Sequencing and association analysis of the type 1 diabetes – linked region on chromosome 10p12-q11 View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-12

AUTHORS

Sergey Nejentsev, Luc J Smink, Deborah Smyth, Rebecca Bailey, Christopher E Lowe, Felicity Payne, Jennifer Masters, Lisa Godfrey, Alex Lam, Oliver Burren, Helen Stevens, Sarah Nutland, Neil M Walker, Anne Smith, Rebecca Twells, Bryan J Barratt, Charmain Wright, Lisa French, Yuan Chen, Panagiotis Deloukas, Jane Rogers, Ian Dunham, John A Todd

ABSTRACT

BACKGROUND: In an effort to locate susceptibility genes for type 1 diabetes (T1D) several genome-wide linkage scans have been undertaken. A chromosomal region designated IDDM10 retained genome-wide significance in a combined analysis of the main linkage scans. Here, we studied sequence polymorphisms in 23 Mb on chromosome 10p12-q11, including the putative IDDM10 region, to identify genes associated with T1D. RESULTS: Initially, we resequenced the functional candidate genes, CREM and SDF1, located in this region, genotyped 13 tag single nucleotide polymorphisms (SNPs) and found no association with T1D. We then undertook analysis of the whole 23 Mb region. We constructed and sequenced a contig tile path from two bacterial artificial clone libraries. By comparison with a clone library from an unrelated person used in the Human Genome Project, we identified 12,058 SNPs. We genotyped 303 SNPs and 25 polymorphic microsatellite markers in 765 multiplex T1D families and followed up 22 associated polymorphisms in up to 2,857 families. We found nominal evidence of association in six loci (P = 0.05 - 0.0026), located near the PAPD1 gene. Therefore, we resequenced 38.8 kb in this region, found 147 SNPs and genotyped 84 of them in the T1D families. We also tested 13 polymorphisms in the PAPD1 gene and in five other loci in 1,612 T1D patients and 1,828 controls from the UK. Overall, only the D10S193 microsatellite marker located 28 kb downstream of PAPD1 showed nominal evidence of association in both T1D families and in the case-control sample (P = 0.037 and 0.03, respectively). CONCLUSION: We conclude that polymorphisms in the CREM and SDF1 genes have no major effect on T1D. The weak T1D association that we detected in the association scan near the PAPD1 gene may be either false or due to a small genuine effect, and cannot explain linkage at the IDDM10 region. More... »

