Analyses of genome architecture and gene expression reveal novel candidate virulence factors in the secretome of Phytophthora infestans View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-12

AUTHORS

Sylvain Raffaele, Joe Win, Liliana M Cano, Sophien Kamoun

ABSTRACT

BACKGROUND: Phytophthora infestans is the most devastating pathogen of potato and a model organism for the oomycetes. It exhibits high evolutionary potential and rapidly adapts to host plants. The P. infestans genome experienced a repeat-driven expansion relative to the genomes of Phytophthora sojae and Phytophthora ramorum and shows a discontinuous distribution of gene density. Effector genes, such as members of the RXLR and Crinkler (CRN) families, localize to expanded, repeat-rich and gene-sparse regions of the genome. This distinct genomic environment is thought to contribute to genome plasticity and host adaptation. RESULTS: We used in silico approaches to predict and describe the repertoire of P. infestans secreted proteins (the secretome). We defined the "plastic secretome" as a subset of the genome that (i) encodes predicted secreted proteins, (ii) is excluded from genome segments orthologous to the P. sojae and P. ramorum genomes and (iii) is encoded by genes residing in gene sparse regions of P. infestans genome. Although including only ~3% of P. infestans genes, the plastic secretome contains ~62% of known effector genes and shows >2 fold enrichment in genes induced in planta. We highlight 19 plastic secretome genes induced in planta but distinct from previously described effectors. This list includes a trypsin-like serine protease, secreted oxidoreductases, small cysteine-rich proteins and repeat containing proteins that we propose to be novel candidate virulence factors. CONCLUSIONS: This work revealed a remarkably diverse plastic secretome. It illustrates the value of combining genome architecture with comparative genomics to identify novel candidate virulence factors from pathogen genomes. More... »

PAGES

637

References to SciGraph publications

  • 2009-09. Genome sequence and analysis of the Irish potato famine pathogen Phytophthora infestans in NATURE
  • 2006-02. Concerted evolution of a tandemly arrayed family of mating-specific genes in Phytophthora analyzed through inter- and intraspecific comparisons in MOLECULAR GENETICS AND GENOMICS
  • 2005-12. A two disulfide bridge Kazal domain from Phytophthora exhibits stable inhibitory activity against serine proteases of the subtilisin family in BMC BIOCHEMISTRY
  • 2010-12. Fungal Secretome Database: Integrated platform for annotation of fungal secretomes in BMC GENOMICS
  • 2010-03-18. Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium in NATURE
  • 2009-10. Unexpected consequences of a sudden and massive transposon amplification on rice gene expression in NATURE
  • 2002-08. A saponin-detoxifying enzyme mediates suppression of plant defences in NATURE
  • 2007-04. Locating proteins in the cell using TargetP, SignalP and related tools in NATURE PROTOCOLS
  • 1994-05. Expression of the Phytophthora infestans ipiB and ipi0 genes in planta and in vitro in MOLECULAR GENETICS AND GENOMICS
  • 2002-03. The pipg1 gene of the oomycete Phytophthora infestans encodes a fungal-like endopolygalacturonase in CURRENT GENETICS
  • 2008-10-09. The genome of the simian and human malaria parasite Plasmodium knowlesi in NATURE
  • 2009-03. Molecular domestication of transposable elements: From detrimental parasites to useful host genes in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2009-05. Impact of Different US Genotypes of Phytophthora infestans on Potato Seed Tuber Rot and Plant Emergence in a Range of Cultivars and Advanced Breeding Lines in POTATO RESEARCH
  • 2009-12. Gene copy number variation throughout the Plasmodium falciparum genome in BMC GENOMICS
  • 2008-12. A concerted mechanism for berberine bridge enzyme in NATURE CHEMICAL BIOLOGY
  • 1999-01. Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori in NATURE
  • 2000-08-01. Structural analysis of the catalytic and binding sites of Clostridium botulinum neurotoxin B in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2008-01. Conserved eukaryotic transposable elements and the evolution of gene regulation in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2005-01. The spores of Phytophthora: weapons of the plant destroyer in NATURE REVIEWS MICROBIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/1471-2164-11-637

