Co-modulated behavior and effects of differentially expressed miRNA in colorectal cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-10-16

AUTHORS

Wei-Shone Chen, Ting-Wen Chen, Tzu-Hsien Yang, Ling-Yueh Hu, Hung-Wei Pan, Chung-Man Leung, Sung-Chou Li, Meng-Ru Ho, Chih-Wen Shu, Pei-Feng Liu, Shou-Yu Yu, Ya-Ting Tu, Wen-Chang Lin, Tony T Wu, Kuo-Wang Tsai

ABSTRACT

BACKGROUND: MicroRNAs (miRNAs) are short noncoding RNAs (approximately 22 nucleotides in length) that play important roles in colorectal cancer (CRC) progression through silencing gene expression. Numerous dysregulated miRNAs simultaneously participate in the process of colon cancer development. However, the detailed mechanisms and biological functions of co-expressed miRNA in colorectal carcinogenesis have yet to be fully elucidated. RESULTS: The objective of this study was to identify the dysfunctional miRNAs and their target mRNAs using a wet-lab experimental and dry-lab bioinformatics approach. The differentially expressed miRNA candidates were identified from 2 miRNA profiles, and were confirmed in CRC clinical samples using reported target genes of dysfunctional miRNAs to perform functional pathway enrichment analysis. Potential target gene candidates were predicted by an in silico search, and their expression levels between normal and colorectal tumor tissues were further analyzed using real-time polymerase chain reaction (RT-PCR). CONCLUSION: Fifteen dysfunctional miRNAs were engaged in metastasis-associated pathways through comodulating 7 target genes, which were identified by using a multi-step approach. The roles of these candidate genes are worth further exploration in the progression of colon cancer, and could potentially be targets in future therapy. More... »

PAGES

s12-s12

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1471-2164-14-s5-s12

DOI

http://dx.doi.org/10.1186/1471-2164-14-s5-s12

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047546486

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24564330


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29 schema:description BACKGROUND: MicroRNAs (miRNAs) are short noncoding RNAs (approximately 22 nucleotides in length) that play important roles in colorectal cancer (CRC) progression through silencing gene expression. Numerous dysregulated miRNAs simultaneously participate in the process of colon cancer development. However, the detailed mechanisms and biological functions of co-expressed miRNA in colorectal carcinogenesis have yet to be fully elucidated. RESULTS: The objective of this study was to identify the dysfunctional miRNAs and their target mRNAs using a wet-lab experimental and dry-lab bioinformatics approach. The differentially expressed miRNA candidates were identified from 2 miRNA profiles, and were confirmed in CRC clinical samples using reported target genes of dysfunctional miRNAs to perform functional pathway enrichment analysis. Potential target gene candidates were predicted by an in silico search, and their expression levels between normal and colorectal tumor tissues were further analyzed using real-time polymerase chain reaction (RT-PCR). CONCLUSION: Fifteen dysfunctional miRNAs were engaged in metastasis-associated pathways through comodulating 7 target genes, which were identified by using a multi-step approach. The roles of these candidate genes are worth further exploration in the progression of colon cancer, and could potentially be targets in future therapy.
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37 Co-modulated behavior
38 Potential target gene candidates
39 RNA
40 analysis
41 approach
42 behavior
43 bioinformatics approach
44 biological functions
45 cancer
46 cancer development
47 cancer progression
48 candidate genes
49 candidates
50 carcinogenesis
51 chain reaction
52 clinical samples
53 co-expressed miRNA
54 colon cancer
55 colon cancer development
56 colorectal cancer
57 colorectal cancer progression
58 colorectal carcinogenesis
59 colorectal tumor tissues
60 detailed mechanism
61 development
62 dry-lab bioinformatics approach
63 dysfunctional miRNAs
64 effect
65 enrichment analysis
66 exploration
67 expression
68 expression levels
69 function
70 functional pathway enrichment analysis
71 further exploration
72 future therapies
73 gene candidates
74 gene expression
75 genes
76 important role
77 levels
78 mRNA
79 mechanism
80 metastasis-associated pathways
81 miRNA
82 miRNA candidates
83 miRNA profiles
84 miRNAs
85 microRNAs
86 multi-step approach
87 noncoding RNAs
88 objective
89 pathway
90 pathway enrichment analysis
91 polymerase chain reaction
92 process
93 profile
94 progression
95 reaction
96 real-time polymerase chain reaction
97 role
98 samples
99 search
100 short noncoding RNAs
101 silico search
102 study
103 target
104 target gene candidates
105 target genes
106 target mRNAs
107 therapy
108 tissue
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