PAGES

24

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1471-2156-8-24

DOI

http://dx.doi.org/10.1186/1471-2156-8-24

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1033944287

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17509149


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Case-Control Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosomes, Human, Pair 10", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Primers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diabetes Mellitus, Type 1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Frequency", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Markers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Physical Chromosome Mapping", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymorphism, Single Nucleotide", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Cambridge", 
          "id": "https://www.grid.ac/institutes/grid.5335.0", 
          "name": [
            "Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nejentsev", 
        "givenName": "Sergey", 
        "id": "sg:person.01334150044.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334150044.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Cambridge", 
          "id": "https://www.grid.ac/institutes/grid.5335.0", 
          "name": [
            "Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Smink", 
        "givenName": "Luc J", 
        "id": "sg:person.01164450361.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164450361.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Cambridge", 
          "id": "https://www.grid.ac/institutes/grid.5335.0", 
          "name": [
            "Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Smyth", 
        "givenName": "Deborah", 
        "id": "sg:person.01247333552.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247333552.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Cambridge", 
          "id": "https://www.grid.ac/institutes/grid.5335.0", 
          "name": [
            "Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bailey", 
        "givenName": "Rebecca", 
        "id": "sg:person.01147514743.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147514743.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Cambridge", 
          "id": "https://www.grid.ac/institutes/grid.5335.0", 
          "name": [
            "Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lowe", 
        "givenName": "Christopher E", 
        "id": "sg:person.01263743343.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263743343.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Cambridge", 
          "id": "https://www.grid.ac/institutes/grid.5335.0", 
          "name": [
            "Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Payne", 
        "givenName": "Felicity", 
        "id": "sg:person.01201220352.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201220352.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Cambridge", 
          "id": "https://www.grid.ac/institutes/grid.5335.0", 
          "name": [
            "Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Masters", 
        "givenName": "Jennifer", 
        "id": "sg:person.01014654220.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014654220.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Cambridge", 
          "id": "https://www.grid.ac/institutes/grid.5335.0", 
          "name": [
            "Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Godfrey", 
        "givenName": "Lisa", 
        "id": "sg:person.0616123560.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616123560.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Cambridge", 
          "id": "https://www.grid.ac/institutes/grid.5335.0", 
          "name": [
            "Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lam", 
        "givenName": "Alex", 
        "id": "sg:person.01123647500.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123647500.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Cambridge", 
          "id": "https://www.grid.ac/institutes/grid.5335.0", 
          "name": [
            "Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Burren", 
        "givenName": "Oliver", 
        "id": "sg:person.0633344577.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0633344577.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Cambridge", 
          "id": "https://www.grid.ac/institutes/grid.5335.0", 
          "name": [
            "Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stevens", 
        "givenName": "Helen", 
        "id": "sg:person.0576262171.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576262171.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Cambridge", 
          "id": "https://www.grid.ac/institutes/grid.5335.0", 
          "name": [
            "Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nutland", 
        "givenName": "Sarah", 
        "id": "sg:person.01007752726.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007752726.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Cambridge", 
          "id": "https://www.grid.ac/institutes/grid.5335.0", 
          "name": [
            "Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Walker", 
        "givenName": "Neil M", 
        "id": "sg:person.01257156522.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257156522.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Cambridge", 
          "id": "https://www.grid.ac/institutes/grid.5335.0", 
          "name": [
            "Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Smith", 
        "givenName": "Anne", 
        "id": "sg:person.0633331440.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0633331440.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Cambridge", 
          "id": "https://www.grid.ac/institutes/grid.5335.0", 
          "name": [
            "Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Twells", 
        "givenName": "Rebecca", 
        "id": "sg:person.01115537320.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115537320.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Cambridge", 
          "id": "https://www.grid.ac/institutes/grid.5335.0", 
          "name": [
            "Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Barratt", 
        "givenName": "Bryan J", 
        "id": "sg:person.01253117260.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253117260.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Wellcome Sanger Institute", 
          "id": "https://www.grid.ac/institutes/grid.10306.34", 
          "name": [
            "The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wright", 
        "givenName": "Charmain", 
        "id": "sg:person.01371545164.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371545164.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Wellcome Sanger Institute", 
          "id": "https://www.grid.ac/institutes/grid.10306.34", 
          "name": [
            "The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "French", 
        "givenName": "Lisa", 
        "id": "sg:person.01211715603.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211715603.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Wellcome Sanger Institute", 
          "id": "https://www.grid.ac/institutes/grid.10306.34", 
          "name": [
            "The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Yuan", 
        "id": "sg:person.01236476426.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01236476426.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Wellcome Sanger Institute", 
          "id": "https://www.grid.ac/institutes/grid.10306.34", 
          "name": [
            "The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Deloukas", 
        "givenName": "Panagiotis", 
        "id": "sg:person.011013226044.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011013226044.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Wellcome Sanger Institute", 
          "id": "https://www.grid.ac/institutes/grid.10306.34", 
          "name": [
            "The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rogers", 
        "givenName": "Jane", 
        "id": "sg:person.014562310447.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014562310447.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Wellcome Sanger Institute", 
