Sex differences in the human peripheral blood transcriptome View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-12

AUTHORS

Rick Jansen, Sandra Batista, Andrew I Brooks, Jay A Tischfield, Gonneke Willemsen, Gerard van Grootheest, Jouke-Jan Hottenga, Yuri Milaneschi, Hamdi Mbarek, Vered Madar, Wouter Peyrot, Jacqueline M Vink, Cor L Verweij, Eco JC de Geus, Johannes H Smit, Fred A Wright, Patrick F Sullivan, Dorret I Boomsma, Brenda WJH Penninx

ABSTRACT

BACKGROUND: Genomes of men and women differ in only a limited number of genes located on the sex chromosomes, whereas the transcriptome is far more sex-specific. Identification of sex-biased gene expression will contribute to understanding the molecular basis of sex-differences in complex traits and common diseases. RESULTS: Sex differences in the human peripheral blood transcriptome were characterized using microarrays in 5,241 subjects, accounting for menopause status and hormonal contraceptive use. Sex-specific expression was observed for 582 autosomal genes, of which 57.7% was upregulated in women (female-biased genes). Female-biased genes were enriched for several immune system GO categories, genes linked to rheumatoid arthritis (16%) and genes regulated by estrogen (18%). Male-biased genes were enriched for genes linked to renal cancer (9%). Sex-differences in gene expression were smaller in postmenopausal women, larger in women using hormonal contraceptives and not caused by sex-specific eQTLs, confirming the role of estrogen in regulating sex-biased genes. CONCLUSIONS: This study indicates that sex-bias in gene expression is extensive and may underlie sex-differences in the prevalence of common diseases. More... »

PAGES

33

References to SciGraph publications

  • 2000-05. Gene Ontology: tool for the unification of biology in NATURE GENETICS
  • 2005-03. X-inactivation profile reveals extensive variability in X-linked gene expression in females in NATURE
  • 2002-10. Progesterone receptors - animal models and cell signaling in breast cancer: The role of oestrogen and progesterone receptors in human mammary development and tumorigenesis in BREAST CANCER RESEARCH
  • 2012-09. Mid-Regional Pro-Adrenomedullin in Acute Heart Failure: A Better Biomarker or Just Another Biomarker? in CURRENT HEART FAILURE REPORTS
  • 2013-11. Population structure, migration, and diversifying selection in the Netherlands in EUROPEAN JOURNAL OF HUMAN GENETICS
  • 2008-12. Sex-specific genetic architecture of human disease in NATURE REVIEWS GENETICS
  • 2009-10. Why are women predisposed to autoimmune rheumatic diseases? in ARTHRITIS RESEARCH & THERAPY
  • 2001-09. Sex differences in autoimmune disease in NATURE IMMUNOLOGY
  • 2006-11. Genome-wide analysis of estrogen receptor binding sites in NATURE GENETICS
  • 2008-12. WGCNA: an R package for weighted correlation network analysis in BMC BIOINFORMATICS
  • 2007-09. The evolution of sex-biased genes and sex-biased gene expression in NATURE REVIEWS GENETICS
  • 2011-12. Strategies for aggregating gene expression data: The collapseRows R function in BMC BIOINFORMATICS
  • 2008-12. The unique genomic properties of sex-biased genes: Insights from avian microarray data in BMC GENOMICS
  • 2013-02. The evolutionary causes and consequences of sex-biased gene expression in NATURE REVIEWS GENETICS
  • 2011-12. The G-protein-coupled estrogen receptor GPER in health and disease in NATURE REVIEWS ENDOCRINOLOGY
  • 2012-12. The Evolution of Antiplatelet Therapy in the Treatment of Acute Coronary Syndromes in DRUGS
  • 2008-03. Genome-wide association of major depression: description of samples for the GAIN Major Depressive Disorder Study: NTR and NESDA biobank projects in EUROPEAN JOURNAL OF HUMAN GENETICS
  • 2010-06. Lactoferrin: the path from protein to gene in BIOMETALS
  • 2005-09. Initial sequence of the chimpanzee genome and comparison with the human genome in NATURE
  • 2004-06. Gene regulation and DNA damage in the ageing human brain in NATURE
  • 2010-06. Sex bias in trials and treatment must end in NATURE
  • 2007-11. Constraint and turnover in sex-biased gene expression in the genus Drosophila in NATURE
  • 2010-04. Perforin deficiency and susceptibility to cancer in CELL DEATH & DIFFERENTIATION
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/1471-2164-15-33

