Genome sequencing of ovine isolates of Mycobacterium avium subspecies paratuberculosis offers insights into host association View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-12

AUTHORS

John P Bannantine, Chia-wei Wu, Chungyi Hsu, Shiguo Zhou, David C Schwartz, Darrell O Bayles, Michael L Paustian, David P Alt, Srinand Sreevatsan, Vivek Kapur, Adel M Talaat

ABSTRACT

BACKGROUND: The genome of Mycobacterium avium subspecies paratuberculosis (MAP) is remarkably homogeneous among the genomes of bovine, human and wildlife isolates. However, previous work in our laboratories with the bovine K-10 strain has revealed substantial differences compared to sheep isolates. To systematically characterize all genomic differences that may be associated with the specific hosts, we sequenced the genomes of three U.S. sheep isolates and also obtained an optical map. RESULTS: Our analysis of one of the isolates, MAP S397, revealed a genome 4.8 Mb in size with 4,700 open reading frames (ORFs). Comparative analysis of the MAP S397 isolate showed it acquired approximately 10 large sequence regions that are shared with the human M. avium subsp. hominissuis strain 104 and lost 2 large regions that are present in the bovine strain. In addition, optical mapping defined the presence of 7 large inversions between the bovine and ovine genomes (~ 2.36 Mb). Whole-genome sequencing of 2 additional sheep strains of MAP (JTC1074 and JTC7565) further confirmed genomic homogeneity of the sheep isolates despite the presence of polymorphisms on the nucleotide level. CONCLUSIONS: Comparative sequence analysis employed here provided a better understanding of the host association, evolution of members of the M. avium complex and could help in deciphering the phenotypic differences observed among sheep and cattle strains of MAP. A similar approach based on whole-genome sequencing combined with optical mapping could be employed to examine closely related pathogens. We propose an evolutionary scenario for M. avium complex strains based on these genome sequences. More... »