          "id": "https://www.grid.ac/institutes/grid.10306.34", 
          "name": [
            "The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dunham", 
        "givenName": "Ian", 
        "id": "sg:person.0723723076.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723723076.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Cambridge", 
          "id": "https://www.grid.ac/institutes/grid.5335.0", 
          "name": [
            "Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Todd", 
        "givenName": "John A", 
        "id": "sg:person.01134314703.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134314703.76"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nature02462", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002255204", 
          "https://doi.org/10.1038/nature02462"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature02462", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002255204", 
          "https://doi.org/10.1038/nature02462"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.50.5.1211", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006430869"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.194201", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008144266"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.54.10.2995", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010242138"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000073729", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014435426"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.51.9.2866", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014786781"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1001-233", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017573512", 
          "https://doi.org/10.1038/ng1001-233"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1001-233", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017573512", 
          "https://doi.org/10.1038/ng1001-233"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4020-6754-9_4160", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018253065", 
          "https://doi.org/10.1007/978-1-4020-6754-9_4160"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/991", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022325746", 
          "https://doi.org/10.1038/991"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/991", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022325746", 
          "https://doi.org/10.1038/991"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ajmg.10737", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024783554"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/gepi.20032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025657577"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1074-7613(01)00202-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034094347"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0198-8859(03)00176-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041125700"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0198-8859(03)00176-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041125700"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ije/dyi183", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041266836"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ije/dyi183", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041266836"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35057062", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042854081", 
          "https://doi.org/10.1038/35057062"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35057062", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042854081", 
          "https://doi.org/10.1038/35057062"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35057149", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046153445", 
          "https://doi.org/10.1038/35057149"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35057149", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046153445", 
          "https://doi.org/10.1038/35057149"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/6.7.1011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046837527"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/429843", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058716351"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074544758", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.166.6.4216", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074780194"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.169.8.4147", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075172299"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/9780471650126.dob0560.pub2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090239289"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2007-12", 
    "datePublishedReg": "2007-12-01", 
    "description": "BACKGROUND: In an effort to locate susceptibility genes for type 1 diabetes (T1D) several genome-wide linkage scans have been undertaken. A chromosomal region designated IDDM10 retained genome-wide significance in a combined analysis of the main linkage scans. Here, we studied sequence polymorphisms in 23 Mb on chromosome 10p12-q11, including the putative IDDM10 region, to identify genes associated with T1D.\nRESULTS: Initially, we resequenced the functional candidate genes, CREM and SDF1, located in this region, genotyped 13 tag single nucleotide polymorphisms (SNPs) and found no association with T1D. We then undertook analysis of the whole 23 Mb region. We constructed and sequenced a contig tile path from two bacterial artificial clone libraries. By comparison with a clone library from an unrelated person used in the Human Genome Project, we identified 12,058 SNPs. We genotyped 303 SNPs and 25 polymorphic microsatellite markers in 765 multiplex T1D families and followed up 22 associated polymorphisms in up to 2,857 families. We found nominal evidence of association in six loci (P = 0.05 - 0.0026), located near the PAPD1 gene. Therefore, we resequenced 38.8 kb in this region, found 147 SNPs and genotyped 84 of them in the T1D families. We also tested 13 polymorphisms in the PAPD1 gene and in five other loci in 1,612 T1D patients and 1,828 controls from the UK. Overall, only the D10S193 microsatellite marker located 28 kb downstream of PAPD1 showed nominal evidence of association in both T1D families and in the case-control sample (P = 0.037 and 0.03, respectively).\nCONCLUSION: We conclude that polymorphisms in the CREM and SDF1 genes have no major effect on T1D. The weak T1D association that we detected in the association scan near the PAPD1 gene may be either false or due to a small genuine effect, and cannot explain linkage at the IDDM10 region.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/1471-2156-8-24", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.3635287", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2786745", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1024251", 
        "issn": [
          "1471-2156"
        ], 
        "name": "BMC Genetics", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "8"
      }
    ], 
    "name": "Sequencing and association analysis of the type 1 diabetes \u2013 linked region on chromosome 10p12-q11", 
    "pagination": "24", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "a1b38cb01fa5162b0cf12619778a692c6f1824d88cd25ae3fa3998397630dafb"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "17509149"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100966978"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1471-2156-8-24"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1033944287"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1471-2156-8-24", 
      "https://app.dimensions.ai/details/publication/pub.1033944287"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T19:07", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8678_00000506.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2F1471-2156-8-24"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1471-2156-8-24'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1471-2156-8-24'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1471-2156-8-24'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1471-2156-8-24'