    DOI

    http://dx.doi.org/10.1186/1471-2164-15-33

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1021134350

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24438232


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Age Factors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Arthritis, Rheumatoid", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Chromosomes, Human, X", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Chromosomes, Human, Y", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Contraceptive Agents, Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Estrogens", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Kidney Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Polymorphism, Single Nucleotide", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Postmenopause", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "RNA", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Sex Factors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Transcriptome", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Amsterdam Neuroscience", 
              "id": "https://www.grid.ac/institutes/grid.484519.5", 
              "name": [
                "Department of Psychiatry, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jansen", 
            "givenName": "Rick", 
            "id": "sg:person.01116161622.29", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116161622.29"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of North Carolina System", 
              "id": "https://www.grid.ac/institutes/grid.410711.2", 
              "name": [
                "Departments of Genetics and Psychiatry, University of North Carolina, North Carolina, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Batista", 
            "givenName": "Sandra", 
            "id": "sg:person.01164275022.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164275022.05"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Rutgers University", 
              "id": "https://www.grid.ac/institutes/grid.430387.b", 
              "name": [
                "Department of Genetics and the Human Genetics Institute, Rutgers University Cell and DNA Repository, Rutgers University, New Jersey, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Brooks", 
            "givenName": "Andrew I", 
            "id": "sg:person.016532571052.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016532571052.46"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Rutgers University", 
              "id": "https://www.grid.ac/institutes/grid.430387.b", 
              "name": [
                "Department of Genetics and the Human Genetics Institute, Rutgers University Cell and DNA Repository, Rutgers University, New Jersey, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tischfield", 
            "givenName": "Jay A", 
            "id": "sg:person.01312515624.98", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01312515624.98"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Amsterdam Neuroscience", 
              "id": "https://www.grid.ac/institutes/grid.484519.5", 
              "name": [
                "Department of Biological Psychology, VU University Amsterdam, Neuroscience Campus Amsterdam, Amsterdam, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Willemsen", 
            "givenName": "Gonneke", 
            "id": "sg:person.0610017257.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610017257.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Amsterdam Neuroscience", 
              "id": "https://www.grid.ac/institutes/grid.484519.5", 
              "name": [
                "Department of Psychiatry, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "van Grootheest", 
            "givenName": "Gerard", 
            "id": "sg:person.0623232522.09", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623232522.09"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Amsterdam Neuroscience", 
              "id": "https://www.grid.ac/institutes/grid.484519.5", 
              "name": [
                "Department of Biological Psychology, VU University Amsterdam, Neuroscience Campus Amsterdam, Amsterdam, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hottenga", 
            "givenName": "Jouke-Jan", 
            "id": "sg:person.0610570026.87", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610570026.87"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Amsterdam Neuroscience", 
              "id": "https://www.grid.ac/institutes/grid.484519.5", 
              "name": [
                "Department of Psychiatry, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Milaneschi", 
            "givenName": "Yuri", 
            "id": "sg:person.0633256337.62", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0633256337.62"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Amsterdam Neuroscience", 
              "id": "https://www.grid.ac/institutes/grid.484519.5", 
              "name": [
                "Department of Biological Psychology, VU University Amsterdam, Neuroscience Campus Amsterdam, Amsterdam, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mbarek", 
            "givenName": "Hamdi", 
            "id": "sg:person.0650417210.95", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650417210.95"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of North Carolina System", 
              "id": "https://www.grid.ac/institutes/grid.410711.2", 
              "name": [
                "Department of Biostatistics, University of North Carolina, North Carolina, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Madar", 
            "givenName": "Vered", 
            "id": "sg:person.01053707522.39", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053707522.39"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Amsterdam Neuroscience", 
              "id": "https://www.grid.ac/institutes/grid.484519.5", 
              "name": [
                "Department of Psychiatry, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Peyrot", 
            "givenName": "Wouter", 
            "id": "sg:person.01201053206.51", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201053206.51"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Amsterdam Neuroscience", 
              "id": "https://www.grid.ac/institutes/grid.484519.5", 
              "name": [
                "Department of Biological Psychology, VU University Amsterdam, Neuroscience Campus Amsterdam, Amsterdam, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Vink", 
            "givenName": "Jacqueline M", 
            "id": "sg:person.013415671257.40", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013415671257.40"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "VU University Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.16872.3a", 
              "name": [
                "Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Verweij", 
            "givenName": "Cor L", 
            "id": "sg:person.014463226344.79", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014463226344.79"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Amsterdam Neuroscience", 
              "id": "https://www.grid.ac/institutes/grid.484519.5", 
              "name": [
                "Department of Biological Psychology, VU University Amsterdam, Neuroscience Campus Amsterdam, Amsterdam, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "de Geus", 
            "givenName": "Eco JC", 
            "id": "sg:person.015224655437.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015224655437.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Amsterdam Neuroscience", 
              "id": "https://www.grid.ac/institutes/grid.484519.5", 
              "name": [
                "Department of Psychiatry, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Smit", 
            "givenName": "Johannes H", 
            "id": "sg:person.014613077322.17", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014613077322.17"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of North Carolina System", 
              "id": "https://www.grid.ac/institutes/grid.410711.2", 
              "name": [
                "Department of Biostatistics, University of North Carolina, North Carolina, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wright", 
            "givenName": "Fred A", 
            "id": "sg:person.01145130774.66", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145130774.66"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of North Carolina System", 
              "id": "https://www.grid.ac/institutes/grid.410711.2", 
              "name": [
                "Departments of Genetics and Psychiatry, University of North Carolina, North Carolina, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sullivan", 
            "givenName": "Patrick F", 
            "id": "sg:person.015012714437.80", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015012714437.80"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Amsterdam Neuroscience", 
              "id": "https://www.grid.ac/institutes/grid.484519.5", 
              "name": [
                "Department of Biological Psychology, VU University Amsterdam, Neuroscience Campus Amsterdam, Amsterdam, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Boomsma", 
            "givenName": "Dorret I", 
            "id": "sg:person.0610667722.81", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610667722.81"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Amsterdam Neuroscience", 
              "id": "https://www.grid.ac/institutes/grid.484519.5", 
              "name": [
                "Department of Psychiatry, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Penninx", 
            "givenName": "Brenda WJH", 
            "id": "sg:person.011235144537.09", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011235144537.09"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/sj.ejhg.5201979", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001360587", 
              "https://doi.org/10.1038/sj.ejhg.5201979"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1673-8527(07)60110-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001451037"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02661", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001579376", 
              "https://doi.org/10.1038/nature02661"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02661", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001579376", 
              "https://doi.org/10.1038/nature02661"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.134981.111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002675432"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.autrev.2011.11.022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002696291"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pbio.0030170", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004200208"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev-clinpsy-032511-143109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004267423"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.juro.2008.01.024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004394519"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg2167", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007115561", 
              "https://doi.org/10.1038/nrg2167"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.5217506", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007457721"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03479", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007477207", 
              "https://doi.org/10.1038/nature03479"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03479", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007477207", 
              "https://doi.org/10.1038/nature03479"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni0901-777", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009034825", 
              "https://doi.org/10.1038/ni0901-777"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni0901-777", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009034825", 
              "https://doi.org/10.1038/ni0901-777"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/ar2825", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009947280", 
              "https://doi.org/10.1186/ar2825"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3109/10408361003791520", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011919205"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10534-010-9310-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012011842", 
              "https://doi.org/10.1007/s10534-010-9310-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10534-010-9310-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012011842", 
              "https://doi.org/10.1007/s10534-010-9310-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1375/twin.9.6.849", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012140273"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1901", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012239798", 
              "https://doi.org/10.1038/ng1901"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1901", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012239798", 
              "https://doi.org/10.1038/ng1901"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cdd.2009.212", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012467921", 
