049c8929a2fca0b2028e5
24 schema:citation sg:pub.10.1007/3-540-29623-9_7146
25 sg:pub.10.1007/978-1-4020-6754-9_6552
26 sg:pub.10.1038/nature00843
27 sg:pub.10.1038/nature02021
28 sg:pub.10.1038/nature04756
29 sg:pub.10.1038/nature735
30 sg:pub.10.1038/ng0502-19
31 sg:pub.10.1038/ng1032
32 sg:pub.10.1046/j.1365-2540.1999.00501.x
33 sg:pub.10.1186/1475-2883-5-4
34 sg:pub.10.1186/gb-2004-5-6-r40
35 https://app.dimensions.ai/details/publication/pub.1075301127
36 https://app.dimensions.ai/details/publication/pub.1077441919
37 https://app.dimensions.ai/details/publication/pub.1080484930
38 https://app.dimensions.ai/details/publication/pub.1083255178
39 https://doi.org/10.1002/bies.10234
40 https://doi.org/10.1002/jcb.20123
41 https://doi.org/10.1006/meth.2001.1262
42 https://doi.org/10.1016/0925-4773(95)00349-5
43 https://doi.org/10.1016/j.ibmb.2004.03.025
44 https://doi.org/10.1016/j.it.2005.02.006
45 https://doi.org/10.1016/j.tim.2006.01.008
46 https://doi.org/10.1016/s0012-1606(02)00082-9
47 https://doi.org/10.1016/s0378-1119(96)00503-3
48 https://doi.org/10.1016/s0925-4773(02)00424-0
49 https://doi.org/10.1016/s0952-7915(02)00005-5
50 https://doi.org/10.1017/s0016672302005827
51 https://doi.org/10.1046/j.1365-2583.2000.00224.x
52 https://doi.org/10.1073/pnas.0400580101
53 https://doi.org/10.1073/pnas.0403853101
54 https://doi.org/10.1073/pnas.0506461102
55 https://doi.org/10.1073/pnas.101304298
56 https://doi.org/10.1073/pnas.161273698
57 https://doi.org/10.1073/pnas.222549199
58 https://doi.org/10.1073/pnas.89.7.2699
59 https://doi.org/10.1073/pnas.93.19.10343
60 https://doi.org/10.1073/pnas.97.3.1263
61 https://doi.org/10.1093/icb/39.2.363
62 https://doi.org/10.1093/jac/47.5.659
63 https://doi.org/10.1098/rspb.1995.0117
64 https://doi.org/10.1098/rspb.2001.1839
65 https://doi.org/10.1098/rspb.2006.3478
66 https://doi.org/10.1101/gad.1168104
67 https://doi.org/10.1101/gad.856901
68 https://doi.org/10.1111/1467-9868.00346
69 https://doi.org/10.1111/j.1462-5822.2005.00508.x
70 https://doi.org/10.1126/science.1079190
71 https://doi.org/10.1126/science.1117607
72 https://doi.org/10.1126/science.8511587
73 https://doi.org/10.1128/aem.68.2.656-660.2002
74 https://doi.org/10.1128/aem.70.9.5366-5372.2004
75 https://doi.org/10.1128/aem.71.6.3199-3204.2005
76 https://doi.org/10.1128/jb.182.22.6529-6531.2000
77 https://doi.org/10.1128/mmbr.67.3.343-359.2003
78 https://doi.org/10.1146/annurev.ento.42.1.587
79 https://doi.org/10.1371/journal.pbio.0030121
80 https://doi.org/10.1371/journal.ppat.0020034
81 https://doi.org/10.1534/genetics.105.052431
82 https://doi.org/10.1645/0022-3395(2002)088[0605:iveoao]2.0.co;2
83 https://doi.org/10.4049/jimmunol.169.12.7009
84 https://doi.org/10.5483/bmbrep.2005.38.2.121
85 schema:datePublished 2008-12
86 schema:datePublishedReg 2008-12-01
87 schema:description BACKGROUND: Intracellular Wolbachia bacteria are obligate, maternally-inherited, endosymbionts found frequently in insects and other invertebrates. The success of Wolbachia can be attributed in part to an ability to alter host reproduction via mechanisms including cytoplasmic incompatibility (CI), parthenogenesis, feminization and male killing. Despite substantial scientific effort, the molecular mechanisms underlying the Wolbachia/host interaction are unknown. RESULTS: Here, an in vitro Wolbachia infection was generated in the Drosophila S2 cell line, and transcription profiles of infected and uninfected cells were compared by microarray. Differentially-expressed patterns related to reproduction, immune response and heat stress response are observed, including multiple genes that have been previously reported to be involved in the Wolbachia/host interaction. Subsequent in vivo characterization of differentially-expressed products in gonads demonstrates that Angiotensin Converting Enzyme (Ance) varies between Wolbachia infected and uninfected flies and that the variation occurs in a sex-specific manner. Consistent with expectations for the conserved CI mechanism, the observed Ance expression pattern is repeatable in different Drosophila species and with different Wolbachia types. To examine Ance involvement in the CI phenotype, compatible and incompatible crosses of Ance mutant flies were conducted. Significant differences are observed in the egg hatch rate resulting from incompatible crosses, providing support for additional experiments examining for an interaction of Ance with the CI mechanism. CONCLUSION: Wolbachia infection is shown to affect the expression of multiple host genes, including Ance. Evidence for potential Ance involvement in the CI mechanism is described, including the prior report of Ance in spermatid differentiation, Wolbachia-induced sex-specific effects on Ance expression and an Ance mutation effect on CI levels. The results support the use of Wolbachia infected cell cultures as an appropriate model for predicting in vivo host/Wolbachia interactions.