PAGES

89

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1471-2164-13-89

DOI

http://dx.doi.org/10.1186/1471-2164-13-89

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1000309144

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22409516


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cattle", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosome Mapping", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Evolution, Molecular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Deletion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Order", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genome, Bacterial", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Host-Pathogen Interactions", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Annotation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutagenesis, Insertional", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mycobacterium avium subsp. paratuberculosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Open Reading Frames", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymorphism, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sequence Alignment", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sequence Analysis, DNA", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sheep", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Agricultural Research Service", 
          "id": "https://www.grid.ac/institutes/grid.463419.d", 
          "name": [
            "National Animal Disease Center, USDA-Agricultural Research Service, Ames, Iowa, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bannantine", 
        "givenName": "John P", 
        "id": "sg:person.01144102564.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144102564.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Wisconsin\u2013Madison", 
          "id": "https://www.grid.ac/institutes/grid.14003.36", 
          "name": [
            "The Laboratory of Bacterial Genomics, Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wu", 
        "givenName": "Chia-wei", 
        "id": "sg:person.0701572672.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701572672.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Wisconsin\u2013Madison", 
          "id": "https://www.grid.ac/institutes/grid.14003.36", 
          "name": [
            "The Laboratory of Bacterial Genomics, Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hsu", 
        "givenName": "Chungyi", 
        "id": "sg:person.0614240046.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0614240046.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Wisconsin\u2013Madison", 
          "id": "https://www.grid.ac/institutes/grid.14003.36", 
          "name": [
            "Laboratory for Molecular and Computational Genomics, Department of Chemistry and Laboratory of Genetics, UW Biotechnology Center, University of Wisconsin-Madison, Madison, Wisconsin, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhou", 
        "givenName": "Shiguo", 
        "id": "sg:person.01073440243.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073440243.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Wisconsin\u2013Madison", 
          "id": "https://www.grid.ac/institutes/grid.14003.36", 
          "name": [
            "Laboratory for Molecular and Computational Genomics, Department of Chemistry and Laboratory of Genetics, UW Biotechnology Center, University of Wisconsin-Madison, Madison, Wisconsin, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schwartz", 
        "givenName": "David C", 
        "id": "sg:person.013453527622.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013453527622.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Agricultural Research Service", 
          "id": "https://www.grid.ac/institutes/grid.463419.d", 
          "name": [
            "National Animal Disease Center, USDA-Agricultural Research Service, Ames, Iowa, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bayles", 
        "givenName": "Darrell O", 
        "id": "sg:person.01110406243.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110406243.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Agricultural Research Service", 
          "id": "https://www.grid.ac/institutes/grid.463419.d", 
          "name": [
            "National Animal Disease Center, USDA-Agricultural Research Service, Ames, Iowa, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Paustian", 
        "givenName": "Michael L", 
        "id": "sg:person.016456657547.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016456657547.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Agricultural Research Service", 
          "id": "https://www.grid.ac/institutes/grid.463419.d", 
          "name": [
            "National Animal Disease Center, USDA-Agricultural Research Service, Ames, Iowa, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Alt", 
        "givenName": "David P", 
        "id": "sg:person.0635364161.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635364161.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Minnesota", 
          "id": "https://www.grid.ac/institutes/grid.17635.36", 
          "name": [
            "Department of Veterinary Population Medicine and Department of Veterinary and Biomedical Sciences, University of Minnesota, St. Paul, Minnesota, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sreevatsan", 
        "givenName": "Srinand", 
        "id": "sg:person.01122222163.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122222163.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pennsylvania State University", 
          "id": "https://www.grid.ac/institutes/grid.29857.31", 
          "name": [
            "Department of Veterinary and Biomedical Sciences and Huck Institutes of the Life Sciences, Penn State University, University Park, Pennsylvania, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kapur", 
        "givenName": "Vivek", 
        "id": "sg:person.0631114411.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631114411.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cairo University", 
          "id": "https://www.grid.ac/institutes/grid.7776.1", 
          "name": [
            "The Laboratory of Bacterial Genomics, Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA", 
            "Department of Food Hygiene, Cairo University, Cairo, Egypt"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Talaat", 
        "givenName": "Adel M", 
        "id": "sg:person.01360737277.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01360737277.17"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1093/oxfordjournals.molbev.a003995", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001282786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0011147", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001774801"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0914638107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002734064"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/aem.68.12.6321-6331.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002815355"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/iai.01411-09", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003200901"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2164-8-278", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003983720", 
          "https://doi.org/10.1186/1471-2164-8-278"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0604040103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004868369"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.micres.2009.03.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005423383"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0505662102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006045474"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0505662102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006045474"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(84)90301-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006653804"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2180-3-10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006694082", 
          "https://doi.org/10.1186/1471-2180-3-10"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2958.1999.01383.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007039640"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jb.00972-10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007501308"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jcm.42.4.1694-1702.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007539369"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/15484", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009646434", 
          "https://doi.org/10.1038/15484"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/15484", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009646434", 
          "https://doi.org/10.1038/15484"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.172101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011318009"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jcm.40.4.1303-1310.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015350729"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/mcpr.1999.0227", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016564759"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jcm.00210-11", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017261412"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/iai.00326-06", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017484154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btq249", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018850654"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.285.5433.1558", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021867073"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jcm.43.8.3704-3712.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021993676"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2164-9-135", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022205646", 