              "https://doi.org/10.1038/cdd.2009.212"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ejhg.2013.48", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012702520", 
              "https://doi.org/10.1038/ejhg.2013.48"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/465688a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013103104", 
              "https://doi.org/10.1038/465688a"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/465688a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013103104", 
              "https://doi.org/10.1038/465688a"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2105-12-322", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013163514", 
              "https://doi.org/10.1186/1471-2105-12-322"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.canlet.2011.11.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013929752"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11897-012-0096-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014359071", 
              "https://doi.org/10.1007/s11897-012-0096-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrendo.2011.122", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015855462", 
              "https://doi.org/10.1038/nrendo.2011.122"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg2415", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016733425", 
              "https://doi.org/10.1038/nrg2415"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/hmg/dds304", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016939095"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/gme.0b013e31803c56b6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017476072"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/gme.0b013e31803c56b6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017476072"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/gme.0b013e31803c56b6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017476072"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.00601-10", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019352008"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jacc.2009.11.050", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020082685"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2105-9-559", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020312314", 
              "https://doi.org/10.1186/1471-2105-9-559"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2202/1544-6115.1128", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020363278"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2011-04-347526", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021260208"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1677/jme.1.01825", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021639235"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2265.2006.02676.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022294092"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.1000100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023554590"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0047371", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023996806"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ecl.2007.03.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024122014"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.bor.0000218949.19860.d1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024588899"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.bor.0000218949.19860.d1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024588899"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.bor.0000218949.19860.d1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024588899"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0023506", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024681437"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1375/twin.7.6.564", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025580843"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/bcr452", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026160274", 
              "https://doi.org/10.1186/bcr452"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0001385", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026184450"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.eururo.2008.10.035", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030116450"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/wrna.115", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030571771"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/mpr.256", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030653166"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/bti551", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032806326"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.1002212", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032831404"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkm764", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033610041"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/physiolgenomics.00110.2009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033893011"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature06323", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033913666", 
              "https://doi.org/10.1038/nature06323"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-11-1232", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034587296"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/bts163", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036235772"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.278.5338.675", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036670098"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.06312-11", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036697989"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2164-9-148", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036887487", 
              "https://doi.org/10.1186/1471-2164-9-148"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/hmg/ddl456", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037560677"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/emboj.2009.88", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039350026"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg3376", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042433143", 
              "https://doi.org/10.1038/nrg3376"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04072", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042676864", 
              "https://doi.org/10.1038/nature04072"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04072", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042676864", 
              "https://doi.org/10.1038/nature04072"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/75556", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044135237", 
              "https://doi.org/10.1038/75556"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/75556", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044135237", 
              "https://doi.org/10.1038/75556"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4061/2011/989438", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044788603"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2011.03.042", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044799507"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.2165/11640880-000000000-00000", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044912900", 
              "https://doi.org/10.2165/11640880-000000000-00000"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1375/twin.13.3.231", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046517074"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/bmj.324.7329.71", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046678775"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fnins.2012.00063", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047025819"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.00280-13", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047396451"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/gme.0b013e318188b260", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049117796"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/gme.0b013e318188b260", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049117796"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/gme.0b013e318188b260", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049117796"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/0264-6021:3520601", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056715172"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj3520601", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056720160"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj3520601", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056720160"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/fpc.0b013e3280121ffe", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060340475"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/fpc.0b013e3280121ffe", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060340475"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/fpc.0b013e3280121ffe", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060340475"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1085881", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062448247"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/er.2003-0035", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064285800"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/me.2008-0044", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064328140"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1375/twin.7.6.670", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1067170085"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2741/212", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1070914426"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/epi.6.7.16517", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072303192"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1080026707", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2014-12", 
        "datePublishedReg": "2014-12-01", 
        "description": "BACKGROUND: Genomes of men and women differ in only a limited number of genes located on the sex chromosomes, whereas the transcriptome is far more sex-specific. Identification of sex-biased gene expression will contribute to understanding the molecular basis of sex-differences in complex traits and common diseases.\nRESULTS: Sex differences in the human peripheral blood transcriptome were characterized using microarrays in 5,241 subjects, accounting for menopause status and hormonal contraceptive use. Sex-specific expression was observed for 582 autosomal genes, of which 57.7% was upregulated in women (female-biased genes). Female-biased genes were enriched for several immune system GO categories, genes linked to rheumatoid arthritis (16%) and genes regulated by estrogen (18%). Male-biased genes were enriched for genes linked to renal cancer (9%). Sex-differences in gene expression were smaller in postmenopausal women, larger in women using hormonal contraceptives and not caused by sex-specific eQTLs, confirming the role of estrogen in regulating sex-biased genes.\nCONCLUSIONS: This study indicates that sex-bias in gene expression is extensive and may underlie sex-differences in the prevalence of common diseases.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1186/1471-2164-15-33", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.3773756", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.4128757", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.4700131", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2669474", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.4118013", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.4113448", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2696437", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3795919", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1023790", 
            "issn": [
              "1471-2164"
            ], 
            "name": "BMC Genomics", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "15"
          }
        ], 
        "name": "Sex differences in the human peripheral blood transcriptome", 
        "pagination": "33", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "64b1d0ab74b6a9bea43fde754ecc09d9110f6e4602b9391466527f3e15b33eea"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "24438232"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "100965258"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/1471-2164-15-33"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1021134350"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/1471-2164-15-33", 
          "https://app.dimensions.ai/details/publication/pub.1021134350"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T22:30", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8690_00000505.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1186%2F1471-2164-15-33"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1471-2164-15-33'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1471-2164-15-33'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1471-2164-15-33'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1471-2164-15-33'


