A parallel genome-wide mRNA and microRNA profiling of the frontal cortex of HIV patients with and without HIV-associated dementia shows ... View Full Text


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Article Info

DATE

2012-11-28

AUTHORS

Li Zhou, Gulietta M Pupo, Priyanka Gupta, Bing Liu, Sieu L Tran, Raany Rahme, Bin Wang, Rejane Rua, Helen Rizos, Adam Carroll, Murray J Cairns, Nitin K Saksena

ABSTRACT

BackgroundHIV-associated dementia (HAD) is the most common dementia type in young adults less than 40 years of age. Although the neurotoxins, oxidative/metabolic stress and impaired activity of neurotrophic factors are believed to be underlying reasons for the development of HAD, the genomic basis, which ultimately defines the virus-host interaction and leads to neurologic manifestation of HIV disease is lacking. Therefore, identifying HIV fingerprints on the host gene machinery and its regulation by microRNA holds a great promise and potential for improving our understanding of HAD pathogenesis, its diagnosis and therapy.ResultsA parallel profiling of mRNA and miRNA of the frontal cortex autopsies from HIV positive patients with and without dementia was performed using Illumina Human-6 BeadChip and Affymetrix version 1.0 miRNA array, respectively. The gene ontology and pathway analysis of the two data sets showed high concordance between miRNA and mRNAs, revealing significant interference with the host axon guidance and its downstream signalling pathways in HAD brains. Moreover, the differentially expressed (DE) miRNAs identified in this study, in particular miR-137, 153 and 218, based on which most correlations were built cumulatively targeted neurodegeneration related pathways, implying their future potential in diagnosis, prognosis and possible therapies for HIV-mediated and possibly other neurodegenerative diseases. Furthermore, this relationship between DE miRNAs and DE mRNAs was also reflected in correlation analysis using Bayesian networks by splitting-averaging strategy (SA-BNs), which revealed 195 statistically significant correlated miRNA-mRNA pairs according to Pearson’s correlation test (P<0.05).ConclusionsOur study provides the first evidence on unambiguous support for intrinsic functional relationship between mRNA and miRNA in the context of HIV-mediated neurodegeneration, which shows that neurologic manifestation in HIV patients possibly occurs through the interference with the host axon guidance and its downstream signalling pathways. These data provide an excellent avenue for the development of new generation of diagnostic/prognostic biomarkers and therapeutic intervention strategies for HIV-associated neurodegeneration. More... »

PAGES

677

References to SciGraph publications

  • 2007-02-27. microRNA expression in the prefrontal cortex of individuals with schizophrenia and schizoaffective disorder in GENOME BIOLOGY
  • 2003-05. Differential transcriptional regulation by human immunodeficiency virus type 1 and gp120 in human astrocytes in JOURNAL OF NEUROVIROLOGY
  • 2011-07-05. Imprinted DLK1-DIO3 region of 14q32 defines a schizophrenia-associated miRNA signature in peripheral blood mononuclear cells in MOLECULAR PSYCHIATRY
  • 2010-06-24. First evidence of overlaps between HIV-Associated Dementia (HAD) and non-viral neurodegenerative diseases: proteomic analysis of the frontal cortex from HIV+ patients with and without dementia in MOLECULAR NEURODEGENERATION
  • 2006-10-30. Non coding RNA and brain in BMC NEUROSCIENCE
  • 2009-12-02. Evidence for predilection of macrophage infiltration patterns in the deeper midline and mesial temporal structures of the brain uniquely in patients with HIV-associated dementia in BMC INFECTIOUS DISEASES
  • 2011-09-18. Genome-wide association study identifies five new schizophrenia loci in NATURE GENETICS
  • 2008-06-24. miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells in BMC MEDICINE
  • 2011-03-07. Transcriptional Regulation of TMP21 by NFAT in MOLECULAR NEURODEGENERATION
  • 2008-10-27. Atrophins’ emerging roles in development and neurodegenerative disease in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2009-12-10. Exploring complex miRNA-mRNA interactions with Bayesian networks by splitting-averaging strategy in BMC BIOINFORMATICS
  • 2000-01. Turning of nerve growth cones induced by localized increases in intracellular calcium ions in NATURE
  • 2008-02-19. A common polymorphism in serotonin receptor 1B mRNA moderates regulation by miR-96 and associates with aggressive human behaviors in MOLECULAR PSYCHIATRY
  • 2002-05-01. Netrin-1-mediated axon outgrowth requires deleted in colorectal cancer-dependent MAPK activation in NATURE
  • 2009-09-01. Schizophrenia is associated with an increase in cortical microRNA biogenesis in MOLECULAR PSYCHIATRY
  • 2004-12. CpG island methylator phenotype in cancer in NATURE REVIEWS CANCER
  • 2008-01-13. Ephrin-B reverse signaling promotes structural and functional synaptic maturation in vivo in NATURE NEUROSCIENCE
  • 2005-11. Glutamate Metabolizing Enzymes in Prefrontal Cortex of Alzheimer’s Disease Patients in NEUROCHEMICAL RESEARCH
  • 2010-09-23. MicroRNA-21 dysregulates the expression of MEF2C in neurons in monkey and human SIV/HIV neurological disease in CELL DEATH & DISEASE
  • 2006-02. The molecular basis for calcium-dependent axon pathfinding in NATURE REVIEWS NEUROSCIENCE
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    http://scigraph.springernature.com/pub.10.1186/1471-2164-13-677

    DOI

    http://dx.doi.org/10.1186/1471-2164-13-677

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1025502642

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23190615


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        "description": "BackgroundHIV-associated dementia (HAD) is the most common dementia type in young adults less than 40 years of age. Although the neurotoxins, oxidative/metabolic stress and impaired activity of neurotrophic factors are believed to be underlying reasons for the development of HAD, the genomic basis, which ultimately defines the virus-host interaction and leads to neurologic manifestation of HIV disease is lacking. Therefore, identifying HIV fingerprints on the host gene machinery and its regulation by microRNA holds a great promise and potential for improving our understanding of HAD pathogenesis, its diagnosis and therapy.ResultsA parallel profiling of mRNA and miRNA of the frontal cortex autopsies from HIV positive patients with and without dementia was performed using Illumina Human-6 BeadChip and Affymetrix version 1.0 miRNA array, respectively. The gene ontology and pathway analysis of the two data sets showed high concordance between miRNA and mRNAs, revealing significant interference with the host axon guidance and its downstream signalling pathways in HAD brains. Moreover, the differentially expressed (DE) miRNAs identified in this study, in particular miR-137, 153 and 218, based on which most correlations were built cumulatively targeted neurodegeneration related pathways, implying their future potential in diagnosis, prognosis and possible therapies for HIV-mediated and possibly other neurodegenerative diseases. Furthermore, this relationship between DE miRNAs and DE mRNAs was also reflected in correlation analysis using Bayesian networks by splitting-averaging strategy (SA-BNs), which revealed 195 statistically significant correlated miRNA-mRNA pairs according to Pearson\u2019s correlation test (P<0.05).ConclusionsOur study provides the first evidence on unambiguous support for intrinsic functional relationship between mRNA and miRNA in the context of HIV-mediated neurodegeneration, which shows that neurologic manifestation in HIV patients possibly occurs through the interference with the host axon guidance and its downstream signalling pathways. These data provide an excellent avenue for the development of new generation of diagnostic/prognostic biomarkers and therapeutic intervention strategies for HIV-associated neurodegeneration.", 
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