          "https://doi.org/10.1186/1471-2164-9-135"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jcm.44.3.881-887.2006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022376642"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0031947", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022760907"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molimm.2009.07.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022857108"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1574-6968.1989.tb03440.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024494945"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1574-6968.1989.tb03440.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024494945"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mcp.2005.06.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025671628"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mcp.2005.06.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025671628"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0022171", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025815775"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jb.188.2.711-723.2006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029838037"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.vetmic.2008.07.021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031106842"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2164-8-289", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031756510", 
          "https://doi.org/10.1186/1471-2164-8-289"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/17.22.9063", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033433788"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.1128803", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034012904"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jcm.41.11.5215-5223.2003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034522602"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/iai.01739-06", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035237625"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1574-6968.1991.tb04544.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035619850"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1574-6968.1991.tb04544.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035619850"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1574-6968.1991.tb04544.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035619850"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.94.18.9869", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035792044"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.rvsc.2011.05.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038834593"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jcm.01349-08", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039052688"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jb.00780-07", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039500390"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.1000711", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039507468"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.2289704", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041222434"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btp393", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041253333"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jb.188.6.2290-2293.2006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042073892"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2164-10-25", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043069640", 
          "https://doi.org/10.1186/1471-2164-10-25"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/aem.01683-08", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046500176"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jb.01340-08", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047280771"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jcm.40.5.1798-1804.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047563327"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.vetmic.2008.10.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048480979"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/molbev/msr121", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049273973"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2180-8-204", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049554618", 
          "https://doi.org/10.1186/1471-2180-8-204"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molbiopara.2004.08.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050802935"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/path.1700630217", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052194655"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ac0496401", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054996644"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ac0496401", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054996644"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1099/mic.0.031948-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060394648"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1099/mic.0.031948-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060394648"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1099/mic.0.26528-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060396821"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jcm.44.2.433-440.2006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062712356"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078056654", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079345446", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079345446", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/oxfordjournals.molbev.a040454", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079752303"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083294147", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-12", 
    "datePublishedReg": "2012-12-01", 
    "description": "BACKGROUND: The genome of Mycobacterium avium subspecies paratuberculosis (MAP) is remarkably homogeneous among the genomes of bovine, human and wildlife isolates. However, previous work in our laboratories with the bovine K-10 strain has revealed substantial differences compared to sheep isolates. To systematically characterize all genomic differences that may be associated with the specific hosts, we sequenced the genomes of three U.S. sheep isolates and also obtained an optical map.\nRESULTS: Our analysis of one of the isolates, MAP S397, revealed a genome 4.8 Mb in size with 4,700 open reading frames (ORFs). Comparative analysis of the MAP S397 isolate showed it acquired approximately 10 large sequence regions that are shared with the human M. avium subsp. hominissuis strain 104 and lost 2 large regions that are present in the bovine strain. In addition, optical mapping defined the presence of 7 large inversions between the bovine and ovine genomes (~ 2.36 Mb). Whole-genome sequencing of 2 additional sheep strains of MAP (JTC1074 and JTC7565) further confirmed genomic homogeneity of the sheep isolates despite the presence of polymorphisms on the nucleotide level.\nCONCLUSIONS: Comparative sequence analysis employed here provided a better understanding of the host association, evolution of members of the M. avium complex and could help in deciphering the phenotypic differences observed among sheep and cattle strains of MAP. A similar approach based on whole-genome sequencing combined with optical mapping could be employed to examine closely related pathogens. We propose an evolutionary scenario for M. avium complex strains based on these genome sequences.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/1471-2164-13-89", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1023790", 
        "issn": [
          "1471-2164"
        ], 
        "name": "BMC Genomics", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "13"
      }
    ], 
    "name": "Genome sequencing of ovine isolates of Mycobacterium avium subspecies paratuberculosis offers insights into host association", 
    "pagination": "89", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "017845d9f757a912fe3f4167d3f5c91d1dee6cbf3164f17b148c106917288f0d"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "22409516"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100965258"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1471-2164-13-89"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1000309144"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1471-2164-13-89", 
      "https://app.dimensions.ai/details/publication/pub.1000309144"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T14:07", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000502.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2F1471-2164-13-89"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1471-2164-13-89'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1471-2164-13-89'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1471-2164-13-89'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1471-2164-13-89'


