High quality de novo sequencing and assembly of the Saccharomyces arboricolus genome View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-12

AUTHORS

Gianni Liti, Alex N Nguyen Ba, Martin Blythe, Carolin A Müller, Anders Bergström, Francisco A Cubillos, Felix Dafhnis-Calas, Shima Khoshraftar, Sunir Malla, Neel Mehta, Cheuk C Siow, Jonas Warringer, Alan M Moses, Edward J Louis, Conrad A Nieduszynski

ABSTRACT

BACKGROUND: Comparative genomics is a formidable tool to identify functional elements throughout a genome. In the past ten years, studies in the budding yeast Saccharomyces cerevisiae and a set of closely related species have been instrumental in showing the benefit of analyzing patterns of sequence conservation. Increasing the number of closely related genome sequences makes the comparative genomics approach more powerful and accurate. RESULTS: Here, we report the genome sequence and analysis of Saccharomyces arboricolus, a yeast species recently isolated in China, that is closely related to S. cerevisiae. We obtained high quality de novo sequence and assemblies using a combination of next generation sequencing technologies, established the phylogenetic position of this species and considered its phenotypic profile under multiple environmental conditions in the light of its gene content and phylogeny. CONCLUSIONS: We suggest that the genome of S. arboricolus will be useful in future comparative genomics analysis of the Saccharomyces sensu stricto yeasts. More... »

PAGES

69

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1471-2164-14-69

DOI

http://dx.doi.org/10.1186/1471-2164-14-69

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048827712

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23368932


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