     

    This table displays all metadata directly associated to this object as RDF triples.

    549 TRIPLES      21 PREDICATES      125 URIs      39 LITERALS      27 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/1471-2164-15-33 schema:about N24d4e153c13e42c29c24131f8365c631
    2 N276a6d2ef4844af2a2b619308e1dfa7c
    3 N28549c82689247a3add66ed3505f354c
    4 N38a995670df34f9caf0606745b2b1341
    5 N4a73f73d0f6745dfae9d5830f9e2c0b5
    6 N55ee85e90fd64129ac9408bf40190447
    7 N5885eb4589b5445dbef38c0c197c8f64
    8 N5e08ffbcb8494da489cbb0696a60ddf0
    9 N5e19617a73f0448e9bbe8c509aa7cc42
    10 N5e78def4905f447fbcaa0cac18f67665
    11 N71897cebe84a44cc9a041577bae28c6d
    12 N74081ffff84d47a7b08c5a9e6aca8ed8
    13 N744d2c91bd5f4909b38adcc74ac67999
    14 N88a4f68583ca48d5ae91ba969186011a
    15 N8a2f21fb7fb74e90b90e5c70cbb239ab
    16 Na9393c37b97743ccbd3641f4eb5348c8
    17 Nb5f88afb016f4803b71c4150bd706919
    18 Nfcb5ff6c44d1458fa51ef9e29624c6d8
    19 anzsrc-for:06
    20 anzsrc-for:0604
    21 schema:author N709fab48d07545deb28a1dc8d5d57cc1
    22 schema:citation sg:pub.10.1007/s10534-010-9310-8
    23 sg:pub.10.1007/s11897-012-0096-6
    24 sg:pub.10.1038/465688a
    25 sg:pub.10.1038/75556
    26 sg:pub.10.1038/cdd.2009.212
    27 sg:pub.10.1038/ejhg.2013.48
    28 sg:pub.10.1038/nature02661
    29 sg:pub.10.1038/nature03479
    30 sg:pub.10.1038/nature04072
    31 sg:pub.10.1038/nature06323
    32 sg:pub.10.1038/ng1901
    33 sg:pub.10.1038/ni0901-777
    34 sg:pub.10.1038/nrendo.2011.122
    35 sg:pub.10.1038/nrg2167
    36 sg:pub.10.1038/nrg2415
    37 sg:pub.10.1038/nrg3376
    38 sg:pub.10.1038/sj.ejhg.5201979
    39 sg:pub.10.1186/1471-2105-12-322
    40 sg:pub.10.1186/1471-2105-9-559
    41 sg:pub.10.1186/1471-2164-9-148
    42 sg:pub.10.1186/ar2825
    43 sg:pub.10.1186/bcr452
    44 sg:pub.10.2165/11640880-000000000-00000
    45 https://app.dimensions.ai/details/publication/pub.1080026707
    46 https://doi.org/10.1002/mpr.256
    47 https://doi.org/10.1002/wrna.115
    48 https://doi.org/10.1016/j.autrev.2011.11.022
    49 https://doi.org/10.1016/j.canlet.2011.11.002
    50 https://doi.org/10.1016/j.cell.2011.03.042
    51 https://doi.org/10.1016/j.ecl.2007.03.011
    52 https://doi.org/10.1016/j.eururo.2008.10.035
    53 https://doi.org/10.1016/j.jacc.2009.11.050
    54 https://doi.org/10.1016/j.juro.2008.01.024
    55 https://doi.org/10.1016/s1673-8527(07)60110-6
    56 https://doi.org/10.1038/emboj.2009.88
    57 https://doi.org/10.1042/0264-6021:3520601
    58 https://doi.org/10.1042/bj3520601
    59 https://doi.org/10.1093/bioinformatics/bti551
    60 https://doi.org/10.1093/bioinformatics/bts163
    61 https://doi.org/10.1093/hmg/ddl456
    62 https://doi.org/10.1093/hmg/dds304
    63 https://doi.org/10.1093/nar/gkm764
    64 https://doi.org/10.1097/01.bor.0000218949.19860.d1
    65 https://doi.org/10.1097/fpc.0b013e3280121ffe
    66 https://doi.org/10.1097/gme.0b013e31803c56b6
    67 https://doi.org/10.1097/gme.0b013e318188b260
    68 https://doi.org/10.1101/gr.134981.111
    69 https://doi.org/10.1101/gr.5217506
    70 https://doi.org/10.1111/j.1365-2265.2006.02676.x
    71 https://doi.org/10.1126/science.1085881
    72 https://doi.org/10.1126/science.278.5338.675
    73 https://doi.org/10.1128/mcb.00280-13
    74 https://doi.org/10.1128/mcb.00601-10
    75 https://doi.org/10.1128/mcb.06312-11
    76 https://doi.org/10.1136/bmj.324.7329.71
    77 https://doi.org/10.1146/annurev-clinpsy-032511-143109
    78 https://doi.org/10.1152/physiolgenomics.00110.2009
    79 https://doi.org/10.1158/0008-5472.can-11-1232
    80 https://doi.org/10.1182/blood-2011-04-347526
    81 https://doi.org/10.1210/er.2003-0035
    82 https://doi.org/10.1210/me.2008-0044
    83 https://doi.org/10.1371/journal.pbio.0030170
    84 https://doi.org/10.1371/journal.pgen.1000100
    85 https://doi.org/10.1371/journal.pgen.1002212
    86 https://doi.org/10.1371/journal.pone.0001385
    87 https://doi.org/10.1371/journal.pone.0023506
    88 https://doi.org/10.1371/journal.pone.0047371
    89 https://doi.org/10.1375/twin.13.3.231
    90 https://doi.org/10.1375/twin.7.6.564
    91 https://doi.org/10.1375/twin.7.6.670
    92 https://doi.org/10.1375/twin.9.6.849
    93 https://doi.org/10.1677/jme.1.01825
    94 https://doi.org/10.2202/1544-6115.1128
    95 https://doi.org/10.2741/212
    96 https://doi.org/10.3109/10408361003791520
    97 https://doi.org/10.3389/fnins.2012.00063
    98 https://doi.org/10.4061/2011/989438
    99 https://doi.org/10.4161/epi.6.7.16517
    100 schema:datePublished 2014-12
    101 schema:datePublishedReg 2014-12-01
    102 schema:description BACKGROUND: Genomes of men and women differ in only a limited number of genes located on the sex chromosomes, whereas the transcriptome is far more sex-specific. Identification of sex-biased gene expression will contribute to understanding the molecular basis of sex-differences in complex traits and common diseases. RESULTS: Sex differences in the human peripheral blood transcriptome were characterized using microarrays in 5,241 subjects, accounting for menopause status and hormonal contraceptive use. Sex-specific expression was observed for 582 autosomal genes, of which 57.7% was upregulated in women (female-biased genes). Female-biased genes were enriched for several immune system GO categories, genes linked to rheumatoid arthritis (16%) and genes regulated by estrogen (18%). Male-biased genes were enriched for genes linked to renal cancer (9%). Sex-differences in gene expression were smaller in postmenopausal women, larger in women using hormonal contraceptives and not caused by sex-specific eQTLs, confirming the role of estrogen in regulating sex-biased genes. CONCLUSIONS: This study indicates that sex-bias in gene expression is extensive and may underlie sex-differences in the prevalence of common diseases.
    103 schema:genre research_article
    104 schema:inLanguage en
    105 schema:isAccessibleForFree true
    106 schema:isPartOf N0f888e6ed4f84d4ea613b2a98823618e
    107 Nc98b18181352446d949a234be52daad3
    108 sg:journal.1023790
    109 schema:name Sex differences in the human peripheral blood transcriptome
    110 schema:pagination 33
    111 schema:productId N09cab70ddd684841821461b9aa41657a
    112 N1f2fd676ccd54a71bb396152d371359a
    113 N5a1415e9ddd44681b8c006a451b02dbe
    114 Nb4d5307fe56848ffaed549a4c71b7cdd
    115 Nefbcce9f3d564ba5834bd13629f75346
    116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021134350
    117 https://doi.org/10.1186/1471-2164-15-33
    118 schema:sdDatePublished 2019-04-10T22:30