    DOI

    http://dx.doi.org/10.1186/1471-2164-11-637

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1043071699

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21080964


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Amino Acid Sequence", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Carbonic Anhydrases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Conserved Sequence", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Enzyme Inhibitors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Regulation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genome", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Molecular Sequence Annotation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Molecular Sequence Data", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Phytophthora", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Phytophthora infestans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein Structure, Tertiary", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Repetitive Sequences, Amino Acid", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Sequence Homology, Nucleic Acid", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Serine Endopeptidases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Virulence", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Virulence Factors", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "John Innes Centre", 
              "id": "https://www.grid.ac/institutes/grid.14830.3e", 
              "name": [
                "The Sainsbury Laboratory, John Innes Centre, NR4 7UH, Norwich, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Raffaele", 
            "givenName": "Sylvain", 
            "id": "sg:person.01017512221.36", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017512221.36"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "John Innes Centre", 
              "id": "https://www.grid.ac/institutes/grid.14830.3e", 
              "name": [
                "The Sainsbury Laboratory, John Innes Centre, NR4 7UH, Norwich, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Win", 
            "givenName": "Joe", 
            "id": "sg:person.01007636764.85", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007636764.85"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "John Innes Centre", 
              "id": "https://www.grid.ac/institutes/grid.14830.3e", 
              "name": [
                "The Sainsbury Laboratory, John Innes Centre, NR4 7UH, Norwich, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cano", 
            "givenName": "Liliana M", 
            "id": "sg:person.0777116376.39", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777116376.39"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "John Innes Centre", 
              "id": "https://www.grid.ac/institutes/grid.14830.3e", 
              "name": [
                "The Sainsbury Laboratory, John Innes Centre, NR4 7UH, Norwich, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kamoun", 
            "givenName": "Sophien", 
            "id": "sg:person.01270641554.56", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270641554.56"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1073/pnas.0709303105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000449347"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.1224503", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000505228"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/16.8.741", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001205116"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1104/pp.108.127845", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002972767"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2958.2004.04288.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003696028"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2958.2004.04177.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003946725"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1105/tpc.109.068247", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005231697"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/bti610", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006001436"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jxb/ern353", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006730947"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btm404", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007683223"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrmicro1064", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007773140", 
              "https://doi.org/10.1038/nrmicro1064"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrmicro1064", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007773140", 
              "https://doi.org/10.1038/nrmicro1064"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrmicro1064", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007773140", 
              "https://doi.org/10.1038/nrmicro1064"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jcc.20084", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008225564"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1105/tpc.105.038687", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008759384"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/jmbi.2001.5080", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009686806"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1105/tpc.105.035980", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009905215"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.910003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010047828"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m506078200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010731996"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0906810106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010990139"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0005863", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011955387"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/aob/mci010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012114518"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m101377200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012176651"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.fgb.2008.03.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012401120"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1742-4658.2007.06070.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013121951"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2958.2008.06547.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014076041"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11540-009-9125-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014903971", 
              "https://doi.org/10.1007/s11540-009-9125-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1104/pp.106.090050", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015031609"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0300-9084(01)01315-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017302284"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/hmg/ddl056", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017554330"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1364-3703.2007.00465.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017580115"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1574-6976.2006.00063.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019091206"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2958.2006.05076.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019833379"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2958.2006.05076.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019833379"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08850", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020062727", 
              "https://doi.org/10.1038/nature08850"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08850", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020062727", 
              "https://doi.org/10.1038/nature08850"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1105/tpc.109.066324", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020554427"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0969-2126(97)00222-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021488679"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.161301298", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021573527"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1105/tpc.105.031807", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023368610"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/pmic.200800933", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023369407"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/pmic.200800933", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023369407"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00438-005-0074-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024133097", 
              "https://doi.org/10.1007/s00438-005-0074-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00438-005-0074-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024133097", 
              "https://doi.org/10.1007/s00438-005-0074-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/molbev/msi049", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024720670"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.270.7.3081", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025029000"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.182427699", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025183490"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1369-5274(00)00250-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025757306"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1104/pp.105.061226", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025771574"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08358", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025806080", 
              "https://doi.org/10.1038/nature08358"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08358", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025806080", 
              "https://doi.org/10.1038/nature08358"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature00950", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026425244", 
              "https://doi.org/10.1038/nature00950"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature00950", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026425244", 
              "https://doi.org/10.1038/nature00950"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/bies.200900026", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026542366"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/bies.200900026", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026542366"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.polymer.2007.07.039", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026985422"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07306", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027102409", 
              "https://doi.org/10.1038/nature07306"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1364-3703.2009.00593.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027512898"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1364-3703.2009.00593.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027512898"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/1040-840291046704", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027518866"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/jmbi.2000.3903", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028412590"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00018-009-8376-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028792632", 
