Sex differences in the human peripheral blood transcriptome View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-12

AUTHORS

Rick Jansen, Sandra Batista, Andrew I Brooks, Jay A Tischfield, Gonneke Willemsen, Gerard van Grootheest, Jouke-Jan Hottenga, Yuri Milaneschi, Hamdi Mbarek, Vered Madar, Wouter Peyrot, Jacqueline M Vink, Cor L Verweij, Eco JC de Geus, Johannes H Smit, Fred A Wright, Patrick F Sullivan, Dorret I Boomsma, Brenda WJH Penninx

ABSTRACT

BACKGROUND: Genomes of men and women differ in only a limited number of genes located on the sex chromosomes, whereas the transcriptome is far more sex-specific. Identification of sex-biased gene expression will contribute to understanding the molecular basis of sex-differences in complex traits and common diseases. RESULTS: Sex differences in the human peripheral blood transcriptome were characterized using microarrays in 5,241 subjects, accounting for menopause status and hormonal contraceptive use. Sex-specific expression was observed for 582 autosomal genes, of which 57.7% was upregulated in women (female-biased genes). Female-biased genes were enriched for several immune system GO categories, genes linked to rheumatoid arthritis (16%) and genes regulated by estrogen (18%). Male-biased genes were enriched for genes linked to renal cancer (9%). Sex-differences in gene expression were smaller in postmenopausal women, larger in women using hormonal contraceptives and not caused by sex-specific eQTLs, confirming the role of estrogen in regulating sex-biased genes. CONCLUSIONS: This study indicates that sex-bias in gene expression is extensive and may underlie sex-differences in the prevalence of common diseases. More... »

PAGES

33

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/1471-2164-15-33

    DOI

    http://dx.doi.org/10.1186/1471-2164-15-33

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1021134350

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24438232


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