Hepatic glucokinase promoter polymorphism is associated with hepatic insulin resistance in Asian Indians. View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2000-12

AUTHORS

Ken C Chiu, Lee-Ming Chuang, Carol Yoon, Mohammad F Saad

ABSTRACT

BACKGROUND: The role of glucokinase (GCK) in the pathogenesis of maturity-onset diabetes of the young is well established. However, its role in the common form of type 2 diabetes is far from convincing. We investigated the role of the G-to-A polymorphism in the hepatic GCK promoter on insulin sensitivity and beta cell function in 63 normotensive Asian Indians with normal glucose tolerance. As proposed by Matsuda and DeFronzo, hepatic insulin sensitivity (ISIH) and total body insulin sensitivity (ISIM) were estimated from the oral glucose tolerance test. Beta cell function was estimated using %B from the Homeostasis Model Assessment and insulingenic index (dI/dG). RESULT: We identified 38 GG, 24 GA, and one AA subjects. The AA subject was pooled with the GA subjects during the analysis. No difference was noted in the demographic features between the two genotypic groups (GG vs. GA/AA). Compared to the GG group, the GA/AA group had a lower ISIH (p=0.002), a lower ISIM (p=0.009), a higher %B (p=0.014), and a higher dI/dG (p=0.030). Multivariate analysis revealed that this polymorphism is an independent determinant for ISIH (p=0.019) and along with age, waist-hip ratio, gender, and diastolic blood pressure accounted for 51.5% of the variation of ISIH. However, this polymorphism was a weak, but independent determinant for ISIM (p=0.089) and %B (p=0.083). Furthermore, it had no independent effect on dI/dG (p=0.135). CONCLUSIONS: These data suggest that the G-to-A polymorphism in the hepatic GCK promoter is associated with hepatic insulin resistance in Asian Indians. More... »

PAGES

2

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1471-2156-1-2

DOI

http://dx.doi.org/10.1186/1471-2156-1-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022424722