 

This table displays all metadata directly associated to this object as RDF triples.

348 TRIPLES      21 PREDICATES      63 URIs      33 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1471-2156-8-24 schema:about N16e7fa484b6444758f8cc454da587e62
2 N203e5e8215174066918ce946dcdc0870
3 N27838ca6cf6f4ad4b99f5582c5eda160
4 N2f04ddd4e1554bf0962c64eba873d0d3
5 N317ff3fc41974788a6b5903c4a520379
6 N36d057d10ed74234962895bd0ae0bfd4
7 N589333cddb6b4458a668d0c9d937b87c
8 N6afeaf8346a24f3da7a99283102b480b
9 N7f8e93d3233d40ddaa96cc278f7e5a55
10 N8d674923fa0b48eaa684634e03292691
11 Na8f9ed19ef324df6acd66706eaa19cde
12 Nb64c49d29eb3439cb3afcf6061310237
13 anzsrc-for:06
14 anzsrc-for:0604
15 schema:author N42821627b13d4806a4ef48c67c664093
16 schema:citation sg:pub.10.1007/978-1-4020-6754-9_4160
17 sg:pub.10.1038/35057062
18 sg:pub.10.1038/35057149
19 sg:pub.10.1038/991
20 sg:pub.10.1038/nature02462
21 sg:pub.10.1038/ng1001-233
22 https://app.dimensions.ai/details/publication/pub.1074544758
23 https://doi.org/10.1002/9780471650126.dob0560.pub2
24 https://doi.org/10.1002/ajmg.10737
25 https://doi.org/10.1002/gepi.20032
26 https://doi.org/10.1016/s0198-8859(03)00176-9
27 https://doi.org/10.1016/s1074-7613(01)00202-3
28 https://doi.org/10.1086/429843
29 https://doi.org/10.1093/hmg/6.7.1011
30 https://doi.org/10.1093/ije/dyi183
31 https://doi.org/10.1101/gr.194201
32 https://doi.org/10.1159/000073729
33 https://doi.org/10.2337/diabetes.50.5.1211
34 https://doi.org/10.2337/diabetes.51.9.2866
35 https://doi.org/10.2337/diabetes.54.10.2995
36 https://doi.org/10.4049/jimmunol.166.6.4216
37 https://doi.org/10.4049/jimmunol.169.8.4147
38 schema:datePublished 2007-12
39 schema:datePublishedReg 2007-12-01
40 schema:description BACKGROUND: In an effort to locate susceptibility genes for type 1 diabetes (T1D) several genome-wide linkage scans have been undertaken. A chromosomal region designated IDDM10 retained genome-wide significance in a combined analysis of the main linkage scans. Here, we studied sequence polymorphisms in 23 Mb on chromosome 10p12-q11, including the putative IDDM10 region, to identify genes associated with T1D. RESULTS: Initially, we resequenced the functional candidate genes, CREM and SDF1, located in this region, genotyped 13 tag single nucleotide polymorphisms (SNPs) and found no association with T1D. We then undertook analysis of the whole 23 Mb region. We constructed and sequenced a contig tile path from two bacterial artificial clone libraries. By comparison with a clone library from an unrelated person used in the Human Genome Project, we identified 12,058 SNPs. We genotyped 303 SNPs and 25 polymorphic microsatellite markers in 765 multiplex T1D families and followed up 22 associated polymorphisms in up to 2,857 families. We found nominal evidence of association in six loci (P = 0.05 - 0.0026), located near the PAPD1 gene. Therefore, we resequenced 38.8 kb in this region, found 147 SNPs and genotyped 84 of them in the T1D families. We also tested 13 polymorphisms in the PAPD1 gene and in five other loci in 1,612 T1D patients and 1,828 controls from the UK. Overall, only the D10S193 microsatellite marker located 28 kb downstream of PAPD1 showed nominal evidence of association in both T1D families and in the case-control sample (P = 0.037 and 0.03, respectively). CONCLUSION: We conclude that polymorphisms in the CREM and SDF1 genes have no major effect on T1D. The weak T1D association that we detected in the association scan near the PAPD1 gene may be either false or due to a small genuine effect, and cannot explain linkage at the IDDM10 region.
41 schema:genre research_article
42 schema:inLanguage en
43 schema:isAccessibleForFree true
44 schema:isPartOf N306c01e0e1e44fb391ed563e32533fd0
45 Nd83c195413834ddc90888bd051c91235
46 sg:journal.1024251
47 schema:name Sequencing and association analysis of the type 1 diabetes – linked region on chromosome 10p12-q11
48 schema:pagination 24
