The nuclear receptor gene family in the Pacific oyster, Crassostrea gigas, contains a novel subfamily group View Full Text


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Article Info

DATE

2014-05-15

AUTHORS

Susanne Vogeler, Tamara S Galloway, Brett P Lyons, Tim P Bean

ABSTRACT

BACKGROUND: Nuclear receptors are a superfamily of transcription factors important in key biological, developmental and reproductive processes. Several of these receptors are ligand- activated and through their ability to bind endogenous and exogenous ligands, are potentially vulnerable to xenobiotics. Molluscs are key ecological species in defining aquatic and terrestrial habitats and are sensitive to xenobiotic compounds in the environment. However, the understanding of nuclear receptor presence, function and xenobiotic disruption in the phylum Mollusca is limited. RESULTS: Here, forty-three nuclear receptor sequences were mined from the genome of the Pacific oyster, Crassostrea gigas. They include members of NR0-NR5 subfamilies, notably lacking any NR6 members. Phylogenetic analyses of the oyster nuclear receptors have been conducted showing the presence of a large novel subfamily group not previously reported, which is named NR1P. Homologues to all previous identified nuclear receptors in other mollusc species have also been determined including the putative heterodimer partner retinoid X receptor, estrogen receptor and estrogen related receptor. CONCLUSION: C. gigas contains a highly diverse set of nuclear receptors including a novel NR1 group, which provides important information on presence and evolution of this transcription factor superfamily in invertebrates. The Pacific oyster possesses two members of NR3, the sex steroid hormone receptor analogues, of which there are 9 in humans. This provides increasing evidence that steroid ligand specific expansion of this family is deuterostome specific. This new knowledge on divergence and emergence of nuclear receptors in C. gigas provides essential information for studying regulation of molluscan gene expression and the potential effects of xenobiotics. More... »

PAGES

369

References to SciGraph publications

  • 2005-12-15. Imposex in marine gastropods may be caused by binding of organotins to retinoid X receptor in MARINE BIOLOGY
  • 2001-07-24. Comparison of complete nuclear receptor sets from the human, Caenorhabditis elegans and Drosophila genomes in GENOME BIOLOGY
  • 2007-01-13. Sex steroid receptor evolution and signalling in aquatic invertebrates in ECOTOXICOLOGY
  • 2005-04. Nuclear receptors — a perspective from Drosophila in NATURE REVIEWS GENETICS
  • 2009-12-04. Establishment of a polyclonal antibody against the retinoid X receptor of the rock shell Thais clavigera and its application to rock shell tissues for imposex research in ECOTOXICOLOGY
  • 2007-02-23. Evolution of a novel subfamily of nuclear receptors with members that each contain two DNA binding domains in BMC EVOLUTIONARY BIOLOGY
  • 2007-01-20. Steroids in aquatic invertebrates in ECOTOXICOLOGY
  • 2008-08. The Trichoplax genome and the nature of placozoans in NATURE
  • 2007-01-13. Sex steroids and potential mechanisms of non-genomic endocrine disruption in invertebrates in ECOTOXICOLOGY
  • 2000-02. Mutation of a nuclear receptor gene, NR2E3, causes enhanced S cone syndrome, a disorder of retinal cell fate in NATURE GENETICS
  • 2009-08-04. Environmental-endocrine control of reproductive maturation in gastropods: implications for the mechanism of tributyltin-induced imposex in prosobranchs in ECOTOXICOLOGY
  • 2012-06-18. Primer-BLAST: A tool to design target-specific primers for polymerase chain reaction in BMC BIOINFORMATICS
  • 1996. Mussels as Bioindicators: Effects of TBT on Survival, Bioaccumulation, and Growth Under Natural Conditions in ORGANOTIN
  • 2007-12-18. Exposure to 9-cis retinoic acid induces penis and vas deferens development in the female rock shell, Thais clavigera in CELL BIOLOGY AND TOXICOLOGY
  • 1998-11. Performance of 18S rRNA in Littorinid Phylogeny (Gastropoda: Caenogastropoda) in JOURNAL OF MOLECULAR EVOLUTION
  • 2009-10-28. Annotation, phylogenetics, and expression of the nuclear receptors in Daphnia pulex in BMC GENOMICS
  • 2012-09-19. The oyster genome reveals stress adaptation and complexity of shell formation in NATURE
  • 2009-10-31. Time course of expression of the retinoid X receptor gene and induction of imposex in the rock shell, Thais clavigera, exposed to triphenyltin chloride in ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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    http://scigraph.springernature.com/pub.10.1186/1471-2164-15-369

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    http://dx.doi.org/10.1186/1471-2164-15-369

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1047407236

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24885009


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    52 deuterostomes
    53 disruption
    54 divergence
    55 diverse set
    56 ecological species
    57 effect
    58 emergence
    59 environment
    60 essential information
    61 estrogen
    62 estrogen receptor
    63 evidence
    64 evolution
    65 exogenous ligands
    66 expansion
    67 expression
    68 factors
    69 family
    70 function
    71 gene expression
    72 gene family
    73 genome
    74 gigas
    75 group
    76 habitats
    77 heterodimer partner retinoid X receptor
    78 homologues
    79 hormone receptor analogues
    80 humans
    81 important information
    82 information
    83 invertebrates
    84 key ecological species
    85 knowledge
    86 large novel subfamily group
    87 ligand specific expansion
    88 ligands
    89 members
    90 members of NR3
    91 mollusc species
    92 molluscan gene expression
    93 molluscs
    94 new knowledge
    95 novel NR1 group
    96 novel subfamily group
    97 nuclear receptor gene family
    98 nuclear receptor presence
    99 nuclear receptor sequences
    100 nuclear receptors
    101 oyster nuclear receptors
    102 oysters
    103 partner retinoid X receptor
    104 phylogenetic analysis
    105 phylum Mollusca
    106 potential effects
    107 presence
    108 process
    109 putative heterodimer partner retinoid X receptor
    110 receptor analogues
    111 receptor gene family
    112 receptor presence
    113 receptor sequences
    114 receptors
    115 regulation
    116 reproductive processes
    117 retinoid X receptor
    118 sequence
    119 set
    120 sex steroid hormone receptor analogues
    121 species
    122 specific expansion
    123 steroid hormone receptor analogues
    124 steroid ligand specific expansion
    125 subfamilies
    126 subfamily groups
    127 superfamily
    128 terrestrial habitats
    129 transcription factors
    130 understanding
    131 xenobiotic compounds
    132 xenobiotic disruption
    133 xenobiotics
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