Genome differentiation in a species pair of coregonine fishes: an extremely rapid speciation driven by stress-activated retrotransposons mediating extensive ribosomal ... View Full Text


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Article Info

DATE

2013-02-14

AUTHORS

Radka Symonová, Zuzana Majtánová, Alexandr Sember, Georg BO Staaks, Jörg Bohlen, Jörg Freyhof, Marie Rábová, Petr Ráb

ABSTRACT

BackgroundSympatric species pairs are particularly common in freshwater fishes associated with postglacial lakes in northern temperate environments. The nature of divergences between co-occurring sympatric species, factors contributing to reproductive isolation and modes of genome evolution is a much debated topic in evolutionary biology addressed by various experimental tools. To the best of our knowledge, nobody approached this field using molecular cytogenetics. We examined chromosomes and genomes of one postglacial species pair, sympatric European winter-spawning Coregonus albula and the local endemic dwarf-sized spring-spawning C. fontanae, both originating in Lake Stechlin. We have employed molecular cytogenetic tools to identify the genomic differences between the two species of the sympatric pair on the sub-chromosomal level of resolution.ResultsFluorescence in situ hybridization (FISH) experiments consistently revealed a distinct variation in the copy number of loci of the major ribosomal DNA (the 45S unit) between C. albula and C. fontanae genomes. In C. fontanae, up to 40 chromosomes were identified to bear a part of the major ribosomal DNA, while in C. albula only 8–10 chromosomes possessed these genes. To determine mechanisms how such extensive genome alternation might have arisen, a PCR screening for retrotransposons from genomic DNA of both species was performed. The amplified retrotransposon Rex1 was used as a probe for FISH mapping onto chromosomes of both species. These experiments showed a clear co-localization of the ribosomal DNA and the retrotransposon Rex1 in a pericentromeric region of one or two acrocentric chromosomes in both species.ConclusionWe demonstrated genomic consequences of a rapid ecological speciation on the level undetectable by neither sequence nor karyotype analysis. We provide indirect evidence that ribosomal DNA probably utilized the spreading mechanism of retrotransposons subsequently affecting recombination rates in both genomes, thus, leading to a rapid genome divergence. We attribute these extensive genome re-arrangements associated with speciation event to stress-induced retrotransposons (re)activation. Such causal interplay between genome differentiation, retrotransposons (re)activation and environmental conditions may become a topic to be explored in a broader genomic context in future evolutionary studies. More... »

PAGES

42

References to SciGraph publications

  • 2004-12-22. Genome evolution and biodiversity in teleost fish in HEREDITY
  • 2001-08. The role of selfish genetic elements in eukaryotic evolution in NATURE REVIEWS GENETICS
  • 1996-04. Creation of genomic methylation patterns in NATURE GENETICS
  • 2011-03-17. The struggle for life of the genome's selfish architects in BIOLOGY DIRECT
  • 1993-12. The nucleolus in BRAIN STRUCTURE AND FUNCTION
  • 1998-09. Chromosomal Localization and Heterochromatin Association of Ribosomal RNA Gene Loci and Silver-stained Nucleolar Organizer Regions in Salmonid Fishes in CHROMOSOME RESEARCH
  • 2005-08-12. Transcribed Tc1-like transposons in salmonid fish in BMC GENOMICS
  • 1981-03. Genetic differentiation in Coregonus albula (L.) (Salmonidae) populations in Finland in HEREDITAS
  • 2001-12-01. Ribosomal genes in Coregonid fishes (Coregonus lavaretus, C. albula and C. peled) (Salmonidae): single and multiple nucleolus organizer regions in HEREDITY
  • 2012. Multicolor 3D Fluorescence In Situ Hybridization for Imaging Interphase Chromosomes in THE NUCLEUS
  • 2007-11-16. Bursts and horizontal evolution of DNA transposons in the speciation of pseudotetraploid salmonids in BMC GENOMICS
  • 1964-12. NOMENCLATURE FOR CENTROMERIC POSITION ON CHROMOSOMES in HEREDITAS
  • 1994-02. Genome and stresses: Reactions against aggressions, behavior of transposable elements in GENETICA
  • 2008-02-25. Transposable elements as drivers of genomic and biological diversity in vertebrates in CHROMOSOME RESEARCH
  • 1945-05. L'évolution de la formule chromosomiale chez les Vertébrés in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 1992-01. Transposable elements and the evolution of genome organization in mammals in GENETICA
  • 2010-03-29. Genetic population structure of sympatric and allopatric populations of Baltic ciscoes (Coregonus albulacomplex, Teleostei, Coregonidae) in BMC ECOLOGY AND EVOLUTION
  • 1999-12. Species pairs of north temperate freshwater fishes: Evolution, taxonomy, and conservation in REVIEWS IN FISH BIOLOGY AND FISHERIES
  • 2010-09-06. Chromosome spreading of associated transposable elements and ribosomal DNA in the fish Erythrinus erythrinus. Implications for genome change and karyoevolution in fish in BMC ECOLOGY AND EVOLUTION
  • 1998-01-01. Selfish genetic elements and speciation in HEREDITY
  • 2001-01. Improved fish lymphocyte culture for chromosome preparation in GENETICA
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    URI

    http://scigraph.springernature.com/pub.10.1186/1471-2148-13-42

    DOI

    http://dx.doi.org/10.1186/1471-2148-13-42

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1006102002

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23410024


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    42 schema:description BackgroundSympatric species pairs are particularly common in freshwater fishes associated with postglacial lakes in northern temperate environments. The nature of divergences between co-occurring sympatric species, factors contributing to reproductive isolation and modes of genome evolution is a much debated topic in evolutionary biology addressed by various experimental tools. To the best of our knowledge, nobody approached this field using molecular cytogenetics. We examined chromosomes and genomes of one postglacial species pair, sympatric European winter-spawning Coregonus albula and the local endemic dwarf-sized spring-spawning C. fontanae, both originating in Lake Stechlin. We have employed molecular cytogenetic tools to identify the genomic differences between the two species of the sympatric pair on the sub-chromosomal level of resolution.ResultsFluorescence in situ hybridization (FISH) experiments consistently revealed a distinct variation in the copy number of loci of the major ribosomal DNA (the 45S unit) between C. albula and C. fontanae genomes. In C. fontanae, up to 40 chromosomes were identified to bear a part of the major ribosomal DNA, while in C. albula only 8–10 chromosomes possessed these genes. To determine mechanisms how such extensive genome alternation might have arisen, a PCR screening for retrotransposons from genomic DNA of both species was performed. The amplified retrotransposon Rex1 was used as a probe for FISH mapping onto chromosomes of both species. These experiments showed a clear co-localization of the ribosomal DNA and the retrotransposon Rex1 in a pericentromeric region of one or two acrocentric chromosomes in both species.ConclusionWe demonstrated genomic consequences of a rapid ecological speciation on the level undetectable by neither sequence nor karyotype analysis. We provide indirect evidence that ribosomal DNA probably utilized the spreading mechanism of retrotransposons subsequently affecting recombination rates in both genomes, thus, leading to a rapid genome divergence. We attribute these extensive genome re-arrangements associated with speciation event to stress-induced retrotransposons (re)activation. Such causal interplay between genome differentiation, retrotransposons (re)activation and environmental conditions may become a topic to be explored in a broader genomic context in future evolutionary studies.
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