88 schema:genre research_article
89 schema:inLanguage en
90 schema:isAccessibleForFree true
91 schema:isPartOf N24126372a01f44568f16a86ae9c374b9
92 Nb0b138a5d12b492f8caf6b2c716827f4
93 sg:journal.1023790
94 schema:name Genome-wide analysis of the interaction between the endosymbiotic bacterium Wolbachia and its Drosophila host
95 schema:pagination 1
96 schema:productId N0b5721f3b88d496986c41464a8202b7a
97 N584bb2436f4f42749905da934a852da4
98 N87b66356e57c471596ed79e1de21d29b
99 N9e218a3e001a4930b717acd2cd1cf74c
100 Nfaff283a024d46b6aae9d0e74ae1fc92
101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003504508
102 https://doi.org/10.1186/1471-2164-9-1
103 schema:sdDatePublished 2019-04-10T14:07
104 schema:sdLicense https://scigraph.springernature.com/explorer/license/
105 schema:sdPublisher Nc873657075b44f18bc2db8788daf810d
106 schema:url http://link.springer.com/10.1186%2F1471-2164-9-1
107 sgo:license sg:explorer/license/
108 sgo:sdDataset articles
109 rdf:type schema:ScholarlyArticle
110 N020b1708368c4e30a0a047ba82b1afe1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Heat-Shock Proteins
112 rdf:type schema:DefinedTerm
113 N0b5721f3b88d496986c41464a8202b7a schema:name nlm_unique_id
114 schema:value 100965258
115 rdf:type schema:PropertyValue
116 N1d057ad0f11e4673870b4d6325c61911 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Cell Line
118 rdf:type schema:DefinedTerm
119 N24126372a01f44568f16a86ae9c374b9 schema:issueNumber 1
120 rdf:type schema:PublicationIssue
121 N3608994fe41b49c587cabc61dd864296 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Gram-Negative Bacterial Infections
123 rdf:type schema:DefinedTerm
124 N471cf4929a164092b94e1743de5f8141 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Gonads
126 rdf:type schema:DefinedTerm
127 N584bb2436f4f42749905da934a852da4 schema:name doi
128 schema:value 10.1186/1471-2164-9-1
129 rdf:type schema:PropertyValue
130 N66cbcecfaa8e438b9cd941db79ee1324 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Gene Expression Profiling
132 rdf:type schema:DefinedTerm
133 N7a990b90fd474ad9827ab65f3c0eec21 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Oligonucleotide Array Sequence Analysis
135 rdf:type schema:DefinedTerm
136 N87b66356e57c471596ed79e1de21d29b schema:name dimensions_id
137 schema:value pub.1003504508
138 rdf:type schema:PropertyValue
139 N8b8b22e78d974365801e536be70935be schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Sex Characteristics
141 rdf:type schema:DefinedTerm
142 N8c51efbd6b09451d911081f8f319ca39 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Up-Regulation
144 rdf:type schema:DefinedTerm
145 N90f8e09c62754437ae75e4cd8aa27a42 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Host-Pathogen Interactions
147 rdf:type schema:DefinedTerm
148 N950fdeb7d1b84e76aebf0ac730d14d2f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Wolbachia
150 rdf:type schema:DefinedTerm
151 N97ac56a8d4f74ec5950df60620480e3e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Phenotype
153 rdf:type schema:DefinedTerm
154 N9e218a3e001a4930b717acd2cd1cf74c schema:name pubmed_id
155 schema:value 18171476
156 rdf:type schema:PropertyValue
157 Nb062ce229a1d4c94891a9bff48be7ca0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Genome, Insect
159 rdf:type schema:DefinedTerm
160 Nb0b138a5d12b492f8caf6b2c716827f4 schema:volumeNumber 9
161 rdf:type schema:PublicationVolume
162 Nb2b6dd0d38d049c8929a2fca0b2028e5 rdf:first sg:person.0703426612.48
163 rdf:rest Nd5f99e85502c47ac9b433fd387770e74
164 Nb81c64035aa949bcaef547cf0da91a17 rdf:first sg:person.0773170272.87
165 rdf:rest rdf:nil
166 Nb8d7ad9c1b59431dbe624e3a240d5162 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Down-Regulation
168 rdf:type schema:DefinedTerm
169 Nbb610b6e771143cc9ebcedd35774800f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Female
171 rdf:type schema:DefinedTerm
172 Nc48c5f7c60d94ce8a91c1d9709d60528 rdf:first sg:person.01365001613.11
173 rdf:rest Nb81c64035aa949bcaef547cf0da91a17
174 Nc5c2f4093eac4181bff4d32f3a894b45 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Peptidyl-Dipeptidase A
176 rdf:type schema:DefinedTerm
177 Nc873657075b44f18bc2db8788daf810d schema:name Springer Nature - SN SciGraph project
178 rdf:type schema:Organization
179 Nd5f99e85502c47ac9b433fd387770e74 rdf:first sg:person.0710455343.71
180 rdf:rest Nc48c5f7c60d94ce8a91c1d9709d60528
181 Nd89791d0a56d400c825d7fd020d858e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Reproduction
183 rdf:type schema:DefinedTerm
184 Ne88dffbcd2ac4f5987d2258ed858abb0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Drosophila
186 rdf:type schema:DefinedTerm
187 Nee150e09ebfa4d5d9dfcefde41bf1da1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Symbiosis
189 rdf:type schema:DefinedTerm
190 Nf597583712234aaf837e4b228464d411 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Animals
192 rdf:type schema:DefinedTerm
193 Nfaff283a024d46b6aae9d0e74ae1fc92 schema:name readcube_id
194 schema:value 10b1f319675a901a22c796b9a6a8416d1d80bace23a0205351dab470a8f661c6
195 rdf:type schema:PropertyValue
196 Nfbec633f92f446078878462ed08ed2ec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Male
198 rdf:type schema:DefinedTerm
199 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
200 schema:name Biological Sciences
201 rdf:type schema:DefinedTerm
202 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