              "https://doi.org/10.1007/s00018-009-8376-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m400941200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030260715"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1462-2920.2007.01408.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030365379"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/jmbi.1993.1626", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030443070"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jmb.2004.05.028", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030482208"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/16495", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031204788", 
              "https://doi.org/10.1038/16495"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/16495", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031204788", 
              "https://doi.org/10.1038/16495"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2164-11-105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031387348", 
              "https://doi.org/10.1186/1471-2164-11-105"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.mib.2007.04.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033039589"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1104022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033632803"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/78005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033857735", 
              "https://doi.org/10.1038/78005"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/emboj/cdf667", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035096807"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08479", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035469674", 
              "https://doi.org/10.1038/nature08479"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08479", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035469674", 
              "https://doi.org/10.1038/nature08479"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/jcs.00138", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035601341"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)80906-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035686582"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0014-5793(00)02022-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035817155"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.phyto.44.070505.143436", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035920979"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/pmic.200300786", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036810519"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00018-007-7369-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036895053", 
              "https://doi.org/10.1007/s00018-007-7369-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0959-437x(00)00249-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037062275"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btg430", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037195157"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nprot.2007.131", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037402439", 
              "https://doi.org/10.1038/nprot.2007.131"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btp070", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039722462"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1105/tpc.107.051037", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041474092"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.phyto.40.120501.101443", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042819004"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/bth397", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043301791"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.284.5418.1322", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043411147"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1128796", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043715710"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1105/tpc.020040", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044181398"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.pbi.2008.02.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044283474"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/protein/12.1.3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044300442"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1105/tpc.002253", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045770502"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1097-0134(199707)28:3<405::aid-prot10>3.0.co;2-l", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046295485"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/25.17.3389", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047265454"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tig.2003.08.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047593060"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tig.2003.08.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047593060"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-3040.2008.01910.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048447704"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00285454", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048551547", 
              "https://doi.org/10.1007/bf00285454"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/16.2.178", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048601183"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.phytochem.2006.10.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048756474"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nchembio.123", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048867035", 
              "https://doi.org/10.1038/nchembio.123"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tplants.2006.05.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050426147"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00294-002-0272-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051851082", 
              "https://doi.org/10.1007/s00294-002-0272-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2091-6-15", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052288185", 
              "https://doi.org/10.1186/1471-2091-6-15"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2164-10-353", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052836746", 
              "https://doi.org/10.1186/1471-2164-10-353"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.pbi.2007.04.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053299181"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkm259", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053546100"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi00464a023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055177277"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1094/mpmi-18-0913", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060078280"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1094/mpmi-18-1130", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060078301"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1094/mpmi-19-1368", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060078454"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1094/mpmi-20-10-1175", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060078517"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1094/mpmi-20-4-0459", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060078593"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1094/mpmi-21-6-0820", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060078767"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1094/mpmi-22-2-0115", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060078863"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1094/mpmi.2000.13.1.32", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060080137"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1094/mpmi.2002.15.1.6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060080468"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1094/mpmi.2002.15.9.907", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060080596"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1094/mpmi.2002.15.9.939", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060080599"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1171661", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062459993"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1171661", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062459993"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/138161208783877884", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069166491"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2307/3871102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1070468915"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075055374", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082424111", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083334419", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2010-12", 
        "datePublishedReg": "2010-12-01", 
        "description": "BACKGROUND: Phytophthora infestans is the most devastating pathogen of potato and a model organism for the oomycetes. It exhibits high evolutionary potential and rapidly adapts to host plants. The P. infestans genome experienced a repeat-driven expansion relative to the genomes of Phytophthora sojae and Phytophthora ramorum and shows a discontinuous distribution of gene density. Effector genes, such as members of the RXLR and Crinkler (CRN) families, localize to expanded, repeat-rich and gene-sparse regions of the genome. This distinct genomic environment is thought to contribute to genome plasticity and host adaptation.\nRESULTS: We used in silico approaches to predict and describe the repertoire of P. infestans secreted proteins (the secretome). We defined the \"plastic secretome\" as a subset of the genome that (i) encodes predicted secreted proteins, (ii) is excluded from genome segments orthologous to the P. sojae and P. ramorum genomes and (iii) is encoded by genes residing in gene sparse regions of P. infestans genome. Although including only ~3% of P. infestans genes, the plastic secretome contains ~62% of known effector genes and shows >2 fold enrichment in genes induced in planta. We highlight 19 plastic secretome genes induced in planta but distinct from previously described effectors. This list includes a trypsin-like serine protease, secreted oxidoreductases, small cysteine-rich proteins and repeat containing proteins that we propose to be novel candidate virulence factors.\nCONCLUSIONS: This work revealed a remarkably diverse plastic secretome. It illustrates the value of combining genome architecture with comparative genomics to identify novel candidate virulence factors from pathogen genomes.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1186/1471-2164-11-637", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1023790", 
            "issn": [
              "1471-2164"
            ], 
            "name": "BMC Genomics", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "11"
          }
        ], 
        "name": "Analyses of genome architecture and gene expression reveal novel candidate virulence factors in the secretome of Phytophthora infestans", 
        "pagination": "637", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "cd2a40ba19ce6d3049336bcf61dcc1f5d0daee81480935497a698d4fd88ee59e"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "21080964"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "100965258"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/1471-2164-11-637"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1043071699"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/1471-2164-11-637", 
          "https://app.dimensions.ai/details/publication/pub.1043071699"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T15:50", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8664_00000507.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1186%2F1471-2164-11-637"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1471-2164-11-637'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1471-2164-11-637'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1471-2164-11-637'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1471-2164-11-637'