    119 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    120 schema:sdPublisher N3e78dd2f8f8541ff96c74260699d3d70
    121 schema:url http://link.springer.com/10.1186%2F1471-2164-15-33
    122 sgo:license sg:explorer/license/
    123 sgo:sdDataset articles
    124 rdf:type schema:ScholarlyArticle
    125 N03a81ffd422d4a069b3eb7d176c4a07d rdf:first sg:person.01053707522.39
    126 rdf:rest N95da53b117b94ce2be8a4163a61c8dd4
    127 N09cab70ddd684841821461b9aa41657a schema:name dimensions_id
    128 schema:value pub.1021134350
    129 rdf:type schema:PropertyValue
    130 N0f888e6ed4f84d4ea613b2a98823618e schema:issueNumber 1
    131 rdf:type schema:PublicationIssue
    132 N1264da2649334d1f8c342299801b1541 rdf:first sg:person.015012714437.80
    133 rdf:rest Ndbcd65250af84797bcf2abde828d3a74
    134 N1f2fd676ccd54a71bb396152d371359a schema:name readcube_id
    135 schema:value 64b1d0ab74b6a9bea43fde754ecc09d9110f6e4602b9391466527f3e15b33eea
    136 rdf:type schema:PropertyValue
    137 N24d4e153c13e42c29c24131f8365c631 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    138 schema:name Transcriptome
    139 rdf:type schema:DefinedTerm
    140 N276a6d2ef4844af2a2b619308e1dfa7c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    141 schema:name Chromosomes, Human, X
    142 rdf:type schema:DefinedTerm
    143 N28549c82689247a3add66ed3505f354c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    144 schema:name DNA
    145 rdf:type schema:DefinedTerm
    146 N29236dc6fd084181bd546b848cd68780 rdf:first sg:person.01312515624.98
    147 rdf:rest Nf136e88751fc462bb342722ab0c1d7be
    148 N2bdcf0200d88479ca1108c95c68f0f8a rdf:first sg:person.013415671257.40
    149 rdf:rest Nce9336055c054f40816a21c85871d9ae
    150 N3199021a85fb4236b35cdd4d445cceab rdf:first sg:person.01164275022.05
    151 rdf:rest Nc59a6fa42edc4636b75be9542c9f965c
    152 N38a995670df34f9caf0606745b2b1341 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    153 schema:name Polymorphism, Single Nucleotide
    154 rdf:type schema:DefinedTerm
    155 N3e78dd2f8f8541ff96c74260699d3d70 schema:name Springer Nature - SN SciGraph project
    156 rdf:type schema:Organization
    157 N4a73f73d0f6745dfae9d5830f9e2c0b5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    158 schema:name Estrogens
    159 rdf:type schema:DefinedTerm
    160 N55ee85e90fd64129ac9408bf40190447 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    161 schema:name Kidney Neoplasms
    162 rdf:type schema:DefinedTerm
    163 N5885eb4589b5445dbef38c0c197c8f64 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    164 schema:name Adult
    165 rdf:type schema:DefinedTerm
    166 N5a1415e9ddd44681b8c006a451b02dbe schema:name nlm_unique_id
    167 schema:value 100965258
    168 rdf:type schema:PropertyValue
    169 N5b21de53922d4127bfa64b933a2c5f94 rdf:first sg:person.01145130774.66
    170 rdf:rest N1264da2649334d1f8c342299801b1541
    171 N5e08ffbcb8494da489cbb0696a60ddf0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    172 schema:name Male
    173 rdf:type schema:DefinedTerm
    174 N5e19617a73f0448e9bbe8c509aa7cc42 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    175 schema:name Age Factors
    176 rdf:type schema:DefinedTerm
    177 N5e78def4905f447fbcaa0cac18f67665 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    178 schema:name Middle Aged
    179 rdf:type schema:DefinedTerm
    180 N65c6ffba029f4fcabd91b4d4331f60ff rdf:first sg:person.0610570026.87
    181 rdf:rest N89c7d3eab49f461685d59b0ca45a5a0c
    182 N709fab48d07545deb28a1dc8d5d57cc1 rdf:first sg:person.01116161622.29
    183 rdf:rest N3199021a85fb4236b35cdd4d445cceab
    184 N71897cebe84a44cc9a041577bae28c6d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    185 schema:name Arthritis, Rheumatoid
    186 rdf:type schema:DefinedTerm
    187 N74081ffff84d47a7b08c5a9e6aca8ed8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    188 schema:name Postmenopause
    189 rdf:type schema:DefinedTerm
    190 N744d2c91bd5f4909b38adcc74ac67999 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    191 schema:name Female
    192 rdf:type schema:DefinedTerm
    193 N7aefdf56dbd145b58ec83482e5cb6e5d rdf:first sg:person.015224655437.42
    194 rdf:rest N837d90836d1742f49d643b44ed8a5b0f
    195 N837d90836d1742f49d643b44ed8a5b0f rdf:first sg:person.014613077322.17
    196 rdf:rest N5b21de53922d4127bfa64b933a2c5f94
    197 N88a4f68583ca48d5ae91ba969186011a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    198 schema:name Chromosomes, Human, Y
    199 rdf:type schema:DefinedTerm
    200 N89c7d3eab49f461685d59b0ca45a5a0c rdf:first sg:person.0633256337.62
    201 rdf:rest Nef5c0f11256d40bfadc05fcf5085a0d9
    202 N8a2f21fb7fb74e90b90e5c70cbb239ab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    203 schema:name Humans
    204 rdf:type schema:DefinedTerm
    205 N95da53b117b94ce2be8a4163a61c8dd4 rdf:first sg:person.01201053206.51
    206 rdf:rest N2bdcf0200d88479ca1108c95c68f0f8a
    207 Na9393c37b97743ccbd3641f4eb5348c8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    208 schema:name Sex Factors
    209 rdf:type schema:DefinedTerm
    210 Nb4d5307fe56848ffaed549a4c71b7cdd schema:name pubmed_id
    211 schema:value 24438232
    212 rdf:type schema:PropertyValue
    213 Nb5f88afb016f4803b71c4150bd706919 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    214 schema:name Contraceptive Agents, Female
    215 rdf:type schema:DefinedTerm
    216 Nbdd762d9666e400084ee01e256f7aeac rdf:first sg:person.0623232522.09
    217 rdf:rest N65c6ffba029f4fcabd91b4d4331f60ff
    218 Nc59a6fa42edc4636b75be9542c9f965c rdf:first sg:person.016532571052.46
    219 rdf:rest N29236dc6fd084181bd546b848cd68780
    220 Nc98b18181352446d949a234be52daad3 schema:volumeNumber 15
    221 rdf:type schema:PublicationVolume
    222 Ncbf16470c78b47918a096190460b30fc rdf:first sg:person.011235144537.09
    223 rdf:rest rdf:nil
    224 Nce9336055c054f40816a21c85871d9ae rdf:first sg:person.014463226344.79
    225 rdf:rest N7aefdf56dbd145b58ec83482e5cb6e5d
    226 Ndbcd65250af84797bcf2abde828d3a74 rdf:first sg:person.0610667722.81
    227 rdf:rest Ncbf16470c78b47918a096190460b30fc
    228 Nef5c0f11256d40bfadc05fcf5085a0d9 rdf:first sg:person.0650417210.95
    229 rdf:rest N03a81ffd422d4a069b3eb7d176c4a07d
    230 Nefbcce9f3d564ba5834bd13629f75346 schema:name doi
    231 schema:value 10.1186/1471-2164-15-33
    232 rdf:type schema:PropertyValue
    233 Nf136e88751fc462bb342722ab0c1d7be rdf:first sg:person.0610017257.08
    234 rdf:rest Nbdd762d9666e400084ee01e256f7aeac
    235 Nfcb5ff6c44d1458fa51ef9e29624c6d8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    236 schema:name RNA
    237 rdf:type schema:DefinedTerm