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11112984


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Asian Continental Ancestry Group", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diabetes Mellitus, Type 2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glucokinase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glucose Intolerance", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "India", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Insulin Resistance", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Islets of Langerhans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymorphism, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Promoter Regions, Genetic", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "National Taiwan University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412094.a", 
          "name": [
            "Division of Endocrinology, Diabetes and Hypertension (KCC, CY, MFS), Department of Medicine, University of California, Los Angeles, School of Medicine, Los Angeles, California, USA; Department of Internal Medicine and Graduate Institute of Clinical Medicine (LMC), National Taiwan University Hospital, Taipei, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chiu", 
        "givenName": "Ken C", 
        "id": "sg:person.0734113146.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734113146.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Taiwan University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412094.a", 
          "name": [
            "Division of Endocrinology, Diabetes and Hypertension (KCC, CY, MFS), Department of Medicine, University of California, Los Angeles, School of Medicine, Los Angeles, California, USA; Department of Internal Medicine and Graduate Institute of Clinical Medicine (LMC), National Taiwan University Hospital, Taipei, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chuang", 
        "givenName": "Lee-Ming", 
        "id": "sg:person.0624613167.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624613167.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Taiwan University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412094.a", 
          "name": [
            "Division of Endocrinology, Diabetes and Hypertension (KCC, CY, MFS), Department of Medicine, University of California, Los Angeles, School of Medicine, Los Angeles, California, USA; Department of Internal Medicine and Graduate Institute of Clinical Medicine (LMC), National Taiwan University Hospital, Taipei, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yoon", 
        "givenName": "Carol", 
        "id": "sg:person.0751014327.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751014327.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Taiwan University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412094.a", 
          "name": [
            "Division of Endocrinology, Diabetes and Hypertension (KCC, CY, MFS), Department of Medicine, University of California, Los Angeles, School of Medicine, Los Angeles, California, USA; Department of Internal Medicine and Graduate Institute of Clinical Medicine (LMC), National Taiwan University Hospital, Taipei, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Saad", 
        "givenName": "Mohammad F", 
        "id": "sg:person.07626016542.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07626016542.23"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1056/nejm198708063170605", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004789483"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.272.36.22570", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019509214"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.271.46.29113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025178989"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00428785", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025956361", 
          "https://doi.org/10.1007/bf00428785"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00428785", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025956361", 
          "https://doi.org/10.1007/bf00428785"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.274.1.305", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027059198"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.86.13.4838", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031040271"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.91.19.9151", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032436197"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0140-6736(92)91958-b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035171507"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0140-6736(92)91958-b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035171507"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199303113281005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037407303"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00400230", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043076797", 
          "https://doi.org/10.1007/bf00400230"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00400230", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043076797", 
          "https://doi.org/10.1007/bf00400230"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00400230", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043076797", 
          "https://doi.org/10.1007/bf00400230"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-2007-979899", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057509287"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.2166335", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062525138"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/mend.6.7.1354840", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064333068"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diab.39.6.647", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070736113"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diab.41.7.843", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070736845"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diab.42.4.579", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070737049"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diab.46.1.11", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070737983"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.39.6.647", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070741846"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diacare.13.6.610", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070745173"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diacare.21.12.2191", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070748075"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diacare.22.9.1462", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070748909"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079013212", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2000-12", 
    "datePublishedReg": "2000-12-01", 
    "description": "BACKGROUND: The role of glucokinase (GCK) in the pathogenesis of maturity-onset diabetes of the young is well established. However, its role in the common form of type 2 diabetes is far from convincing. We investigated the role of the G-to-A polymorphism in the hepatic GCK promoter on insulin sensitivity and beta cell function in 63 normotensive Asian Indians with normal glucose tolerance. As proposed by Matsuda and DeFronzo, hepatic insulin sensitivity (ISIH) and total body insulin sensitivity (ISIM) were estimated from the oral glucose tolerance test. Beta cell function was estimated using %B from the Homeostasis Model Assessment and insulingenic index (dI/dG).\nRESULT: We identified 38 GG, 24 GA, and one AA subjects. The AA subject was pooled with the GA subjects during the analysis. No difference was noted in the demographic features between the two genotypic groups (GG vs. GA/AA). Compared to the GG group, the GA/AA group had a lower ISIH (p=0.002), a lower ISIM (p=0.009), a higher %B (p=0.014), and a higher dI/dG (p=0.030). Multivariate analysis revealed that this polymorphism is an independent determinant for ISIH (p=0.019) and along with age, waist-hip ratio, gender, and diastolic blood pressure accounted for 51.5% of the variation of ISIH. However, this polymorphism was a weak, but independent determinant for ISIM (p=0.089) and %B (p=0.083). Furthermore, it had no independent effect on dI/dG (p=0.135).\nCONCLUSIONS: These data suggest that the G-to-A polymorphism in the hepatic GCK promoter is associated with hepatic insulin resistance in Asian Indians.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/1471-2156-1-2", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2495857", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1024251", 
        "issn": [
          "1471-2156"
        ], 
        "name": "BMC Genetics", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "1"
      }
    ], 
    "name": "Hepatic glucokinase promoter polymorphism is associated with hepatic insulin resistance in Asian Indians.", 
    "pagination": "2", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "6ad5eff7d71e1dcaea93854e1d598ffa58a08be78e649152cca5815e28d3dbc7"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "11112984"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100966978"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1471-2156-1-2"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1022424722"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1471-2156-1-2", 
      "https://app.dimensions.ai/details/publication/pub.1022424722"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T01:58", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8700_00000505.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2F1471-2156-1-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1471-2156-1-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1471-2156-1-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1471-2156-1-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1471-2156-1-2'


 

This table displays all metadata directly associated to this object as RDF triples.