203 schema:name Genetics
204 rdf:type schema:DefinedTerm
205 sg:grant.2455792 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2164-9-1
206 rdf:type schema:MonetaryGrant
207 sg:journal.1023790 schema:issn 1471-2164
208 schema:name BMC Genomics
209 rdf:type schema:Periodical
210 sg:person.01365001613.11 schema:affiliation https://www.grid.ac/institutes/grid.266539.d
211 schema:familyName Xie
212 schema:givenName Yan
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365001613.11
214 rdf:type schema:Person
215 sg:person.0703426612.48 schema:affiliation https://www.grid.ac/institutes/grid.17088.36
216 schema:familyName Xi
217 schema:givenName Zhiyong
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703426612.48
219 rdf:type schema:Person
220 sg:person.0710455343.71 schema:affiliation https://www.grid.ac/institutes/grid.121334.6
221 schema:familyName Gavotte
222 schema:givenName Laurent
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710455343.71
224 rdf:type schema:Person
225 sg:person.0773170272.87 schema:affiliation https://www.grid.ac/institutes/grid.266539.d
226 schema:familyName Dobson
227 schema:givenName Stephen L
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773170272.87
229 rdf:type schema:Person
230 sg:pub.10.1007/3-540-29623-9_7146 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037739161
231 https://doi.org/10.1007/3-540-29623-9_7146
232 rdf:type schema:CreativeWork
233 sg:pub.10.1007/978-1-4020-6754-9_6552 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051155383
234 https://doi.org/10.1007/978-1-4020-6754-9_6552
235 rdf:type schema:CreativeWork
236 sg:pub.10.1038/nature00843 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026150449
237 https://doi.org/10.1038/nature00843
238 rdf:type schema:CreativeWork
239 sg:pub.10.1038/nature02021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022282224
240 https://doi.org/10.1038/nature02021
241 rdf:type schema:CreativeWork
242 sg:pub.10.1038/nature04756 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023497716
243 https://doi.org/10.1038/nature04756
244 rdf:type schema:CreativeWork
245 sg:pub.10.1038/nature735 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032740616
246 https://doi.org/10.1038/nature735
247 rdf:type schema:CreativeWork
248 sg:pub.10.1038/ng0502-19 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022919343
249 https://doi.org/10.1038/ng0502-19
250 rdf:type schema:CreativeWork
251 sg:pub.10.1038/ng1032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006930818
252 https://doi.org/10.1038/ng1032
253 rdf:type schema:CreativeWork
254 sg:pub.10.1046/j.1365-2540.1999.00501.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1027523279
255 https://doi.org/10.1046/j.1365-2540.1999.00501.x
256 rdf:type schema:CreativeWork
257 sg:pub.10.1186/1475-2883-5-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029480245
258 https://doi.org/10.1186/1475-2883-5-4
259 rdf:type schema:CreativeWork
260 sg:pub.10.1186/gb-2004-5-6-r40 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044612502
261 https://doi.org/10.1186/gb-2004-5-6-r40
262 rdf:type schema:CreativeWork
263 https://app.dimensions.ai/details/publication/pub.1075301127 schema:CreativeWork
264 https://app.dimensions.ai/details/publication/pub.1077441919 schema:CreativeWork
265 https://app.dimensions.ai/details/publication/pub.1080484930 schema:CreativeWork
266 https://app.dimensions.ai/details/publication/pub.1083255178 schema:CreativeWork
267 https://doi.org/10.1002/bies.10234 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005877403
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1002/jcb.20123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037787028
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1006/meth.2001.1262 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027621591
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1016/0925-4773(95)00349-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026410539
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/j.ibmb.2004.03.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049743382
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1016/j.it.2005.02.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052226951
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1016/j.tim.2006.01.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004207708
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1016/s0012-1606(02)00082-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038988728
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1016/s0378-1119(96)00503-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009991463
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1016/s0925-4773(02)00424-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024587838
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1016/s0952-7915(02)00005-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021412234
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1017/s0016672302005827 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053964071
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1046/j.1365-2583.2000.00224.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1023223258
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1073/pnas.0400580101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005108107