49 schema:productId N37eaec29056f42a7bc1f03708dfb8f46
50 N39b32f3d257a481aba43023f7a3775c7
51 N8a2694886c58409eb02ef8a9cac3153f
52 Ne08546405d9349658e31694663ba229f
53 Nfd353a78081b459b982c5b58883b82d7
54 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033944287
55 https://doi.org/10.1186/1471-2156-8-24
56 schema:sdDatePublished 2019-04-10T19:07
57 schema:sdLicense https://scigraph.springernature.com/explorer/license/
58 schema:sdPublisher N41da4dc054574923b35e52b628b5b01f
59 schema:url http://link.springer.com/10.1186%2F1471-2156-8-24
60 sgo:license sg:explorer/license/
61 sgo:sdDataset articles
62 rdf:type schema:ScholarlyArticle
63 N0a34d17aef344a039faa09dd52b843b7 rdf:first sg:person.01257156522.04
64 rdf:rest Nb459e81adbfd44d3b47c764981bfd2cb
65 N16e7fa484b6444758f8cc454da587e62 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
66 schema:name Female
67 rdf:type schema:DefinedTerm
68 N1b3b47fa6fc3446f89d0c5e2ed52b0af rdf:first sg:person.01253117260.59
69 rdf:rest N5b1cd20060364faf9683a9c77f12db01
70 N203e5e8215174066918ce946dcdc0870 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
71 schema:name Genetic Markers
72 rdf:type schema:DefinedTerm
73 N218ea3b112304afb8d64b9fb123ab6b2 rdf:first sg:person.01201220352.85
74 rdf:rest N71efd63574bf40e08e178264d23b688a
75 N27838ca6cf6f4ad4b99f5582c5eda160 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name Diabetes Mellitus, Type 1
77 rdf:type schema:DefinedTerm
78 N2f04ddd4e1554bf0962c64eba873d0d3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Male
80 rdf:type schema:DefinedTerm
81 N30431827b45d48df9f84d9f046ba3018 rdf:first sg:person.01211715603.68
82 rdf:rest Nef43d697068b4ac99bda40f5a13764c3
83 N306c01e0e1e44fb391ed563e32533fd0 schema:volumeNumber 8
84 rdf:type schema:PublicationVolume
85 N317ff3fc41974788a6b5903c4a520379 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Case-Control Studies
87 rdf:type schema:DefinedTerm
88 N36d057d10ed74234962895bd0ae0bfd4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name DNA Primers
90 rdf:type schema:DefinedTerm
91 N37eaec29056f42a7bc1f03708dfb8f46 schema:name readcube_id
92 schema:value a1b38cb01fa5162b0cf12619778a692c6f1824d88cd25ae3fa3998397630dafb
93 rdf:type schema:PropertyValue
94 N39b32f3d257a481aba43023f7a3775c7 schema:name doi
95 schema:value 10.1186/1471-2156-8-24
96 rdf:type schema:PropertyValue
97 N41da4dc054574923b35e52b628b5b01f schema:name Springer Nature - SN SciGraph project
98 rdf:type schema:Organization
99 N42821627b13d4806a4ef48c67c664093 rdf:first sg:person.01334150044.66
100 rdf:rest N5885191f7e684e38907059dd841f5a97
101 N5331da13868f463aaa4feb3e3b0c65cf rdf:first sg:person.0723723076.31
102 rdf:rest N9e1ccf07f3604e868cf8443c633e31f3
103 N5885191f7e684e38907059dd841f5a97 rdf:first sg:person.01164450361.32
104 rdf:rest Ne9ee185b709d48ea969dae91fee9adb6
105 N589333cddb6b4458a668d0c9d937b87c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Genotype
107 rdf:type schema:DefinedTerm
108 N596172017dd3459b8ec5fd7e6b176b1f rdf:first sg:person.014562310447.09
109 rdf:rest N5331da13868f463aaa4feb3e3b0c65cf
110 N5b1cd20060364faf9683a9c77f12db01 rdf:first sg:person.01371545164.62
111 rdf:rest N30431827b45d48df9f84d9f046ba3018
112 N6afeaf8346a24f3da7a99283102b480b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Physical Chromosome Mapping
114 rdf:type schema:DefinedTerm
115 N71efd63574bf40e08e178264d23b688a rdf:first sg:person.01014654220.54
116 rdf:rest N87d0273509764ed38e379636cd68d3dd
117 N7c5343e122864d21b56d3b4bb16309c9 rdf:first sg:person.01115537320.20
118 rdf:rest N1b3b47fa6fc3446f89d0c5e2ed52b0af
119 N7f8e93d3233d40ddaa96cc278f7e5a55 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Chromosomes, Human, Pair 10
121 rdf:type schema:DefinedTerm
122 N8040b6946f09483b80c287decbf8f046 rdf:first sg:person.011013226044.60
123 rdf:rest N596172017dd3459b8ec5fd7e6b176b1f
124 N837069bff63b4db7beddd14ab9f3c45d rdf:first sg:person.01263743343.47
