Map of open and closed chromatin domains in Drosophila genome View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-11-18

AUTHORS

Beatrice Milon, Yezhou Sun, Weizhong Chang, Todd Creasy, Anup Mahurkar, Amol Shetty, Dmitry Nurminsky, Maria Nurminskaya

ABSTRACT

BackgroundChromatin compactness has been considered a major determinant of gene activity and has been associated with specific chromatin modifications in studies on a few individual genetic loci. At the same time, genome-wide patterns of open and closed chromatin have been understudied, and are at present largely predicted from chromatin modification and gene expression data. However the universal applicability of such predictions is not self-evident, and requires experimental verification.ResultsWe developed and implemented a high-throughput analysis for general chromatin sensitivity to DNase I which provides a comprehensive epigenomic assessment in a single assay. Contiguous domains of open and closed chromatin were identified by computational analysis of the data, and correlated to other genome annotations including predicted chromatin “states”, individual chromatin modifications, nuclear lamina interactions, and gene expression. While showing that the widely trusted predictions of chromatin structure are correct in the majority of cases, we detected diverse “exceptions” from the conventional rules. We found a profound paucity of chromatin modifications in a major fraction of closed chromatin, and identified a number of loci where chromatin configuration is opposite to that expected from modification and gene expression patterns. Further, we observed that chromatin of large introns tends to be closed even when the genes are expressed, and that a significant proportion of active genes including their promoters are located in closed chromatin.ConclusionsThese findings reveal limitations of the existing predictive models, indicate novel mechanisms of epigenetic regulation, and provide important insights into genome organization and function. More... »