     

    This table displays all metadata directly associated to this object as RDF triples.

    519 TRIPLES      21 PREDICATES      161 URIs      39 LITERALS      27 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/1471-2164-11-637 schema:about N0b442c12399a4cedb141c66220210581
    2 N0ded011fb0e240cd9b8c43fbb670c4d3
    3 N200fd5dc18344ec5b747f50f0ad87578
    4 N304a037d0fc244199b67d01f0258e1c0
    5 N32ac29582bd64b33bb333593a2acdf12
    6 N3a57baf9b61b475cb7a8475d2ab40c90
    7 N46f0e9ad784845f39dea4034b4720fe8
    8 N53cda96f123542a48d1420f2cd16dbc4
    9 N618babfe49804c66a156465266ea655d
    10 N6389858474c44b9d97ab0e8414044e5c
    11 N6694c0c295dd44df935012a4624d7ced
    12 N749538d30c5a459bac4127d30f91308f
    13 N7fa9e0bd44114bc2a27504568786db47
    14 Nb6e5108db5ea47888b8a5fe061a6bfd3
    15 Nd85e312216684c02a716d712030b889f
    16 Nee31bee529a34ec28a9aeb5df925a178
    17 Neeab7030d49e4a37a4aa5f06fbf557c4
    18 Nfb3fd13d10524bebbb59742379459c45
    19 anzsrc-for:06
    20 anzsrc-for:0604
    21 schema:author N55e903d6115340ae984c761f7a3ddf50
    22 schema:citation sg:pub.10.1007/bf00285454
    23 sg:pub.10.1007/s00018-007-7369-3
    24 sg:pub.10.1007/s00018-009-8376-3
    25 sg:pub.10.1007/s00294-002-0272-4
    26 sg:pub.10.1007/s00438-005-0074-8
    27 sg:pub.10.1007/s11540-009-9125-6
    28 sg:pub.10.1038/16495
    29 sg:pub.10.1038/78005
    30 sg:pub.10.1038/nature00950
    31 sg:pub.10.1038/nature07306
    32 sg:pub.10.1038/nature08358
    33 sg:pub.10.1038/nature08479
    34 sg:pub.10.1038/nature08850
    35 sg:pub.10.1038/nchembio.123
    36 sg:pub.10.1038/nprot.2007.131
    37 sg:pub.10.1038/nrmicro1064
    38 sg:pub.10.1186/1471-2091-6-15
    39 sg:pub.10.1186/1471-2164-10-353
    40 sg:pub.10.1186/1471-2164-11-105
    41 https://app.dimensions.ai/details/publication/pub.1075055374
    42 https://app.dimensions.ai/details/publication/pub.1082424111
    43 https://app.dimensions.ai/details/publication/pub.1083334419
    44 https://doi.org/10.1002/(sici)1097-0134(199707)28:3<405::aid-prot10>3.0.co;2-l
    45 https://doi.org/10.1002/bies.200900026
    46 https://doi.org/10.1002/jcc.20084
    47 https://doi.org/10.1002/pmic.200300786
    48 https://doi.org/10.1002/pmic.200800933
    49 https://doi.org/10.1006/jmbi.1993.1626
    50 https://doi.org/10.1006/jmbi.2000.3903
    51 https://doi.org/10.1006/jmbi.2001.5080
    52 https://doi.org/10.1016/j.fgb.2008.03.012
    53 https://doi.org/10.1016/j.jmb.2004.05.028
    54 https://doi.org/10.1016/j.mib.2007.04.005
    55 https://doi.org/10.1016/j.pbi.2007.04.017
    56 https://doi.org/10.1016/j.pbi.2008.02.012
    57 https://doi.org/10.1016/j.phytochem.2006.10.004
    58 https://doi.org/10.1016/j.polymer.2007.07.039
    59 https://doi.org/10.1016/j.tig.2003.08.004
    60 https://doi.org/10.1016/j.tplants.2006.05.006
    61 https://doi.org/10.1016/s0014-5793(00)02022-6
    62 https://doi.org/10.1016/s0092-8674(00)80906-x
    63 https://doi.org/10.1016/s0300-9084(01)01315-3
    64 https://doi.org/10.1016/s0959-437x(00)00249-5
    65 https://doi.org/10.1016/s0969-2126(97)00222-0
    66 https://doi.org/10.1016/s1369-5274(00)00250-2
    67 https://doi.org/10.1021/bi00464a023
    68 https://doi.org/10.1073/pnas.0709303105
    69 https://doi.org/10.1073/pnas.0906810106
    70 https://doi.org/10.1073/pnas.161301298
    71 https://doi.org/10.1073/pnas.182427699
    72 https://doi.org/10.1074/jbc.270.7.3081
    73 https://doi.org/10.1074/jbc.m101377200
    74 https://doi.org/10.1074/jbc.m400941200
    75 https://doi.org/10.1074/jbc.m506078200
    76 https://doi.org/10.1080/1040-840291046704
    77 https://doi.org/10.1093/aob/mci010
    78 https://doi.org/10.1093/bioinformatics/16.2.178
    79 https://doi.org/10.1093/bioinformatics/16.8.741
    80 https://doi.org/10.1093/bioinformatics/btg430
    81 https://doi.org/10.1093/bioinformatics/bth397
    82 https://doi.org/10.1093/bioinformatics/bti610
    83 https://doi.org/10.1093/bioinformatics/btm404
    84 https://doi.org/10.1093/bioinformatics/btp070
    85 https://doi.org/10.1093/emboj/cdf667
    86 https://doi.org/10.1093/hmg/ddl056
    87 https://doi.org/10.1093/jxb/ern353
    88 https://doi.org/10.1093/molbev/msi049
    89 https://doi.org/10.1093/nar/25.17.3389
    90 https://doi.org/10.1093/nar/gkm259
    91 https://doi.org/10.1093/protein/12.1.3
    92 https://doi.org/10.1094/mpmi-18-0913
    93 https://doi.org/10.1094/mpmi-18-1130
    94 https://doi.org/10.1094/mpmi-19-1368
    95 https://doi.org/10.1094/mpmi-20-10-1175
    96 https://doi.org/10.1094/mpmi-20-4-0459
    97 https://doi.org/10.1094/mpmi-21-6-0820
    98 https://doi.org/10.1094/mpmi-22-2-0115
    99 https://doi.org/10.1094/mpmi.2000.13.1.32
    100 https://doi.org/10.1094/mpmi.2002.15.1.6
    101 https://doi.org/10.1094/mpmi.2002.15.9.907
    102 https://doi.org/10.1094/mpmi.2002.15.9.939
    103 https://doi.org/10.1101/gr.1224503
    104 https://doi.org/10.1101/gr.910003
    105 https://doi.org/10.1104/pp.105.061226
    106 https://doi.org/10.1104/pp.106.090050
    107 https://doi.org/10.1104/pp.108.127845
    108 https://doi.org/10.1105/tpc.002253
    109 https://doi.org/10.1105/tpc.020040
    110 https://doi.org/10.1105/tpc.105.031807
    111 https://doi.org/10.1105/tpc.105.035980
    112 https://doi.org/10.1105/tpc.105.038687
    113 https://doi.org/10.1105/tpc.107.051037
    114 https://doi.org/10.1105/tpc.109.066324
    115 https://doi.org/10.1105/tpc.109.068247
    116 https://doi.org/10.1111/j.1364-3703.2007.00465.x
    117 https://doi.org/10.1111/j.1364-3703.2009.00593.x
    118 https://doi.org/10.1111/j.1365-2958.2004.04177.x
    119 https://doi.org/10.1111/j.1365-2958.2004.04288.x
    120 https://doi.org/10.1111/j.1365-2958.2006.05076.x
    121 https://doi.org/10.1111/j.1365-2958.2008.06547.x
    122 https://doi.org/10.1111/j.1365-3040.2008.01910.x
    123 https://doi.org/10.1111/j.1462-2920.2007.01408.x
    124 https://doi.org/10.1111/j.1574-6976.2006.00063.x
    125 https://doi.org/10.1111/j.1742-4658.2007.06070.x
    126 https://doi.org/10.1126/science.1104022
    127 https://doi.org/10.1126/science.1128796
    128 https://doi.org/10.1126/science.1171661
    129 https://doi.org/10.1126/science.284.5418.1322
    130 https://doi.org/10.1146/annurev.phyto.40.120501.101443
    131 https://doi.org/10.1146/annurev.phyto.44.070505.143436
    132 https://doi.org/10.1242/jcs.00138
    133 https://doi.org/10.1371/journal.pone.0005863
    134 https://doi.org/10.2174/138161208783877884
    135 https://doi.org/10.2307/3871102
    136 schema:datePublished 2010-12
    137 schema:datePublishedReg 2010-12-01