222 TRIPLES      21 PREDICATES      67 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1471-2156-1-2 schema:about N028531d4b74946daa41f08f949be061e
2 N296f9eda9f9f42b78701b3baf5fe5986
3 N50b815f958c84eaf8edb05745a56c357
4 N5e70ffa6f97241b3a7679d6a95fd8b6c
5 N5ff489baa1904ed691a7a5ac6f5744a2
6 N6b325870e1fc478191db913b9d975602
7 N761f675fdb20477591b781b583cf9616
8 N77863975af614809b0b0ea7757a27017
9 N8b6a101e21be45e28085f114b6457855
10 N9368237c1c7c479f8c34576c1ef06c16
11 N9385ce1255de4f8c9334748658332df1
12 Nc1131fea653840978d6ebb770e349aa5
13 Nda78302919164c208944fff9822b35fb
14 Nea533ffe9e054427b3ea255bc93c5c60
15 Nead42746af444e1bab03b631009f98eb
16 Nf4df7b50442b4b72b3965c65b894ee90
17 anzsrc-for:11
18 anzsrc-for:1103
19 schema:author N85dc858581df4f65b3a184a85f07a873
20 schema:citation sg:pub.10.1007/bf00400230
21 sg:pub.10.1007/bf00428785
22 https://app.dimensions.ai/details/publication/pub.1079013212
23 https://doi.org/10.1016/0140-6736(92)91958-b
24 https://doi.org/10.1055/s-2007-979899
25 https://doi.org/10.1056/nejm198708063170605
26 https://doi.org/10.1056/nejm199303113281005
27 https://doi.org/10.1073/pnas.86.13.4838
28 https://doi.org/10.1073/pnas.91.19.9151
29 https://doi.org/10.1074/jbc.271.46.29113
30 https://doi.org/10.1074/jbc.272.36.22570
31 https://doi.org/10.1074/jbc.274.1.305
32 https://doi.org/10.1126/science.2166335
33 https://doi.org/10.1210/mend.6.7.1354840
34 https://doi.org/10.2337/diab.39.6.647
35 https://doi.org/10.2337/diab.41.7.843
36 https://doi.org/10.2337/diab.42.4.579
37 https://doi.org/10.2337/diab.46.1.11
38 https://doi.org/10.2337/diabetes.39.6.647
39 https://doi.org/10.2337/diacare.13.6.610
40 https://doi.org/10.2337/diacare.21.12.2191
41 https://doi.org/10.2337/diacare.22.9.1462
42 schema:datePublished 2000-12
43 schema:datePublishedReg 2000-12-01
44 schema:description BACKGROUND: The role of glucokinase (GCK) in the pathogenesis of maturity-onset diabetes of the young is well established. However, its role in the common form of type 2 diabetes is far from convincing. We investigated the role of the G-to-A polymorphism in the hepatic GCK promoter on insulin sensitivity and beta cell function in 63 normotensive Asian Indians with normal glucose tolerance. As proposed by Matsuda and DeFronzo, hepatic insulin sensitivity (ISIH) and total body insulin sensitivity (ISIM) were estimated from the oral glucose tolerance test. Beta cell function was estimated using %B from the Homeostasis Model Assessment and insulingenic index (dI/dG). RESULT: We identified 38 GG, 24 GA, and one AA subjects. The AA subject was pooled with the GA subjects during the analysis. No difference was noted in the demographic features between the two genotypic groups (GG vs. GA/AA). Compared to the GG group, the GA/AA group had a lower ISIH (p=0.002), a lower ISIM (p=0.009), a higher %B (p=0.014), and a higher dI/dG (p=0.030). Multivariate analysis revealed that this polymorphism is an independent determinant for ISIH (p=0.019) and along with age, waist-hip ratio, gender, and diastolic blood pressure accounted for 51.5% of the variation of ISIH. However, this polymorphism was a weak, but independent determinant for ISIM (p=0.089) and %B (p=0.083). Furthermore, it had no independent effect on dI/dG (p=0.135). CONCLUSIONS: These data suggest that the G-to-A polymorphism in the hepatic GCK promoter is associated with hepatic insulin resistance in Asian Indians.
45 schema:genre research_article
46 schema:inLanguage en
47 schema:isAccessibleForFree true
48 schema:isPartOf N09d027e1a945445fa0c13464809ab86d
49 Ne561abe81ea84a3aac586ed43df603e2
50 sg:journal.1024251
51 schema:name Hepatic glucokinase promoter polymorphism is associated with hepatic insulin resistance in Asian Indians.
52 schema:pagination 2
53 schema:productId N0cece061acfa4b53bbaae406e2aa94e2
54 N204876c5710f4e24a4eef86a46cde1f5
55 N21dc425fc0904f79b005a05a088a58f4
56 N23db30a0da9a4435917f1faaa2802e13
57 Nb8bcefa5e52f4a0b92ee033d8644b75e
58 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022424722
59 https://doi.org/10.1186/1471-2156-1-2
60 schema:sdDatePublished 2019-04-11T01:58
61 schema:sdLicense https://scigraph.springernature.com/explorer/license/
62 schema:sdPublisher Nedee72a09284417f9edb295eb12de826
63 schema:url http://link.springer.com/10.1186%2F1471-2156-1-2
64 sgo:license sg:explorer/license/