PAGES

988

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1471-2164-15-988

DOI

http://dx.doi.org/10.1186/1471-2164-15-988

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046903415

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25407537


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Binding Sites", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromatin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromatin Assembly and Disassembly", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosome Mapping", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Computational Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Deoxyribonuclease I", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drosophila", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genome, Insect", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Binding", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Biochemistry and Molecular Biology, School of Medicine, University of Maryland, 108 N. Greene St., 21201, Baltimore, MD, USA", 
          "id": "http://www.grid.ac/institutes/grid.411024.2", 
          "name": [
            "Department of Biochemistry and Molecular Biology, School of Medicine, University of Maryland, 108 N. Greene St., 21201, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Milon", 
        "givenName": "Beatrice", 
        "id": "sg:person.01134217473.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134217473.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute for Genome Sciences, School of Medicine, University of Maryland, 21201, Baltimore, MD, USA", 
          "id": "http://www.grid.ac/institutes/grid.411024.2", 
          "name": [
            "Institute for Genome Sciences, School of Medicine, University of Maryland, 21201, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sun", 
        "givenName": "Yezhou", 
        "id": "sg:person.01101614041.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101614041.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute for Genome Sciences, School of Medicine, University of Maryland, 21201, Baltimore, MD, USA", 
          "id": "http://www.grid.ac/institutes/grid.411024.2", 
          "name": [
            "Institute for Genome Sciences, School of Medicine, University of Maryland, 21201, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chang", 
        "givenName": "Weizhong", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute for Genome Sciences, School of Medicine, University of Maryland, 21201, Baltimore, MD, USA", 
          "id": "http://www.grid.ac/institutes/grid.411024.2", 
          "name": [
            "Institute for Genome Sciences, School of Medicine, University of Maryland, 21201, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Creasy", 
        "givenName": "Todd", 
        "id": "sg:person.01113607272.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01113607272.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute for Genome Sciences, School of Medicine, University of Maryland, 21201, Baltimore, MD, USA", 
          "id": "http://www.grid.ac/institutes/grid.411024.2", 
          "name": [
            "Institute for Genome Sciences, School of Medicine, University of Maryland, 21201, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mahurkar", 
        "givenName": "Anup", 
        "id": "sg:person.01051370761.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051370761.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute for Genome Sciences, School of Medicine, University of Maryland, 21201, Baltimore, MD, USA", 
          "id": "http://www.grid.ac/institutes/grid.411024.2", 
          "name": [
            "Institute for Genome Sciences, School of Medicine, University of Maryland, 21201, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shetty", 
        "givenName": "Amol", 
        "id": "sg:person.0705703554.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705703554.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biochemistry and Molecular Biology, School of Medicine, University of Maryland, 108 N. Greene St., 21201, Baltimore, MD, USA", 
          "id": "http://www.grid.ac/institutes/grid.411024.2", 
          "name": [
            "Department of Biochemistry and Molecular Biology, School of Medicine, University of Maryland, 108 N. Greene St., 21201, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nurminsky", 
        "givenName": "Dmitry", 
        "id": "sg:person.01143017535.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143017535.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biochemistry and Molecular Biology, School of Medicine, University of Maryland, 108 N. Greene St., 21201, Baltimore, MD, USA", 
          "id": "http://www.grid.ac/institutes/grid.411024.2", 
          "name": [
            "Department of Biochemistry and Molecular Biology, School of Medicine, University of Maryland, 108 N. Greene St., 21201, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nurminskaya", 
        "givenName": "Maria", 
        "id": "sg:person.0717034151.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717034151.90"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nature01216", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016219953", 
          "https://doi.org/10.1038/nature01216"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/7651_2014_77", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020243884", 
          "https://doi.org/10.1007/7651_2014_77"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09725", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023233286", 
          "https://doi.org/10.1038/nature09725"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt.1505", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051483764", 
          "https://doi.org/10.1038/nbt.1505"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth.2688", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020615304", 
          "https://doi.org/10.1038/nmeth.2688"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth.2762", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033430428", 
          "https://doi.org/10.1038/nmeth.2762"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt.1662", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050061238", 
          "https://doi.org/10.1038/nbt.1662"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2005-6-8-r64", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029515090", 
          "https://doi.org/10.1186/gb-2005-6-8-r64"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-11-18", 
    "datePublishedReg": "2014-11-18", 
    "description": "BackgroundChromatin compactness has been considered a major determinant of gene activity and has been associated with specific chromatin modifications in studies on a few individual genetic loci. At the same time, genome-wide patterns of open and closed chromatin have been understudied, and are at present largely predicted from chromatin modification and gene expression data. However the universal applicability of such predictions is not self-evident, and requires experimental verification.ResultsWe developed and implemented a high-throughput analysis for general chromatin sensitivity to DNase I which provides a comprehensive epigenomic assessment in a single assay. Contiguous domains of open and closed chromatin were identified by computational analysis of the data, and correlated to other genome annotations including predicted chromatin \u201cstates\u201d, individual chromatin modifications, nuclear lamina interactions, and gene expression. While showing that the widely trusted predictions of chromatin structure are correct in the majority of cases, we detected diverse \u201cexceptions\u201d from the conventional rules. We found a profound paucity of chromatin modifications in a major fraction of closed chromatin, and identified a number of loci where chromatin configuration is opposite to that expected from modification and gene expression patterns. Further, we observed that chromatin of large introns tends to be closed even when the genes are expressed, and that a significant proportion of active genes including their promoters are located in closed chromatin.ConclusionsThese findings reveal limitations of the existing predictive models, indicate novel mechanisms of epigenetic regulation, and provide important insights into genome organization and function.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/1471-2164-15-988", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2516646", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1023790", 
        "issn": [
          "1471-2164"
        ], 
        "name": "BMC Genomics", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "15"
      }
    ], 
    "keywords": [
      "chromatin modifications", 
      "closed chromatin", 
      "specific chromatin modifications", 
      "genome-wide patterns", 
      "individual genetic loci", 
      "nuclear lamina interactions", 
      "gene expression patterns", 
      "number of loci", 
      "gene expression data", 
      "Drosophila genome", 
      "genome organization", 
      "chromatin domains", 
      "chromatin structure", 
      "genome annotation", 
      "active genes", 
      "chromatin sensitivity", 
      "epigenetic regulation", 
      "large intron", 
      "gene activity", 
      "chromatin configuration", 
      "high-throughput analysis", 
      "genetic loci", 
      "chromatin", 
      "lamina interactions", 
      "DNase I", 
      "gene expression", 
      "expression patterns", 
      "expression data", 
      "contiguous domains", 
      "novel mechanism", 
      "genes", 
      "loci", 
      "single assay", 
      "computational analysis", 
      "important insights", 
      "introns", 
      "genome", 
      "major fraction", 
      "major determinant", 
      "profound paucity", 
      "promoter", 
      "domain", 
      "modification", 
      "regulation", 
      "annotation", 
      "expression", 
      "assays", 
      "patterns", 
      "such predictions", 
      "significant proportion", 
      "insights", 
      "mechanism", 
      "interaction", 
      "activity", 
      "function", 
      "analysis", 
      "determinants", 
      "exception", 
      "structure", 
      "proportion", 
      "data", 
      "ConclusionsThese findings", 
      "fraction", 
      "maps", 
      "majority", 
      "number", 
      "predictive model", 
      "ResultsWe", 
      "prediction", 
      "organization", 
      "findings", 
      "universal applicability", 
      "paucity", 
      "study", 
      "sensitivity", 
      "majority of cases", 
      "same time", 
      "limitations", 
      "state", 
      "time", 
      "model", 
      "assessment", 
      "experimental verification", 
      "applicability", 
      "compactness", 
      "cases", 
      "rules", 
      "verification", 
      "configuration", 
      "conventional rules"
    ], 
    "name": "Map of open and closed chromatin domains in Drosophila genome", 
    "pagination": "988", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1046903415"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1471-2164-15-988"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25407537"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1471-2164-15-988", 
      "https://app.dimensions.ai/details/publication/pub.1046903415"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-06-01T22:12", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220601/entities/gbq_results/article/article_649.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/1471-2164-15-988"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1471-2164-15-988'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1471-2164-15-988'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1471-2164-15-988'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1471-2164-15-988'