 

This table displays all metadata directly associated to this object as RDF triples.

413 TRIPLES      21 PREDICATES      109 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1471-2164-13-89 schema:about N10b2c3dc3d0643018b3b2f86bdb9309e
2 N12221bfd674c44d3b21330b63fe009ec
3 N18619ad2a75d4717bc484876287a9510
4 N1bacc7df0ef847b78a441097172889c8
5 N21f63823ef7740a6a70a44f3acc3960f
6 N33479efa35f14017b3600c4d0586f760
7 N3a5fa8c260c24c02aa712cc00d33c606
8 N53eb3a4e63e6477f81dcedcdf4243d46
9 N851f56117d8f4860a5b35faa9eff1fcb
10 N8d4ba59ddc4349459d3387739825edfc
11 Nbe6b63f4f4714b29a56f72bae9d6b799
12 Nd0326ec6e42e454a88724d2af9d61ecc
13 Nd05f115baab54deba51dc685e40bd5b4
14 Nd97063f5c27f469c85e9d0eb7cf7541d
15 Ne46bc3c03a844264a29b60e390131080
16 Nee09f12d839748689d49f0dd1f6d50dd
17 Nff3c437ea67b4d4aa37b5a556613c16d
18 anzsrc-for:06
19 anzsrc-for:0604
20 schema:author Nb631f0ad03ca44a0b8a48700a451eabf
21 schema:citation sg:pub.10.1038/15484
22 sg:pub.10.1186/1471-2164-10-25
23 sg:pub.10.1186/1471-2164-8-278
24 sg:pub.10.1186/1471-2164-8-289
25 sg:pub.10.1186/1471-2164-9-135
26 sg:pub.10.1186/1471-2180-3-10
27 sg:pub.10.1186/1471-2180-8-204
28 https://app.dimensions.ai/details/publication/pub.1078056654
29 https://app.dimensions.ai/details/publication/pub.1079345446
30 https://app.dimensions.ai/details/publication/pub.1083294147
31 https://doi.org/10.1002/path.1700630217
32 https://doi.org/10.1006/mcpr.1999.0227
33 https://doi.org/10.1016/0092-8674(84)90301-5
34 https://doi.org/10.1016/j.mcp.2005.06.005
35 https://doi.org/10.1016/j.micres.2009.03.007
36 https://doi.org/10.1016/j.molbiopara.2004.08.002
37 https://doi.org/10.1016/j.molimm.2009.07.002
38 https://doi.org/10.1016/j.rvsc.2011.05.017
39 https://doi.org/10.1016/j.vetmic.2008.07.021
40 https://doi.org/10.1016/j.vetmic.2008.10.003
41 https://doi.org/10.1021/ac0496401
42 https://doi.org/10.1046/j.1365-2958.1999.01383.x
43 https://doi.org/10.1073/pnas.0505662102
44 https://doi.org/10.1073/pnas.0604040103
45 https://doi.org/10.1073/pnas.0914638107
46 https://doi.org/10.1073/pnas.94.18.9869
47 https://doi.org/10.1093/bioinformatics/btp393
48 https://doi.org/10.1093/bioinformatics/btq249
49 https://doi.org/10.1093/molbev/msr121
50 https://doi.org/10.1093/nar/17.22.9063
51 https://doi.org/10.1093/oxfordjournals.molbev.a003995
52 https://doi.org/10.1093/oxfordjournals.molbev.a040454
53 https://doi.org/10.1099/mic.0.031948-0
54 https://doi.org/10.1099/mic.0.26528-0
55 https://doi.org/10.1101/gr.1128803
56 https://doi.org/10.1101/gr.172101
57 https://doi.org/10.1101/gr.2289704
58 https://doi.org/10.1111/j.1574-6968.1989.tb03440.x
59 https://doi.org/10.1111/j.1574-6968.1991.tb04544.x
60 https://doi.org/10.1126/science.285.5433.1558
61 https://doi.org/10.1128/aem.01683-08
62 https://doi.org/10.1128/aem.68.12.6321-6331.2002
63 https://doi.org/10.1128/iai.00326-06
64 https://doi.org/10.1128/iai.01411-09
65 https://doi.org/10.1128/iai.01739-06
66 https://doi.org/10.1128/jb.00780-07
67 https://doi.org/10.1128/jb.00972-10
68 https://doi.org/10.1128/jb.01340-08
69 https://doi.org/10.1128/jb.188.2.711-723.2006
70 https://doi.org/10.1128/jb.188.6.2290-2293.2006
71 https://doi.org/10.1128/jcm.00210-11
72 https://doi.org/10.1128/jcm.01349-08
73 https://doi.org/10.1128/jcm.40.4.1303-1310.2002
74 https://doi.org/10.1128/jcm.40.5.1798-1804.2002
75 https://doi.org/10.1128/jcm.41.11.5215-5223.2003
76 https://doi.org/10.1128/jcm.42.4.1694-1702.2004
77 https://doi.org/10.1128/jcm.43.8.3704-3712.2005
78 https://doi.org/10.1128/jcm.44.2.433-440.2006
79 https://doi.org/10.1128/jcm.44.3.881-887.2006
80 https://doi.org/10.1371/journal.pgen.1000711
81 https://doi.org/10.1371/journal.pone.0011147
82 https://doi.org/10.1371/journal.pone.0022171
83 https://doi.org/10.1371/journal.pone.0031947
84 schema:datePublished 2012-12
85 schema:datePublishedReg 2012-12-01
86 schema:description BACKGROUND: The genome of Mycobacterium avium subspecies paratuberculosis (MAP) is remarkably homogeneous among the genomes of bovine, human and wildlife isolates. However, previous work in our laboratories with the bovine K-10 strain has revealed substantial differences compared to sheep isolates. To systematically characterize all genomic differences that may be associated with the specific hosts, we sequenced the genomes of three U.S. sheep isolates and also obtained an optical map. RESULTS: Our analysis of one of the isolates, MAP S397, revealed a genome 4.8 Mb in size with 4,700 open reading frames (ORFs). Comparative analysis of the MAP S397 isolate showed it acquired approximately 10 large sequence regions that are shared with the human M. avium subsp. hominissuis strain 104 and lost 2 large regions that are present in the bovine strain. In addition, optical mapping defined the presence of 7 large inversions between the bovine and ovine genomes (~ 2.36 Mb). Whole-genome sequencing of 2 additional sheep strains of MAP (JTC1074 and JTC7565) further confirmed genomic homogeneity of the sheep isolates despite the presence of polymorphisms on the nucleotide level. CONCLUSIONS: Comparative sequence analysis employed here provided a better understanding of the host association, evolution of members of the M. avium complex and could help in deciphering the phenotypic differences observed among sheep and cattle strains of MAP. A similar approach based on whole-genome sequencing combined with optical mapping could be employed to examine closely related pathogens. We propose an evolutionary scenario for M. avium complex strains based on these genome sequences.