125 rdf:rest N218ea3b112304afb8d64b9fb123ab6b2
126 N87d0273509764ed38e379636cd68d3dd rdf:first sg:person.0616123560.17
127 rdf:rest Nf7faddd90f7949e9bd145b9163b2032f
128 N8a2694886c58409eb02ef8a9cac3153f schema:name nlm_unique_id
129 schema:value 100966978
130 rdf:type schema:PropertyValue
131 N8d674923fa0b48eaa684634e03292691 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Polymorphism, Single Nucleotide
133 rdf:type schema:DefinedTerm
134 N9e1ccf07f3604e868cf8443c633e31f3 rdf:first sg:person.01134314703.76
135 rdf:rest rdf:nil
136 Na78ebece12654966a6e2676e19b7afb9 rdf:first sg:person.01007752726.79
137 rdf:rest N0a34d17aef344a039faa09dd52b843b7
138 Na8f9ed19ef324df6acd66706eaa19cde schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Humans
140 rdf:type schema:DefinedTerm
141 Nb459e81adbfd44d3b47c764981bfd2cb rdf:first sg:person.0633331440.36
142 rdf:rest N7c5343e122864d21b56d3b4bb16309c9
143 Nb64c49d29eb3439cb3afcf6061310237 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Gene Frequency
145 rdf:type schema:DefinedTerm
146 Nbda150f06b514c57ac4ffad6b43d8b80 rdf:first sg:person.0576262171.71
147 rdf:rest Na78ebece12654966a6e2676e19b7afb9
148 Nd83c195413834ddc90888bd051c91235 schema:issueNumber 1
149 rdf:type schema:PublicationIssue
150 Ndebadcec257748b0a4b5221e21a1c7ea rdf:first sg:person.01147514743.31
151 rdf:rest N837069bff63b4db7beddd14ab9f3c45d
152 Ne08546405d9349658e31694663ba229f schema:name pubmed_id
153 schema:value 17509149
154 rdf:type schema:PropertyValue
155 Ne9ee185b709d48ea969dae91fee9adb6 rdf:first sg:person.01247333552.50
156 rdf:rest Ndebadcec257748b0a4b5221e21a1c7ea
157 Nebb7dc39bbd448e1a15ef1880daed7a9 rdf:first sg:person.0633344577.46
158 rdf:rest Nbda150f06b514c57ac4ffad6b43d8b80
159 Nef43d697068b4ac99bda40f5a13764c3 rdf:first sg:person.01236476426.25
160 rdf:rest N8040b6946f09483b80c287decbf8f046
161 Nf7faddd90f7949e9bd145b9163b2032f rdf:first sg:person.01123647500.83
162 rdf:rest Nebb7dc39bbd448e1a15ef1880daed7a9
163 Nfd353a78081b459b982c5b58883b82d7 schema:name dimensions_id
164 schema:value pub.1033944287
165 rdf:type schema:PropertyValue
166 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
167 schema:name Biological Sciences
168 rdf:type schema:DefinedTerm
169 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
170 schema:name Genetics
171 rdf:type schema:DefinedTerm
172 sg:grant.2786745 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2156-8-24
173 rdf:type schema:MonetaryGrant
174 sg:grant.3635287 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2156-8-24
175 rdf:type schema:MonetaryGrant
176 sg:journal.1024251 schema:issn 1471-2156
177 schema:name BMC Genetics
178 rdf:type schema:Periodical
179 sg:person.01007752726.79 schema:affiliation https://www.grid.ac/institutes/grid.5335.0
180 schema:familyName Nutland
181 schema:givenName Sarah
182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007752726.79
183 rdf:type schema:Person
184 sg:person.01014654220.54 schema:affiliation https://www.grid.ac/institutes/grid.5335.0
185 schema:familyName Masters
186 schema:givenName Jennifer
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014654220.54
188 rdf:type schema:Person
189 sg:person.011013226044.60 schema:affiliation https://www.grid.ac/institutes/grid.10306.34
190 schema:familyName Deloukas
191 schema:givenName Panagiotis
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011013226044.60
193 rdf:type schema:Person
194 sg:person.01115537320.20 schema:affiliation https://www.grid.ac/institutes/grid.5335.0
195 schema:familyName Twells
196 schema:givenName Rebecca
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115537320.20
198 rdf:type schema:Person
199 sg:person.01123647500.83 schema:affiliation https://www.grid.ac/institutes/grid.5335.0
200 schema:familyName Lam
201 schema:givenName Alex
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123647500.83
203 rdf:type schema:Person