 

This table displays all metadata directly associated to this object as RDF triples.

275 TRIPLES      22 PREDICATES      134 URIs      118 LITERALS      17 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1471-2164-15-988 schema:about N02dedc0bfe874587add0d511ca829f8a
2 N091447ca99bc4f589c66d5b3408c6954
3 N48c6f0f630f44bbaace6251e2f9bd99d
4 N4949edec5fc04181856d2add92fe2f17
5 N6a7b366f5355479a8abddf2b42f42c10
6 N6b90cb9fbd124cddb27a65a3ecafd7fb
7 N73c7489b0ee04bf4a099422e45c83f4a
8 Nca49afb32b6f4f699c03793dd2dac16e
9 Nd77b4a5b92ac4f07a44de32056ecc35b
10 Nf1bf964ddfa94f6b9435248bb491df77
11 anzsrc-for:06
12 anzsrc-for:0604
13 schema:author N940871105dfa478292595c1a8516ebbf
14 schema:citation sg:pub.10.1007/7651_2014_77
15 sg:pub.10.1038/nature01216
16 sg:pub.10.1038/nature09725
17 sg:pub.10.1038/nbt.1505
18 sg:pub.10.1038/nbt.1662
19 sg:pub.10.1038/nmeth.2688
20 sg:pub.10.1038/nmeth.2762
21 sg:pub.10.1186/gb-2005-6-8-r64
22 schema:datePublished 2014-11-18
23 schema:datePublishedReg 2014-11-18
24 schema:description BackgroundChromatin compactness has been considered a major determinant of gene activity and has been associated with specific chromatin modifications in studies on a few individual genetic loci. At the same time, genome-wide patterns of open and closed chromatin have been understudied, and are at present largely predicted from chromatin modification and gene expression data. However the universal applicability of such predictions is not self-evident, and requires experimental verification.ResultsWe developed and implemented a high-throughput analysis for general chromatin sensitivity to DNase I which provides a comprehensive epigenomic assessment in a single assay. Contiguous domains of open and closed chromatin were identified by computational analysis of the data, and correlated to other genome annotations including predicted chromatin “states”, individual chromatin modifications, nuclear lamina interactions, and gene expression. While showing that the widely trusted predictions of chromatin structure are correct in the majority of cases, we detected diverse “exceptions” from the conventional rules. We found a profound paucity of chromatin modifications in a major fraction of closed chromatin, and identified a number of loci where chromatin configuration is opposite to that expected from modification and gene expression patterns. Further, we observed that chromatin of large introns tends to be closed even when the genes are expressed, and that a significant proportion of active genes including their promoters are located in closed chromatin.ConclusionsThese findings reveal limitations of the existing predictive models, indicate novel mechanisms of epigenetic regulation, and provide important insights into genome organization and function.
25 schema:genre article
26 schema:inLanguage en
27 schema:isAccessibleForFree true
28 schema:isPartOf N492aa77ca5de4136a191bb759974f345
29 N9d431a60514348d6b736e3048659cd03
30 sg:journal.1023790
31 schema:keywords ConclusionsThese findings
32 DNase I
33 Drosophila genome
34 ResultsWe
35 active genes
36 activity
37 analysis
38 annotation
39 applicability
40 assays
41 assessment
42 cases
43 chromatin
44 chromatin configuration
45 chromatin domains
46 chromatin modifications
47 chromatin sensitivity
48 chromatin structure
49 closed chromatin
50 compactness
51 computational analysis
52 configuration
53 contiguous domains
54 conventional rules
55 data
56 determinants
57 domain
58 epigenetic regulation
59 exception
60 experimental verification
61 expression
62 expression data
63 expression patterns
64 findings
65 fraction
66 function
67 gene activity
68 gene expression
69 gene expression data
70 gene expression patterns
71 genes
72 genetic loci
73 genome
74 genome annotation
75 genome organization
76 genome-wide patterns
77 high-throughput analysis
78 important insights
79 individual genetic loci
80 insights
81 interaction
82 introns
83 lamina interactions
84 large intron
85 limitations
86 loci
87 major determinant
88 major fraction
89 majority
90 majority of cases
91 maps
92 mechanism
93 model
94 modification
95 novel mechanism
96 nuclear lamina interactions