87 schema:genre research_article
88 schema:inLanguage en
89 schema:isAccessibleForFree true
90 schema:isPartOf N1eef5dfe536f47a18a88a48ed32342fc
91 N30772268a1c4461aa880b3c553b99c54
92 sg:journal.1023790
93 schema:name Genome sequencing of ovine isolates of Mycobacterium avium subspecies paratuberculosis offers insights into host association
94 schema:pagination 89
95 schema:productId N230bacb1b0b544698bea7869d2b59e0a
96 N4c14dcef68ef4399a9bb295e2e1b3609
97 N56d11e994aa24be68bb1ae7dfdd8f8a5
98 N615ccfd5a9324b80b9a43e5cd28b37eb
99 Nbfcc04dee5b94534a2e45e68b363587d
100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000309144
101 https://doi.org/10.1186/1471-2164-13-89
102 schema:sdDatePublished 2019-04-10T14:07
103 schema:sdLicense https://scigraph.springernature.com/explorer/license/
104 schema:sdPublisher N5b89fac0a1a145c0a7a7eefff29ddd5a
105 schema:url http://link.springer.com/10.1186%2F1471-2164-13-89
106 sgo:license sg:explorer/license/
107 sgo:sdDataset articles
108 rdf:type schema:ScholarlyArticle
109 N10b2c3dc3d0643018b3b2f86bdb9309e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Cattle
111 rdf:type schema:DefinedTerm
112 N12221bfd674c44d3b21330b63fe009ec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Sequence Analysis, DNA
114 rdf:type schema:DefinedTerm
115 N13e0440935b140a7a2251185067b3b42 rdf:first sg:person.0635364161.15
116 rdf:rest N8c91d86b140f422c8bea90bc328458db
117 N18619ad2a75d4717bc484876287a9510 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Polymorphism, Genetic
119 rdf:type schema:DefinedTerm
120 N1bacc7df0ef847b78a441097172889c8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Open Reading Frames
122 rdf:type schema:DefinedTerm
123 N1eef5dfe536f47a18a88a48ed32342fc schema:volumeNumber 13
124 rdf:type schema:PublicationVolume
125 N21f63823ef7740a6a70a44f3acc3960f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Gene Order
127 rdf:type schema:DefinedTerm
128 N230bacb1b0b544698bea7869d2b59e0a schema:name dimensions_id
129 schema:value pub.1000309144
130 rdf:type schema:PropertyValue
131 N30772268a1c4461aa880b3c553b99c54 schema:issueNumber 1
132 rdf:type schema:PublicationIssue
133 N30910f7ac78b4bd2b356f4417c55f680 rdf:first sg:person.013453527622.12
134 rdf:rest N8c60a2bc256447a6880259bb24a620e8
135 N33479efa35f14017b3600c4d0586f760 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Mutagenesis, Insertional
137 rdf:type schema:DefinedTerm
138 N3a5fa8c260c24c02aa712cc00d33c606 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Host-Pathogen Interactions
140 rdf:type schema:DefinedTerm
141 N4c14dcef68ef4399a9bb295e2e1b3609 schema:name readcube_id
142 schema:value 017845d9f757a912fe3f4167d3f5c91d1dee6cbf3164f17b148c106917288f0d
143 rdf:type schema:PropertyValue
144 N519caddaa61041aeb8cb485a100921d4 rdf:first sg:person.01073440243.39
145 rdf:rest N30910f7ac78b4bd2b356f4417c55f680
146 N53eb3a4e63e6477f81dcedcdf4243d46 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Genome, Bacterial
148 rdf:type schema:DefinedTerm
149 N56d11e994aa24be68bb1ae7dfdd8f8a5 schema:name doi
150 schema:value 10.1186/1471-2164-13-89
151 rdf:type schema:PropertyValue
152 N5b89fac0a1a145c0a7a7eefff29ddd5a schema:name Springer Nature - SN SciGraph project
153 rdf:type schema:Organization
154 N615ccfd5a9324b80b9a43e5cd28b37eb schema:name nlm_unique_id
155 schema:value 100965258
156 rdf:type schema:PropertyValue
157 N851f56117d8f4860a5b35faa9eff1fcb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Mycobacterium avium subsp. paratuberculosis
159 rdf:type schema:DefinedTerm
160 N8c60a2bc256447a6880259bb24a620e8 rdf:first sg:person.01110406243.90
161 rdf:rest Na1796b3329b54658b6fb7636f5daad7c
162 N8c91d86b140f422c8bea90bc328458db rdf:first sg:person.01122222163.99
163 rdf:rest Nc8287b721b094b46928378db63da1e5e
164 N8d4ba59ddc4349459d3387739825edfc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Sequence Alignment
166 rdf:type schema:DefinedTerm
167 Na1796b3329b54658b6fb7636f5daad7c rdf:first sg:person.016456657547.45
168 rdf:rest N13e0440935b140a7a2251185067b3b42
169 Nb631f0ad03ca44a0b8a48700a451eabf rdf:first sg:person.01144102564.37
170 rdf:rest Nbe25a7662f6d4339aa5f7f7f3afbb5fb
171 Nbe25a7662f6d4339aa5f7f7f3afbb5fb rdf:first sg:person.0701572672.25
172 rdf:rest Nccdae1bb01f74cf8935b6709a8aef8b7