65 sgo:sdDataset articles
66 rdf:type schema:ScholarlyArticle
67 N028531d4b74946daa41f08f949be061e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
68 schema:name India
69 rdf:type schema:DefinedTerm
70 N09d027e1a945445fa0c13464809ab86d schema:issueNumber 1
71 rdf:type schema:PublicationIssue
72 N0cece061acfa4b53bbaae406e2aa94e2 schema:name doi
73 schema:value 10.1186/1471-2156-1-2
74 rdf:type schema:PropertyValue
75 N1b51d56358374a15818c3192cc6f1838 rdf:first sg:person.0624613167.94
76 rdf:rest N4460547968174e7aaec1e2bd2dec2c5a
77 N204876c5710f4e24a4eef86a46cde1f5 schema:name nlm_unique_id
78 schema:value 100966978
79 rdf:type schema:PropertyValue
80 N21dc425fc0904f79b005a05a088a58f4 schema:name readcube_id
81 schema:value 6ad5eff7d71e1dcaea93854e1d598ffa58a08be78e649152cca5815e28d3dbc7
82 rdf:type schema:PropertyValue
83 N23db30a0da9a4435917f1faaa2802e13 schema:name pubmed_id
84 schema:value 11112984
85 rdf:type schema:PropertyValue
86 N296f9eda9f9f42b78701b3baf5fe5986 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Adult
88 rdf:type schema:DefinedTerm
89 N4460547968174e7aaec1e2bd2dec2c5a rdf:first sg:person.0751014327.19
90 rdf:rest Nd05f12d53d3342939817b4990127e312
91 N50b815f958c84eaf8edb05745a56c357 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Polymorphism, Genetic
93 rdf:type schema:DefinedTerm
94 N5e70ffa6f97241b3a7679d6a95fd8b6c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Diabetes Mellitus, Type 2
96 rdf:type schema:DefinedTerm
97 N5ff489baa1904ed691a7a5ac6f5744a2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Islets of Langerhans
99 rdf:type schema:DefinedTerm
100 N6b325870e1fc478191db913b9d975602 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Aged
102 rdf:type schema:DefinedTerm
103 N761f675fdb20477591b781b583cf9616 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Male
105 rdf:type schema:DefinedTerm
106 N77863975af614809b0b0ea7757a27017 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Female
108 rdf:type schema:DefinedTerm
109 N85dc858581df4f65b3a184a85f07a873 rdf:first sg:person.0734113146.22
110 rdf:rest N1b51d56358374a15818c3192cc6f1838
111 N8b6a101e21be45e28085f114b6457855 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Middle Aged
113 rdf:type schema:DefinedTerm
114 N9368237c1c7c479f8c34576c1ef06c16 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Glucose Intolerance
116 rdf:type schema:DefinedTerm
117 N9385ce1255de4f8c9334748658332df1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Promoter Regions, Genetic
119 rdf:type schema:DefinedTerm
120 Nb8bcefa5e52f4a0b92ee033d8644b75e schema:name dimensions_id
121 schema:value pub.1022424722
122 rdf:type schema:PropertyValue
123 Nc1131fea653840978d6ebb770e349aa5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Liver
125 rdf:type schema:DefinedTerm
126 Nd05f12d53d3342939817b4990127e312 rdf:first sg:person.07626016542.23
127 rdf:rest rdf:nil
128 Nda78302919164c208944fff9822b35fb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Humans
130 rdf:type schema:DefinedTerm
131 Ne561abe81ea84a3aac586ed43df603e2 schema:volumeNumber 1
132 rdf:type schema:PublicationVolume
133 Nea533ffe9e054427b3ea255bc93c5c60 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Glucokinase
135 rdf:type schema:DefinedTerm
136 Nead42746af444e1bab03b631009f98eb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Insulin Resistance
138 rdf:type schema:DefinedTerm
139 Nedee72a09284417f9edb295eb12de826 schema:name Springer Nature - SN SciGraph project
140 rdf:type schema:Organization
141 Nf4df7b50442b4b72b3965c65b894ee90 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Asian Continental Ancestry Group
143 rdf:type schema:DefinedTerm
144 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
145 schema:name Medical and Health Sciences
146 rdf:type schema:DefinedTerm
147 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
148 schema:name Clinical Sciences
149 rdf:type schema:DefinedTerm
150 sg:grant.2495857 http://pending.schema.org/fundedItem sg:pub.10.1186/1471-2156-1-2
151 rdf:type schema:MonetaryGrant
152 sg:journal.1024251 schema:issn 1471-2156
153 schema:name BMC Genetics
154 rdf:type schema:Periodical
155 sg:person.0624613167.94 schema:affiliation https://www.grid.ac/institutes/grid.412094.a
156 schema:familyName Chuang
157 schema:givenName Lee-Ming