204 sg:person.01134314703.76 schema:affiliation https://www.grid.ac/institutes/grid.5335.0
205 schema:familyName Todd
206 schema:givenName John A
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134314703.76
208 rdf:type schema:Person
209 sg:person.01147514743.31 schema:affiliation https://www.grid.ac/institutes/grid.5335.0
210 schema:familyName Bailey
211 schema:givenName Rebecca
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147514743.31
213 rdf:type schema:Person
214 sg:person.01164450361.32 schema:affiliation https://www.grid.ac/institutes/grid.5335.0
215 schema:familyName Smink
216 schema:givenName Luc J
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164450361.32
218 rdf:type schema:Person
219 sg:person.01201220352.85 schema:affiliation https://www.grid.ac/institutes/grid.5335.0
220 schema:familyName Payne
221 schema:givenName Felicity
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201220352.85
223 rdf:type schema:Person
224 sg:person.01211715603.68 schema:affiliation https://www.grid.ac/institutes/grid.10306.34
225 schema:familyName French
226 schema:givenName Lisa
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211715603.68
228 rdf:type schema:Person
229 sg:person.01236476426.25 schema:affiliation https://www.grid.ac/institutes/grid.10306.34
230 schema:familyName Chen
231 schema:givenName Yuan
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01236476426.25
233 rdf:type schema:Person
234 sg:person.01247333552.50 schema:affiliation https://www.grid.ac/institutes/grid.5335.0
235 schema:familyName Smyth
236 schema:givenName Deborah
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247333552.50
238 rdf:type schema:Person
239 sg:person.01253117260.59 schema:affiliation https://www.grid.ac/institutes/grid.5335.0
240 schema:familyName Barratt
241 schema:givenName Bryan J
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253117260.59
243 rdf:type schema:Person
244 sg:person.01257156522.04 schema:affiliation https://www.grid.ac/institutes/grid.5335.0
245 schema:familyName Walker
246 schema:givenName Neil M
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257156522.04
248 rdf:type schema:Person
249 sg:person.01263743343.47 schema:affiliation https://www.grid.ac/institutes/grid.5335.0
250 schema:familyName Lowe
251 schema:givenName Christopher E
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263743343.47
253 rdf:type schema:Person
254 sg:person.01334150044.66 schema:affiliation https://www.grid.ac/institutes/grid.5335.0
255 schema:familyName Nejentsev
256 schema:givenName Sergey
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334150044.66
258 rdf:type schema:Person
259 sg:person.01371545164.62 schema:affiliation https://www.grid.ac/institutes/grid.10306.34
260 schema:familyName Wright
261 schema:givenName Charmain
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371545164.62
263 rdf:type schema:Person
264 sg:person.014562310447.09 schema:affiliation https://www.grid.ac/institutes/grid.10306.34
265 schema:familyName Rogers
266 schema:givenName Jane
267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014562310447.09
268 rdf:type schema:Person
269 sg:person.0576262171.71 schema:affiliation https://www.grid.ac/institutes/grid.5335.0
270 schema:familyName Stevens
271 schema:givenName Helen
272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576262171.71
273 rdf:type schema:Person
274 sg:person.0616123560.17 schema:affiliation https://www.grid.ac/institutes/grid.5335.0
275 schema:familyName Godfrey
276 schema:givenName Lisa
277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616123560.17
278 rdf:type schema:Person
279 sg:person.0633331440.36 schema:affiliation https://www.grid.ac/institutes/grid.5335.0
280 schema:familyName Smith
281 schema:givenName Anne
282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0633331440.36
283 rdf:type schema:Person
284 sg:person.0633344577.46 schema:affiliation https://www.grid.ac/institutes/grid.5335.0
285 schema:familyName Burren