173 Nbe6b63f4f4714b29a56f72bae9d6b799 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Gene Deletion
175 rdf:type schema:DefinedTerm
176 Nbfcc04dee5b94534a2e45e68b363587d schema:name pubmed_id
177 schema:value 22409516
178 rdf:type schema:PropertyValue
179 Nc8287b721b094b46928378db63da1e5e rdf:first sg:person.0631114411.35
180 rdf:rest Ndf538571949b4490947085ff7eb5d5a1
181 Nccdae1bb01f74cf8935b6709a8aef8b7 rdf:first sg:person.0614240046.15
182 rdf:rest N519caddaa61041aeb8cb485a100921d4
183 Nd0326ec6e42e454a88724d2af9d61ecc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Molecular Sequence Annotation
185 rdf:type schema:DefinedTerm
186 Nd05f115baab54deba51dc685e40bd5b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Humans
188 rdf:type schema:DefinedTerm
189 Nd97063f5c27f469c85e9d0eb7cf7541d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Sheep
191 rdf:type schema:DefinedTerm
192 Ndf538571949b4490947085ff7eb5d5a1 rdf:first sg:person.01360737277.17
193 rdf:rest rdf:nil
194 Ne46bc3c03a844264a29b60e390131080 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Animals
196 rdf:type schema:DefinedTerm
197 Nee09f12d839748689d49f0dd1f6d50dd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Evolution, Molecular
199 rdf:type schema:DefinedTerm
200 Nff3c437ea67b4d4aa37b5a556613c16d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
201 schema:name Chromosome Mapping
202 rdf:type schema:DefinedTerm
203 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
204 schema:name Biological Sciences
205 rdf:type schema:DefinedTerm
206 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
207 schema:name Genetics
208 rdf:type schema:DefinedTerm
209 sg:journal.1023790 schema:issn 1471-2164
210 schema:name BMC Genomics
211 rdf:type schema:Periodical
212 sg:person.01073440243.39 schema:affiliation https://www.grid.ac/institutes/grid.14003.36
213 schema:familyName Zhou
214 schema:givenName Shiguo
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073440243.39
216 rdf:type schema:Person
217 sg:person.01110406243.90 schema:affiliation https://www.grid.ac/institutes/grid.463419.d
218 schema:familyName Bayles
219 schema:givenName Darrell O
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110406243.90
221 rdf:type schema:Person
222 sg:person.01122222163.99 schema:affiliation https://www.grid.ac/institutes/grid.17635.36
223 schema:familyName Sreevatsan
224 schema:givenName Srinand
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122222163.99
226 rdf:type schema:Person
227 sg:person.01144102564.37 schema:affiliation https://www.grid.ac/institutes/grid.463419.d
228 schema:familyName Bannantine
229 schema:givenName John P
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144102564.37
231 rdf:type schema:Person
232 sg:person.013453527622.12 schema:affiliation https://www.grid.ac/institutes/grid.14003.36
233 schema:familyName Schwartz
234 schema:givenName David C
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013453527622.12
236 rdf:type schema:Person
237 sg:person.01360737277.17 schema:affiliation https://www.grid.ac/institutes/grid.7776.1
238 schema:familyName Talaat
239 schema:givenName Adel M
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01360737277.17
241 rdf:type schema:Person
242 sg:person.016456657547.45 schema:affiliation https://www.grid.ac/institutes/grid.463419.d
243 schema:familyName Paustian
244 schema:givenName Michael L
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016456657547.45
246 rdf:type schema:Person
247 sg:person.0614240046.15 schema:affiliation https://www.grid.ac/institutes/grid.14003.36
248 schema:familyName Hsu
249 schema:givenName Chungyi
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0614240046.15
251 rdf:type schema:Person
252 sg:person.0631114411.35 schema:affiliation https://www.grid.ac/institutes/grid.29857.31
253 schema:familyName Kapur
254 schema:givenName Vivek
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631114411.35
256 rdf:type schema:Person
257 sg:person.0635364161.15 schema:affiliation https://www.grid.ac/institutes/grid.463419.d
258 schema:familyName Alt
259 schema:givenName David P
260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635364161.15
261 rdf:type schema:Person
262 sg:person.0701572672.25 schema:affiliation https://www.grid.ac/institutes/grid.14003.36
263 schema:familyName Wu
264 schema:givenName Chia-wei
265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701572672.25
266 rdf:type schema:Person
267 sg:pub.10.1038/15484 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009646434
268 https://doi.org/10.1038/15484
269 rdf:type schema:CreativeWork
270 sg:pub.10.1186/1471-2164-10-25 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043069640
271 https://doi.org/10.1186/1471-2164-10-25
272 rdf:type schema:CreativeWork
273 sg:pub.10.1186/1471-2164-8-278 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003983720
274 https://doi.org/10.1186/1471-2164-8-278
275 rdf:type schema:CreativeWork