97 number
98 number of loci
99 organization
100 patterns
101 paucity
102 prediction
103 predictive model
104 profound paucity
105 promoter
106 proportion
107 regulation
108 rules
109 same time
110 sensitivity
111 significant proportion
112 single assay
113 specific chromatin modifications
114 state
115 structure
116 study
117 such predictions
118 time
119 universal applicability
120 verification
121 schema:name Map of open and closed chromatin domains in Drosophila genome
122 schema:pagination 988
123 schema:productId N32ea97c5143e4a419fa0c042f6f4b800
124 Nb02078310b9342f9971bfb7a0887df28
125 Nb991b26a7795405e830faaeb94917cf6
126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046903415
127 https://doi.org/10.1186/1471-2164-15-988
128 schema:sdDatePublished 2022-06-01T22:12
129 schema:sdLicense https://scigraph.springernature.com/explorer/license/
130 schema:sdPublisher N35f3001ace124fd0b5e56dd0558d95a7
131 schema:url https://doi.org/10.1186/1471-2164-15-988
132 sgo:license sg:explorer/license/
133 sgo:sdDataset articles
134 rdf:type schema:ScholarlyArticle
135 N02dedc0bfe874587add0d511ca829f8a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Chromatin
137 rdf:type schema:DefinedTerm
138 N091447ca99bc4f589c66d5b3408c6954 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Genome, Insect
140 rdf:type schema:DefinedTerm
141 N32ea97c5143e4a419fa0c042f6f4b800 schema:name pubmed_id
142 schema:value 25407537
143 rdf:type schema:PropertyValue
144 N35f3001ace124fd0b5e56dd0558d95a7 schema:name Springer Nature - SN SciGraph project
145 rdf:type schema:Organization
146 N47a331e5927547eba46d5cc2a2263ccf rdf:first sg:person.01143017535.95
147 rdf:rest Na1eb20129fe94c87ab28cafca0dd1ce5
148 N48c6f0f630f44bbaace6251e2f9bd99d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Protein Binding
150 rdf:type schema:DefinedTerm
151 N492aa77ca5de4136a191bb759974f345 schema:issueNumber 1
152 rdf:type schema:PublicationIssue
153 N4949edec5fc04181856d2add92fe2f17 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Drosophila
155 rdf:type schema:DefinedTerm
156 N6a7b366f5355479a8abddf2b42f42c10 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Deoxyribonuclease I
158 rdf:type schema:DefinedTerm
159 N6b90cb9fbd124cddb27a65a3ecafd7fb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Animals
161 rdf:type schema:DefinedTerm
162 N70d728242ed646b58ce4fbfe1cb5ebb9 rdf:first Nc52accd6d53649cbb6b9ff52c61ac863
163 rdf:rest Nece3ab614a4544d38df8ce148790a9ef
164 N73c7489b0ee04bf4a099422e45c83f4a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Binding Sites
166 rdf:type schema:DefinedTerm
167 N940871105dfa478292595c1a8516ebbf rdf:first sg:person.01134217473.10
168 rdf:rest Nad8fcacb116d41eea44340bb867d5e2b
169 N9d431a60514348d6b736e3048659cd03 schema:volumeNumber 15
170 rdf:type schema:PublicationVolume
171 Na1eb20129fe94c87ab28cafca0dd1ce5 rdf:first sg:person.0717034151.90
172 rdf:rest rdf:nil
173 Nad8fcacb116d41eea44340bb867d5e2b rdf:first sg:person.01101614041.14
174 rdf:rest N70d728242ed646b58ce4fbfe1cb5ebb9
175 Nb02078310b9342f9971bfb7a0887df28 schema:name dimensions_id
176 schema:value pub.1046903415
177 rdf:type schema:PropertyValue
178 Nb991b26a7795405e830faaeb94917cf6 schema:name doi
179 schema:value 10.1186/1471-2164-15-988
180 rdf:type schema:PropertyValue
181 Nc45509e29b5d488cba08348cc1d9ab0e rdf:first sg:person.0705703554.98
182 rdf:rest N47a331e5927547eba46d5cc2a2263ccf
183 Nc52accd6d53649cbb6b9ff52c61ac863 schema:affiliation grid-institutes:grid.411024.2
184 schema:familyName Chang
185 schema:givenName Weizhong
186 rdf:type schema:Person
187 Nca49afb32b6f4f699c03793dd2dac16e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Chromosome Mapping
189 rdf:type schema:DefinedTerm
190 Nd77b4a5b92ac4f07a44de32056ecc35b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Computational Biology
192 rdf:type schema:DefinedTerm
193 Ndf33255ade654e09b889470519a3c99c rdf:first sg:person.01051370761.80
194 rdf:rest Nc45509e29b5d488cba08348cc1d9ab0e
195 Nece3ab614a4544d38df8ce148790a9ef rdf:first sg:person.01113607272.47
196 rdf:rest Ndf33255ade654e09b889470519a3c99c