158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624613167.94
159 rdf:type schema:Person
160 sg:person.0734113146.22 schema:affiliation https://www.grid.ac/institutes/grid.412094.a
161 schema:familyName Chiu
162 schema:givenName Ken C
163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734113146.22
164 rdf:type schema:Person
165 sg:person.0751014327.19 schema:affiliation https://www.grid.ac/institutes/grid.412094.a
166 schema:familyName Yoon
167 schema:givenName Carol
168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751014327.19
169 rdf:type schema:Person
170 sg:person.07626016542.23 schema:affiliation https://www.grid.ac/institutes/grid.412094.a
171 schema:familyName Saad
172 schema:givenName Mohammad F
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07626016542.23
174 rdf:type schema:Person
175 sg:pub.10.1007/bf00400230 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043076797
176 https://doi.org/10.1007/bf00400230
177 rdf:type schema:CreativeWork
178 sg:pub.10.1007/bf00428785 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025956361
179 https://doi.org/10.1007/bf00428785
180 rdf:type schema:CreativeWork
181 https://app.dimensions.ai/details/publication/pub.1079013212 schema:CreativeWork
182 https://doi.org/10.1016/0140-6736(92)91958-b schema:sameAs https://app.dimensions.ai/details/publication/pub.1035171507
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1055/s-2007-979899 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057509287
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1056/nejm198708063170605 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004789483
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1056/nejm199303113281005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037407303
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1073/pnas.86.13.4838 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031040271
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1073/pnas.91.19.9151 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032436197
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1074/jbc.271.46.29113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025178989
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1074/jbc.272.36.22570 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019509214
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1074/jbc.274.1.305 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027059198
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1126/science.2166335 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062525138
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1210/mend.6.7.1354840 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064333068
203 rdf:type schema:CreativeWork
204 https://doi.org/10.2337/diab.39.6.647 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070736113
205 rdf:type schema:CreativeWork
206 https://doi.org/10.2337/diab.41.7.843 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070736845
207 rdf:type schema:CreativeWork
208 https://doi.org/10.2337/diab.42.4.579 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070737049
209 rdf:type schema:CreativeWork
210 https://doi.org/10.2337/diab.46.1.11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070737983
211 rdf:type schema:CreativeWork
212 https://doi.org/10.2337/diabetes.39.6.647 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070741846
213 rdf:type schema:CreativeWork
214 https://doi.org/10.2337/diacare.13.6.610 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070745173
215 rdf:type schema:CreativeWork
216 https://doi.org/10.2337/diacare.21.12.2191 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070748075
217 rdf:type schema:CreativeWork
218 https://doi.org/10.2337/diacare.22.9.1462 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070748909
219 rdf:type schema:CreativeWork
220 https://www.grid.ac/institutes/grid.412094.a schema:alternateName National Taiwan University Hospital
221 schema:name Division of Endocrinology, Diabetes and Hypertension (KCC, CY, MFS), Department of Medicine, University of California, Los Angeles, School of Medicine, Los Angeles, California, USA; Department of Internal Medicine and Graduate Institute of Clinical Medicine (LMC), National Taiwan University Hospital, Taipei, Taiwan
222 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...