276 sg:pub.10.1186/1471-2164-8-289 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031756510
277 https://doi.org/10.1186/1471-2164-8-289
278 rdf:type schema:CreativeWork
279 sg:pub.10.1186/1471-2164-9-135 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022205646
280 https://doi.org/10.1186/1471-2164-9-135
281 rdf:type schema:CreativeWork
282 sg:pub.10.1186/1471-2180-3-10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006694082
283 https://doi.org/10.1186/1471-2180-3-10
284 rdf:type schema:CreativeWork
285 sg:pub.10.1186/1471-2180-8-204 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049554618
286 https://doi.org/10.1186/1471-2180-8-204
287 rdf:type schema:CreativeWork
288 https://app.dimensions.ai/details/publication/pub.1078056654 schema:CreativeWork
289 https://app.dimensions.ai/details/publication/pub.1079345446 schema:CreativeWork
290 https://app.dimensions.ai/details/publication/pub.1083294147 schema:CreativeWork
291 https://doi.org/10.1002/path.1700630217 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052194655
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1006/mcpr.1999.0227 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016564759
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1016/0092-8674(84)90301-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006653804
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1016/j.mcp.2005.06.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025671628
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1016/j.micres.2009.03.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005423383
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1016/j.molbiopara.2004.08.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050802935
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1016/j.molimm.2009.07.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022857108
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1016/j.rvsc.2011.05.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038834593
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1016/j.vetmic.2008.07.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031106842
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1016/j.vetmic.2008.10.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048480979
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1021/ac0496401 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054996644
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1046/j.1365-2958.1999.01383.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1007039640
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1073/pnas.0505662102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006045474
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1073/pnas.0604040103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004868369
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1073/pnas.0914638107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002734064
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1073/pnas.94.18.9869 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035792044
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1093/bioinformatics/btp393 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041253333
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1093/bioinformatics/btq249 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018850654
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1093/molbev/msr121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049273973
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1093/nar/17.22.9063 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033433788
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1093/oxfordjournals.molbev.a003995 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001282786
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1093/oxfordjournals.molbev.a040454 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079752303
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1099/mic.0.031948-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060394648
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1099/mic.0.26528-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060396821
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1101/gr.1128803 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034012904
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1101/gr.172101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011318009
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1101/gr.2289704 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041222434
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1111/j.1574-6968.1989.tb03440.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1024494945
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1111/j.1574-6968.1991.tb04544.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1035619850