286 schema:givenName Oliver
287 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0633344577.46
288 rdf:type schema:Person
289 sg:person.0723723076.31 schema:affiliation https://www.grid.ac/institutes/grid.10306.34
290 schema:familyName Dunham
291 schema:givenName Ian
292 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723723076.31
293 rdf:type schema:Person
294 sg:pub.10.1007/978-1-4020-6754-9_4160 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018253065
295 https://doi.org/10.1007/978-1-4020-6754-9_4160
296 rdf:type schema:CreativeWork
297 sg:pub.10.1038/35057062 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042854081
298 https://doi.org/10.1038/35057062
299 rdf:type schema:CreativeWork
300 sg:pub.10.1038/35057149 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046153445
301 https://doi.org/10.1038/35057149
302 rdf:type schema:CreativeWork
303 sg:pub.10.1038/991 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022325746
304 https://doi.org/10.1038/991
305 rdf:type schema:CreativeWork
306 sg:pub.10.1038/nature02462 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002255204
307 https://doi.org/10.1038/nature02462
308 rdf:type schema:CreativeWork
309 sg:pub.10.1038/ng1001-233 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017573512
310 https://doi.org/10.1038/ng1001-233
311 rdf:type schema:CreativeWork
312 https://app.dimensions.ai/details/publication/pub.1074544758 schema:CreativeWork
313 https://doi.org/10.1002/9780471650126.dob0560.pub2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090239289
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1002/ajmg.10737 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024783554
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1002/gepi.20032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025657577
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1016/s0198-8859(03)00176-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041125700
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1016/s1074-7613(01)00202-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034094347
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1086/429843 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058716351
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1093/hmg/6.7.1011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046837527
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1093/ije/dyi183 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041266836
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1101/gr.194201 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008144266
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1159/000073729 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014435426
332 rdf:type schema:CreativeWork
333 https://doi.org/10.2337/diabetes.50.5.1211 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006430869
334 rdf:type schema:CreativeWork
335 https://doi.org/10.2337/diabetes.51.9.2866 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014786781
336 rdf:type schema:CreativeWork
337 https://doi.org/10.2337/diabetes.54.10.2995 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010242138
338 rdf:type schema:CreativeWork
339 https://doi.org/10.4049/jimmunol.166.6.4216 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074780194
340 rdf:type schema:CreativeWork
341 https://doi.org/10.4049/jimmunol.169.8.4147 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075172299
342 rdf:type schema:CreativeWork
343 https://www.grid.ac/institutes/grid.10306.34 schema:alternateName Wellcome Sanger Institute
344 schema:name The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
345 rdf:type schema:Organization
346 https://www.grid.ac/institutes/grid.5335.0 schema:alternateName University of Cambridge
347 schema:name Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK
348 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...