    238 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    239 schema:name Biological Sciences
    240 rdf:type schema:DefinedTerm
    241 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    242 schema:name Genetics
    243 rdf:type schema:DefinedTerm
    244 sg:grant.2669474 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2164-15-33
    245 rdf:type schema:MonetaryGrant
    246 sg:grant.2696437 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2164-15-33
    247 rdf:type schema:MonetaryGrant
    248 sg:grant.3773756 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2164-15-33
    249 rdf:type schema:MonetaryGrant
    250 sg:grant.3795919 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2164-15-33
    251 rdf:type schema:MonetaryGrant
    252 sg:grant.4113448 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2164-15-33
    253 rdf:type schema:MonetaryGrant
    254 sg:grant.4118013 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2164-15-33
    255 rdf:type schema:MonetaryGrant
    256 sg:grant.4128757 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2164-15-33
    257 rdf:type schema:MonetaryGrant
    258 sg:grant.4700131 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2164-15-33
    259 rdf:type schema:MonetaryGrant
    260 sg:journal.1023790 schema:issn 1471-2164
    261 schema:name BMC Genomics
    262 rdf:type schema:Periodical
    263 sg:person.01053707522.39 schema:affiliation https://www.grid.ac/institutes/grid.410711.2
    264 schema:familyName Madar
    265 schema:givenName Vered
    266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053707522.39
    267 rdf:type schema:Person
    268 sg:person.01116161622.29 schema:affiliation https://www.grid.ac/institutes/grid.484519.5
    269 schema:familyName Jansen
    270 schema:givenName Rick
    271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116161622.29
    272 rdf:type schema:Person
    273 sg:person.011235144537.09 schema:affiliation https://www.grid.ac/institutes/grid.484519.5
    274 schema:familyName Penninx
    275 schema:givenName Brenda WJH
    276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011235144537.09
    277 rdf:type schema:Person
    278 sg:person.01145130774.66 schema:affiliation https://www.grid.ac/institutes/grid.410711.2
    279 schema:familyName Wright
    280 schema:givenName Fred A
    281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145130774.66
    282 rdf:type schema:Person
    283 sg:person.01164275022.05 schema:affiliation https://www.grid.ac/institutes/grid.410711.2
    284 schema:familyName Batista
    285 schema:givenName Sandra
    286 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164275022.05
    287 rdf:type schema:Person
    288 sg:person.01201053206.51 schema:affiliation https://www.grid.ac/institutes/grid.484519.5
    289 schema:familyName Peyrot
    290 schema:givenName Wouter
    291 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201053206.51
    292 rdf:type schema:Person
    293 sg:person.01312515624.98 schema:affiliation https://www.grid.ac/institutes/grid.430387.b
    294 schema:familyName Tischfield
    295 schema:givenName Jay A
    296 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01312515624.98
    297 rdf:type schema:Person
    298 sg:person.013415671257.40 schema:affiliation https://www.grid.ac/institutes/grid.484519.5
    299 schema:familyName Vink
    300 schema:givenName Jacqueline M
    301 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013415671257.40
    302 rdf:type schema:Person
    303 sg:person.014463226344.79 schema:affiliation https://www.grid.ac/institutes/grid.16872.3a
    304 schema:familyName Verweij
    305 schema:givenName Cor L
    306 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014463226344.79
    307 rdf:type schema:Person
    308 sg:person.014613077322.17 schema:affiliation https://www.grid.ac/institutes/grid.484519.5
    309 schema:familyName Smit
    310 schema:givenName Johannes H
    311 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014613077322.17
    312 rdf:type schema:Person
    313 sg:person.015012714437.80 schema:affiliation https://www.grid.ac/institutes/grid.410711.2
    314 schema:familyName Sullivan
    315 schema:givenName Patrick F
    316 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015012714437.80
    317 rdf:type schema:Person
    318 sg:person.015224655437.42 schema:affiliation https://www.grid.ac/institutes/grid.484519.5
    319 schema:familyName de Geus
    320 schema:givenName Eco JC
    321 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015224655437.42
    322 rdf:type schema:Person
    323 sg:person.016532571052.46 schema:affiliation https://www.grid.ac/institutes/grid.430387.b
    324 schema:familyName Brooks
    325 schema:givenName Andrew I
    326 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016532571052.46
    327 rdf:type schema:Person
    328 sg:person.0610017257.08 schema:affiliation https://www.grid.ac/institutes/grid.484519.5
    329 schema:familyName Willemsen
    330 schema:givenName Gonneke
    331 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610017257.08
    332 rdf:type schema:Person
    333 sg:person.0610570026.87 schema:affiliation https://www.grid.ac/institutes/grid.484519.5
    334 schema:familyName Hottenga
    335 schema:givenName Jouke-Jan
    336 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610570026.87
    337 rdf:type schema:Person
    338 sg:person.0610667722.81 schema:affiliation https://www.grid.ac/institutes/grid.484519.5
    339 schema:familyName Boomsma
    340 schema:givenName Dorret I
    341 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610667722.81
    342 rdf:type schema:Person
    343 sg:person.0623232522.09 schema:affiliation https://www.grid.ac/institutes/grid.484519.5
    344 schema:familyName van Grootheest
    345 schema:givenName Gerard
    346 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623232522.09
    347 rdf:type schema:Person
    348 sg:person.0633256337.62 schema:affiliation https://www.grid.ac/institutes/grid.484519.5
    349 schema:familyName Milaneschi
    350 schema:givenName Yuri
    351 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0633256337.62
    352 rdf:type schema:Person
    353 sg:person.0650417210.95 schema:affiliation https://www.grid.ac/institutes/grid.484519.5
    354 schema:familyName Mbarek
    355 schema:givenName Hamdi
    356 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650417210.95
    357 rdf:type schema:Person
    358 sg:pub.10.1007/s10534-010-9310-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012011842
    359 https://doi.org/10.1007/s10534-010-9310-8