    138 schema:description BACKGROUND: Phytophthora infestans is the most devastating pathogen of potato and a model organism for the oomycetes. It exhibits high evolutionary potential and rapidly adapts to host plants. The P. infestans genome experienced a repeat-driven expansion relative to the genomes of Phytophthora sojae and Phytophthora ramorum and shows a discontinuous distribution of gene density. Effector genes, such as members of the RXLR and Crinkler (CRN) families, localize to expanded, repeat-rich and gene-sparse regions of the genome. This distinct genomic environment is thought to contribute to genome plasticity and host adaptation. RESULTS: We used in silico approaches to predict and describe the repertoire of P. infestans secreted proteins (the secretome). We defined the "plastic secretome" as a subset of the genome that (i) encodes predicted secreted proteins, (ii) is excluded from genome segments orthologous to the P. sojae and P. ramorum genomes and (iii) is encoded by genes residing in gene sparse regions of P. infestans genome. Although including only ~3% of P. infestans genes, the plastic secretome contains ~62% of known effector genes and shows >2 fold enrichment in genes induced in planta. We highlight 19 plastic secretome genes induced in planta but distinct from previously described effectors. This list includes a trypsin-like serine protease, secreted oxidoreductases, small cysteine-rich proteins and repeat containing proteins that we propose to be novel candidate virulence factors. CONCLUSIONS: This work revealed a remarkably diverse plastic secretome. It illustrates the value of combining genome architecture with comparative genomics to identify novel candidate virulence factors from pathogen genomes.
    139 schema:genre research_article
    140 schema:inLanguage en
    141 schema:isAccessibleForFree true
    142 schema:isPartOf Nbd49fe8e54fc4e7fb93a0b122cacf95d
    143 Nfc9b879da414455e8bc8f84970b3f586
    144 sg:journal.1023790
    145 schema:name Analyses of genome architecture and gene expression reveal novel candidate virulence factors in the secretome of Phytophthora infestans
    146 schema:pagination 637
    147 schema:productId N419973308062472b820d43bf9d13cd14
    148 N64ee53b388a64b8ca91942ead20452ad
    149 N70bd04bdce014bd28ff3b7cb690a92bd
    150 Naff42668c1594216a9cdead0367b029a
    151 Nc17be96cbb47401a8f9784cf8ce6b865
    152 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043071699
    153 https://doi.org/10.1186/1471-2164-11-637
    154 schema:sdDatePublished 2019-04-10T15:50
    155 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    156 schema:sdPublisher Na4f509e577794699bfdf31073c1598d9
    157 schema:url http://link.springer.com/10.1186%2F1471-2164-11-637
    158 sgo:license sg:explorer/license/
    159 sgo:sdDataset articles
    160 rdf:type schema:ScholarlyArticle
    161 N0b442c12399a4cedb141c66220210581 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    162 schema:name Genes
    163 rdf:type schema:DefinedTerm
    164 N0c4a3d7a64a44981a868c53f67240233 rdf:first sg:person.0777116376.39
    165 rdf:rest N5b4b56fa863c4e05b36c78ec4700b760
    166 N0ded011fb0e240cd9b8c43fbb670c4d3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    167 schema:name Enzyme Inhibitors
    168 rdf:type schema:DefinedTerm
    169 N152a8586e7fe4a4eb8b6f247786003c8 rdf:first sg:person.01007636764.85
    170 rdf:rest N0c4a3d7a64a44981a868c53f67240233
    171 N200fd5dc18344ec5b747f50f0ad87578 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    172 schema:name Phytophthora infestans
    173 rdf:type schema:DefinedTerm
    174 N304a037d0fc244199b67d01f0258e1c0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    175 schema:name Protein Structure, Tertiary
    176 rdf:type schema:DefinedTerm
    177 N32ac29582bd64b33bb333593a2acdf12 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    178 schema:name Virulence Factors
    179 rdf:type schema:DefinedTerm
    180 N3a57baf9b61b475cb7a8475d2ab40c90 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    181 schema:name Phytophthora
    182 rdf:type schema:DefinedTerm
    183 N419973308062472b820d43bf9d13cd14 schema:name pubmed_id
    184 schema:value 21080964
    185 rdf:type schema:PropertyValue
    186 N46f0e9ad784845f39dea4034b4720fe8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    187 schema:name Repetitive Sequences, Amino Acid
    188 rdf:type schema:DefinedTerm
    189 N53cda96f123542a48d1420f2cd16dbc4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    190 schema:name Molecular Sequence Annotation
    191 rdf:type schema:DefinedTerm
    192 N55e903d6115340ae984c761f7a3ddf50 rdf:first sg:person.01017512221.36
    193 rdf:rest N152a8586e7fe4a4eb8b6f247786003c8
    194 N5b4b56fa863c4e05b36c78ec4700b760 rdf:first sg:person.01270641554.56
    195 rdf:rest rdf:nil
    196 N618babfe49804c66a156465266ea655d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    197 schema:name Serine Endopeptidases
    198 rdf:type schema:DefinedTerm
    199 N6389858474c44b9d97ab0e8414044e5c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    200 schema:name Genome
    201 rdf:type schema:DefinedTerm
    202 N64ee53b388a64b8ca91942ead20452ad schema:name doi
    203 schema:value 10.1186/1471-2164-11-637
    204 rdf:type schema:PropertyValue
    205 N6694c0c295dd44df935012a4624d7ced schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    206 schema:name Sequence Homology, Nucleic Acid
    207 rdf:type schema:DefinedTerm
    208 N70bd04bdce014bd28ff3b7cb690a92bd schema:name readcube_id
    209 schema:value cd2a40ba19ce6d3049336bcf61dcc1f5d0daee81480935497a698d4fd88ee59e
    210 rdf:type schema:PropertyValue
    211 N749538d30c5a459bac4127d30f91308f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    212 schema:name Carbonic Anhydrases
    213 rdf:type schema:DefinedTerm
    214 N7fa9e0bd44114bc2a27504568786db47 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    215 schema:name Virulence
    216 rdf:type schema:DefinedTerm
    217 Na4f509e577794699bfdf31073c1598d9 schema:name Springer Nature - SN SciGraph project
    218 rdf:type schema:Organization
    219 Naff42668c1594216a9cdead0367b029a schema:name dimensions_id
    220 schema:value pub.1043071699
    221 rdf:type schema:PropertyValue
    222 Nb6e5108db5ea47888b8a5fe061a6bfd3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    223 schema:name Molecular Sequence Data
    224 rdf:type schema:DefinedTerm
    225 Nbd49fe8e54fc4e7fb93a0b122cacf95d schema:issueNumber 1
    226 rdf:type schema:PublicationIssue
    227 Nc17be96cbb47401a8f9784cf8ce6b865 schema:name nlm_unique_id