197 Nf1bf964ddfa94f6b9435248bb491df77 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Chromatin Assembly and Disassembly
199 rdf:type schema:DefinedTerm
200 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
201 schema:name Biological Sciences
202 rdf:type schema:DefinedTerm
203 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
204 schema:name Genetics
205 rdf:type schema:DefinedTerm
206 sg:grant.2516646 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2164-15-988
207 rdf:type schema:MonetaryGrant
208 sg:journal.1023790 schema:issn 1471-2164
209 schema:name BMC Genomics
210 schema:publisher Springer Nature
211 rdf:type schema:Periodical
212 sg:person.01051370761.80 schema:affiliation grid-institutes:grid.411024.2
213 schema:familyName Mahurkar
214 schema:givenName Anup
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051370761.80
216 rdf:type schema:Person
217 sg:person.01101614041.14 schema:affiliation grid-institutes:grid.411024.2
218 schema:familyName Sun
219 schema:givenName Yezhou
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101614041.14
221 rdf:type schema:Person
222 sg:person.01113607272.47 schema:affiliation grid-institutes:grid.411024.2
223 schema:familyName Creasy
224 schema:givenName Todd
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01113607272.47
226 rdf:type schema:Person
227 sg:person.01134217473.10 schema:affiliation grid-institutes:grid.411024.2
228 schema:familyName Milon
229 schema:givenName Beatrice
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134217473.10
231 rdf:type schema:Person
232 sg:person.01143017535.95 schema:affiliation grid-institutes:grid.411024.2
233 schema:familyName Nurminsky
234 schema:givenName Dmitry
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143017535.95
236 rdf:type schema:Person
237 sg:person.0705703554.98 schema:affiliation grid-institutes:grid.411024.2
238 schema:familyName Shetty
239 schema:givenName Amol
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705703554.98
241 rdf:type schema:Person
242 sg:person.0717034151.90 schema:affiliation grid-institutes:grid.411024.2
243 schema:familyName Nurminskaya
244 schema:givenName Maria
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717034151.90
246 rdf:type schema:Person
247 sg:pub.10.1007/7651_2014_77 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020243884
248 https://doi.org/10.1007/7651_2014_77
249 rdf:type schema:CreativeWork
250 sg:pub.10.1038/nature01216 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016219953
251 https://doi.org/10.1038/nature01216
252 rdf:type schema:CreativeWork
253 sg:pub.10.1038/nature09725 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023233286
254 https://doi.org/10.1038/nature09725
255 rdf:type schema:CreativeWork
256 sg:pub.10.1038/nbt.1505 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051483764
257 https://doi.org/10.1038/nbt.1505
258 rdf:type schema:CreativeWork
259 sg:pub.10.1038/nbt.1662 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050061238
260 https://doi.org/10.1038/nbt.1662
261 rdf:type schema:CreativeWork
262 sg:pub.10.1038/nmeth.2688 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020615304
263 https://doi.org/10.1038/nmeth.2688
264 rdf:type schema:CreativeWork
265 sg:pub.10.1038/nmeth.2762 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033430428
266 https://doi.org/10.1038/nmeth.2762
267 rdf:type schema:CreativeWork
268 sg:pub.10.1186/gb-2005-6-8-r64 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029515090
269 https://doi.org/10.1186/gb-2005-6-8-r64
270 rdf:type schema:CreativeWork
271 grid-institutes:grid.411024.2 schema:alternateName Department of Biochemistry and Molecular Biology, School of Medicine, University of Maryland, 108 N. Greene St., 21201, Baltimore, MD, USA
272 Institute for Genome Sciences, School of Medicine, University of Maryland, 21201, Baltimore, MD, USA
273 schema:name Department of Biochemistry and Molecular Biology, School of Medicine, University of Maryland, 108 N. Greene St., 21201, Baltimore, MD, USA
274 Institute for Genome Sciences, School of Medicine, University of Maryland, 21201, Baltimore, MD, USA
275 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...