    360 rdf:type schema:CreativeWork
    361 sg:pub.10.1007/s11897-012-0096-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014359071
    362 https://doi.org/10.1007/s11897-012-0096-6
    363 rdf:type schema:CreativeWork
    364 sg:pub.10.1038/465688a schema:sameAs https://app.dimensions.ai/details/publication/pub.1013103104
    365 https://doi.org/10.1038/465688a
    366 rdf:type schema:CreativeWork
    367 sg:pub.10.1038/75556 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044135237
    368 https://doi.org/10.1038/75556
    369 rdf:type schema:CreativeWork
    370 sg:pub.10.1038/cdd.2009.212 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012467921
    371 https://doi.org/10.1038/cdd.2009.212
    372 rdf:type schema:CreativeWork
    373 sg:pub.10.1038/ejhg.2013.48 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012702520
    374 https://doi.org/10.1038/ejhg.2013.48
    375 rdf:type schema:CreativeWork
    376 sg:pub.10.1038/nature02661 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001579376
    377 https://doi.org/10.1038/nature02661
    378 rdf:type schema:CreativeWork
    379 sg:pub.10.1038/nature03479 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007477207
    380 https://doi.org/10.1038/nature03479
    381 rdf:type schema:CreativeWork
    382 sg:pub.10.1038/nature04072 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042676864
    383 https://doi.org/10.1038/nature04072
    384 rdf:type schema:CreativeWork
    385 sg:pub.10.1038/nature06323 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033913666
    386 https://doi.org/10.1038/nature06323
    387 rdf:type schema:CreativeWork
    388 sg:pub.10.1038/ng1901 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012239798
    389 https://doi.org/10.1038/ng1901
    390 rdf:type schema:CreativeWork
    391 sg:pub.10.1038/ni0901-777 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009034825
    392 https://doi.org/10.1038/ni0901-777
    393 rdf:type schema:CreativeWork
    394 sg:pub.10.1038/nrendo.2011.122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015855462
    395 https://doi.org/10.1038/nrendo.2011.122
    396 rdf:type schema:CreativeWork
    397 sg:pub.10.1038/nrg2167 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007115561
    398 https://doi.org/10.1038/nrg2167
    399 rdf:type schema:CreativeWork
    400 sg:pub.10.1038/nrg2415 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016733425
    401 https://doi.org/10.1038/nrg2415
    402 rdf:type schema:CreativeWork
    403 sg:pub.10.1038/nrg3376 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042433143
    404 https://doi.org/10.1038/nrg3376
    405 rdf:type schema:CreativeWork
    406 sg:pub.10.1038/sj.ejhg.5201979 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001360587
    407 https://doi.org/10.1038/sj.ejhg.5201979
    408 rdf:type schema:CreativeWork
    409 sg:pub.10.1186/1471-2105-12-322 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013163514
    410 https://doi.org/10.1186/1471-2105-12-322
    411 rdf:type schema:CreativeWork
    412 sg:pub.10.1186/1471-2105-9-559 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020312314
    413 https://doi.org/10.1186/1471-2105-9-559
    414 rdf:type schema:CreativeWork
    415 sg:pub.10.1186/1471-2164-9-148 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036887487
    416 https://doi.org/10.1186/1471-2164-9-148
    417 rdf:type schema:CreativeWork
    418 sg:pub.10.1186/ar2825 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009947280
    419 https://doi.org/10.1186/ar2825
    420 rdf:type schema:CreativeWork
    421 sg:pub.10.1186/bcr452 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026160274
    422 https://doi.org/10.1186/bcr452
    423 rdf:type schema:CreativeWork
    424 sg:pub.10.2165/11640880-000000000-00000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044912900
    425 https://doi.org/10.2165/11640880-000000000-00000
    426 rdf:type schema:CreativeWork
    427 https://app.dimensions.ai/details/publication/pub.1080026707 schema:CreativeWork
    428 https://doi.org/10.1002/mpr.256 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030653166
    429 rdf:type schema:CreativeWork
    430 https://doi.org/10.1002/wrna.115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030571771
    431 rdf:type schema:CreativeWork
    432 https://doi.org/10.1016/j.autrev.2011.11.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002696291
    433 rdf:type schema:CreativeWork
    434 https://doi.org/10.1016/j.canlet.2011.11.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013929752
    435 rdf:type schema:CreativeWork
    436 https://doi.org/10.1016/j.cell.2011.03.042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044799507
    437 rdf:type schema:CreativeWork
    438 https://doi.org/10.1016/j.ecl.2007.03.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024122014
    439 rdf:type schema:CreativeWork
    440 https://doi.org/10.1016/j.eururo.2008.10.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030116450
    441 rdf:type schema:CreativeWork
    442 https://doi.org/10.1016/j.jacc.2009.11.050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020082685
    443 rdf:type schema:CreativeWork
    444 https://doi.org/10.1016/j.juro.2008.01.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004394519
    445 rdf:type schema:CreativeWork
    446 https://doi.org/10.1016/s1673-8527(07)60110-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001451037
    447 rdf:type schema:CreativeWork
    448 https://doi.org/10.1038/emboj.2009.88 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039350026
    449 rdf:type schema:CreativeWork
    450 https://doi.org/10.1042/0264-6021:3520601 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056715172
    451 rdf:type schema:CreativeWork
    452 https://doi.org/10.1042/bj3520601 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056720160
    453 rdf:type schema:CreativeWork
    454 https://doi.org/10.1093/bioinformatics/bti551 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032806326
    455 rdf:type schema:CreativeWork
    456 https://doi.org/10.1093/bioinformatics/bts163 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036235772
    457 rdf:type schema:CreativeWork
    458 https://doi.org/10.1093/hmg/ddl456 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037560677
    459 rdf:type schema:CreativeWork
    460 https://doi.org/10.1093/hmg/dds304 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016939095
    461 rdf:type schema:CreativeWork
    462 https://doi.org/10.1093/nar/gkm764 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033610041
