Whole genome sequencing of Turkish genomes reveals functional private alleles and impact of genetic interactions with Europe, Asia and Africa View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-12

AUTHORS

Can Alkan, Pinar Kavak, Mehmet Somel, Omer Gokcumen, Serkan Ugurlu, Ceren Saygi, Elif Dal, Kuyas Bugra, Tunga Güngör, S Cenk Sahinalp, Nesrin Özören, Cemalettin Bekpen

ABSTRACT

BACKGROUND: Turkey is a crossroads of major population movements throughout history and has been a hotspot of cultural interactions. Several studies have investigated the complex population history of Turkey through a limited set of genetic markers. However, to date, there have been no studies to assess the genetic variation at the whole genome level using whole genome sequencing. Here, we present whole genome sequences of 16 Turkish individuals resequenced at high coverage (32×-48×). RESULTS: We show that the genetic variation of the contemporary Turkish population clusters with South European populations, as expected, but also shows signatures of relatively recent contribution from ancestral East Asian populations. In addition, we document a significant enrichment of non-synonymous private alleles, consistent with recent observations in European populations. A number of variants associated with skin color and total cholesterol levels show frequency differentiation between the Turkish populations and European populations. Furthermore, we have analyzed the 17q21.31 inversion polymorphism region (MAPT locus) and found increased allele frequency of 31.25% for H1/H2 inversion polymorphism when compared to European populations that show about 25% of allele frequency. CONCLUSION: This study provides the first map of common genetic variation from 16 western Asian individuals and thus helps fill an important geographical gap in analyzing natural human variation and human migration. Our data will help develop population-specific experimental designs for studies investigating disease associations and demographic history in Turkey. More... »

PAGES

963

References to SciGraph publications

  • 2010-12. Ethnic differences in total and HDL cholesterol among Turkish, Moroccan and Dutch ethnic groups living in Amsterdam, the Netherlands in BMC PUBLIC HEALTH
  • 2012-06. Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo in NATURE GENETICS
  • 2011-11. Common Familial Mediterranean Fever gene mutations in a Turkish cohort in MOLECULAR BIOLOGY REPORTS
  • 2012-11-28. Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants in NATURE
  • 2005-02. A common inversion under selection in Europeans in NATURE GENETICS
  • 2006-09. Discovery of previously unidentified genomic disorders from the duplication architecture of the human genome in NATURE GENETICS
  • 2010-08. Biological, clinical and population relevance of 95 loci for blood lipids in NATURE
  • 2012-08. Structural diversity and African origin of the 17q21.31 inversion polymorphism in NATURE GENETICS
  • 2012-11. An integrated map of genetic variation from 1,092 human genomes in NATURE
  • 2010-05. Genome-wide association studies in diverse populations in NATURE REVIEWS GENETICS
  • 2011-03. Discovery and genotyping of genome structural polymorphism by sequencing on a population scale in NATURE GENETICS
  • 2009-02. Plasma lipoproteins: genetic influences and clinical implications in NATURE REVIEWS GENETICS
  • 2014-09. Ancient human genomes suggest three ancestral populations for present-day Europeans in NATURE
  • 2010-10-28. A map of human genome variation from population-scale sequencing in NATURE
  • 2010-08. Collaborative genomics for human health and cooperation in the Mediterranean region in NATURE GENETICS
  • 2007-01. Identifying genes underlying skin pigmentation differences among human populations in HUMAN GENETICS
  • 2009-10. Personalized copy number and segmental duplication maps using next-generation sequencing in NATURE GENETICS
  • 2010-08. Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease in NATURE GENETICS
  • 2004-01. Excavating Y-chromosome haplotype strata in Anatolia in HUMAN GENETICS
  • 2011-08. Extensive genomic and transcriptional diversity identified through massively parallel DNA and RNA sequencing of eighteen Korean individuals in NATURE GENETICS
  • 2011-05. A framework for variation discovery and genotyping using next-generation DNA sequencing data in NATURE GENETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/1471-2164-15-963

    DOI

    http://dx.doi.org/10.1186/1471-2164-15-963

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1040602865

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25376095


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