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1126/science.285.5433.1558 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021867073
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1128/aem.01683-08 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046500176
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1128/aem.68.12.6321-6331.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002815355
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1128/iai.00326-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017484154
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1128/iai.01411-09 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003200901
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1128/iai.01739-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035237625
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1128/jb.00780-07 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039500390
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1128/jb.00972-10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007501308
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1128/jb.01340-08 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047280771
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1128/jb.188.2.711-723.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029838037
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1128/jb.188.6.2290-2293.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042073892
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1128/jcm.00210-11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017261412
372 rdf:type schema:CreativeWork
373 https://doi.org/10.1128/jcm.01349-08 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039052688
374 rdf:type schema:CreativeWork
375 https://doi.org/10.1128/jcm.40.4.1303-1310.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015350729
376 rdf:type schema:CreativeWork
377 https://doi.org/10.1128/jcm.40.5.1798-1804.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047563327
378 rdf:type schema:CreativeWork
379 https://doi.org/10.1128/jcm.41.11.5215-5223.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034522602
380 rdf:type schema:CreativeWork
381 https://doi.org/10.1128/jcm.42.4.1694-1702.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007539369
382 rdf:type schema:CreativeWork
383 https://doi.org/10.1128/jcm.43.8.3704-3712.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021993676
384 rdf:type schema:CreativeWork
385 https://doi.org/10.1128/jcm.44.2.433-440.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062712356
386 rdf:type schema:CreativeWork
387 https://doi.org/10.1128/jcm.44.3.881-887.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022376642
388 rdf:type schema:CreativeWork
389 https://doi.org/10.1371/journal.pgen.1000711 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039507468
390 rdf:type schema:CreativeWork
391 https://doi.org/10.1371/journal.pone.0011147 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001774801
392 rdf:type schema:CreativeWork
393 https://doi.org/10.1371/journal.pone.0022171 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025815775
394 rdf:type schema:CreativeWork
395 https://doi.org/10.1371/journal.pone.0031947 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022760907
396 rdf:type schema:CreativeWork
397 https://www.grid.ac/institutes/grid.14003.36 schema:alternateName University of Wisconsin–Madison
398 schema:name Laboratory for Molecular and Computational Genomics, Department of Chemistry and Laboratory of Genetics, UW Biotechnology Center, University of Wisconsin-Madison, Madison, Wisconsin, USA
399 The Laboratory of Bacterial Genomics, Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA
400 rdf:type schema:Organization
401 https://www.grid.ac/institutes/grid.17635.36 schema:alternateName University of Minnesota
402 schema:name Department of Veterinary Population Medicine and Department of Veterinary and Biomedical Sciences, University of Minnesota, St. Paul, Minnesota, USA
403 rdf:type schema:Organization
404 https://www.grid.ac/institutes/grid.29857.31 schema:alternateName Pennsylvania State University
405 schema:name Department of Veterinary and Biomedical Sciences and Huck Institutes of the Life Sciences, Penn State University, University Park, Pennsylvania, USA
406 rdf:type schema:Organization
407 https://www.grid.ac/institutes/grid.463419.d schema:alternateName Agricultural Research Service
408 schema:name National Animal Disease Center, USDA-Agricultural Research Service, Ames, Iowa, USA
409 rdf:type schema:Organization
410 https://www.grid.ac/institutes/grid.7776.1 schema:alternateName Cairo University
411 schema:name Department of Food Hygiene, Cairo University, Cairo, Egypt
412 The Laboratory of Bacterial Genomics, Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA
413 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...