A genome-wide scan for type 1 diabetes susceptibility genes in nuclear families with multiple affected siblings in Finland View Full Text


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Article Info

DATE

2007-12-19

AUTHORS

Qing Qiao, Anne-May Österholm, Bing He, Janne Pitkäniemi, Heather J Cordell, Cinzia Sarti, Leena Kinnunen, Eva Tuomilehto-Wolf, Karl Tryggvason, Jaakko Tuomilehto

ABSTRACT

BACKGROUND: A genome-wide search for genes that predispose to type 1 diabetes using linkage analysis was performed using 900 microsatellite markers in 70 nuclear families with affected siblings from Finland, a population expected to be more genetically homogeneous than others, and having the highest incidence of type 1 diabetes in the world and, yet, the highest proportion in Europe of cases (10%) carrying neither of the highest risk HLA haplotypes that include DR3 or DR4 alleles. RESULTS: In addition to the evidence of linkage to the HLA region on 6p21 (nominal p = 4.0 x 10-6), significant evidence of linkage in other chromosome regions was not detected with a single-locus analysis. The two-locus analysis conditional on the HLA gave a maximum lod score (MLS) of 3.1 (nominal p = 2 x 10-4) on chromosome 9p13 under an additive model; MLS of 2.1 (nominal p = 6.1 x 10-3) on chromosome 17p12 and MLS of 2.5 (nominal p = 2.9 x 10-3) on chromosome 18p11 under a general model. CONCLUSION: Our genome scan data confirmed the primary contribution of the HLA genes also in the high-risk Finnish population, and suggest that non-HLA genes also contribute to the familial clustering of type 1 diabetes in Finland. More... »

PAGES

84-84

References to SciGraph publications

  • 1994-09. Genetic mapping of a susceptibility locus for insulin-dependent diabetes mellitus on chromosome llq in NATURE
  • 2002-01. Genetic linkage and association studies of Type I diabetes: challenges and rewards in DIABETOLOGIA
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  • 1998-07. A search for type 1 diabetes susceptibility genes in families from the United Kingdom in NATURE GENETICS
  • 2001-12-03. Merlin—rapid analysis of dense genetic maps using sparse gene flow trees in NATURE GENETICS
  • 1988-10. The significance of the concordance rate for Type 1 (insulin-dependent) diabetes in identical twins in DIABETOLOGIA
  • 1992-11. Concordance for Type 1 (insulin-dependent) and Type 2 (non-insulin-dependent) diabetes mellitus in a population-based cohort of twins in Finland in DIABETOLOGIA
  • 1994-09. A genome-wide search for human type 1 diabetes susceptibility genes in NATURE
  • 1995-03. Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus in NATURE GENETICS
  • 1993-10. A review of the recent epidemiological data on the worldwide incidence of Type 1 (insulin-dependent) diabetes mellitus in DIABETOLOGIA
  • 1998-07. A second-generation screen of the human genome for susceptibility to insulin-dependent diabetes mellitus in NATURE GENETICS
  • 2004-04-02. Increasing incidence of Type 1 diabetes – role for genes? in BMC GENETICS
  • 1981-02. Diabetes in identical twins in DIABETOLOGIA
  • 2007-06-06. Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes in NATURE GENETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/1471-2156-8-84

    DOI

    http://dx.doi.org/10.1186/1471-2156-8-84

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/18093291


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    35 schema:description BACKGROUND: A genome-wide search for genes that predispose to type 1 diabetes using linkage analysis was performed using 900 microsatellite markers in 70 nuclear families with affected siblings from Finland, a population expected to be more genetically homogeneous than others, and having the highest incidence of type 1 diabetes in the world and, yet, the highest proportion in Europe of cases (10%) carrying neither of the highest risk HLA haplotypes that include DR3 or DR4 alleles. RESULTS: In addition to the evidence of linkage to the HLA region on 6p21 (nominal p = 4.0 x 10-6), significant evidence of linkage in other chromosome regions was not detected with a single-locus analysis. The two-locus analysis conditional on the HLA gave a maximum lod score (MLS) of 3.1 (nominal p = 2 x 10-4) on chromosome 9p13 under an additive model; MLS of 2.1 (nominal p = 6.1 x 10-3) on chromosome 17p12 and MLS of 2.5 (nominal p = 2.9 x 10-3) on chromosome 18p11 under a general model. CONCLUSION: Our genome scan data confirmed the primary contribution of the HLA genes also in the high-risk Finnish population, and suggest that non-HLA genes also contribute to the familial clustering of type 1 diabetes in Finland.
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    105 schema:name A genome-wide scan for type 1 diabetes susceptibility genes in nuclear families with multiple affected siblings in Finland
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