    228 schema:value 100965258
    229 rdf:type schema:PropertyValue
    230 Nd85e312216684c02a716d712030b889f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    231 schema:name Conserved Sequence
    232 rdf:type schema:DefinedTerm
    233 Nee31bee529a34ec28a9aeb5df925a178 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    234 schema:name Proteins
    235 rdf:type schema:DefinedTerm
    236 Neeab7030d49e4a37a4aa5f06fbf557c4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    237 schema:name Amino Acid Sequence
    238 rdf:type schema:DefinedTerm
    239 Nfb3fd13d10524bebbb59742379459c45 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    240 schema:name Gene Expression Regulation
    241 rdf:type schema:DefinedTerm
    242 Nfc9b879da414455e8bc8f84970b3f586 schema:volumeNumber 11
    243 rdf:type schema:PublicationVolume
    244 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    245 schema:name Biological Sciences
    246 rdf:type schema:DefinedTerm
    247 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    248 schema:name Genetics
    249 rdf:type schema:DefinedTerm
    250 sg:journal.1023790 schema:issn 1471-2164
    251 schema:name BMC Genomics
    252 rdf:type schema:Periodical
    253 sg:person.01007636764.85 schema:affiliation https://www.grid.ac/institutes/grid.14830.3e
    254 schema:familyName Win
    255 schema:givenName Joe
    256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007636764.85
    257 rdf:type schema:Person
    258 sg:person.01017512221.36 schema:affiliation https://www.grid.ac/institutes/grid.14830.3e
    259 schema:familyName Raffaele
    260 schema:givenName Sylvain
    261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017512221.36
    262 rdf:type schema:Person
    263 sg:person.01270641554.56 schema:affiliation https://www.grid.ac/institutes/grid.14830.3e
    264 schema:familyName Kamoun
    265 schema:givenName Sophien
    266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270641554.56
    267 rdf:type schema:Person
    268 sg:person.0777116376.39 schema:affiliation https://www.grid.ac/institutes/grid.14830.3e
    269 schema:familyName Cano
    270 schema:givenName Liliana M
    271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777116376.39
    272 rdf:type schema:Person
    273 sg:pub.10.1007/bf00285454 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048551547
    274 https://doi.org/10.1007/bf00285454
    275 rdf:type schema:CreativeWork
    276 sg:pub.10.1007/s00018-007-7369-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036895053
    277 https://doi.org/10.1007/s00018-007-7369-3
    278 rdf:type schema:CreativeWork
    279 sg:pub.10.1007/s00018-009-8376-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028792632
    280 https://doi.org/10.1007/s00018-009-8376-3
    281 rdf:type schema:CreativeWork
    282 sg:pub.10.1007/s00294-002-0272-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051851082
    283 https://doi.org/10.1007/s00294-002-0272-4
    284 rdf:type schema:CreativeWork
    285 sg:pub.10.1007/s00438-005-0074-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024133097
    286 https://doi.org/10.1007/s00438-005-0074-8
    287 rdf:type schema:CreativeWork
    288 sg:pub.10.1007/s11540-009-9125-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014903971
    289 https://doi.org/10.1007/s11540-009-9125-6
    290 rdf:type schema:CreativeWork
    291 sg:pub.10.1038/16495 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031204788
    292 https://doi.org/10.1038/16495
    293 rdf:type schema:CreativeWork
    294 sg:pub.10.1038/78005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033857735
    295 https://doi.org/10.1038/78005
    296 rdf:type schema:CreativeWork
    297 sg:pub.10.1038/nature00950 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026425244
    298 https://doi.org/10.1038/nature00950
    299 rdf:type schema:CreativeWork
    300 sg:pub.10.1038/nature07306 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027102409
    301 https://doi.org/10.1038/nature07306
    302 rdf:type schema:CreativeWork
    303 sg:pub.10.1038/nature08358 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025806080
    304 https://doi.org/10.1038/nature08358
    305 rdf:type schema:CreativeWork
    306 sg:pub.10.1038/nature08479 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035469674
    307 https://doi.org/10.1038/nature08479
    308 rdf:type schema:CreativeWork
    309 sg:pub.10.1038/nature08850 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020062727
    310 https://doi.org/10.1038/nature08850
    311 rdf:type schema:CreativeWork
    312 sg:pub.10.1038/nchembio.123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048867035
    313 https://doi.org/10.1038/nchembio.123
    314 rdf:type schema:CreativeWork
    315 sg:pub.10.1038/nprot.2007.131 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037402439
    316 https://doi.org/10.1038/nprot.2007.131
    317 rdf:type schema:CreativeWork
    318 sg:pub.10.1038/nrmicro1064 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007773140
    319 https://doi.org/10.1038/nrmicro1064
    320 rdf:type schema:CreativeWork
    321 sg:pub.10.1186/1471-2091-6-15 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052288185
    322 https://doi.org/10.1186/1471-2091-6-15
    323 rdf:type schema:CreativeWork
    324 sg:pub.10.1186/1471-2164-10-353 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052836746
    325 https://doi.org/10.1186/1471-2164-10-353
    326 rdf:type schema:CreativeWork
    327 sg:pub.10.1186/1471-2164-11-105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031387348
    328 https://doi.org/10.1186/1471-2164-11-105
    329 rdf:type schema:CreativeWork
    330 https://app.dimensions.ai/details/publication/pub.1075055374 schema:CreativeWork
    331 https://app.dimensions.ai/details/publication/pub.1082424111 schema:CreativeWork
    332 https://app.dimensions.ai/details/publication/pub.1083334419 schema:CreativeWork
    333 https://doi.org/10.1002/(sici)1097-0134(199707)28:3<405::aid-prot10>3.0.co;2-l schema:sameAs https://app.dimensions.ai/details/publication/pub.1046295485
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1002/bies.200900026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026542366
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1002/jcc.20084 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008225564
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1002/pmic.200300786 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036810519