    463 rdf:type schema:CreativeWork
    464 https://doi.org/10.1097/01.bor.0000218949.19860.d1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024588899
    465 rdf:type schema:CreativeWork
    466 https://doi.org/10.1097/fpc.0b013e3280121ffe schema:sameAs https://app.dimensions.ai/details/publication/pub.1060340475
    467 rdf:type schema:CreativeWork
    468 https://doi.org/10.1097/gme.0b013e31803c56b6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017476072
    469 rdf:type schema:CreativeWork
    470 https://doi.org/10.1097/gme.0b013e318188b260 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049117796
    471 rdf:type schema:CreativeWork
    472 https://doi.org/10.1101/gr.134981.111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002675432
    473 rdf:type schema:CreativeWork
    474 https://doi.org/10.1101/gr.5217506 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007457721
    475 rdf:type schema:CreativeWork
    476 https://doi.org/10.1111/j.1365-2265.2006.02676.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1022294092
    477 rdf:type schema:CreativeWork
    478 https://doi.org/10.1126/science.1085881 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062448247
    479 rdf:type schema:CreativeWork
    480 https://doi.org/10.1126/science.278.5338.675 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036670098
    481 rdf:type schema:CreativeWork
    482 https://doi.org/10.1128/mcb.00280-13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047396451
    483 rdf:type schema:CreativeWork
    484 https://doi.org/10.1128/mcb.00601-10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019352008
    485 rdf:type schema:CreativeWork
    486 https://doi.org/10.1128/mcb.06312-11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036697989
    487 rdf:type schema:CreativeWork
    488 https://doi.org/10.1136/bmj.324.7329.71 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046678775
    489 rdf:type schema:CreativeWork
    490 https://doi.org/10.1146/annurev-clinpsy-032511-143109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004267423
    491 rdf:type schema:CreativeWork
    492 https://doi.org/10.1152/physiolgenomics.00110.2009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033893011
    493 rdf:type schema:CreativeWork
    494 https://doi.org/10.1158/0008-5472.can-11-1232 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034587296
    495 rdf:type schema:CreativeWork
    496 https://doi.org/10.1182/blood-2011-04-347526 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021260208
    497 rdf:type schema:CreativeWork
    498 https://doi.org/10.1210/er.2003-0035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064285800
    499 rdf:type schema:CreativeWork
    500 https://doi.org/10.1210/me.2008-0044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064328140
    501 rdf:type schema:CreativeWork
    502 https://doi.org/10.1371/journal.pbio.0030170 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004200208
    503 rdf:type schema:CreativeWork
    504 https://doi.org/10.1371/journal.pgen.1000100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023554590
    505 rdf:type schema:CreativeWork
    506 https://doi.org/10.1371/journal.pgen.1002212 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032831404
    507 rdf:type schema:CreativeWork
    508 https://doi.org/10.1371/journal.pone.0001385 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026184450
    509 rdf:type schema:CreativeWork
    510 https://doi.org/10.1371/journal.pone.0023506 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024681437
    511 rdf:type schema:CreativeWork
    512 https://doi.org/10.1371/journal.pone.0047371 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023996806
    513 rdf:type schema:CreativeWork
    514 https://doi.org/10.1375/twin.13.3.231 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046517074
    515 rdf:type schema:CreativeWork
    516 https://doi.org/10.1375/twin.7.6.564 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025580843
    517 rdf:type schema:CreativeWork
    518 https://doi.org/10.1375/twin.7.6.670 schema:sameAs https://app.dimensions.ai/details/publication/pub.1067170085
    519 rdf:type schema:CreativeWork
    520 https://doi.org/10.1375/twin.9.6.849 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012140273
    521 rdf:type schema:CreativeWork
    522 https://doi.org/10.1677/jme.1.01825 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021639235
    523 rdf:type schema:CreativeWork
    524 https://doi.org/10.2202/1544-6115.1128 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020363278
    525 rdf:type schema:CreativeWork
    526 https://doi.org/10.2741/212 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070914426
    527 rdf:type schema:CreativeWork
    528 https://doi.org/10.3109/10408361003791520 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011919205
    529 rdf:type schema:CreativeWork
    530 https://doi.org/10.3389/fnins.2012.00063 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047025819
    531 rdf:type schema:CreativeWork
    532 https://doi.org/10.4061/2011/989438 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044788603
    533 rdf:type schema:CreativeWork
    534 https://doi.org/10.4161/epi.6.7.16517 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072303192
    535 rdf:type schema:CreativeWork
    536 https://www.grid.ac/institutes/grid.16872.3a schema:alternateName VU University Medical Center
    537 schema:name Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    538 rdf:type schema:Organization
    539 https://www.grid.ac/institutes/grid.410711.2 schema:alternateName University of North Carolina System
    540 schema:name Department of Biostatistics, University of North Carolina, North Carolina, USA
    541 Departments of Genetics and Psychiatry, University of North Carolina, North Carolina, USA
    542 rdf:type schema:Organization
    543 https://www.grid.ac/institutes/grid.430387.b schema:alternateName Rutgers University
    544 schema:name Department of Genetics and the Human Genetics Institute, Rutgers University Cell and DNA Repository, Rutgers University, New Jersey, USA
    545 rdf:type schema:Organization
    546 https://www.grid.ac/institutes/grid.484519.5 schema:alternateName Amsterdam Neuroscience
    547 schema:name Department of Biological Psychology, VU University Amsterdam, Neuroscience Campus Amsterdam, Amsterdam, The Netherlands
    548 Department of Psychiatry, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, The Netherlands
    549 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...