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1073/pnas.0403853101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016431264
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1073/pnas.0506461102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006446064
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1073/pnas.101304298 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010050086
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1073/pnas.161273698 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040273064
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1073/pnas.222549199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037853812
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1073/pnas.89.7.2699 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029781764
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1073/pnas.93.19.10343 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023920716
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1073/pnas.97.3.1263 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033714331
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1093/icb/39.2.363 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026027533
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1093/jac/47.5.659 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006519058
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1098/rspb.1995.0117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022453191
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1098/rspb.2001.1839 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004564911
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1098/rspb.2006.3478 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013625793
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1101/gad.1168104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012106152
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1101/gad.856901 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038830468
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1111/1467-9868.00346 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018285816
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1111/j.1462-5822.2005.00508.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1006569622
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1126/science.1079190 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044897060
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1126/science.1117607 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062452579
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1126/science.8511587 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062656415
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1128/aem.68.2.656-660.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023297799
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1128/aem.70.9.5366-5372.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003728102
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1128/aem.71.6.3199-3204.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032884384
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1128/jb.182.22.6529-6531.2000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021217256
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1128/mmbr.67.3.343-359.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012498586
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1146/annurev.ento.42.1.587 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013372740
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1371/journal.pbio.0030121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020703803
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1371/journal.ppat.0020034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046313760
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1534/genetics.105.052431 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003329740
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1645/0022-3395(2002)088[0605:iveoao]2.0.co;2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041327260
354 rdf:type schema:CreativeWork
355 https://doi.org/10.4049/jimmunol.169.12.7009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075200960
356 rdf:type schema:CreativeWork
357 https://doi.org/10.5483/bmbrep.2005.38.2.121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053665896
358 rdf:type schema:CreativeWork
359 https://www.grid.ac/institutes/grid.121334.6 schema:alternateName University of Montpellier
360 schema:name Department of Entomology, University of Kentucky, KY 40546, Lexington, USA
361 Institut des Sciences de l'Evolution. UMR-CNRS 5554, Bat 24, CC063, Université Montpellier II, Place Eugène Bataillon, 34095, Montpellier Cedex 5, France
362 rdf:type schema:Organization
363 https://www.grid.ac/institutes/grid.17088.36 schema:alternateName Michigan State University
364 schema:name Department of Entomology, Michigan State University, 48824, East Lansing, MI, USA
365 Department of Entomology, University of Kentucky, KY 40546, Lexington, USA
366 rdf:type schema:Organization
367 https://www.grid.ac/institutes/grid.266539.d schema:alternateName University of Kentucky
368 schema:name Department of Entomology, University of Kentucky, KY 40546, Lexington, USA
369 Department of Statistics, University of Kentucky, KY 40546, Lexington, USA
370 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...