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.1002/pmic.200800933 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023369407
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.1006/jmbi.1993.1626 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030443070
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.1006/jmbi.2000.3903 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028412590
    346 rdf:type schema:CreativeWork
    347 https://doi.org/10.1006/jmbi.2001.5080 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009686806
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.1016/j.fgb.2008.03.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012401120
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.1016/j.jmb.2004.05.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030482208
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.1016/j.mib.2007.04.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033039589
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.1016/j.pbi.2007.04.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053299181
    356 rdf:type schema:CreativeWork
    357 https://doi.org/10.1016/j.pbi.2008.02.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044283474
    358 rdf:type schema:CreativeWork
    359 https://doi.org/10.1016/j.phytochem.2006.10.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048756474
    360 rdf:type schema:CreativeWork
    361 https://doi.org/10.1016/j.polymer.2007.07.039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026985422
    362 rdf:type schema:CreativeWork
    363 https://doi.org/10.1016/j.tig.2003.08.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047593060
    364 rdf:type schema:CreativeWork
    365 https://doi.org/10.1016/j.tplants.2006.05.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050426147
    366 rdf:type schema:CreativeWork
    367 https://doi.org/10.1016/s0014-5793(00)02022-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035817155
    368 rdf:type schema:CreativeWork
    369 https://doi.org/10.1016/s0092-8674(00)80906-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1035686582
    370 rdf:type schema:CreativeWork
    371 https://doi.org/10.1016/s0300-9084(01)01315-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017302284
    372 rdf:type schema:CreativeWork
    373 https://doi.org/10.1016/s0959-437x(00)00249-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037062275
    374 rdf:type schema:CreativeWork
    375 https://doi.org/10.1016/s0969-2126(97)00222-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021488679
    376 rdf:type schema:CreativeWork
    377 https://doi.org/10.1016/s1369-5274(00)00250-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025757306
    378 rdf:type schema:CreativeWork
    379 https://doi.org/10.1021/bi00464a023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055177277
    380 rdf:type schema:CreativeWork
    381 https://doi.org/10.1073/pnas.0709303105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000449347
    382 rdf:type schema:CreativeWork
    383 https://doi.org/10.1073/pnas.0906810106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010990139
    384 rdf:type schema:CreativeWork
    385 https://doi.org/10.1073/pnas.161301298 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021573527
    386 rdf:type schema:CreativeWork
    387 https://doi.org/10.1073/pnas.182427699 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025183490
    388 rdf:type schema:CreativeWork
    389 https://doi.org/10.1074/jbc.270.7.3081 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025029000
    390 rdf:type schema:CreativeWork
    391 https://doi.org/10.1074/jbc.m101377200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012176651
    392 rdf:type schema:CreativeWork
    393 https://doi.org/10.1074/jbc.m400941200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030260715
    394 rdf:type schema:CreativeWork
    395 https://doi.org/10.1074/jbc.m506078200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010731996
    396 rdf:type schema:CreativeWork
    397 https://doi.org/10.1080/1040-840291046704 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027518866
    398 rdf:type schema:CreativeWork
    399 https://doi.org/10.1093/aob/mci010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012114518
    400 rdf:type schema:CreativeWork
    401 https://doi.org/10.1093/bioinformatics/16.2.178 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048601183
    402 rdf:type schema:CreativeWork
    403 https://doi.org/10.1093/bioinformatics/16.8.741 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001205116
    404 rdf:type schema:CreativeWork
    405 https://doi.org/10.1093/bioinformatics/btg430 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037195157
    406 rdf:type schema:CreativeWork
    407 https://doi.org/10.1093/bioinformatics/bth397 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043301791
    408 rdf:type schema:CreativeWork
    409 https://doi.org/10.1093/bioinformatics/bti610 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006001436
    410 rdf:type schema:CreativeWork
    411 https://doi.org/10.1093/bioinformatics/btm404 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007683223
    412 rdf:type schema:CreativeWork
    413 https://doi.org/10.1093/bioinformatics/btp070 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039722462
    414 rdf:type schema:CreativeWork
    415 https://doi.org/10.1093/emboj/cdf667 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035096807
    416 rdf:type schema:CreativeWork
    417 https://doi.org/10.1093/hmg/ddl056 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017554330
    418 rdf:type schema:CreativeWork
    419 https://doi.org/10.1093/jxb/ern353 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006730947
    420 rdf:type schema:CreativeWork
    421 https://doi.org/10.1093/molbev/msi049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024720670
    422 rdf:type schema:CreativeWork
    423 https://doi.org/10.1093/nar/25.17.3389 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047265454
    424 rdf:type schema:CreativeWork
    425 https://doi.org/10.1093/nar/gkm259 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053546100
    426 rdf:type schema:CreativeWork
    427 https://doi.org/10.1093/protein/12.1.3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044300442
    428 rdf:type schema:CreativeWork
    429 https://doi.org/10.1094/mpmi-18-0913 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060078280
    430 rdf:type schema:CreativeWork
    431 https://doi.org/10.1094/mpmi-18-1130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060078301
    432 rdf:type schema:CreativeWork
    433 https://doi.org/10.1094/mpmi-19-1368 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060078454
    434 rdf:type schema:CreativeWork
    435 https://doi.org/10.1094/mpmi-20-10-1175 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060078517
    436 rdf:type schema:CreativeWork
    437 https://doi.org/10.1094/mpmi-20-4-0459 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060078593
    438 rdf:type schema:CreativeWork
    439 https://doi.org/10.1094/mpmi-21-6-0820 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060078767
    440 rdf:type schema:CreativeWork
    441 https://doi.org/10.1094/mpmi-22-2-0115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060078863
    442 rdf:type schema:CreativeWork
    443 https://doi.org/10.1094/mpmi.2000.13.1.32 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060080137
    444 rdf:type schema:CreativeWork
    445 https://doi.org/10.1094/mpmi.2002.15.1.6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060080468
    446 rdf:type schema:CreativeWork
    447 https://doi.org/10.1094/mpmi.2002.15.9.907 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060080596
    448 rdf:type schema:CreativeWork
    449 https://doi.org/10.1094/mpmi.2002.15.9.939 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060080599
    450 rdf:type schema:CreativeWork
    451 https://doi.org/10.1101/gr.1224503 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000505228
    452 rdf:type schema:CreativeWork
    453 https://doi.org/10.1101/gr.910003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010047828
    454 rdf:type schema:CreativeWork
    455 https://doi.org/10.1104/pp.105.061226 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025771574
    456 rdf:type schema:CreativeWork
    457 https://doi.org/10.1104/pp.106.090050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015031609
    458 rdf:type schema:CreativeWork
    459 https://doi.org/10.1104/pp.108.127845 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002972767
    460 rdf:type schema:CreativeWork
    461 https://doi.org/10.1105/tpc.002253 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045770502
    462 rdf:type schema:CreativeWork
    463 https://doi.org/10.1105/tpc.020040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044181398
    464 rdf:type schema:CreativeWork
    465 https://doi.org/10.1105/tpc.105.031807 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023368610
    466 rdf:type schema:CreativeWork
    467 https://doi.org/10.1105/tpc.105.035980 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009905215
    468 rdf:type schema:CreativeWork
    469 https://doi.org/10.1105/tpc.105.038687 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008759384
    470 rdf:type schema:CreativeWork
    471 https://doi.org/10.1105/tpc.107.051037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041474092
    472 rdf:type schema:CreativeWork
    473 https://doi.org/10.1105/tpc.109.066324 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020554427
    474 rdf:type schema:CreativeWork
    475 https://doi.org/10.1105/tpc.109.068247 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005231697
    476 rdf:type schema:CreativeWork
    477 https://doi.org/10.1111/j.1364-3703.2007.00465.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1017580115
    478 rdf:type schema:CreativeWork
    479 https://doi.org/10.1111/j.1364-3703.2009.00593.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1027512898
    480 rdf:type schema:CreativeWork
    481 https://doi.org/10.1111/j.1365-2958.2004.04177.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1003946725
    482 rdf:type schema:CreativeWork
    483 https://doi.org/10.1111/j.1365-2958.2004.04288.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1003696028
    484 rdf:type schema:CreativeWork
    485 https://doi.org/10.1111/j.1365-2958.2006.05076.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1019833379
    486 rdf:type schema:CreativeWork
    487 https://doi.org/10.1111/j.1365-2958.2008.06547.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1014076041
    488 rdf:type schema:CreativeWork
    489 https://doi.org/10.1111/j.1365-3040.2008.01910.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1048447704
    490 rdf:type schema:CreativeWork
    491 https://doi.org/10.1111/j.1462-2920.2007.01408.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030365379
    492 rdf:type schema:CreativeWork
    493 https://doi.org/10.1111/j.1574-6976.2006.00063.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1019091206
    494 rdf:type schema:CreativeWork
    495 https://doi.org/10.1111/j.1742-4658.2007.06070.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1013121951
    496 rdf:type schema:CreativeWork
    497 https://doi.org/10.1126/science.1104022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033632803
    498 rdf:type schema:CreativeWork
    499 https://doi.org/10.1126/science.1128796 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043715710
    500 rdf:type schema:CreativeWork
    501 https://doi.org/10.1126/science.1171661 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062459993
    502 rdf:type schema:CreativeWork
    503 https://doi.org/10.1126/science.284.5418.1322 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043411147
    504 rdf:type schema:CreativeWork
    505 https://doi.org/10.1146/annurev.phyto.40.120501.101443 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042819004
    506 rdf:type schema:CreativeWork
    507 https://doi.org/10.1146/annurev.phyto.44.070505.143436 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035920979
    508 rdf:type schema:CreativeWork
    509 https://doi.org/10.1242/jcs.00138 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035601341
    510 rdf:type schema:CreativeWork
    511 https://doi.org/10.1371/journal.pone.0005863 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011955387
    512 rdf:type schema:CreativeWork
    513 https://doi.org/10.2174/138161208783877884 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069166491
    514 rdf:type schema:CreativeWork
    515 https://doi.org/10.2307/3871102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070468915
    516 rdf:type schema:CreativeWork
    517 https://www.grid.ac/institutes/grid.14830.3e schema:alternateName John Innes Centre
    518 schema:name The Sainsbury Laboratory, John Innes Centre, NR4 7UH, Norwich, UK
    519 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...